Title:
DIAGNOSTIC AND THERAPEUTIC USE OF A SULFOTRANSFERASE FOR NEURODEGENERATIVE DISEASES
Document Type and Number:
WIPO Patent Application WO2005030947
Kind Code:
A3
Abstract:
The present invention discloses the differential expression of a cytosolic sulfotransferase in specific brain regions of Alzheimer's disease patients. Based on this finding, this invention provides a method for diagnosing or prognosticating a neurodegenerative disease, in particular Alzheimer's disease, in a subject, or for determining whether a subject is at increased risk of developing such a disease. Furthermore, this invention provides therapeutic and prophylactic methods for treating or preventing Alzheimer's disease and related neurodegenerative disorders using a gene coding for SULT4A1. A method of screening for modulating agents of neurodegenerative diseases and recombinant animal models are also, disclosed.
Inventors:
VON DER KAMMER HEINZ (DE)
POHLNER JOHANNES (DE)
POHLNER JOHANNES (DE)
Application Number:
PCT/EP2004/052353
Publication Date:
June 23, 2005
Filing Date:
September 29, 2004
Export Citation:
Assignee:
EVOTEC NEUROSCIENCES GMBH (DE)
VON DER KAMMER HEINZ (DE)
POHLNER JOHANNES (DE)
VON DER KAMMER HEINZ (DE)
POHLNER JOHANNES (DE)
International Classes:
A01K67/027; A01K67/033; C12N9/10; C12N15/85; C12Q1/48; C12Q1/68; G01N33/68; (IPC1-7): C12Q1/68; A01K67/00; C12Q1/48
Domestic Patent References:
| WO2002018541A2 | 2002-03-07 | |||
| WO2000014251A2 | 2000-03-16 |
Other References:
FALANY C N ET AL: "Molecular cloning and expression of novel sulphotransferase-like cDNAs from human and rat brain", BIOCHEMICAL JOURNAL, THE BIOCHEMICAL SOCIETY, LONDON, GB, vol. 346, no. 3, 15 March 2000 (2000-03-15), pages 857 - 864, XP002275713, ISSN: 0264-6021
GLATT H ET AL: "Human cytosolic sulphotransferases: Genetics, characteristics, toxicological aspects", MUTATION RESEARCH, AMSTERDAM, NL, vol. 482, no. 1-2, 1 October 2001 (2001-10-01), pages 27 - 40, XP002275714, ISSN: 0027-5107
HAN X ET AL: "Substantial sulfatide deficiency and ceramide elevation in very early Alzheimer's disease", MEDLINE, 1 August 2002 (2002-08-01), XP002965337
KIM S-B ET AL: "Neurosteroids: Cerebrospinal fluid levels for Alzheimer's disease and vascular dementia diagnostics", JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, NEW YORK, NY, US, vol. 88, no. 11, November 2003 (2003-11-01), pages 5199 - 5206, XP009028705, ISSN: 0021-972X
JANUS C ET AL: "Transgenic mouse models of Alzheimer's disease", BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR BASIS OF DISEASE, AMSTERDAM, NL, vol. 1502, no. 1, 26 July 2000 (2000-07-26), pages 63 - 75, XP004276974, ISSN: 0925-4439
GLATT H ET AL: "Human cytosolic sulphotransferases: Genetics, characteristics, toxicological aspects", MUTATION RESEARCH, AMSTERDAM, NL, vol. 482, no. 1-2, 1 October 2001 (2001-10-01), pages 27 - 40, XP002275714, ISSN: 0027-5107
HAN X ET AL: "Substantial sulfatide deficiency and ceramide elevation in very early Alzheimer's disease", MEDLINE, 1 August 2002 (2002-08-01), XP002965337
KIM S-B ET AL: "Neurosteroids: Cerebrospinal fluid levels for Alzheimer's disease and vascular dementia diagnostics", JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, NEW YORK, NY, US, vol. 88, no. 11, November 2003 (2003-11-01), pages 5199 - 5206, XP009028705, ISSN: 0021-972X
JANUS C ET AL: "Transgenic mouse models of Alzheimer's disease", BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR BASIS OF DISEASE, AMSTERDAM, NL, vol. 1502, no. 1, 26 July 2000 (2000-07-26), pages 63 - 75, XP004276974, ISSN: 0925-4439
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