Title:
DIARYLTHIOHYDANTOIN COMPOUND AS ANDROGEN RECEPTOR ANTAGONIST
Document Type and Number:
WIPO Patent Application WO/2019/029521
Kind Code:
A1
Abstract:
The present application belongs to the field of medicine. In particular, the present application relates to a diarylthiohydantoin compound as an androgen receptor antagonist or a pharmaceutically acceptable salt thereof, a preparation method of the same, a pharmaceutical composition comprising the compound, and a use thereof in treating a cell proliferative disease mediated by androgen. The compound of the present application has good antagonistic effect on androgen receptor and exhibits excellent antitumor effect.
Inventors:
SHEN CHUNLI (CN)
WU CHENGDE (CN)
CHEN SHENGLIN (CN)
CHEN SHUHUI (CN)
ZHANG XIQUAN (CN)
TIAN XIN (CN)
WU CHENGDE (CN)
CHEN SHENGLIN (CN)
CHEN SHUHUI (CN)
ZHANG XIQUAN (CN)
TIAN XIN (CN)
Application Number:
PCT/CN2018/099161
Publication Date:
February 14, 2019
Filing Date:
August 07, 2018
Export Citation:
Assignee:
CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD (CN)
MEDSHINE DISCOVERY INC (CN)
MEDSHINE DISCOVERY INC (CN)
International Classes:
C07D403/04; A61K31/4178; A61K31/4184; A61P19/00; A61P35/00; C07D471/04; C07D491/107
Foreign References:
CN103804358A | 2014-05-21 | |||
CN104341396A | 2015-02-11 | |||
CN106146474A | 2016-11-23 |
Other References:
"Greene's Protective Groups in Organic Synthesis", JOHN WILEY & SONS, INC
See also references of EP 3666772A4
See also references of EP 3666772A4
Attorney, Agent or Firm:
INSIGHT INTELLECTUAL PROPERTY LIMITED (CN)
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