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Title:
DIAMINO HETEROCYCLIC CARBOXAMIDE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2010/128659
Kind Code:
A1
Abstract:
Disclosed are a compound represented by formula (I) or a salt thereof; a kinase inhibitor for EML4-ALK fusion protein containing the compound; and use of the compound for the treatment of cancers. (In formula (I), -X- represents a group represented by formula (II) or formula (III); A represents –H, a halogen atom, a lower alkyl group, a cycloalkyl group or a lower alkenyl group; R1 represents a substituted phenyl group, a (substituted) heterocyclic group or a (substituted) bicyclic fused ring; R2 represents a (substituted) cycloalkyl group, a (substituted) non-aromatic heterocyclic group, a (substituted) phenyl group, a (substituted) pyridyl group or a (substituted) lower alkyl group; and R3 represents –H or a lower alkyl group; or alternatively R2 and R3 may combine together to form a cyclic amino group.)

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Inventors:
SHIMADA ITSURO (JP)
KUROSAWA KAZUO (JP)
MATSUYA TAKAHIRO (JP)
IIKUBO KAZUHIKO (JP)
KONDOH YUTAKA (JP)
KAMIKAWA AKIO (JP)
TOMIYAMA HIROSHI (JP)
IWAI YOSHINORI (JP)
Application Number:
PCT/JP2010/057751
Publication Date:
November 11, 2010
Filing Date:
May 06, 2010
Export Citation:
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Assignee:
ASTELLAS PHARMA INC (JP)
KOTOBUKI PHARMACEUTICAL CO LTD (JP)
SHIMADA ITSURO (JP)
KUROSAWA KAZUO (JP)
MATSUYA TAKAHIRO (JP)
IIKUBO KAZUHIKO (JP)
KONDOH YUTAKA (JP)
KAMIKAWA AKIO (JP)
TOMIYAMA HIROSHI (JP)
IWAI YOSHINORI (JP)
International Classes:
C07D239/48; A61K31/4965; A61K31/497; A61K31/505; A61K31/506; A61K31/5377; A61K31/541; A61K31/55; A61P35/00; A61P43/00; C07D241/26; C07D401/12; C07D401/14; C07D403/12; C07D405/12; C07D405/14; C07D409/12; C07D413/12; C07D417/12; C07D471/08; C07D491/113
Domestic Patent References:
WO2000076980A12000-12-21
WO2009145856A12009-12-03
WO2009136995A22009-11-12
WO2009089042A12009-07-16
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EP1184376A12002-03-06
EP1914240A12008-04-23
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See also references of EP 2428508A4
Attorney, Agent or Firm:
ONO, Shinjiro et al. (JP)
Ono Shinjiro (JP)
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