Title:
DIAMINOQUINAZOLINE ESTERS FOR USE AS DIHYDROFOLATE REDUCTADE INHIBITORS
Document Type and Number:
WIPO Patent Application WO2002068397
Kind Code:
A8
Abstract:
Compounds of the formula (I) wherein R1, R2, R1' and R2' are independently hydrogen or a group releasing the free amine in vivo, R6 is a substituted phenyl or an optionally substituted, bicyclic or tricyclic aryl ring system or an optionally substituted mono, bi- or tricyclic heteroaryl ring system having utility as dihydrofolate reductase (DHFR) inhibitors with favourable pharmacokinetic properties.
Inventors:
LUNDSTEDT TORBJOERN (SE)
HAELLGREN ANNELI (SE)
ANDERSSON PER (SE)
HALLBERG ANDERS (SE)
NORDBERG MALIN GRAFFNER (SE)
HAELLGREN ANNELI (SE)
ANDERSSON PER (SE)
HALLBERG ANDERS (SE)
NORDBERG MALIN GRAFFNER (SE)
Application Number:
PCT/GB2002/000888
Publication Date:
December 04, 2003
Filing Date:
February 28, 2002
Export Citation:
Assignee:
MELACURE THERAPEUTICS AB (SE)
PETT CHRISTOPHER PHINEAS (GB)
LUNDSTEDT TORBJOERN (SE)
HAELLGREN ANNELI (SE)
ANDERSSON PER (SE)
HALLBERG ANDERS (SE)
NORDBERG MALIN GRAFFNER (SE)
PETT CHRISTOPHER PHINEAS (GB)
LUNDSTEDT TORBJOERN (SE)
HAELLGREN ANNELI (SE)
ANDERSSON PER (SE)
HALLBERG ANDERS (SE)
NORDBERG MALIN GRAFFNER (SE)
International Classes:
A61K31/517; A61P1/04; A61P11/00; A61P11/06; A61P15/00; A61P17/06; A61P19/02; A61P29/00; A61P31/04; A61P33/02; A61P35/00; A61P37/06; A61P43/00; C07D239/95; C07D405/12; C07D407/12; C07D409/12; (IPC1-7): C07D239/95; C07D409/12; C07D405/12; A61K31/505; A61P35/00
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