DIARYL UREAS WITH KINASE INHIBITING ACTIVITY

Title:

DIARYL UREAS WITH KINASE INHIBITING ACTIVITY

Document Type and Number:

WIPO Patent Application WO2004113274

Kind Code:

A3

Abstract:

The present invention provides methods of using aryl ureas to treat diseases and conditions associated with signal transduction pathways comprising at least one of raf, VEGFR, PDGFR, p38 and/or FLT-3. The present invention also provides compositions and methods for identifying conditions and diseases which can be modulated with compounds of the present invention. These methods facilitate the selection of subjects who can be efficiently treated with compounds of the present invention. Additionally, the invention provides methods for monitoring subjects who have been administered a compound of the present invention.

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Inventors:

WILHELM SCOTT (US)
DUMAS JACQUES (US)
LADOUCEUR GAETAN (US)
LYNCH MARK (US)
SCOTT WILLIAM J (US)

Application Number:

PCT/US2004/015655

Publication Date:

March 03, 2005

Filing Date:

May 19, 2004

Export Citation:

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Assignee:

BAYER PHARMACEUTICALS CORP (US)
WILHELM SCOTT (US)
DUMAS JACQUES (US)
LADOUCEUR GAETAN (US)
LYNCH MARK (US)
SCOTT WILLIAM J (US)

International Classes:

A61K31/00; A61K31/4412; A61K31/4418; A61K31/443; A61K45/06; A61L31/16; (IPC1-7): G01N33/574

Domestic Patent References:

WO2003068228A1	2003-08-21
WO2002025286A2	2002-03-28

Other References: