DIARYLSULTAM DERIVATIVES - MITSUBISHI CHEM CORP

Title:

DIARYLSULTAM DERIVATIVES

Document Type and Number:

WIPO Patent Application WO/1997/030038

Kind Code:

A1

Abstract:

Compounds represented by the following general formula: A-C(X)(Y)-C(R1)(R2)-Z wherein Z represents, for example, -N(R3)-(CH2)p-B [wherein R3 represents alkyl, etc.; p is an integer of from 3 to 8; and B represents a group represented by general formula: (I), (II), (III) or (IV) wherein R7, R8, R9 and R10 represent each hydrogen, halogeno, alkyl, etc.; X' represents -S-, -S(O)-, -S(O)2-, -O- or -R(R11)- wherein R11 represents hydrogen, alkyl or acyl; and W and W' represent each a benzene ring or 5- to 7-membered heterocycle]; X represents cycloalkyl, aryl, etc.; Y represents hydrogen, alkyl, alkenyl, etc.; A represents -O-R6 wherein R6 represents hydrogen, alkyl, cycloalkyl, etc.; and R1 and R2 represent each hydrogen, alkyl, etc. Because of having high affinity and selectivity for a sigma 2-binding site, these compounds are useful as a selective sigma 2-ligand in treating and/or preventing various diseases or symptoms in which sigma 2-ligand participates.

Inventors:

ROCHER JEAN-PHILIPPE (JP)

Application Number:

PCT/JP1997/000400

Publication Date:

August 21, 1997

Filing Date:

February 14, 1997

Export Citation:

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Assignee:

MITSUBISHI CHEM CORP (JP)
ROCHER JEAN PHILIPPE (JP)

International Classes:

C07D285/00; C07D285/36; C07D291/08; (IPC1-7): C07D285/36; A61K31/55; C07D291/08; C07D513/04; C07D513/12; C07D515/04; C07D515/14

Foreign References:

JPH06509069A	1994-10-13
JPH07506107A	1995-07-06
JPS463060B1

Other References: