Title:
DIARYL-Β-LACTAM COMPOUND AND PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/167183
Kind Code:
A1
Abstract:
The present invention relates to the field of synthetic medicinal chemistry and provides a novel diaryl-β-lactam compound having significant anti-tumor activity, and a pharmaceutical use thereof. The present invention also comprises a use of the compound, pharmaceutical salt, and pharmaceutical composition thereof for preparing a pharmaceutical for the prevention or treatment of tumor-associated disease. The diaryl-β-lactam compound of the present invention has the following general formula: (I).
Inventors:
WANG YANG (CN)
LIU MINGMING (CN)
ZHOU PENGFEI (CN)
FENG KECHANG (CN)
DING KUILING (CN)
WANG XIAOMING (CN)
LIU MINGMING (CN)
ZHOU PENGFEI (CN)
FENG KECHANG (CN)
DING KUILING (CN)
WANG XIAOMING (CN)
Application Number:
PCT/CN2017/078444
Publication Date:
October 05, 2017
Filing Date:
March 28, 2017
Export Citation:
Assignee:
UNIV FUDAN (CN)
SHANGHAI INST ORGANIC CHEMISTRY CAS (CN)
SHANGHAI INST ORGANIC CHEMISTRY CAS (CN)
International Classes:
C07D403/04; A61K31/397; A61K31/4192; A61K31/4427; A61K31/5377; A61K31/695; A61P35/00; C07D205/08; C07D205/085; C07D401/12; C07D491/113
Domestic Patent References:
| WO2014012495A1 | 2014-01-23 |
Foreign References:
| US4803266A | 1989-02-07 | |||
| EP0264232A1 | 1988-04-20 |
Other References:
O'BOYLE, N.M. ET AL.: "Synthesis, Evaluation and Structural Studies of Antiproliferative Tubulin-Targeting Azetidin-2-Ones", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 19, 17 February 2011 (2011-02-17), pages 2306 - 2325, XP028157415
BARI, S.S. ET AL.: "Facile synthesis of (Z)- and (E)-3-allylidene-β-lactams via thermal β-elimination of trans-3-allyl-3-sulfinyl-β-lactams", TETRAHEDRON LETTERS, vol. 51, no. 13, 1 February 2010 (2010-02-01), pages 1719 - 1722, XP026920711
TIWARI, D.K. ET AL.: "Stereoselective Synthesis of 3-Alkylide-Ne/Alkylazetidin-2-Ones from Azetidin-2, 3-Diones", TETRAHEDRON, vol. 63, no. 11, 30 January 2007 (2007-01-30), pages 2524 - 2534, XP005877837
KIRKUP, M.P. ET AL.: "SCH 57939: Synthesis and Pharmacological Proper-Ties of a Potent, Metabolically Stable Cholesterol Absorption Inhibitor", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 6, no. 17, 31 December 1996 (1996-12-31), pages 2069 - 2072, XP004135657
PALOMO, C.; AIZPURUA ET AL.: "Addition of a-Bromo Esters to Azetidi-Ne-2, 3-Diones Promoted by Zinc-Trimethylchlorosilane: A General Synthesis of 3-Trimethylsilyloxyazetidin-2-Ones and a-Alkylidene beta-Lactams", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 31, no. 44, 31 December 1990 (1990-12-31), pages 6425 - 6428, XP055526715
J AYARAMAN, M. ET AL.: "Organic Reactions in Water: Indium Mediated Synthesis of alpha-Alkylidene-beta-Lactams", HETEROCYCLES, vol. 49, no. 1, 31 December 1998 (1998-12-31), pages 97 - 100, ISSN: 0385-5414, DOI: 10.3987/COM-98-S44
BARI, S.S. ET AL.: "Facile synthesis of (Z)- and (E)-3-allylidene-β-lactams via thermal β-elimination of trans-3-allyl-3-sulfinyl-β-lactams", TETRAHEDRON LETTERS, vol. 51, no. 13, 1 February 2010 (2010-02-01), pages 1719 - 1722, XP026920711
TIWARI, D.K. ET AL.: "Stereoselective Synthesis of 3-Alkylide-Ne/Alkylazetidin-2-Ones from Azetidin-2, 3-Diones", TETRAHEDRON, vol. 63, no. 11, 30 January 2007 (2007-01-30), pages 2524 - 2534, XP005877837
KIRKUP, M.P. ET AL.: "SCH 57939: Synthesis and Pharmacological Proper-Ties of a Potent, Metabolically Stable Cholesterol Absorption Inhibitor", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 6, no. 17, 31 December 1996 (1996-12-31), pages 2069 - 2072, XP004135657
PALOMO, C.; AIZPURUA ET AL.: "Addition of a-Bromo Esters to Azetidi-Ne-2, 3-Diones Promoted by Zinc-Trimethylchlorosilane: A General Synthesis of 3-Trimethylsilyloxyazetidin-2-Ones and a-Alkylidene beta-Lactams", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 31, no. 44, 31 December 1990 (1990-12-31), pages 6425 - 6428, XP055526715
J AYARAMAN, M. ET AL.: "Organic Reactions in Water: Indium Mediated Synthesis of alpha-Alkylidene-beta-Lactams", HETEROCYCLES, vol. 49, no. 1, 31 December 1998 (1998-12-31), pages 97 - 100, ISSN: 0385-5414, DOI: 10.3987/COM-98-S44
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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