1. A compound, or a pharmaceuticall acceptable salt thereof, of Formula I:

wherein:

R¹, R², R⁴, and R⁵ are independently absent or selected from the group consisting of H, halide, unsubstituted -(C1-3 haloalkyl), and unsubstituted -(C1-3 alkyl);

R³ is selected from the group consisting of -aryl optionally substituted with 1-5 R⁷ and - heteroaryl optionally substituted with 1-4 R⁸;

R⁶ is selected from the group consisting of -(C₁-4 alkylene)_paryl substituted with 1-5 R⁹, - (C2-4 alkenylene)_paryl substituted with 1-5 R⁹, -(C1-4 alkylene)pheteroaryl optionally substituted with 1-6 R¹⁰; -(C1-4 alkylene)pheterocyclyl optionally substituted with 1-10 R¹¹, -(C1-4 alkylene)_pcarbocyclyl optionally substituted with 1-12 R¹², -(C1-4 alkylene)N(R¹ )(R¹⁴), - N(R¹⁵)(R¹⁶), -CF(Ci-9 alkyl)₂, -(C1-4 alkylene)pO(C₃-₉ alkyl), and -(C2-9 alkynyl) optionally substituted with one or more halides; wherein each alkyl of -CF(Ci-9 alkyl)₂ is, independently, optionally substituted with one or more halides; wherein each -(C1-4 alkylene) is, independently, optionally substituted with one or more substituents; wherein -(C1-4 alkenylene) is, optionally substituted with one or more substituents;

R⁷ is selected from the group consisting of halide and -N(R¹⁷)2;

each R⁸ is independently selected from the group consisting of H, halide, unsubstituted - (Ci-9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), unsubstituted -(C1-9 haloalkyl), -CN, -N(R¹⁵)(R¹⁸), -(C1-4 alkylene)_pXR¹⁹, -C(=0)N(R¹⁵)₂, -(C1-4 alkylene)_pheterocyclyl optionally substituted with 1-10 R²⁰, and -carbocyclyl optionally substituted with 1-12 R²¹; wherein each -(C ₁-4 alkylene) is, independently, optionally substituted with one or more substituents;

alternatively, two adjacent R⁸ are taken together to form a ring which is selected from the group consisting of -heterocyclyl optionally substituted with 1-10 R²² and -carbocyclyl optionally substituted with 1-12 R²¹;

each R⁹ is independently selected from the group consisting of halide, unsubstituted -(Ci- 9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), unsubstituted -(C 1-9 haloalkyl), -XR² ,-C(=0)N(R¹⁵)₂, -(Ci-4 alkylene)_pN(R²⁴)₂, -(C1-4 alkylene)pheterocyclyl optionally substituted with 1-10 R²², and -(C1-4 alkylene )_pcarbocyclyl optionally substituted with 1-12 R²¹; wherein each -(C1-4 alkylene) is, independently, optionally substituted with one or more substituents; with the proviso that when Y² is N then R⁹ is not -OMe or ^— / ;

each R¹⁰ is independently selected from the group consisting of halide, unsubstituted -(Ci- 9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), unsubstituted -(Ci-9 haloalkyl), -CN, -XR²³, -C(=0)N(R¹⁵)₂, -(Ci-4 alkylene)_pN(R²⁴)₂, -(C1-4 alkylene)pheterocyclyl optionally substituted with 1-10 R²², and -(C1-4 alkylene )_pcarbocyclyl optionally substituted with 1-12 R²¹; wherein each -(C1-4 alkylene) is, independently, optionally substituted with one or more substituents;

each R¹¹ is independently selected from the group consisting of halide, unsubstituted -(Ci- 9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), unsubstituted -(Ci-9 haloalkyl), -(Ci-4 alkylene)pOR¹⁹, -(C1-4 alkylene )_pheterocyclyl optionally substituted with 1-10 R²², -(C1-4 alkylene)_pcarbocyclyl optionally substituted with 1-12 R²¹, -N(R¹⁵)(R²⁵), -C(=0)(R²⁶), -(Ci-₄ alkylene)C(=0)OR²⁷, -(C1-4 alkylene)aryl optionally substituted with one or more halides, -(C1-4 alkylene)pheteroaryl optionally substituted with one or more halides, and -S02(R²⁸); wherein each -(Ci-4 alkylene) is, independently, optionally substituted with one or more substituents;

alternatively, two R¹¹ attached to the same carbon atom can together represent =0 to form a carbonyl group;

each R¹² is independently selected from the group consisting of halide, unsubstituted -(Ci- 9 alkyl), unsubstituted -(C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), unsubstituted -(Ci-9 haloalkyl), -(Ci-4 alkylene)pOR¹⁹, -N(R¹⁵)(R²⁹), -C(=0)(R²⁶), -C(=0)OR²⁷, -(C1-4 alkylene)pheterocyclyl optionally substituted with 1-10 R²², and -(C1-4 alkylene)_pcarbocyclyl optionally substituted with 1-12 R²¹; wherein each -(C1-4 alkylene) is, independently, optionally substituted with one or more substituents;

R¹³ is selected from the group consisting of H, unsubstituted -(C1-9 alkyl), unsubstituted - (C2-9 alkenyl), unsubstituted -(C2-9 alkynyl), unsubstituted -(C1-9 haloalkyl), -(C1-4 alkylene)_pheterocyclyl optionally substituted with 1-10 R²⁰, and -carbocyclyl optionally substituted with 1-12 R²¹; wherein -(C1-4 alkylene) is, optionally substituted with one or more substituents;

R¹⁴ is selected from the group consisting of unsubstituted -(C1-9 alkyl), unsubstituted -(C2- 9 alkenyl), unsubstituted -(C2-9 alkynyl), unsubstituted -(C1-9 haloalkyl), -(C1-4 alkylene)pheterocyclyl optionally substituted with 1 -10 R²⁰, and -carbocyclyl optionally substituted with 1-12 R²¹; wherein -(C1-4 alkylene) is, optionally substituted with one or more substituents; each R¹⁵ is selected from the group consisting of H, unsubstituted -(C1-5 alkyl), unsubstituted -(C2-5 alkenyl), unsubstituted -(C2-5 alkynyl), and unsubstituted -(C1-5 haloalkyl);

R¹⁶ is selected from the group consisting of -(C1-4 alkylene )_pheterocyclyl optionally substituted with 1-10 R²⁰, and— (C1-4 alkylene )_pcarbocyclyl optionally substituted with 1-12 R²¹; wherein each -(C1-4 alkylene) is, independently, optionally substituted with one or more substituents;

R¹⁷ is independently selected from the group consisting of H, unsubstituted -(C1-5 alkyl), unsubstituted -(C2-5 alkenyl), unsubstituted -(C2-5 alkynyl), and unsubstituted -(C1-5 haloalkyl); alternatively, two adjacent R¹⁷ are taken together to form a -heterocyclyl ring optionally substituted with 1-10 R²²;

R¹⁸ is independently selected from the group consisting of H, unsubstituted -(C1-5 alkyl), unsubstituted -(C2-5 alkenyl), unsubstituted -(C2-5 alkynyl), unsubstituted -(C1-5 haloalkyl), - (C=0)R¹⁵, and -(C1-4 alkylene)pheterocyclyl optionally substituted with one or more halides or one or more unsubstituted -(C1-5 alkyl); wherein -(C1-4 alkylene) is, independently, optionally substituted with one or more substituents;

each R¹⁹ is independently selected from the group consisting of H, unsubstituted -(C1-5 alkyl), unsubstituted -(C2-5 alkenyl), unsubstituted -(C2-5 alkynyl), unsubstituted -(C1-5 haloalkyl), -(Ci-4 alkylene)pheterocyclyl optionally substituted with one or more halides or one or more unsubstituted -(C1-5 alkyl), and -(C1-4 alkylene )_pcarbocyclyl optionally substituted with 1 -12 R²¹; wherein each -(C1-4 alkylene) is, independently, optionally substituted with one or more substituents;

each R²⁰ independently is selected from the group consisting of halide, unsubstituted -(Ci- 5 alkyl), unsubstituted -(C2-5 alkenyl), unsubstituted -(C2-5 alkynyl), unsubstituted -(C1-5 haloalkyl), -CN, -OH, -N(R¹⁵)2, and -(C1-4 alkylene)_pcarbocyclyl optionally substituted with 1 -12 R²¹; wherein each -(C1-4 alkylene) is, independently, optionally substituted with one or more substituents;

each R²¹ is independently selected from the group consisting of halide, unsubstituted -(Ci- 5 alkyl), unsubstituted -(C2-5 alkenyl), unsubstituted -(C2-5 alkynyl), unsubstituted -(C1-5 haloalkyl), and -CN;

each R²² is independently selected from the group consisting of halide, unsubstituted -(Ci- 5 alkyl), unsubstituted -(C2-5 alkenyl), unsubstituted -(C2-5 alkynyl), unsubstituted -(C1-5 haloalkyl), -CN, -OH, -N(R¹⁵)₂, -C(=0)R³⁴, and -(C1-4 alkylene)_pcarbocyclyl optionally substituted with 1 - 12 R²¹; wherein each -(Ci-4 alkylene) is, independently, optionally substituted with one or more substituents;

each R²³ is independently selected from the group consisting of H, unsubstituted -(C1-5 alkyl), unsubstituted -(C2-5 alkenyl), unsubstituted -(C2-5 alkynyl), unsubstituted -(C1-5 haloalkyl), -(Ci-4 alkylene)N(R¹⁵)2, -(C1-4 alkylene )_paryl optionally substituted with 1 -10 R³⁰, -(C1-4 alkylene)_pheterocyclyl optionally substituted with 1 -12 R³¹, and -(C1-4 alkylene )_pcarbocyclyl optionally substituted with 1-12 R²¹; wherein each -(C1-4 alkylene) is, independently, optionally substituted with one or more substituents;

each R²⁴ is independently selected from the group consisting of H, unsubstituted -(C1-5 alkyl), unsubstituted -(C2-5 alkenyl), unsubstituted -(C2-5 alkynyl), unsubstituted -(C1-5 haloalkyl), -(Ci-4 alkylene)pheterocyclyl optionally substituted with one or more halides or one or more unsubstituted -(C1-5 alkyl), and -(C1-4 alkylene )N(R¹⁵)2; wherein each -(C1-4 alkylene) is, independently, optionally substituted with one or more substituents;

each R²⁵ is selected from the group consisting of H, unsubstituted -(C1-5 alkyl), unsubstituted -(C2-5 alkenyl), unsubstituted -(C2-5 alkynyl), unsubstituted -(C1-5 haloalkyl), -(C1-4 alkylene)_pheterocyclyl optionally substituted with 1-10 R³², -(Ci-4 alkylene)_pcarbocyclyl optionally substituted with 1-12 R²¹, -(C1-4 alkylene)OR³³; wherein each -(C 1-4 alkylene) is, independently, optionally substituted with one or more substituents;

R²⁶ is selected from the group consisting of H, unsubstituted -(C3-5 alkyl), unsubstituted - (C2-5 alkenyl), unsubstituted -(C2-5 alkynyl), unsubstituted -(C1-5 haloalkyl), -(C1-4 alkylene)_paryl optionally substituted with one or more halides or unsubstituted -(C1-5 alkyl), -(C1-4 alkylene)pheteroaryl optionally substituted with one or more halides or one or more unsubstituted -(Ci-5 alkyl), and -(C1-4 alkylene )_pheterocyclyl optionally substituted with one or more halides or one or more unsubstituted -(C1-5 alkyl); wherein each -(C1-4 alkylene) is, independently, optionally substituted with one or more substituents;

R²⁷ is selected from the group consisting of H, unsubstituted -(C1-5 alkyl), unsubstituted - (C2-5 alkenyl), unsubstituted -(C2-5 alkynyl), unsubstituted -(C1-5 haloalkyl), -(C1-4 alkylene)_paryl optionally substituted with one or more halides or one or more unsubstituted -(C1-5 alkyl), -(C1-4 alkylene)pheteroaryl optionally substituted with one or more halides or unsubstituted -(C1-5 alkyl), and -(Ci-4 alkylene)pheterocyclyl optionally substituted with one or more halides or one or more unsubstituted -(C1-5 alkyl); wherein each -(C1-4 alkylene) is, independently, optionally substituted with one or more substituents;

R²⁸ is selected from the group consisting of unsubstituted -(C1-5 alkyl), unsubstituted -(C2- 5 alkenyl), unsubstituted -(C2-5 alkynyl), unsubstituted -(C1-5 haloalkyl), -(C1-4 alkylene)_paryl optionally substituted with one or more halides or one or more unsubstituted -(C1-5 alkyl), -(C1-4 alkylene)pheteroaryl optionally substituted with one or more halides or one or more unsubstituted -(Ci-5 alkyl), and -(C1-4 alkylene)_pheterocyclyl optionally substituted with one or more halides or one or more unsubstituted -(C1-5 alkyl); wherein -(C1-4 alkylene) is, optionally substituted with one or more substituents;

each R²⁹ is selected from the group consisting of H, unsubstituted -(C1-5 alkyl), unsubstituted -(C2-5 alkenyl), unsubstituted -(C2-5 alkynyl), unsubstituted -(C1-5 haloalkyl), -(C1-4 alkylene)_pheterocyclyl optionally substituted with 1-10 R³², -(Ci-4 alkylene)_pcarbocyclyl optionally substituted with 1-12 R²¹, -(C1-4 alkylene)OR³³, and -C(=0)0(Ci-5 alkyl); wherein each -(C1-4 alkylene) is, independently, optionally substituted with one or more substituents;

each R³⁰ is independently selected from the group consisting of halide, unsubstituted -(Ci- 5 alkyl), unsubstituted -(C2-5 alkenyl), unsubstituted -(C2-5 alkynyl), unsubstituted -(C1-5 haloalkyl), and -CN;

each R³¹ is independently selected from the group consisting of halide, unsubstituted -(Ci- 5 alkyl), unsubstituted -(C2-5 alkenyl), unsubstituted -(C2-5 alkynyl), unsubstituted -(C1-5 haloalkyl), -CN, -OH, -C(=0)R³⁴, -N(R²⁴)₂, and -(C1-4 alkylene)_pcarbocyclyl optionally substituted with 1- 12 R²¹; wherein each -(C1-4 alkylene) is, independently, optionally substituted with one or more substituents;

each R³² is independently selected from the group consisting of halide and unsubstituted - (Ci-5 alkyl);

each R³³ is independently selected from the group consisting of H and unsubstituted -(Ci-

5 alkyl);

each R³⁴ is independently selected from the group consisting of -0(Ci-5 alkyl) and a heteroaryl optionally substituted with 1-6 R³⁵;

each R³⁵ is a -heterocyclyl optionally substituted with one or more halides or one or more unsubstituted -(C1-5 alkyl);

each X is selected from the group consisting of O and S;

Y³ is CH or nitrogen;

Y¹, Y², Y⁴, and Y⁵ are independently selected from the group consisting of carbon and nitrogen; wherein

if Y¹ is nitrogen then Y², Y⁴, and Y⁵ are carbon, Y³ is CH, and R⁴ is absent;

if Y² is nitrogen then Y¹, Y⁴, and Y⁵ are carbon, Y³ is CH, and R⁵ is absent;

if Y³ is nitrogen then Y¹, Y², Y⁴, and Y⁵ are carbon;

if Y⁴ is nitrogen then Y¹, Y², and Y⁵ are carbon, Y³ is CH, and R¹ is absent; if Y⁵ is nitrogen then Y¹, Y², and Y⁴ are carbon, Y³ is CH, and R² is absent; and each p is independently 0 or 1.

2. The compound of claim 1, wherein R¹, R², R⁴, and R⁵ are H.

3. The compound according to any one of claims 1 -2, wherein R³ is selected from the group consisting of pyrazolyl, imidazolyl, triazolyl, thiadiazolyl, and oxazolyl, each optionally substituted with 1-4 R⁸.

4. The compound according to any one of claims 1-3, wherein R³ is selected from the group consisting of pyrazol-4-yl, imidazol-5-yl, l,2,3-triazol-4-yl, thiadiazol-2-yl, and oxazol-5- yl, each optionally substituted with 1-4 R⁸.

5. The compound according to any one of claims 1-4, wherein R³ is an unsubstituted pyrazol-4-yl,.

6. The compound according to any one of claims 1-5, wherein R³ is a pyrazol-4-yl, substituted with one -(C1-3 alkyl).

7. The compound according to any one of claims 1-6, wherein R³ is a imidazol-5-yl, substituted with one -(C1-3 alkyl).

8. The compound according to any one of claims 1-7, wherein R³ is a imidazol-5-yl, substituted with two -(C1-3 alkyl).

9. The compound according to any one of claims 1-8, wherein R³ is an unsubstituted l,2,3-triazol-4-yl.

10. The compound according to any one of claims 1-9, wherein R³ is a l,2,3-triazol-4- yl, substituted with one -(C1-3 alkyl).

11. The compound according to any one of claims 1-10, wherein R³ is an unsubstituted thiadiazol-2-yl.

12. The compound according to any one of claims 1-11, wherein R³ is a thiadiazol-2-yl, substituted with one -(C1-3 alkyl).

13. The compound according to any one of claims 1-12, wherein R³ is an unsubstituted oxazol-5 -yl.

14. The compound according to any one of claims 1-13, wherein R³ is a oxazol-5-yl, substituted with one -(C1-3 alkyl).

15. The compound according to any one of claims 1-14, wherein R⁶ is -heterocyclyl, optionally substituted with 1-2 R¹¹.

16. The compound according to any one of claims 1-15, wherein R⁶ is a - Grbheterocyclyl optionally substituted with 1-2 R¹¹.

17. The compound according to any one of claims 1-16, wherein R⁶ is either a piperidinyl or a pyrrolidinyl both optionally substituted with 1-2 R¹¹.

18. The compound according to any one of claims 1-17, wherein R⁶ is a piperidinyl substituted with one -N(R¹⁵)(R²⁵).

19. The compound according to any one of claims 1-18, wherein R¹⁵ and R²⁵ are independently selected from the group consisting of H, Me, and -Ci-t haloalkyl.

20. The compound according to any one of claims 1-19, wherein the compound of Formula I is selected from the group consisting of:

N-(2-( lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl)- 1 -isobutylpiperidine-4-carboxamide [1] ;

N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)cyclopropanecarboxamide [2];

4,4-difluoro-N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)cyclohexane-l-carboxamide

[3];

fr «5-4-methoxy-N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)cyclohexane-l- carboxamide [4];

trans-N-(2-( 1 -methyl- lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl)-4-morpholinocyclohexane- 1 - carboxamide [5];

trans-4-((3 -fluoroazetidin- 1 -yl)methyl)-N-(2-( 1 -methyl- 1 H-pyrazol -4 -yl)-l ,6-naphthyridin-7-yl) cyclohexane-1 -carboxamide [6];

trans-N-(2-( 1 -methyl -1 H-pyrazol -4 -yl)-l ,6-naphthyridin-7-yl)-4-((4-methylpiperazin- 1 -yl)

methyl)cyclohexane - 1 -carboxamide [7] ;

N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-2-(pyrrolidin-l-yl)acetamide [8];

(S)-2-(3 -fluoropyrrolidin- 1 -yl)-N-(2-( 1 -methyl- 1 H-pyrazol -4 -yl)- 1 ,6-naphthyridin-7-yl)

acetamide [9];

(S)-N-(2-( 1 -methyl-lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl)tetrahydrofuran-2 -carboxamide [10] ; N-(2-( 1 -methyl -1 H-pyrazol -4 -yl)- 1 ,6-naphthyridin-7-yl)piperidine-4-carboxamide [11];

1 -methyl -N-(2 -( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 ,6 -naphthyridin-7-yl)piperidine -4 -carboxamide [12]; 1 -isopropyl-N-(2-( 1 -methyl- lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl)piperidine-4-carboxamide

[13];

1 -(fert-butyl)-N-(2-( 1 -methyl- 1 H-pyrazol -4 -yl)- 1 ,6-naphthyridin-7-yl)piperidine-4-carboxamide

[14];

l-cyclopropyl-N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)piperidine-4-carboxamide

[15];

1 -isobutyl-N-(2-( 1 -methyl- lH-pyrazol-4-yl)-l ,6-naphthyridin-7-yl)piperidine-4-carboxamide

[16]; N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-l-neopentylpiperidine-4-carboxamide

[17];

1 -(2-fluoroethyl)-N-(2-( 1 -methyl- lH-pyrazol-4-yl)-l ,6-naphthyridin-7-yl)piperidine-4- carboxamide [18];

N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-l-(3,3,3-trifluoropropyl)piperidine-4- carboxamide [19];

1 -butyl -N-(2-( 1 -methyl- lH-pyrazol-4-yl)-l ,6-naphthyridin-7-yl)piperidine-4-carboxamide [20] ; 1 -benzoyl -N-(2-( 1 -methyl- lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl)piperidine-4-carboxamide

[21];

l-(2,2-difluoropropyl)-N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)piperidine-4- carboxamide [22];

N-(2-( 1 -methyl -lH-pyrazol -4 -yl)- 1 ,6-naphthyridin-7-yl)azetidine-3 -carboxamide [23] ;

1 -(2,2-difluoroethyl)-N-(2-( 1 -methyl- lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl)piperidine-4- carboxamide [24];

1 -(2-fluoro-2-methylpropyl)-N-(2-( 1 -methyl- lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl)piperidine- 4-carboxamide [25];

N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-l-(oxetan-3-yl)piperidine-4- carboxamide [26];

N-(2-( 1 -methyl -lH-pyrazol -4 -yl)- 1 ,6-naphthyridin-7-yl)- 1 -((3-methyloxetan-3 -yl)methyl)

piperidine-4-carboxamide [27];

1 -(2-methoxyethyl)-N-(2-( 1 -methyl-lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl)piperidine-4- carboxamide [28];

l-(2-isopropoxyethyl)-N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)piperidine-4- carboxamide [29];

1 , 1 -diisobutyl-4-((2-( 1 -methyl- lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl)carbamoyl)piperidin- 1 - ium [30];

4-fluoro-N-(2-( 1 -methyl- lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl)piperidine-4-carboxamide [31] ; 4-fluoro- 1 -methyl -N-(2-( 1 -methyl-lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl)piperidine-4- carboxamide [32];

4-fluoro- 1 -isobutyl-N-(2-( 1 -methyl- lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl)piperidine-4- carboxamide [33];

(S)-N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)piperidine-3-carboxamide [34]; (R)-N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)piperidine-3-carboxamide [35]; (S)- 1 -isobutyl-N-(2-( 1 -methyl- lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl)piperidine-3 -carboxamide

[36];

(R)-l -isobutyl-N-(2-( 1 -methyl-lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl)piperidine-3 -carboxamide

[37];

N-(2-( l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)tetrahydro-2H-pyran-4-carboxamide

[38];

N-(2 -( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 ,6 -naphthyridin-7-y 1) -2-(piperidin- 1 -yl)acetamide [39] ; 2-(4-fluoropiperidin-l -yl)-N-(2-( 1 -methyl- 1 H-pyrazol -4 -yl)- 1 ,6-naphthyridin-7-yl)acetamide

[40];

fr «5-4-amino-N-(2-( 1 -methyl-lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl)cyclohexane- 1 - carboxamide [41];

N-(2 -( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 ,6 -naphthyridin-7 -yl)-2-(4 -methylpiperazin- 1 -yl)acetamide

[42];

(S)-N-(2-( l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)piperidine-2 -carboxamide [43]; 2-(4-isobutylpiperazin-l -yl)-N-(2-(l -methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)acetamide

[44];

2-(3,3-dimethylazetidin-l-yl)-N-(2-( l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)acetamide

[45];

(R)-2-(3-fluoropyrrolidin- 1 -yl)-N-(2-( 1 -methyl- lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl)

acetamide [46];

(S)-N-(2-( l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-2-(2-methylpyrrolidin-l -yl)

acetamide [47];

2-(3-azabicyclo[3.1.0]hexan-3 -yl)-N-(2-( 1 -methyl- lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl) acetamide [48];

2-(7-azabicyclo[2.2.1]heptan-7-yl)-N-(2-(l -methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl) acetamide [49];

N-(2-( 1 -methyl -1 H-pyrazol -4 -yl)- 1 ,6-naphthyridin-7-yl)-2-(4-methylpiperidin- 1 -yl)acetamide

[50];

N-(2-( l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-2-(4-(trifluoromethyl)piperidin-l -yl) acetamide [51];

2-(4-(difluoromethyl)piperidin-l-yl)-N-(2-( l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl) acetamide [52];

N-(2-( l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-2-(6-azaspiro[2.5]octan-6-yl)acetamide

[53]; N-(2 -( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 ,6 -naphthyridin-7 -yl)-2-(pyrrolidin- 1 -yl)propanamide [54] ; (R)-N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-2-(2-methylpyrrolidin-l-yl)

acetamide [55];

2-(cyclobutyl(methyl)amino)-N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)acetamide

[56];

2-(diethylamino)-N-(2-( 1 -methyl- 1 H-pyrazol -4 -yl)-l ,6-naphthyridin-7-yl)acetamide [57] ;

7-(2-fluoroethyl)-N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-7-azaspiro[3.5]

nonane-2 -carboxamide [58];

4-methyl-N-(2 -( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 ,6 -naphthyridin-7-yl)piperazine - 1 -carboxamide [59] ; (S)-N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-2-(pyrrolidin-l-yl)propanamide

[60];

(R)-N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-2-(pyrrolidin-l-yl)propanamide

[61];

(R)-N-(2-( 1 -methyl-lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl)pyrrolidine-2 -carboxamide [62] ; 2-methyl-N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-2-azaspiro[3.3]heptane-6- carboxamide [63];

N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-2-(2,2,2-trifluoroacetyl)-2-azaspiro[3.3] heptane-6-carboxamide [64] ;

2-(2-fluoroethyl)-N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-2-azaspiro[3.3]

heptane-6-carboxamide [65] ;

fr «5-4-(dimethylamino)-N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)cyclohexane-l- carboxamide [66];

l-acetyl-N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)piperidine-4-carboxamide [67]; N-(2-( 1 -methyl -1 H-pyrazol -4 -yl)- 1 ,6-naphthyridin-7-yl)- 1 -(( 1 -(trifluoromethyl)cyclopropyl) methyl)piperidine -4 -carboxamide [68] ;

(S)-l-(2-fluoropropyl)-N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)piperidine-4- carboxamide [69];

(R)-l-(2-fluoropropyl)-N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)piperidine-4- carboxamide [70];

N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-l-(methylsulfonyl)piperidine-4- carboxamide [71];

l'-methyl-N-(2-( 1 -methyl- lH-pyrazol-4-yl)-l ,6-naphthyridin-7-yl)-[ 1 ,4'-bipiperidine] -4- carboxamide [72]; fra«s-4-(hydroxymethyl)-N-(2-( 1 -methyl- lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl)cyclohexane- 1 - carboxamide [73];

methyl 2 -(4 -((2-( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 , 6-naphthyridin-7 -yl)carbamoyl)piperidin- 1 -yl) acetate [74];

1- benzyl-N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)piperidine-4-carboxamide [75]; N-(2-( 1 -methyl -1 H-pyrazol -4 -yl)- 1 ,6-naphthyridin-7-yl)- 1 -(2-(pyrrolidin-l -yl)acetyl)piperidine-

4-carboxamide [76];

N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-2-moφholinoacetamide [77];

(S)-N-(2-( 1 -methyl-lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl)-2-(3 -methylmo holino)acetamide

[78];

(R)-N-(2-( 1 -methyl- lH-pyrazol-4-yl)-l ,6-naphthyridin-7-yl)-2-(3 -methylmo holino)acetamide

[79];

(S)-N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-2-(2-methylmo holino)acetamide

[80];

2- ((2R,6S)-2,6-dimethylmoφholino)-N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl) acetamide [81];

2-((lS,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6- naphthyridin-7-yl)acetamide [82];

2-((lR,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6- naphthyridin-7-yl)acetamide [83];

2-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl) acetamide [84];

(S)-N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-2-moφholinopropanamide [85]; N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-2-(moφholin-2-yl)acetamide [86]; N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-2-(4-methylmoφholin-2-yl)acetamide

[87];

2-(4-ethylpiperazin-l-yl)-N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)acetamide [88]; 2-(4-isopropylpiperazin- 1 -yl)-N-(2-( 1 -methyl- lH-pyrazol-4-yl)-l ,6-naphthyridin-7-yl)acetamide

[89];

2-(4-cyclopropylpiperazin- 1 -yl)-N-(2-( 1 -methyl-lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl)

acetamide [90];

2-(4-(2-fluoroethyl)piperazin- 1 -yl)-N-(2-( 1 -methyl-lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl) acetamide [91]; (S)-2-(2,4-dimethylpiperazin-l-yl)-N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl) acetamide [92];

1 -(2-hydroxyethyl)-N-(2-( 1 -methyl- lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl)piperidine-4- carboxamide [93];

N-(2-( 1 -methyl -lH-pyrazol -4 -yl)- 1 ,6-naphthyridin-7-yl)- 1 -(pyridin-2-ylmethyl)piperidine-4- carboxamide [94];

N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-l-(oxazol-2-ylmethyl)piperidine-4- carboxamide [95];

(R)-N-(2-( 1 -methyl-lH-pyrazol-4-yl)-l ,6-naphthyridin-7-yl)- 1 -oxotetrahydro- lH-pyrrolo[ 1 ,2-c] imidazole-2(3H)-carboxamide [96];

(R)-l -methyl -N-(2-( 1 -methyl- lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl)pyrrolidine-2-carboxamide

[97];

N-(2-( 1 -methyl -lH-pyrazol -4 -yl)- 1 ,6-naphthyridin-7-yl)- 1 -(tetrahydro-2H-pyran-4-yl)piperidine- 4-carboxamide [98];

N-(2-( 1 -methyl -lH-pyrazol -4 -yl)- 1 ,6-naphthyridin-7-yl)- 1 -(pyrimidin-2-ylmethyl)piperidine-4- carboxamide [99];

N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-l-(pyrazin-2-ylmethyl)piperidine-4- carboxamide [100];

1 -((5 -methyl- 1 ,2,4-oxadiazol-3-yl)methyl)-N-(2-( 1 -methyl- lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7- yl)piperidine-4-carboxamide [101];

1 -(2-hydroxy-2-methylpropyl)-N-(2-( 1 -methyl- lH-pyrazol-4-yl)-l ,6-naphthyridin-7-yl)

piperidine-4-carboxamide [102];

fert-butyl 2-(4-((2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)carbamoyl)piperidin-l- yl)acetate [103];

2-(4-((2-( 1 -methyl- lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl)carbamoyl)piperidin-l -yl)acetic acid

[104];

2-(4-methyl- 1 ,4-diazepan- 1 -yl)-N-(2-( 1 -methyl-lH-pyrazol-4-yl)-l ,6-naphthyridin-7-yl)

acetamide [105];

fert-butyl (2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)carbamate [106];

N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)but-2-ynamide [107];

trans-4-((2-( 1 -methyl- lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl)carbamoyl)cyclohexane- 1 - carboxylic acid [108];

N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-3-moφholinopropanamide [109]; trans-N-(2-( 1 -methyl- lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl)-3-moφholinocyclobutane- 1 - carboxamide [110];

N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)quinuclidine-4-carboxamide [111]; N-(2-( 1 -methyl-lH-pyrazol-4-yl)-l ,6-naphthyridin-7-yl)-2-(piperidin- 1 -yl)propanamide [112]; 1 -isobutyl-N-(2-( 1 -methyl- lH-pyrazol-4-yl)-l ,6-naphthyridin-7-yl)azepane-4-carboxamide [113]; 2-(4-methoxypiperidin- 1 -yl)-N-(2-( 1 -methyl- lH-pyrazol-4-yl)-l ,6-naphthyridin-7-yl)acetamide

[114];

2- (4-hydroxypiperidin-l -yl)-N-(2-( 1 -methyl- lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl)acetamide

[115];

3- (hydroxymethyl)-N-(2-( 1 -methyl- lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl)bicyclo[ 1.1.1]

pentane-1 -carboxamide [116];

1 -methyl -N-(2-( 1 -methyl -lH-pyrazol -4 -yl)- 1 ,6-naphthyridin-7-yl)azepane-4-carboxamide [117]; fr «5-4-(dimethylamino)-N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)cyclohexane-l- carboxamide [118];

fr «5-4-(bis(methyl-£/3)amino)-N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)

cyclohexane-1 -carboxamide [119];

N-(2-( 1 -methyl -lH-pyrazol -4 -yl)- 1 ,6-naphthyridin-7-yl)-3-((4-methylpiperazin- 1 -yl)methyl) bicyclo[l .1. l]pentane-l -carboxamide [120];

methyl trans-4-((2-( 1 -methyl- lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl)carbamoyl)cyclohexane- 1 - carboxylate [121];

2-( 1 -isobutylpyrrolidin-3 -yl)-N-(2-( 1 -methyl- lH-pyrazol-4-yl)-l ,6-naphthyridin-7-yl)acetamide

[122];

trans -N-(2-( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 , 6-naphthyridin-7-yl) -4 -(4 -methylpiperazine - 1 - carbonyl)cyclohexane- 1 -carboxamide [123] ;

1 -isobutyl-N-(2-( 1 -methyl- lH-pyrazol-4-yl)-l ,6-naphthyridin-7-yl)piperidine-4-carboxamide

[124];

N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-l-(phenylsulfonyl)piperidine-4- carboxamide [125];

8 -methyl -N-(2 -( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 ,6 -naphthyridin-7-yl) -3 , 8 -diazabicyclo [3.2.1] octane - 3-carboxamide [126];

3 -methyl -N-(2 -( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 ,6 -naphthyridin-7-yl) -3 , 8 -diazabicyclo [3.2.1] octane - 8-carboxamide [127];

(lR,3s,5S)-3-amino-N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-8-azabicyclo[3.2.1] octane-8-carboxamide [128]; (lR,3s,5S)-N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-3-((3,3,3-trifluoropropyl) amino)-8 -azabicyclo [3.2.1] octane -8 -carboxamide [ 129] ;

(lR,3s,5S)-3-((l,3-difluoropropan-2-yl)amino)-N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6- naphthyridin-7-yl)-8-azabicyclo[3.2. l]octane-8-carboxamide [130];

N-(2 -( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 ,6 -naphthyridin-7 -yl)morpholine -4 -carboxamide [131];

4-(dimethylamino)-N-(2-( 1 -methyl-lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl)piperidine- 1 - carboxamide [132];

(S)-2,4-dimethyl-N-(2-( 1 -methyl- lH-pyrazol-4-yl)-l ,6-naphthyridin-7-yl)piperazine- 1 - carboxamide [133];

1 -methyl-3 -(2 -( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 ,6 -naphthyridin-7-yl) - 1 -( 1 -methylpiperidin-4 -yl)urea

[134];

1 -(2-( 1 -methyl-lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl)-3 -( 1 -methylpiperidin-4-yl)urea [135] ; 4-isopropyl-N-(2-( 1 -methyl- lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl)piperazine-l -carboxamide

[136];

(R)-3,4-dimethyl-N-(2-( 1 -methyl- lH-pyrazol-4-yl)-l ,6-naphthyridin-7-yl)piperazine- 1 - carboxamide [137];

N-(2-( lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl)-2-(4-methylpiperazin-l -yl)isonicotinamide [138] ; N-(2-( 1 -methyl-lH-pyrazol-4-yl)-l ,6-naphthyridin-7-yl)-3 -(piperazin- 1 -yl)benzamide [139] ; N-(2 -( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 ,6 -naphthyridin-7 -yl)-3 -(4 -methylpiperazin- 1 -yl)benzamide

[140];

N-(2 -( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 ,6 -naphthyridin-7 -yl)-3 -(pyrrolidin- 1 -ylmethyl)benzamide

[141];

N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-3-(piperidin-4-yloxy)benzamide [142]; N-(2 -( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 ,6 -naphthyridin-7 -yl)-3 -(( 1 -methylpiperidin-4-yl)oxy)

benzamide [143];

N-(2 -( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 ,6 -naphthyridin-7-y 1) -4 -(piperidin-4-yloxy)benzamide [144]; N-(2-( 1 -methyl -1 H-pyrazol -4 -yl)- 1 ,6-naphthyridin-7-yl)-4-(( 1 -methylpiperidin-4-yl)oxy)

benzamide [145];

N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-2-(piperazin-l-yl)isonicotinamide [146]; N-(2 -( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 ,6 -naphthyridin-7 -yl)-2-(4 -methylpiperazin- 1 -yl)

isonicotinamide [147];

2-(4-isopropylpiperazin- 1 -yl)-N-(2-( 1 -methyl- lH-pyrazol-4-yl)-l ,6-naphthyridin-7-yl)

isonicotinamide [148]; 2-(4-cyclopropylpiperazin- 1 -yl)-N-(2-( 1 -methyl-lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl) isonicotinamide [149];

2-(4-(2-fluoroethyl)piperazin- 1 -yl)-N-(2-( 1 -methyl-lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl) isonicotinamide [150];

N-(2-( 1 -methyl -lH-pyrazol -4 -yl)- 1 ,6-naphthyridin-7-yl)-6-(4-methylpiperazin- 1 -yl)nicotinamide

[151];

N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-5-(piperidin-4-yloxy)nicotinamide

[152];

N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-2-(piperidin-4-yloxy)isonicotinamide

[153];

N-(2-( 1 -methyl -lH-pyrazol -4 -yl)- 1 ,6-naphthyridin-7-yl)-2-(( 1 -methylpiperidin-4-yl)oxy)

isonicotinamide [154];

N-(2 -( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 ,6 -naphthyridin-7-y 1) -5 -(piperidin-4-ylamino)nicotinamide

[155];

N-(2 -( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 ,6 -naphthyridin-7 -yl)-5 -(( 1 -methylpiperidin-4-yl)amino) nicotinamide [156];

2-(4-aminopiperidin-l-yl)-N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)

isonicotinamide [157];

N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-2-(4-(methylamino)piperidin-l-yl) isonicotinamide [158];

2-(4-(dimethylamino)piperidin-l -yl)-N-(2-( 1 -methyl- 1 H-pyrazol -4 -yl)- 1 ,6-naphthyridin-7-yl) isonicotinamide [159];

2-(( 1 -isopropylpiperidin-4-yl)oxy)-N-(2-( 1 -methyl- lH-pyrazol-4-yl)-l ,6-naphthyridin-7-yl) isonicotinamide [160];

2-(3 -aminoazetidin- 1 -yl)-N-(2-( 1 -methyl -1 H-pyrazol -4 -yl)- 1 ,6-naphthyridin-7-yl)

isonicotinamide [161];

2-(3 -(dimethylamino)azetidin- 1 -yl)-N-(2-( 1 -methyl- lH-pyrazol-4-yl)-l ,6-naphthyridin-7-yl) isonicotinamide [162];

N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-2-mo holinoisonicotinamide [163]; 2-((2-(dimethylamino)ethyl)amino)-N-(2-( 1 -methyl- lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl) isonicotinamide [164];

2-(2-(dimethylamino)ethoxy)-N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)

isonicotinamide [165]; 2-(4-isobutylpiperazin-l-yl)-N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl) isonicotinamide [166];

2-(azetidin-3 -yloxy)-N-(2-( 1 -methyl-lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl)isonicotinamide

[167];

N-(2-( 1 -methyl -1 H-pyrazol -4 -yl)- 1 ,6-naphthyridin-7-yl)-2-(( 1 -methylazetidin-3 -yl)oxy)

isonicotinamide [168];

2-(4-ethylpiperazin-l-yl)-N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)

isonicotinamide [169];

4-((dimethylamino)methyl)-N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)benzamide

[170];

N-(2 -( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 ,6 -naphthyridin-7 -yl)-3 -( 1 -methylpiperidin-4 -yl)benzamide

[171];

N-(2-( 1 -methyl -1 H-pyrazol -4 -yl)- 1 ,6-naphthyridin-7-yl)-3-((4-methylpiperazin- 1 -yl)methyl) benzamide [172];

N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)isonicotinamide [173];

