Title:
DIAGNOSTIC OR RADIOTHERAPEUTIC COMPOSITION COMPRISING A HYDROGEN CONTAINING COMPOUND
Document Type and Number:
WIPO Patent Application WO1989001342
Kind Code:
A3
Abstract:
PCT No. PCT/NL88/00033 Sec. 371 Date Nov. 21, 1989 Sec. 102(e) Date Nov. 21, 1989 PCT Filed Jul. 8, 1988 PCT Pub. No. WO89/01342 PCT Pub. Date Feb. 23, 1989.The invention relates to a diagnostic or radiotherapeutic composition, comprising a hydrogen containing compound in addition to a pharmaceutically acceptable formulation means and optionally an inactive carrier and/or one or more auxiliary substances, wherein the hydrogen containing compound comprises at least one deuterium atom. The invention further relates to a compound to be used for said composition and to a kit for preparing a radio-diagnostic composition.
Inventors:
WENZEL MARTIN (DE)
Application Number:
PCT/NL1988/000033
Publication Date:
March 23, 1989
Filing Date:
July 08, 1988
Export Citation:
Assignee:
MALLINCKRODT INC (US)
MALLINCKRODT DIAGNOSTICA BV (US)
MALLINCKRODT DIAGNOSTICA BV (US)
International Classes:
A61K49/00; A61K49/04; A61K51/04; (IPC1-7): A61K49/00; A61K49/02; A61K49/04
Foreign References:
| FR2159411A1 | 1973-06-22 | |||
| US4223004A | 1980-09-16 | |||
| EP0199260A2 | 1986-10-29 | |||
| EP0123504A2 | 1984-10-31 |
Other References:
Chemical Abstracts, volume 97, no. 15, 11 October 1982, (Columbus, Ohio, US), M. Schneider et al.: "Labeling of acetylruthenocene with ruthenium-97, deuterium, or tritium", see page 741
IEEE Engineering in Medicine and Biology, volume 4, no. 3, September 1985, IEEE, (New York, US), J.C. Gore: "Physical factors in the design of contract agents for MRI", pages 39-42
Chemical Abstracts, volume 96, no. 25, 21 June 1982, (Columbus, Ohio, US), R. Matalon et al.: "The use of deuterated phanylalanine for the in vivo assay of phenylalanine hydroxylase activity in children", see page 292
Chemical Abstracts, volume 104, no. 1, 6 January 1986, (Columbus, Ohio, US), H.C. Curtius et al.: "Tetrahydrobiopterin deficiency, a heterogenous group of diseases. Studies of tetra-hydrobiopterin biosynthesis using deuterated pyridine nucleotides and GC-MS-SIM(1)", see page 377
Journal of Neurochemistry, volume 46, no. 2, 1986, Raven Press, (New York, US), L.E. Dyck et al.: "Effects of deuterium substitution on the catabolism of B-phenylethylamine: an in vivo study", pages 399-404
IEEE Engineering in Medicine and Biology, volume 4, no. 3, September 1985, IEEE, (New York, US), J.C. Gore: "Physical factors in the design of contract agents for MRI", pages 39-42
Chemical Abstracts, volume 96, no. 25, 21 June 1982, (Columbus, Ohio, US), R. Matalon et al.: "The use of deuterated phanylalanine for the in vivo assay of phenylalanine hydroxylase activity in children", see page 292
Chemical Abstracts, volume 104, no. 1, 6 January 1986, (Columbus, Ohio, US), H.C. Curtius et al.: "Tetrahydrobiopterin deficiency, a heterogenous group of diseases. Studies of tetra-hydrobiopterin biosynthesis using deuterated pyridine nucleotides and GC-MS-SIM(1)", see page 377
Journal of Neurochemistry, volume 46, no. 2, 1986, Raven Press, (New York, US), L.E. Dyck et al.: "Effects of deuterium substitution on the catabolism of B-phenylethylamine: an in vivo study", pages 399-404
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