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Patent Searching and Data


Title:
DIARYL MACROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/206069
Kind Code:
A1
Abstract:
The present invention provides a compound as represented by formula (1), or a pharmaceutically acceptable salt, a solvate, an active metabolite, a polymorph, an isotopic label, an isomer, or a prodrug thereof. The present invention also provides a pharmaceutical composition comprising same, and the use of the compound and the pharmaceutical composition in preparation of drugs for treating tyrosine kinase-mediated diseases. The compound and the pharmaceutical composition comprising same provided by the present invention have significant tyrosine kinase inhibitory activity, can overcome tumor drug resistance and break through blood-brain barrier, also have excellent pharmacokinetic properties and excellent oral bioavailability, and can be administered in a small dosage, thereby reducing treatment costs of and possible side effects to a patient. Thus, the application potential is very great.

Inventors:
ZHU LI (CN)
WU WEI (CN)
YANG YANQING (CN)
HU WEI (CN)
Application Number:
CN2019/083644
Publication Date:
October 31, 2019
Filing Date:
April 22, 2019
Export Citation:
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Assignee:
PRIMEGENE BEIJING CO LTD (CN)
International Classes:
C07D498/12; A61K31/5025; C07D487/04; C07D498/02
Foreign References:
CN106170289A2016-11-30
Attorney, Agent or Firm:
BEIJING INTELLEGAL INTELLECTUAL PROPERTY AGENT LTD. (CN)
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