DIAGNOSTIC REAGENT FOR NUCLEAR MAGNETIC RESONANCE IMAGINATION

WIPO Patent Application WO/2003/028769

A1

A diagnostic reagent for nuclear magnetic resonance imagination, characterized in that it is an aqueous solution being acceptable to an organism and containing, as an active component, a molecule having a hydrogen atom bonded directly with a quadrupole nucleus, wherein the aqueous solution exhibits a T2 relaxation degree of 0.1 s⁻¹atom%⁻¹ or more. The diagnostic reagent for nuclear magnetic resonance imagination has an enhanced T2 relaxation degree and exhibits a little effect on an organism even when administrated rapidly in a large amount, and thus can be used for obtaining stable information on the tissue perfusion in nuclear magnetic resonance imaging or nuclear magnetic resonance spectroscopy.

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OTSUKA AKIHIRO (JP)
NAKATANI AKIRA (JP)
IWAI KUMIKO (JP)

PCT/JP2002/009872

April 10, 2003

September 25, 2002

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NIHON MEDIPHYSICS CO LTD (JP)
OTSUKA AKIHIRO (JP)
NAKATANI AKIRA (JP)
IWAI KUMIKO (JP)

G01R33/28; A61B5/055; A61K49/00; A61K49/10; F16C13/00; G03G15/20; H05B3/00; H05B3/52; (IPC1-7): A61K49/06; A61B5/055

RONEN I. ET AL.: "Imaging of H2170 distribution in the brain of a live rat by using proton-detected 170 MRI", PROC. NATL. ACAD. SCI. USA, vol. 95, no. 22, 1998, pages 12934 - 12939, XP002960758

Asamura, Kiyoshi (New Ohtemachi Bldg. 2-1, Ohtemachi 2-chom, Chiyoda-ku Tokyo, JP)

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