Title:
DIAGNOSTIC OF RHEUMATOID ARTHRITIS
Document Type and Number:
WIPO Patent Application WO/2019/009231
Kind Code:
A1
Abstract:
Provided are: a method for diagnosis of rheumatoid arthritis in a subject; a method for auxiliary diagnosis of rheumatoid arthritis; and a method for monitoring disease activity of rheumatoid arthritis and/or a therapeutic effect of a rheumatoid arthritis drug, each method being characterized by comprising detecting citrullination of an arginine residue in inter-α-trypsin inhibitor heavy chain (ITIH) 4 in a biological sample derived from the subject. Also provided are: a citrullinated protein, wherein, in a protein having the amino acid sequence represented by SEQ ID NO: 1 or 5, the 438-th arginine residue has been modified into a citrulline residue, or a fragment of said protein; an antibody capable of binding to the citrullinated protein; and a diagnostic of rheumatoid arthritis which comprises the antibody.
Inventors:
MATSUMOTO ISAO (JP)
SUMIDA TAKAYUKI (JP)
KAWAGUCHI HOSHIMI (JP)
SUMIDA TAKAYUKI (JP)
KAWAGUCHI HOSHIMI (JP)
Application Number:
PCT/JP2018/025020
Publication Date:
January 10, 2019
Filing Date:
July 02, 2018
Export Citation:
Assignee:
UNIV TSUKUBA (JP)
International Classes:
G01N33/68; C07K16/38; G01N27/62; G01N33/53
Domestic Patent References:
| WO2016183310A1 | 2016-11-17 |
Foreign References:
| JP2017507337A | 2017-03-16 | |||
| JP2017514915A | 2017-06-08 | |||
| JP2012103142A | 2012-05-31 |
Other References:
LIAO, C-C. ET AL.: "Comparative analysis of novel autoantibody isotypes against citrullinated-inter- alpha-trypsin inhibitor heavy chain 3 (ITIH3)542- 556peptide in serum from Taiwan ese females with rheumatoid arthritis, primary Sjogren's syndrome and secondary Sjogren's syndrome in rheumatoid arthritis", JOURNAL OF PROTEOMICS, vol. 141, 9 April 2016 (2016-04-09), pages 1 - 11, XP029539200
KAWAGUCHI, H. ET AL.: "Identification of novel biomarker as citrullinated inter-alpha-trypsin inhibitor heavy chain 4, specifically increased in sera with experimental and rheumatoid arthritis", ARTHRITIS RESEARCH & THERAPY, vol. 20, no. 66, 10 April 2018 (2018-04-10), pages 1 - 13, XP055564850, Retrieved from the Internet
KAWAGUCHI, H. ET AL.: "Identification of novel biomarker as citrullinated inter-alpha-trypsin inhibitor heavy chain 4, specifically increased in sera with experimental and rheumatoid arthritis", ARTHRITIS RESEARCH & THERAPY, vol. 20, no. 66, 10 April 2018 (2018-04-10), pages 1 - 13, XP055564850, Retrieved from the Internet
Attorney, Agent or Firm:
HIRAKI & ASSOCIATES (JP)
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