Title:
DIAGNOSTIC AND THERAPEUTIC METHODS FOR CANCER
Document Type and Number:
WIPO Patent Application WO/2017/214373
Kind Code:
A8
Abstract:
The present invention provides diagnostic and therapeutic methods for cancer. The invention provides methods of determining whether a patient having a cancer is likely to respond to treatment comprising an inhibitor of H3K27 methylation, methods of predicting responsiveness of a patient having a cancer to treatment comprising one or more inhibitors of H3K27 methylation, methods of selecting a therapy for a patient having a cancer, and methods of treating cancer based on expression levels of biomarkers of the invention (e.g., the expression level of SIV1ARCA2 or the occupancy level of H3K27 at a SMARCA2 promoter).
Inventors:
YAUCH ROBERT L (US)
YE XIAOFEN (US)
JANUARIO THOMAS E (US)
YE XIAOFEN (US)
JANUARIO THOMAS E (US)
Application Number:
PCT/US2017/036515
Publication Date:
March 01, 2018
Filing Date:
June 08, 2017
Export Citation:
Assignee:
GENENTECH INC (US)
HOFFMANN LA ROCHE (CH)
HOFFMANN LA ROCHE (CH)
International Classes:
C12Q1/68
Attorney, Agent or Firm:
ELBING, Karen, L. (US)
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