2-hydroxy-N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)isonicotinamide [174];

2-isopropoxy-N-(2-( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 , 6 -naphthyridin-7 -yl)isonicotinamide [ 175] ; N-(2-( 1 -methyl -1 H-pyrazol -4 -yl)- 1 ,6-naphthyridin-7-yl)-2-( 1 -methylpiperidin-4 -yl)

isonicotinamide [176];

r-methyl-N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-r,2',3',6'-tetrahydro-[2,4'- bipyridine]-4-carboxamide [177];

N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-2-(4-(6-(4-methylpiperazin-l-yl)

nicotinoyl)piperazin- 1 -yl)isonicotinamide [178] ;

2-(4-hydroxy-4-methyl-4 ⁴-piperazin-l-yl)-N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7- yl)isonicotinamide [179];

2- methyl-N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-6-(4-methylpiperazin-l-yl) isonicotinamide [180];

3- methyl-N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-2-(4-methylpiperazin-l-yl) isonicotinamide [181];

2-(4-methyl- 1 ,4-diazepan- 1 -yl)-N-(2-( 1 -methyl-lH-pyrazol-4-yl)-l ,6-naphthyridin-7-yl)

isonicotinamide [182];

2-((2S,6R)-2,6-dimethylmo holino)-N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl) isonicotinamide [183]; N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-2-(2J-diazaspiro[3.5]nonan-2-yl) isonicotinamide [184];

N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-2-(7-methyl-2 -diazaspiro[3.5]nonan-

2-yl)isonicotinamide [185];

N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-2-(2,7-diazaspiro[3.5]nonan-7-yl)

isonicotinamide [186];

N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-2-(2-methyl-2,7-diazaspiro[3.5]nonan-

7-yl)isonicotinamide [187];

2-(methyl( 1 -methylpiperidin-4-yl)amino)-N-(2-( 1 -methyl- lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7- yl)isonicotinamide [188];

N-(2-( 1 -methyl -1 H-pyrazol -4 -yl)- 1 ,6-naphthyridin-7-yl)-2-(( 1 -methylpiperidin-4-yl)thio)

isonicotinamide [189];

N-(2 -( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 ,6 -naphthyridin-7 -yl)-2-(4 -methylpiperazin- 1 -yl)pyrimidine - 4-carboxamide [190];

N-(2 -( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 ,6 -naphthyridin-7 -yl)-6-(4 -methylpiperazin- 1 -yl)pyridazine -4 - carboxamide [191];

N-(2 -( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 ,6 -naphthyridin-7 -yl)-6-(4 -methylpiperazin- 1 -yl)pyrimidine -

4-carboxamide [192];

N-(2 -( 1 -methyl - 1 H-pyrazol -4-yl) - 1 ,6 -naphthyridin-7-yl) -2 -phenylacetamide [193];

N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-3-phenylpropanamide [194];

N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-2-(pyridin-3-yl)acetamide [195];

N-(2 -( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 ,6 -naphthyridin-7 -yl)-3 -(pyridin-3 -yl)propanamide [196]; N-(2-( 1 -methyl -1 H-pyrazol -4-yl)- 1 ,6-naphthyridin-7-yl)-2-(pyridin-4-yl)acetamide [197] ;

N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-3-(pyridin-4-yl)propanamide [198]; N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)isoindoline-5-carboxamide [199];

2-methyl-N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)isoindoline-5-carboxamide

[200];

N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-l,2,3,4-tetrahydroisoquinoline-7- carboxamide [201];

2-methyl-N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-l,2,3,4- tetrahydroisoquinoline-7 -carboxamide [202] ;

2-methyl-N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-l,2,3,4- tetrahydroisoquinoline-6-carboxamide [203] ; N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-l,2,3,4 etrahydroisoquinoline-6- carboxamide [204];

N-(2 -( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 ,6 -naphthyridin-7-yl) - 1 H-indole-5 -carboxamide [205] ;

N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)benzofuran-5-carboxamide [206];

N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)furo[2,3-c]pyridine-5-carboxamide

[207];

N-(2 -( 1 -methyl - 1 H-pyrazol-4-yl) -1,6 -naphthyridin-7 -yl)benzo [b]thiophene -5 -carboxamide [208] ; N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)benzofuran-6-carboxamide [209];

N-(2 -( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 ,6 -naphthyridin-7 -yl)benzo [d] oxazole -6 -carboxamide [210]; N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)benzo[d]thiazole-6-carboxamide [211]; N-(2 -( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 ,6 -naphthyridin-7 -yl)benzo [d] oxazole -5 -carboxamide [212]; N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)benzo[d]thiazole-5-carboxamide [213]; N-(2 -( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 ,6 -naphthyridin-7 -yl)quinoline -3 -carboxamide [214];

N-(2-( 1 -methyl -1 H-pyrazol -4 -yl)- 1 ,6-naphthyridin-7-yl)quinoline-6-carboxamide [215] ;

N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)quinoxaline-6-carboxamide [216];

5-chloro-N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-2-(4-methylpiperazin-l-yl) isonicotinamide [217];

3-chloro-N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-2-(4-methylpiperazin-l-yl) isonicotinamide [218];

2- (2,5-diazabicyclo[2.2.1]heptan-2-yl)-N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7- yl)isonicotinamide [219];

N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-2-(5-methyl-2,5-diazabicyclo[2.2.1] heptan-2-yl)isonicotinamide [220] ;

3- fluoro-N-(2-( 1 -methyl- 1 H-pyrazol -4 -yl)- 1 ,6-naphthyridin-7-yl)-2-(4-methylpiperazin- 1 -yl) isonicotinamide [221];

N-(2-( 1 -methyl -1 H-pyrazol -4 -yl)- 1 ,6-naphthyridin-7-yl)-2-((4-methylpiperazin- 1 -yl)methyl) isonicotinamide [222];

N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-2-(mo holinomethyl)isonicotinamide

[223];

N-(2-( 1 -methyl -1 H-pyrazol -4 -yl)- 1 ,6-naphthyridin-7-yl)-2-(pyrrolidin- 1 -ylmethyl)

isonicotinamide [224];

N-(2-( 1 -methyl -1 H-pyrazol -4 -yl)- 1 ,6-naphthyridin-7-yl)-2-(2-(4-methylpiperazin- 1 -yl)pyridin-4- yl)acetamide [225]; 1 -methyl -N-(2 -( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 ,6 -naphthyridin-7-yl) - 1 H-indazole -5 -carboxamide

[226];

1 -methyl -N-(2 -( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 ,6 -naphthyridin-7-yl) - 1 H-benzo [d] imidazole-5 - carboxamide [227];

N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-l-(piperidin-4-yl)-lH-pyrazole-4- carboxamide [228];

N-(2-( 1 -methyl -1 H-pyrazol -4 -yl)- 1 ,6-naphthyridin-7-yl)- 1 -( 1 -methylpiperidin-4-yl)- 1H- pyrazole -4 -carboxamide [229];

1 -( 1 -ethylpiperidin-4-yl)-N-(2-( 1 -methyl- lH-pyrazol-4-yl)-l ,6-naphthyridin-7-yl)- lH-pyrazole-

4-carboxamide [230];

1 -( 1 -(2-fluoroethyl)piperidin-4-yl)-N-(2-( 1 -methyl-lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl)-lH- pyrazole -4 -carboxamide [231];

1- (l-isopropylpiperidin-4-yl)-N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-lH- pyrazole -4 -carboxamide [232];

1 -( 1 -cyclopropylpiperidin-4-yl)-N-(2-( 1 -methyl-lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl)- 1H- pyrazole -4 -carboxamide [233];

isopropyl 4-(4-((2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)carbamoyl)-lH-pyrazol-l- yl)piperidine-l-carboxylate [234];

N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-l-(piperidin-4-yl)-lH-l,2,3-triazole-4- carboxamide [235];

N-(2-( 1 -methyl-lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl)- 1 -( 1 -methylpiperidin-4-yl)- 1H- 1,2,3- triazole -4 -carboxamide [236];

1 -( 1 -(2-fluoroethyl)piperidin-4-yl)-N-(2-( 1 -methyl-lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl)-lH- l,2,3-triazole-4-carboxamide [237];

1 -( 1 -isopropylpiperidin-4-yl)-N-(2-( 1 -methyl-lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl)-lH-l ,2,3 - triazole -4 -carboxamide [238];

N-(2 -( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 ,6 -naphthyridin-7 -yl)-2-(4 -methylpiperazin- 1 -yl)oxazole -5 - carboxamide [239];

2- (3 -(dimethylamino)azetidin- 1 -yl)-N-(2-( 1 -methyl- lH-pyrazol-4-yl)-l ,6-naphthyridin-7-yl) oxazole -4 -carboxamide [240];

N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-2-(piperidin-4-yl)oxazole-4- carboxamide [241];

N-(2-( 1 -methyl -1 H-pyrazol -4 -yl)- 1 ,6-naphthyridin-7-yl)-2-( 1 -methylpiperidin-4-yl)oxazole-4- carboxamide [242]; 2-( 1 -(2-fluoroethyl)piperidin-4-yl)-N-(2-( 1 -methyl-lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl) oxazole-4-carboxamide [243];

2-( 1 -isopropylpiperidin-4-yl)-N-(2-( 1 -methyl-lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl)oxazole-4- carboxamide [244];

N-(2 -( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 ,6 -naphthyridin-7 -yl)-2-(4 -methylpiperazin- 1 -yl)oxazole -4 - carboxamide [245];

2-(3 -(dimethylamino)azetidin- 1 -yl)-N-(2-( 1 -methyl- lH-pyrazol-4-yl)-l ,6-naphthyridin-7-yl) thiazole-5 -carboxamide [246];

N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-2-(piperidin-4-yl)thiazole-4- carboxamide [247];

N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-2-(4-methylpiperazin-l-yl)thiazole-4- carboxamide [248];

2-( 1 -(2-fluoroethyl)piperidin-4-yl)-N-(2-( 1 -methyl-lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl) thiazole-4-carboxamide [249] ;

2-( 1 -isopropylpiperidin-4-yl)-N-(2-( 1 -methyl-lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl)thiazole-4- carboxamide [250];

l-methyl-N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl-8-£/)piperidine-4-carboxamide

[251];

N-(2-( 1 -methyl-lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl)- 1 -(2-(methyl-£¾)propyl- 1 , 1 ,2,3,3,3- ₆) piperidine-4-carboxamide [252];

N^-il-methyl-lH-pyrazol^-y^-l^-naphthyridin^-y^^-ipyrrolidin-l-yl^^^^-i ^acetamide

[253];

N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-2-(4-(methyl-£/3)piperazin-l-yl)

acetamide [254];

N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-2-(moφholino-ί s)acetamide [255]; ( S) -N-(2 -( 1 -(methyl -ds) - 1 H-pyrazol -4 -yl) - 1 ,6 -naphthyridin-7 -yl) -2 -(pyrrolidin- 1 -yl)propanamide

[256];

1 -isobutyl-N-(2-( 1 -(methyl -<¾)-lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl)piperidine-4-carboxamide

[257];

N-(2-( 1 -(methyl -<¾)- lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl)-2-(4-methylpiperazin- 1 -yl)

acetamide [258];

N-(2-( 1 -(methyl -<¾)- lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl)-2-(pyrrolidin-l -yl)acetamide [259] ; N-(2-( 1 -(methyl -<¾)- lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl)-2-(piperidin-l -yl)acetamide [260] ; N-(2-( 1 -(methyl -<¾)- lH-pyrazol-4-yl)-l ,6-naphthyridin-7-yl)- 1 -(3,3,3 -trifluoropropyl)piperidine- 4-carboxamide [261];

N-(2-(lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-2-(4-(methyl- 3)piperazin-l-yl)isonicotinamide

[262];

N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-2-(4-(methyl-£/3)piperazin-l-yl)

isonicotinamide [263];

N-(2-( 1 -(methyl -<¾)- lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl)-2-(4-methylpiperazin- 1 -yl)

isonicotinamide [264];

N-(2-( 1 -(methyl -<¾)- lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl)-2-(4-(methyl-<i3)piperazin- 1 -yl) isonicotinamide [265];

N-(2-( 1 -(methyl -<¾)- lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl)- 1 -(piperidin-4-yl)-lH-pyrazole-4- carboxamide [266];

N-(2-( 1 -(methyl-^)- lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl)-l -( 1 -methylpiperidin-4-yl)-lH- pyrazole-4-carboxamide [267];

N-(2-( 1 -(methyl -<¾)- lH-pyrazol-4-yl)- 1 ,6-naphthyridin -7 -yl)-2-(piperidin-4-yl)oxazole-4- carboxamide [268];

N-(2-( 1 -(methyl -<¾)- lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl)-2-( 1 -methylpiperidin-4-yl)oxazole- 4-carboxamide [269];

N-(2-( 1 -ethyl- lH-pyrazol-4-yl)-l ,6-naphthyridin-7-yl)-2-(pyrrolidin-l -yl)acetamide [270] ;

N-(2-( l-cyclopropyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-2 -(pyrrolidin-1 -yl)acetamide [271]; N-(2-(l-cyclopropyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-l-(3,3,3-trifluoropropyl)piperidine-

4-carboxamide [272];

N-(2-( 1 -( 1 -methylpiperidin-4-yl)-lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl)

cyclohexanecarboxamide [273];

2-(pyrrolidin- 1 -yl)-N-(2-(5-(trifluoromethyl)- lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl)acetamide

[274];

