Title:
DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH HUMAN PHOSPHODIESTERASE 11A3 (PDE11A3)
Document Type and Number:
WIPO Patent Application WO2004042386
Kind Code:
A3
Abstract:
The invention provides a human PDE11A3 which is associated with the disorders of the peripheral and central nervous system (e.g. Alzheimer), cancer (e.g. lung tumor, breast tumor), gastroenterological diseases (e.g. liver cirrhosis), reproduction disorders and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of disorders of the peripheral and central nervous system, cancer, gastroenterological diseases, reproduction disorders and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of PDE11A3 as well as pharmaceutical compositions comprising such compounds.
Inventors:
GOLZ STEFAN (DE)
BRUEGGEMEIER ULF (DE)
GEERTS ANDREAS (DE)
BRUEGGEMEIER ULF (DE)
GEERTS ANDREAS (DE)
Application Number:
PCT/EP2003/011873
Publication Date:
July 15, 2004
Filing Date:
October 25, 2003
Export Citation:
Assignee:
BAYER HEALTHCARE AG (DE)
GOLZ STEFAN (DE)
BRUEGGEMEIER ULF (DE)
GEERTS ANDREAS (DE)
GOLZ STEFAN (DE)
BRUEGGEMEIER ULF (DE)
GEERTS ANDREAS (DE)
International Classes:
C12Q1/44; G01N33/574; G01N33/68; (IPC1-7): C12Q1/44; G01N33/574; G01N33/68
Domestic Patent References:
| WO2001066716A1 | 2001-09-13 | |||
| WO2001046436A1 | 2001-06-28 | |||
| WO2002031111A2 | 2002-04-18 |
Foreign References:
| EP1085089A2 | 2001-03-21 |
Other References:
PEREZ-TORRES S ET AL: "Cellular expression of cAMP phosphodiesterase PDE4A, PDE4B and PDE4D mRNAs in Alzheimer's disease brains", SOCIETY FOR NEUROSCIENCE ABSTRACTS, vol. 27, no. 1, 2001, 31st Annual Meeting of the Society for Neuroscience;San Diego, California, USA; November 10-15, 2001, pages 1134, XP002271232, ISSN: 0190-5295
MORITA Y ET AL: "Distribution of neurons expressing the PDE10A mRNA in the rat brain", SOCIETY FOR NEUROSCIENCE ABSTRACTS, vol. 27, no. 1, 2001, 31st Annual Meeting of the Society for Neuroscience;San Diego, California, USA; November 10-15, 2001, pages 105, XP001176686, ISSN: 0190-5295
MORITA Y ET AL: "Distribution of neurons expressing the PDE10A mRNA in the rat brain", SOCIETY FOR NEUROSCIENCE ABSTRACTS, vol. 27, no. 1, 2001, 31st Annual Meeting of the Society for Neuroscience;San Diego, California, USA; November 10-15, 2001, pages 105, XP001176686, ISSN: 0190-5295
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