N-(2-(5-(hydroxymethyl)-l -methyl-lH-pyrazol-4-yl)-l ,6-naphthyridin-7-yl)-l -methylpiperidine- 4-carboxamide [275];

N-(2-(5-(hydroxymethyl)-l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)tetrahydro-2H-pyran-

4-carboxamide [276];

N-(2-(5-(azetidin-l-ylmethyl)-l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-4,4- difluorocyclohexane- 1 -carboxamide [277] ;

4,4-difluoro-N-(2-( 1 -methyl -5 -(pyrrolidin-1 -ylmethyl)- lH-pyrazol-4-yl)-l ,6-naphthyridin-7-yl) cyclohexane-1 -carboxamide [278]; 4,4-difluoro-N-(2-( 1 -methyl -5 -(piperidin-1 -ylmethyl)- lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl) cyclohexane-l-carboxamide [279];

2-(2 -fluoroethyl) -N-(2 -( 1 -methyl -5 -(piperidin- 1 -ylmethyl) - 1 H-pyrazol -4 -yl) - 1 , 6-naphthyridin-7- yl)-2-azaspiro[3.3]heptane-6-carboxamide [280] ;

fert-butyl 6-((2-( 1 -methyl -5 -(piperidin- 1 -ylmethyl) -1 H-pyrazol -4 -yl)-l ,6-naphthyridin-7- yl)carbamoyl)-2-azaspiro[3.3]heptane-2-carboxylate [281] ;

2-fluoro-2 -methyl -N-(2-( 1 -methyl-5 -(piperidin- 1 -ylmethyl)- lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7- yl)propanamide [282];

2-(diethylamino)-N-(2-( 1 -methyl-5 -(piperidin- 1 -ylmethyl) -1 H-pyrazol -4 -yl)-l ,6-naphthyridin-7- yl)acetamide [283];

fr «5-4-methoxy-N-(2-(l -methyl -5-(piperidin-l-ylmethyl)-lH-pyrazol-4-yl)-l,6-naphthyridin-7- yl)cyclohexane - 1 -carboxamide [284] ;

fr «5-4-(hydroxymethyl)-N-(2-( 1 -methyl-5 -(piperidin- 1 -ylmethyl)- lH-pyrazol-4-yl)-l ,6- naphthyridin-7 -yl)cyclohexane - 1 -carboxamide [285] ;

(R)-N-(2-(l-methyl-5-(piperidin-l-ylmethyl)-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)pyrrolidine-

2-carboxamide [286];

l-isobutyl-N-(2-(l-methyl-5-(piperidin-l-ylmethyl)-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl) piperidine-4-carboxamide [287];

N-(2-( 1 -methyl-5 -(piperidin- 1 -ylmethyl)- lH-pyrazol-4-yl)-l ,6-naphthyridin-7-yl)- 1 -(oxetan-3- yl)piperidine -4 -carboxamide [288] ;

1 -benzoyl -N-(2-( 1 -methyl -5 -(piperidin-1 -ylmethyl)- 1 H-pyrazol -4 -yl)- 1 ,6-naphthyridin-7-yl) piperidine-4-carboxamide [289];

N-(2-( 1 -methyl-5 -(piperidin- 1 -ylmethyl)- lH-pyrazol-4-yl)-l ,6-naphthyridin-7-yl)tetrahydro-2H- pyran-4-carboxamide [290];

N-(2-( 1 -methyl-5 -(piperidin- 1 -ylmethyl)- lH-pyrazol-4-yl)-l ,6-naphthyridin-7-yl)-2-(4- methylpiperidin- 1 -yl)acetamide [291] ;

N-(2-( 1 -(difluoromethyl)-l H-pyrazol -4 -yl)- 1 ,6-naphthyridin-7-yl)-2-(4-methylpiperazin- 1 -yl) isonicotinamide [292];

N-(2-( 1 -ethyl- 1 H-pyrazol-4-yl) - 1 ,6-naphthyridin-7-yl)-2-(4-methylpiperazin- 1 -yl)

isonicotinamide [293];

N-(2-(l-isopropyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-3-(piperidin-4-yloxy)benzamide

[294];

N-(2-(l-isopropyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-3-((l-methylpiperidin-4-yl)oxy) benzamide [295]; N-(2-(l-isopropyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-4-(piperidin-4-yloxy)benzamide [296];

N-(2-( 1 -cyclopropyl-lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl)-2-(4-methylpiperazin- 1 -yl)

isonicotinamide [297];

4-fluoro-N-(2-( 1 -( 1 -methylpiperidin-4-yl)- lH-pyrazol-4-yl)-l ,6-naphthyridin-7-yl)benzamide

[298];

4- (difluoromethoxy)-N-(2-( 1 -( 1 -methylpiperidin-4-yl)- lH-pyrazol-4-yl)-l ,6-naphthyridin-7-yl) benzamide [299];

5- fluoro-N-(2-(l-(l-methylpiperidin-4-yl)-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)nicotinam

[300];

N² -methyl -N⁵-(2-( 1 -( 1 -methylpiperidin-4-yl)- lH-pyrazol-4-yl)-l ,6-naphthyridin-7-yl)pyridine-

2,5-dicarboxamide [301];

1 -isopropyl-N-(2-( 1 -( 1 -methylpiperidin-4-yl)-lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl)-lH- pyrazole-4-carboxamide [302];

2-methyl-N-(2-( 1 -( 1 -methylpiperidin-4-yl)- lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl)thiazole-5- carboxamide [303];

N-(2-(5-amino-l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-2-(4-methylpiperazin-l-yl) isonicotinamide [304];

4-(difluoromethoxy)-N-(2-(5-(hydroxymethyl)-l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl) benzamide [305];

N-(2-(5-(hydroxymethyl)-l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-2-(4- methylpiperazin-l-yl)isonicotinamide [306];

N-(2-(5-(hydroxymethyl)- 1 -methyl- lH-pyrazol-4-yl)- 1 ,6-naphthyridin-7-yl)-2-(7-methyl-2,7- diazaspiro[3.5]nonan-2-yl)isonicotinamide [307];

4-fluoro-N-(2-(l-methyl-5-(pyrrolidin-l-ylmethyl)-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl) benzamide [308];

4-fluoro-N-(2-(l-methyl-5-(piperidin-l-ylmethyl)-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)

benzamide [309];

4-(difluoromethoxy)-N-(2-(l-methyl-5-(piperidin-l-ylmethyl)-lH-pyrazol-4-yl)-l,6- naphthyridin-7-yl)benzamide [310];

N-(2-( 1 -methyl -5 -(piperidin- 1 -ylmethyl)- lH-pyrazol-4-yl)-l ,6-naphthyridin-7-yl)-3-(pyrrolidin-

1 -ylmethyl)benzamide [311];

N-(2-( 1 -methyl -5 -(piperidin- 1 -ylmethyl)- lH-pyrazol-4-yl)-l , 6-naphthyridin-7 -yl)-2-(7-methyl-

2,7-diazaspiro[3.5]nonan-2-yl)isonicotinamide [312]; N-(2-( 1 -methyl -5 -(piperidin- 1 -ylmethyl)- lH-pyrazol-4-yl)-l ,6-naphthyridin-7-yl)-2- moφholinoisonicotinamide [313];

N-(2-( 1 -methyl -5 -^ο ^1ίηοΓηεΐ1τγ1)-1Η^^ο1-4^1)- 1 ,6-naphthyridin-7-yl)-2- moφholinoisonicotinamide [314];

N-(2-(4,5 ,6,7-tetrahydropyrazolo[ 1 ,5-a]pyrazin-3 -yl)-l ,6-naphthyridin-7-yl)- 1 -(( 1 -

(trifluoromethyl)cyclopropyl)methyl)piperidine -4 -carboxamide [315];

3,3-difluoro-N-(2-(5-methyl-4,5,6,7-tetrahydropyrazolo[l,5-a]pyrazin-3-yl)-l,6-naphthyridin-7- yl)cyclobutane - 1 -carboxamide [316];

N-((4,4-difluorocyclohexyl)methyl)-2-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[l,5-a] pyrazin-3-yl)-l,6-naphthyridin-7 -amine [317];

N-(2-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[l,5-a]pyrazin-3-yl)-l,6-naphthyridin-7-yl)-l-

(( 1 -(trifluoromethyl)cyclopropyl)methyl)piperidine-4-carboxamide [318] ;

N-(2-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[l,5-a]pyrazin-3-yl)-l,6-naphthyridin-7-yl)-2-

(pyrrolidin- 1 -yl)acetamide [319] ;

2-(7-azabicyclo[2.2.1]heptan-7-yl)-N-(2-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[l,5- a]pyrazin-3-yl)- 1 ,6-naphthyridin-7-yl)acetamide [320] ;

(R)-N-(2-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[ 1 ,5 -a]pyrazin-3 -yl)-l ,6-naphthyridin-7- yl)-l-isobutylpiperidine-3-carboxamide [321];

N-(2-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[l,5-a]pyrazin-3-yl)-l,6-naphthyridin-7-yl) piperidine-4-carboxamide [322];

4-fluoro-N-(2-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[l,5-a]pyrazin-3-yl)-l,6- naphthyridin-7-yl)- 1 -isobutylpiperidine-4-carboxamide [323] ;

N-(2-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[l,5-a]pyrazin-3-yl)-l,6-naphthyridin-7-yl)-2-

(4-methylpiperazin- 1 -yl)acetamide [324] ;

4-fluoro-N-(2-(4,5,6,7-tetrahydropyrazolo[l,5-a]pyrazin-3-yl)-l,6-naphthyridin-7-yl)benzamide

[325];

N-(2-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[l,5-a]pyrazin-3-yl)-l,6-naphthyridin-7-yl)-3-

(4-methylpiperazin- 1 -yl)benzamide [326] ;

N⁵-(2-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[l,5-a]pyrazin-3-yl)-l,6-naphthyridin-7-yl)-

N²-methylpyridine-2,5 -dicarboxamide [327] ;

N-(2-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[l,5-a]pyrazin-3-yl)-l,6-naphthyridin-7-yl)-6-

(4-methylpiperazin- 1 -yl)nicotinamide [328] ;

2-(azetidin-3-yloxy)-N-(2-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[l,5-a]pyrazin-3-yl)-l,6- naphthyridin-7-yl)isonicotinamide [329] ; N-(2-(l-methyl-lH-pyrazol-5-yl)-l,6-naphthyridin-7-yl)-l-(3,3,3 rifluoropropyl)piperidine-4- carboxamide [330];

1 -methyl -N-(2 -( 1 -methyl - 1 H-pyrazol -3 -yl) - 1 ,6 -naphthyridin-7-yl)piperidine -4 -carboxamide

[331];

N-(2 -( 1 -methyl - 1 H-pyrazol -3 -yl) - 1 ,6 -naphthyridin-7 -yl)-2-(4 -methylpiperazin- 1 -yl)

isonicotinamide [332];

2-fluoro-2 -methyl -N-(2-( 1 -methyl-lH- 1 ,2,3 -triazol-4-yl)-l ,6-naphthyridin-7-yl)propanamide

[333];

2,2,3, 3-tetramethyl-N-(2-(l-methyl-lH-l,2,3-triazol-4-yl)-l,6-naphthyridin-7-yl)cyclopropane-l- carboxamide [334];

fr «5-N-(2-(l-methyl-lH-l,2,3-triazol-4-yl)-l,6-naphthyridin-7-yl)-4-(pyrrolidin-l-yl)

cyclohexane - 1 -carboxamide [335] ;

fr rø-N-(2-(l-methyl-lH-l,2,3-triazol-4-yl)-l,6-naphthyridin-7-yl)-4-mo holinocyclohexane-l- carboxamide [336];

N-(2-(l-methyl-lH-l,2,3-triazol-4-yl)-l,6-naphthyridin-7-yl)-2-(piperidin-l-yl)acetamide [337]; 1 -ethyl -4-fluoro-N-(2-( 1 -methyl- 1H- 1 ,2,3 -triazol-4-yl)-l ,6-naphthyridin-7-yl)piperidine-4- carboxamide [338];

4-fluoro- 1 -isobutyl-N-(2-( 1 -methyl- 1H- 1 ,2,3 -triazol-4-yl)-l ,6-naphthyridin-7-yl)piperidine-4- carboxamide [339];

N-(2-(l-methyl-lH-l,2,3-triazol-4-yl)-l,6-naphthyridin-7-yl)-l-(3,3,3-trifluoropropyl)piperidine- 4-carboxamide [340];

N-(2-(l-methyl-lH-l,2,3-triazol-4-yl)-l,6-naphthyridin-7-yl)cyclopropanecarboxamide [341]; 4,4-difluoro-N-(2-( 1 -methyl- 1H- 1 ,2,3 -triazol-4-yl)- 1 ,6-naphthyridin-7-yl)cyclohexane- 1 - carboxamide [342];

fr «5-4-(dimethylamino)-N-(2-( 1 -methyl-lH- 1 ,2,3-triazol-4-yl)- 1 ,6-naphthyridin-7-yl)

cyclohexane - 1 -carboxamide [343] ;

fr «5-N-(2-(l-methyl-lH-l,2,3-triazol-4-yl)-l,6-naphthyridin-7-yl)-4-((4-methylpiperazin-l-yl) methyl)cyclohexane - 1 -carboxamide [344] ;

N-(2-(l-methyl-lH-l,2,3-triazol-4-yl)-l,6-naphthyridin-7-yl)piperidine-4-carboxamide [345]; 1 -isobutyl-N-(2-( 1 -methyl- lH-1 ,2,3-triazol-4-yl)-l ,6-naphthyridin -7 -yl)piperidine-4- carboxamide [346];

N-(2-( 1 -methyl- lH-1 ,2,3-triazol-4-yl)- 1 ,6-naphthyridin -7 -yl)- 1 -(( 1 -(trifluoromethyl)cyclopropyl) methyl)piperidine -4 -carboxamide [347] ; N-(2-( 1 -methyl-lH-1 ,2,3-triazol-4-yl)- 1 ,6-naphthyridin-7-yl)- 1 -((3-methyloxetan-3 -yl)methyl) piperidine-4-carboxamide [348];

N-(2-( 1 -methyl-lH-1 ,2,3-triazol-4-yl)- 1 ,6-naphthyridin-7-yl)- 1 -(2-(pyrrolidin- 1 -yl)acetyl)

piperidine-4-carboxamide [349];

1 '-methyl-N-(2-( 1 -methyl- lH-1 ,2,3 -triazol-4-yl)-l ,6-naphthyridin-7-yl)-[ 1 ,4'-bipiperidine] -4- carboxamide [350];

(R)-N-(2-(l-methyl-lH-l,2,3-triazol-4-yl)-l,6-naphthyridin-7-yl)piperidine-3-carboxamide [351]; (R)-l-isobutyl-N-(2-(l-methyl-lH-l,2,3-triazol-4-yl)-l,6-naphthyridin-7-yl)piperidine-3- carboxamide [352];

N-(2-(l-methyl-lH-l,2,3-triazol-4-yl)-l,6-naphthyridin-7-yl)-2-(pyrrolidin-l-yl)acetamide [353]; N-(2-( 1 -methyl-lH-1 ,2,3-triazol-4-yl)- 1 ,6-naphthyridin-7-yl)-2-(4-methylpiperazin- 1 -yl)

acetamide [354];

2-(7-azabicyclo[2.2.1]heptan-7-yl)-N-(2-(l-methyl-lH-l,2,3-triazol-4-yl)-l,6-naphthyridin-7-yl) acetamide [355];

1 -(2-hydroxy-2-methylpropyl)-N-(2-( 1 -methyl- IH- 1 ,2,3-triazol-4-yl)- 1 ,6-naphthyridin-7-yl) piperidine-4-carboxamide [356];

N-(2-(l-methyl-lH-l,2,3-triazol-4-yl)-l,6-naphthyridin-7-yl)-2-moφholinoacetamide [357]; 2-(4-methoxypiperidin-l-yl)-N-(2-(l-methyl-lH-l,2,3-triazol-4-yl)-l,6-naphthyridin-7-yl)

acetamide [358];

N-(2-(l-methyl-lH-l,2,3-triazol-4-yl)-l,6-naphthyridin-7-yl)mo holine-4-carboxamide [359]; N-(2-(l-methyl-lH-l,2,3-triazol-4-yl)-l,6-naphthyridin-7-yl)-l-(piperidin-4-yl)-lH-pyrazole-4- carboxamide [360];

N-(2-(l-methyl-lH-l,2,3-triazol-4-yl)-l,6-naphthyridin-7-yl)-l-(l-methylpiperidin-4-yl)-lH- pyrazole-4-carboxamide [361];

1 -( 1 -ethylpiperidin-4-yl)-N-(2-( 1 -methyl- IH- 1 ,2,3 -triazol-4-yl)- 1 ,6-naphthyridin-7-yl)-lH- pyrazole-4-carboxamide [362];

l-(l-isopropylpiperidin-4-yl)-N-(2-(l-methyl-lH-l,2,3-triazol-4-yl)-l,6-naphthyridin-7-yl)-lH- pyrazole-4-carboxamide [363];

N-(2-(l-methyl-lH-l,2,3-triazol-4-yl)-l,6-naphthyridin-7-yl)-l-(piperidin-4-yl)-lH-l,2,3- triazole-4-carboxamide [364];

1 -( 1 -(2-fluoroethyl)piperidin-4-yl)-N-(2-( 1 -methyl-lH- 1 ,2,3-triazol-4-yl)-l ,6-naphthyridin-7-yl)- lH-l,2,3-triazole-4-carboxamide [365];

l-(l-isopropylpiperidin-4-yl)-N-(2-(l-methyl-lH-l,2,3-triazol-4-yl)-l,6-naphthyridin-7-yl)-lH- l,2,3-triazole-4-carboxamide [366]; N-(2-(l-methyl-lH-l,2,3-triazol-4-yl)-l,6-naphthyridin-7-yl)-2-(piperidin-4-yl)oxazole-4- carboxamide [367];

N-(2-(l-methyl-lH-l,2,3 riazol-4-yl)-l,6-naphthyridin-7-yl)-2-(l-methylpiperidin-4-yl)oxazole- 4-carboxamide [368];

2-( 1 -isopropylpiperidin-4-yl)-N-(2-( 1 -methyl- 1H- 1 ,2,3-triazol-4-yl)-l ,6-naphthyridin-7-yl) oxazole-4-carboxamide [369];

2-fluoro-N-(2-( 1 -methyl- 1H- 1 ,2,3 -triazol-4-yl)-l ,6-naphthyridin-7-yl)benzamide [370] ;

N-(2-( 1 -methyl-lH-1 ,2,3-triazol-4-yl)- 1 ,6-naphthyridin-7-yl)-3 -(( 1 -methylpiperidin-4-yl)oxy) benzamide [371];

N²-methyl-N⁵-(2-(l-methyl-lH-l,2,3-triazol-4-yl)-l,6-naphthyridin-7-yl)pyridine-2,5- dicarboxamide [372];

N-(2-( 1 -methyl-lH-1 ,2,3-triazol-4-yl)- 1 ,6-naphthyridin-7-yl)-6-(4-methylpiperazin- 1 -yl)

nicotinamide [373];

2-(3 -(dimethylamino)azetidin- 1 -yl)-N-(2-( 1 -methyl- 1H- 1 ,2,3-triazol-4-yl)- 1 ,6-naphthyridin-7-yl) isonicotinamide [374];

N-(2-( 1 -methyl-lH-1 ,2,3-triazol-4-yl)- 1 ,6-naphthyridin-7-yl)-2-( 1 -methylpiperidin-4-yl)

isonicotinamide [375];

2-(4-(dimethylamino)piperidin-l-yl)-N-(2-(l-methyl-lH-l,2,3-triazol-4-yl)-l,6-naphthyridin-7- yl)isonicotinamide [376];

N-(2-(l-methyl-lH-l,2,3-triazol-4-yl)-l,6-naphthyridin-7-yl)-2-moφholinoisonicotinamide

[377];

N-(2-( 1 -methyl-lH-1 ,2,3-triazol-4-yl)- 1 ,6-naphthyridin-7-yl)-2-(4-methylpiperazin- 1 -yl)

isonicotinamide [378];

2-(4-methyl- 1 ,4-diazepan- 1 -yl)-N-(2-( 1 -methyl-lH-1 ,2,3-triazol-4-yl)-l ,6-naphthyridin-7-yl) isonicotinamide [379];

2-(4-isopropylpiperazin-l -yl)-N-(2-( 1 -methyl- 1H- 1 ,2,3-triazol-4-yl)-l ,6-naphthyridin-7-yl) isonicotinamide [380];

N-(2-(l-methyl-lH-l,2,3-triazol-4-yl)-l,6-naphthyridin-7-yl)-2-(piperidin-4-ylamino)

isonicotinamide [381];

2-(methyl( 1 -methylpiperidin-4-yl)amino)-N-(2-( 1 -methyl- 1H- 1 ,2,3 -triazol-4-yl)-l ,6- naphthyridin-7-yl)isonicotinamide [382] ;

N-(2-(l-methyl-lH-l,2,3-triazol-4-yl)-l,6-naphthyridin-7-yl)-2-((l-methylpiperidin-4-yl)thio) isonicotinamide [383]; 2-methyl-N-(2-(l-methyl-lH-l,2,3-triazol-4-yl)-l,6-naphthyridin-7-yl)-l,2,3,4- tetrahydroisoquinoline-6-carboxamide [384] ;

N-(2-(l-methyl-lH-l,2,3 riazol-4-yl)-l,6-naphthyridin-7-yl)-2-(piperazin-l-yl)isonicotinami

[385];

N-(2-(l-methyl-lH-l,2,3 riazol-4-yl)-l,6-naphthyridin-7-yl)-2-(2-(4-methylpiperazin-l-yl) pyridin-4-yl)acetamide [386];

1 , 1 -bis(methyl-£¾)-4-(4-((2-( 1 -methyl- 1H- 1 ,2,3 -triazol-4-yl)- 1 ,6-naphthyridin-7-yl)carbamoyl) pyridin-2-yl)piperazin- 1 -ium [387] ;

N-(2-(l-methyl-lH-l,2,3-triazol-4-yl)-l,6-naphthyridin-7-yl)-2-(4-(methyl-d3)piperazin-l-yl) isonicotinamide [388];

N-(2-(l-methyl-lH-l,2,3-triazol-5-yl)-l,6-naphthyridin-7-yl)-l-(3,3,3-trifluoropropyl)piperidine- 4-carboxamide [389];

N-(2-(4-methyl-4H-l ,2,4-triazol-3 -yl)- 1 ,6-naphthyridin-7-yl)-2-moφholinoacetamide [390] ; N-(2-(4-methyl-4H-l ,2,4-triazol-3 -yl)- 1 ,6-naphthyridin-7-yl)- 1 -(3,3,3 -trifluoropropyl)piperidine- 4-carboxamide [391];

4-fluoro- 1 -isobutyl-N-(2-(4-methyl-4H- 1 ,2,4-triazol-3 -yl)-l ,6-naphthyridin-7-yl)piperidine-4- carboxamide [392];

N-(2-(4,5-dimethyl-4H-l,2,4-triazol-3-yl)-l,6-naphthyridin-7-yl)-2-moφholinoacetamide [393]; N-(2-(4,5-dimethyl-4H-l,2,4-triazol-3-yl)-l,6-naphthyridin-7-yl)-l-(3,3,3-trifluoropropyl)

piperidine-4-carboxamide [394];

N-(2-( 1H- 1 ,2,3 -triazol-1 -yl)- 1 ,6-naphthyridin-7-yl)-4-fluoro- 1 -isobutylpiperidine-4-carboxamide

[395];

N-(2-(2H- 1 ,2,3 -triazol-2-yl)- 1 ,6-naphthyridin-7-yl)-4-fluoro- 1 -isobutylpiperidine-4-carboxamide

[396];

N-(2-( 1H- 1 ,2,4-triazol-l -yl)- 1 ,6-naphthyridin-7-yl)-2-(4-methylpiperazin-l -yl)isonicotinamide

[397];

1 -isobutyl-N-(2-( 1 -methyl- lH-tetrazol-5-yl)-l ,6-naphthyridin-7-yl)piperidine-4-carboxamide

[398];

2,2,3, 3-tetramethyl-N-(2-( 1 -methyl -IH-imidazol -5 -yl)- 1 ,6-naphthyridin-7-yl)cyclopropane- 1 - carboxamide [399];

4,4-difluoro-N-(2-(l-methyl-lH-imidazol-5-yl)-l,6-naphthyridin-7-yl)cyclohexane-l- carboxamide [400];

N-(2-(l-methyl-lH-imidazol-5-yl)-l,6-naphthyridin-7-yl)-2-(piperidin-l-yl)acetamide [401]; 2 -fluoro-2 -methyl -N-(2-( 1 -methyl -IH-imidazol -5 -yl)- 1 ,6-naphthyridin-7-yl)propanamide [402] ; 1 -fluoro-N-(2-( 1 -methyl- lH-imidazol-5 -yl)- 1 ,6-naphthyridin-7-yl)cyclopropane- 1 -carboxamide

[403];

2-methyl-N-(2-(l-methyl-lH-imidazol-5-yl)-l,6-naphthyridin-7-yl)-2-azaspiro[3.3]heptane-6- carboxamide [404];

1 -fluoro -N-(2 -( 1 -methyl - 1 H-imidazol-5 -yl) - 1 , 6-naphthyridin-7-yl)cyclohexane - 1 -carboxamide

[405];

fr «5-4-methoxy-N-(2-( 1 -methyl- lH-imidazol-5-yl)- 1 ,6-naphthyridin-7-yl)cyclohexane-l - carboxamide [406];

fr «5-4-(hydroxymethyl)-N-(2-(l-methyl-lH-imidazol-5-yl)-l,6-naphthyridin-7-yl)cyclohexane- 1 -carboxamide [407];

N-(2 -( 1 -methyl - 1 H-imidazol-5 -yl) - 1 , 6-naphthyridin-7 -yl)azetidine -3 -carboxamide [408] ;

(R) -N-(2 -( 1 -methyl - 1 H-imidazol-5 -yl) - 1 , 6-naphthyridin-7 -yl)tetrahydrofuran-2 -carboxamide

[409];

1- (2-methoxyethyl)-N-(2-(l-methyl-lH-imidazol-5-yl)-l,6-naphthyridin-7-yl)piperidine-4- carboxamide [410];

N-(2 -( 1 -methyl - 1 H-imidazol-5 -yl) - 1 , 6-naphthyridin-7 -yl) - 1 -(3 , 3 ,3 -trifluoropropyl)piperidine -4 - carboxamide [411];

1 -isobutyl-N-(2-( 1 -methyl- lH-imidazol-5-yl)-l ,6-naphthyridin -7 -yl)piperidine-4-carboxamide

[412];

N-(2-( 1 -methyl-lH-imidazol-5-yl)- 1 ,6-naphthyridin-7-yl)- 1 -(methylsulfonyl)piperidine-4- carboxamide [413];

N-(2-( 1 -methyl-lH-imidazol-5-yl)- 1 ,6-naphthyridin -7 -yl)-2-(pyrrolidin- 1 -yl)propanamide [414] ;

2- isopropoxy-N-(2-( 1 -methyl- lH-imidazol-5 -yl)- 1 ,6-naphthyridin-7-yl)acetamide [415] ;

3- isopropoxy-N-(2-( 1 -methyl -1 H-imidazol-5 -yl)- 1 ,6-naphthyridin-7-yl)propanamide [416] ; N-(2-(l,2-dimethyl-lH-imidazol-5-yl)-l,6-naphthyridin-7-yl)cyclopropanecarboxamide [417]; N-(2-(l,2-dimethyl-lH-imidazol-5-yl)-l,6-naphthyridin-7-yl)cyclohexanecarboxamide [418]; N-(2-( 1 ,2-dimethyl- lH-imidazol-5-yl)-l ,6-naphthyridin-7-yl)-4,4-difluorocyclohexane- 1 - carboxamide [419];

(S)-N-(2-( 1 ,2-dimethyl- lH-imidazol-5 -yl)- 1 ,6-naphthyridin -7 -yl)tetrahydrofuran-2 -carboxamide

[420];

N-(2-(l,2-dimethyl-lH-imidazol-5-yl)-l,6-naphthyridin-7-yl)-3,3-difluorocyclobutane-l- carboxamide [421];

N-(2-( 1 ,2-dimethyl- lH-imidazol-5-yl)-l ,6-naphthyridin-7-yl)- 1 -fluorocyclopropane-1 - carboxamide [422]; N-(2-(l,2-dimethyl-lH-imidazol-5-yl)-l,6-naphthyridm^ [423]; N-(2-(l,2-dimethyl-lH-imidazol-5-yl)-l,6-naphthyridm^

[424];

1 -methyl -N-(2-( 1 -methyl- 1 H-imidazol-5 ^

[425];

l-ethyl-N-(2-(l-methyl-lH-imidazol-5-yl)-l,6-naphthyridin-7-yl)-lH-pyrazole-4-carboxamide

[426];

1 -isopropyl-N-(2-( 1 -methyl- lH-imidazol-5-yl)- 1 ,6-naphthyridin-7-yl)- lH-pyrazole-4- carboxamide [427];

1 -cyclopropyl-N-(2-( 1 -methyl -lH-imidazol -5 -yl)- 1 ,6-naphthyridin-7-yl)- lH-pyrazole-4- carboxamide [428];

1- isobutyl-N-(2-(l-methyl-lH-imidazol-5-yl)-l,6-naphthyridin-7-yl)-lH-pyrazole-4-carboxamide

[429];

1 -methyl -N-(2 -( 1 -methyl - 1 H-imidazol-5 -yl) - 1 ,6 -naphthyridin-7 -yl) - 1 H-pyrazole -3 -carboxamide

[430];

N-(2-(l-methyl-lH-imidazol-5-yl)-l,6-naphthyridin-7-yl)-2-(l-methyl-lH-pyrazol-4-yl)

acetamide [431];

1 -methyl -N-(2 -( 1 -methyl - 1 H-imidazol-5 -yl) - 1 ,6 -naphthyridin-7 -yl) - 1 H-imidazole -4 -carboxamide

[432];

1 -isopropyl-N-(2-( 1 -methyl- lH-imidazol-5-yl)- 1 ,6-naphthyridin-7-yl)- lH-imidazole-4- carboxamide [433];

N-(2-( 1 -methyl-lH-imidazol-5-yl)-l ,6-naphthyridin-7-yl)- 1 -(tetrahydro-2H-pyran-4-yl)- 1H- imidazole -4 -carboxamide [434] ;

1 ,2-dimethyl-N-(2-( 1 -methyl -1 H-imidazol-5 -yl)- 1 ,6-naphthyridin-7-yl)- lH-imidazole-5- carboxamide [435];

1 -methyl-N-(2-( 1 -methyl-lH-imidazol-5 -yl)- 1 ,6-naphthyridin-7-yl)-lH-l ,2,4-triazole-3 - carboxamide [436];

2- methyl-N-(2-( 1 -methyl-lH-imidazol-5 -yl)- 1 ,6-naphthyridin-7-yl)oxazole-4-carboxamide [437] ; 2-isopropyl-N-(2-( 1 -methyl- lH-imidazol-5-yl)- 1 ,6-naphthyridin-7-yl)oxazole-4-carboxamide

[438];

4-methyl-N-(2-( 1 -methyl-lH-imidazol-5 -yl)- 1 ,6-naphthyridin -7 -yl)oxazole-2 -carboxamide [439] ; 4-methyl-N-(2-( 1 -methyl-lH-imidazol-5 -yl)- 1 ,6-naphthyridin -7 -yl)thiazole-2 -carboxamide [440] ; 2-methyl-N-(2-( 1 -methyl-lH-imidazol-5 -yl)- 1 ,6-naphthyridin -7 -yl)thiazole -4 -carboxamide [441] ; 5 -methyl -N-(2 -( 1 -methyl - 1 H-imidazol-5 -yl) - 1 ,6 -naphthyridin-7 -yl) - 1 , 3 ,4 -oxadiazole -2 - carboxamide [442];

5 -methyl -N-(2 -( 1 -methyl - 1 H-imidazol-5 -yl) - 1 ,6 -naphthyridin-7 -yl) - 1 , 3 ,4 -thiadiazole -2 - carboxamide [443];

1 -isopropyl -N-(2-( 1 -isopropyl- lH-imidazol-5-yl)- 1 ,6-naphthyridin-7-yl)- lH-pyrazole-4- carboxamide [444];

N-(2-( 1 ,2-dimethyl- lH-imidazol-5-yl)-l ,6-naphthyridin-7-yl)- 1 -methyl- lH-pyrazole-4- carboxamide [445];

N-(2-( l,2-dimethyl-lH-imidazol-5-yl)-l,6-naphthyridin-7-yl)-l-isopropyl-lH-pyrazole-4- carboxamide [446];

N-(2-( l,2-dimethyl-lH-imidazol-5-yl)-l,6-naphthyridin-7-yl)-2-methylthiazole-5-carboxamide

[447];

4-fluoro-N-(2-( 1 -methyl- lH-imidazol-5 -yl)- 1 ,6-naphthyridin-7-yl)benzamide [448] ;

4-(difluoromethoxy)-N-(2-( l-methyl-lH-imidazol-5-yl)-l,6-naphthyridin-7-yl)benzamide [449]; N-(2 -( 1 -methyl - 1 H-imidazol-5 -yl) - 1 , 6-naphthyridin-7 -yl) -3 -(pyrrolidin- 1 -ylmethyl)benzamide

[450];

2-fluoro-N-(2-( l-methyl-lH-imidazol-5-yl)-l,6-naphthyridin-7-yl)benzamide-3,4,5,6-£/4 [451] ; 4-fluoro-N-(2-( l-methyl-lH-imidazol-5-yl)-l,6-naphthyridin-7-yl)benzamide-2,3,5,6-£/4 [452] ; 2-chloro-N-(2-( l-methyl-lH-imidazol-5-yl)-l,6-naphthyridin-7-yl)benzamide-3,4,5,6-£/4 [453]; 4-chloro-N-(2-( 1 -methyl- 1 H-imidazol-5 -yl)- 1 ,6-naphthyridin-7-yl)benzamide-2,3 ,5,6-d4 [454] ; 4-(methyl-£/3)-N-(2-(l -methyl-lH-imidazol-5-yl)-l,6-naphthyridin-7-yl)benzamide [455];

4-methyl-N-(2-( 1 -methyl-lH-imidazol-5 -yl)- 1 ,6-naphthyridin-7-yl)benzamide-2,3 ,5,6-d4 [456] ; 4-(methyl-£/3)-N-(2-(l -methyl-lH-imidazol-5-yl)-l,6-naphthyridin-7-yl)benzamide-2,3,5,6-ii4

[257];

4-(methoxy-£/3)-N-(2-( l -methyl-lH-imidazol-5-yl)-l,6-naphthyridin-7-yl)benzamide [458]; 4-(methoxy- 3)-N-(2-( l -methyl-lH-imidazol-5-yl)-l,6-naphthyridin-7-yl)benzamide-2,3,5,6-£/4

[459];

4-methoxy-N-(2-( 1 -methyl- 1 H-imidazol-5 -yl)- 1 ,6-naphthyridin-7-yl)benzamide-2,3,5,6-<¾ [460] ; (E)-N-(2-(l,2-dimethyl-lH-imidazol-5-yl)-l,6-naphthyridin-7-yl)-3-(phenyl-2,3,4,5,6- j)

acrylamide [461];

(E)-N-(2-(l,2-dimethyl-lH-imidazol-5-yl)-l,6-naphthyridin-7-yl)-3-(phenyl-2,3,4,5,6- j)

acrylamide-2,3-£/2 [462];

N-(2-( l,2-dimethyl-lH-imidazol-5-yl)-l,6-naphthyridin-7-yl)-2-(4-fluorophenyl)acetamide-2,2- d₂ [463] ; (E)-N-(2-(l-methyl-lH-imidazol-5-yl)-l,6-^

[464];

(E)-N-(2-(l-methyl-lH-imidazol-5-yl)-l,6-naphthyridin-7-yl)-3-(phenyl-2,3,4,5,6- j)acrylam 2,2-d₂ [465];

2-(4-fluorophenyl)-N-(2-(l-methyl-lH-imidazol-5-yl^^

[466];

N-(2 -( 1 -methyl - 1 H-imidazol-5 -yl) - 1 , 6-naphthyridin-7 -yl) -2-(4 -methylpiperazin- 1 -yl)

isonicotinamide [467];

2-(dimethylamino)-N-(2-( 1 -methyl- lH-imidazol-5-yl)- 1 ,6-naphthyridin-7-yl)isonicotinamide

[468];

2-(3 -aminoazetidin- 1 -yl)-N-(2-( 1 -methyl -lH-imidazol -5 -yl)- 1 ,6-naphthyridin-7-yl)

isonicotinamide [469];

N-(2-( 1 -methyl-lH-imidazol-5-yl)- 1 ,6-naphthyridin-7-yl)-2-(pyrrolidin- 1 -yl)isonicotinamide

[470];

N-(2-(l-methyl-lH-imidazol-5-yl)-l,6-naphthyridin-7-yl)-2-(piperidin-l-yl)isonicotinamide

[471];

N-(2-(l-methyl-lH-imidazol-5-yl)-l,6-naphthyridin-7-yl)-2-moφholinoisonicotinamide [472]; 2-(4-isopropylpiperazin- 1 -yl)-N-(2-( 1 -methyl- lH-imidazol-5 -yl)- 1 ,6-naphthyridin-7-yl)

isonicotinamide [473];

2-(4-cyclopropylpiperazin- 1 -yl)-N-(2-( 1 -methyl- lH-imidazol-5 -yl)- 1 ,6-naphthyridin-7-yl)

isonicotinamide [474];

N-(2-(l-methyl-lH-imidazol-5-yl)-l,6-naphthyridin-7-yl)-2-(2,7-diazaspiro[3.5]nonan-2-yl) isonicotinamide [475];

N-(2-(l-methyl-lH-imidazol-5-yl)-l,6-naphthyridin-7-yl)-2-(7-methyl-2,7-diazaspiro[3.5]nonan-

2-yl)isonicotinamide [476];

N-(2-(l-methyl-lH-imidazol-5-yl)-l,6-naphthyridin-7-yl)isoindoline-5-carboxamide [477]; 2-methyl-N-(2-( 1 -methyl-lH-imidazol-5 -yl)- 1 ,6-naphthyridin-7-yl)isoindoline-5 -carboxamide

[478];

2-(azetidin-l-yl)-N-(2-(l-methyl-lH-imidazol-5-yl)-l,6-naphthyridin-7-yl)isonicotinamide [479]; 2-methoxy-N-(2-( 1 -methyl- 1 H-imidazol-5 -yl)- 1 ,6-naphthyridin-7-yl)isonicotinamide [480] ; 2-methyl-N-(2-( 1 -methyl-lH-imidazol-5 -yl)- 1 ,6-naphthyridin-7-yl)isonicotinamide [481] ;

2-cyano-N-(2-( 1 -methyl-lH-imidazol-5 -yl)- 1 ,6-naphthyridin-7-yl)isonicotinamide [482] ;

2-(3,3-difluoroazetidin-l-yl)-N-(2-(l-methyl-lH-imidazol-5-yl)-l,6-naphthyridin-7-yl)

isonicotinamide [483]; 2-(4,4-difluoropiperidin-l -yl)-N-(2-( 1 -methyl- lH-imidazol-5 -yl)- 1 ,6-naphthyridin-7-yl) isonicotinamide [484];

2-isopropoxy-N-(2-( 1 -methyl -IH-imidazol -5 -yl)- 1 ,6-naphthyridin-7-yl)isonicotinamide [485] ; N-(2-(l-methyl-lH-imidazol-5-yl)-l,6-naphthyridin-7-yl)-2-(pyrrolidin-l-yl-2,2,5,5-£/4)

isonicotinamide [486];

N-(2-( 1 -methyl-lH-imidazol-5-yl)- 1 ,6-naphthyridin-7-yl)-2-(pyrrolidin- 1 -yl-<¾)isonicotinamide

[487];

N-(2-(l-methyl-lH-imidazol-5-yl)-l,6-naphthyridin-7-yl)-2-(piperidin-l-yl- ;o)isonicotinamide

[488];

N-(2-(l-methyl-lH-imidazol-5-yl)-l,6-naphthyridin-7-yl)-2-(moφholino-ί s)isonicotinamide

[489];

N-(2-(l,2-dimethyl-lH-imidazol-5-yl)-l,6-naphthyridin-7-yl)-4-isopropoxybenzamide [490]; N-(2-(l,2-dimethyl-lH-imidazol-5-yl)-l,6-naphthyridin-7-yl)-4-(piperidin-4-yloxy)benzamide

[491];

4-(benzyloxy)-N-(2-( 1 ,2-dimethyl- lH-imidazol-5-yl)- 1 ,6-naphthyridin-7-yl)benzamide [492] ; N-(2-(l,2-dimethyl-lH-imidazol-5-yl)-l,6-naphthyridin-7-yl)-2-fluorobenzamide-3,4,5,6-£/4

[493];

N-(2-(l,2-dimethyl-lH-imidazol-5-yl)-l,6-naphthyridin-7-yl)-4-fluorobenzamide-2,3,5,6-£/4

[494];

2-chloro-N-(2-(l,2-dimethyl-lH-imidazol-5-yl)-l,6-naphthyridin-7-yl)benzamide-3,4,5,6-£/4

[495];

4-chloro-N-(2-(l,2-dimethyl-lH-imidazol-5-yl)-l,6-naphthyridin-7-yl)benzamide-2,3,5,6-£/4

[496];

N-(2-(l,2-dimethyl-lH-imidazol-5-yl)-l,6-naphthyridin-7-yl)-4-(methyl- 3)benzamide [497]; N-(2-(l,2-dimethyl-lH-imidazol-5-yl)-l,6-naphthyridin-7-yl)-4-methylbenzamide-2,3,5,6-£/4

[498];

N-(2-(l,2-dimethyl-lH-imidazol-5-yl)-l,6-naphthyridin-7-yl)-4-(methyl-£/3)benzamide-2,3,5,6-£/4

[499];

N-(2-(l,2-dimethyl-lH-imidazol-5-yl)-l,6-naphthyridin-7-yl)-4-(methoxy-£/3)benzamide [500]; N-(2-(l,2-dimethyl-lH-imidazol-5-yl)-l,6-naphthyridin-7-yl)-4-(methoxy-£/3)benzamide-2,3,5,6- d₄ [501];

N-(2-(l,2-dimethyl-lH-imidazol-5-yl)-l,6-naphthyridin-7-yl)-4-methoxybenzamide-2,3,5,6-£/4

[502]; N-(2-( 1 ,2-dimethyl- lH-imidazol-5-yl)-l ,6-naphthyridin-7-yl)-2-(4-methylpiperazin- 1 -yl) isonicotinamide [503];

N-(2-(l,2-dimethyl-lH-imidazol-5-yl)-l,6-nap

[504];

N-(2-(l,2-dimethyl-lH-imidazol-5-yl)-l,6-naphthyridin-7-yl)-2-(pyrrolidin-l-yl)isonicotm^

[505];

N-(2-(l,2-dimethyl-lH-imidazol-5-yl)-l,6-naphth^^

[506];

N-(2-(l,2-dimethyl-lH-imidazol-5-yl)-l,6-naphthyridin-7-yl)-2-(pyrrolidin-l-yl-2,2,5,5- 4) isonicotinamide [507];

N-(2-(l,2-dimethyl-lH-imidazol-5-yl)-l,6-naphthyridin-7-yl)-2-(pyrrolidin-l-yl-£/s)

isonicotinamide [508];

N-(2-(l,2-dimethyl-lH-imidazol-5-yl)-l,6-naphthyridin-7-yl)-2-(piperidin-l-yl-£/;o)

isonicotinamide [509];

[510];

N-(2-(5,6,7,8-tetrahydroimidazo[l,2-a]pyrazin-3-yl)-l,6-naphthyridin-7-yl)

cyclopropanecarboxamide [511];

N-(2-(7-methyl-5,6,7,8-tetrahydroimidazo[l,2-a]pyrazin-3-yl)-l,6-naphthyridin-7-yl)

cyclopropanecarboxamide [512];

3,3-difluoro-N-(2-(5,6,7,8-tetrahydroimidazo[l,2-a]pyrazin-3-yl)-l,6-naphthyridin-7-yl)

cyclobutane-l-carboxamide [513];

(R)-N-(2-(5,6,7,8-tetrahydroimidazo[l,2-a]pyrazin-3-yl)-l,6-naphthyridin-7-yl)pyrrolidine-2- carboxamide [514];

(R)-N-(2-(5,6,7,8-tetrahydroimidazo[l,2-a]pyrazin-3-yl)-l,6-naphthyridin-7-yl)piperidine-3- carboxamide [515];

l-methyl-N-(2-(5,6,7,8-tetrahydroimidazo[l,2-a]pyrazin-3-yl)-l,6-naphthyridin-7-yl)piperidine-

4-carboxamide [516];

N-(2-(5,6,7,8-tetrahydroimidazo[l,2-a]pyrazin-3-yl)-l,6-naphthyridin-7-yl)-l-((l-

(trifluoromethyl)cyclopropyl)methyl)piperidine -4 -carboxamide [517];

l-benzoyl-N-(2-(5,6J,8-tetrahydroimidazo[l,2-a]pyrazin-3-yl)-l,6-naphthyridin-7-yl)piperidine-

4-carboxamide [518];

4-fluoro-l-isobutyl-N-(2-(5,6J,8-tetrahydroimidazo[l,2-a]pyrazin-3-yl)-l,6-naphthyridin-7-yl) piperidine-4-carboxamide [519]; (R)-2-(2-methylpyrrolidin-l-yl)-N-(2-(5,6,7,8 etrahydroimidazo[l,2-a]pyrazin-3-yl)-l,6- naphthyridin-7-yl)acetamide [520];

2-(cyclobutyl(methyl)amino)-N-(2-(5,6J,8 etrahydroimidazo[l,2-a]pyrazin-3-yl)-l,6- naphthyridin-7-yl)acetamide [521];

4-fluoro-N-(2-(5,6,7,8 etrahydroimidazo[l,2-a]pyrazin-3-yl)-l,6-naphthyridin-7-yl)benzamide

[522];

4-isopropoxy-N-(2-(5,6,7,8 etrahydroimidazo[l,2-a]pyrazin-3-yl)-l,6-naphthyridin-7-yl)

benzamide [523];

4-(difluoromethoxy)-N-(2-(5,6,7,8-tetrahydroim

benzamide [524];

2-((2-(dimethylamino)ethyl)amino)-N-(2-(5,6J,8 etrahydroimidazo[l,2-a]pyrazin-3-yl)-l,6- naphthyridin-7-yl)isonicotinamide [525] ;

2-(( 1 -isopropylpiperidin-4-yl)oxy)-N-(2-(5,6,7,8-tetrahydroimidazo[ 1 ,2-a]pyrazin-3 -yl)- 1 ,6- naphthyridin-7-yl)isonicotinamide [526] ;

N-(2-(oxazol-5 -yl)- 1 ,6-naphthyridin-7-yl)- 1 -(3,3,3 -trifluoropropyl)piperidine-4-carboxamide

[527];

N-(2-(oxazol-5-yl)-l,6-naphthyridin-7-yl)cyclopropanecarboxamide [528];

(R) -N-(2 -(oxazol -5 -yl) - 1 , 6-naphthyridin-7 -yl)tetrahydrofuran-2-carboxamide [529] ;

(R)-N-(2-(oxazol-5-yl)-l,6-naphthyridin-7-yl)piperidine-3-carboxamide [530];

N-(2-(oxazol-5 -yl)- 1 ,6-naphthyridin-7-yl)tetrahydro-2H-pyran-4-carboxamide [531] ;

N-(2-(oxazol-5 -yl)- 1 ,6-naphthyridin-7-yl)- 1 -(2-(pyrrolidin- 1 -yl)acetyl)piperidine-4-carboxamide

[532];

1 '-methyl -N-(2 -(oxazol -5 -yl)- 1 ,6-naphthyridin-7-yl)-[ 1 ,4'-bipiperidine] -4-carboxamide [533] ; c/. ·-4-moφholino-N-(2-(oxazol-5-yl)-l,6-naphthyridin-7-yl)cyclohexane-l-carboxamide [534]; 2-(cyclobutyl(methyl)amino)-N-(2-(oxazol-5-yl)-l,6-naphthyridin-7-yl)acetamide [535];

N-(2-(oxazol-5 -yl)- 1 ,6-naphthyridin-7-yl)-2-(pyrrolidin- 1 -yl)acetamide [536] ;

(R) -2 -(2-methylpyrrolidin- 1 -yl) -N-(2 -(oxazol -5 -yl) -1,6 -naphthyridin-7 -yl)acetamide [537] ; 2-(4-methylpiperazin- 1 -yl)-N-(2-(oxazol-5 -yl)- 1 ,6-naphthyridin-7-yl)acetamide [538] ;

fr «5-4-((4-methylpiperazin-l-yl)methyl)-N-(2-(oxazol-5-yl)-l,6-naphthyridin-7-yl)cyclohexane- 1-carboxamide [539];

l-(2,2-difluoropropyl)-N-(2-(oxazol-5-yl)-l,6-naphthyridin-7-yl)piperidine-4-carboxamide [540]; fr «5-4-(hydroxymethyl)-N-(2-(2-methyloxazol-5-yl)- 1 ,6-naphthyridin-7-yl)cyclohexane- 1 - carboxamide [541]; trans -4 -(methylamino) -N-(2-(2 -methyloxazol -5 -yl) - 1 , 6-naphthyridin-7-yl)cyclohexane - 1 - carboxamide [542];

trans-4-(( 1 ,3 -difluoropropan-2-yl)amino)-N-(2-(2-methyloxazol-5 -yl)- 1 ,6-naphthyridin-7-yl) cyclohexane - 1 -carboxamide [543] ;

fr «5-N-(2-(2-methyloxazol-5 -yl)- 1 ,6-naphthyridin-7-yl)-4-((propan-2-yl-l , 1 , 1 ,3,3,3-d6)amino) cyclohexane - 1 -carboxamide [544] ;

fr «5-4-((2,2-difluoroethyl)amino)-N-(2-(2-methyloxazol-5-yl)-l,6-naphthyridin-7-yl)

cyclohexane - 1 -carboxamide [545] ;

fr «5-N-(2-(2-methyloxazol-5-yl)-l,6-naphthyridin-7-yl)-4-((3,3,3-trifluoropropyl)amino)

cyclohexane - 1 -carboxamide [546] ;

fr «5-4-((2-methoxyethyl)amino)-N-(2-(2-methyloxazol-5 -yl)- 1 ,6-naphthyridin-7-yl)

cyclohexane -1 -carboxamide [547];

fr «5-4-(dimethylamino)-N-(2-(2-methyloxazol-5-yl)-l,6-naphthyridin-7-yl)cyclohexane-l- carboxamide [548];

fr «5-4-(bis(methyl-£/3)amino)-N-(2-(2-methyloxazol-5-yl)- 1 ,6-naphthyridin-7-yl)cyclohexane- 1 - carboxamide [549];

c/5-4-(dimethylamino)-N-(2-(2-methyloxazol-5-yl)- 1 ,6-naphthyridin-7-yl)cyclohexane- 1 - carboxamide [550];

fr «5-4-((2,2-difluoroethyl)(methyl)amino)-N-(2-(2-methyloxazol-5-yl)-l,6-naphthyridin-7-yl) cyclohexane -1 -carboxamide [551];

fr «5-4-(methyl(oxetan-3-yl)amino)-N-(2-(2-methyloxazol-5-yl)-l,6-naphthyridin-7-yl)

cyclohexane - 1 -carboxamide [552] ;

fr «5-4-((2-fluoroethyl)amino)-N-(2-(2-methyloxazol-5-yl)-l,6-naphthyridin-7-yl)cyclohexane-l- carboxamide [553];

fr «5-4-(2-(fluoromethyl)aziridin-l-yl)-N-(2-(2-methyloxazol-5-yl)-l,6-naphthyridin-7-yl)

cyclohexane - 1 -carboxamide [554] ;

trans-4-((3 -fluoroazetidin- 1 -yl)methyl)-N-(2-(2-methyloxazol-5 -yl)- 1 ,6-naphthyridin-7-yl)

cyclohexane - 1 -carboxamide [555] ;

fr «5-N-(2-(2-methyloxazol-5 -yl)- 1 ,6-naphthyridin-7-yl)-3-morpholinocyclobutane- 1 - carboxamide [556];

fr rø-N-(2-(2-methyloxazol-5-yl)-l,6-naphthyridin-7-yl)-4-moφholinocyclohexane-l- carboxamide [557];

N-(2-(2-methyloxazol-5-yl)- 1 ,6-naphthyridin-7-yl)-2-(piperidin- 1 -yl)acetamide [558] ;

2-(4-methoxypiperidin-l-yl)-N-(2-(2-methyloxazol-5-yl)-l,6-naphthyridin-7-yl)acetamide [559]; N-(2-(2-methyloxazol-5-yl)-l,6-naphthyridin-7-yl)-2-(4-methylpiperazin-l-yl)acetamide [560]; N-(2-(2-methyloxazol-5-yl)-l,6-naphthyridin-7-yl)mo holine-4-carboxamide [561];

N-(2-(2-methyloxazol-5-yl)-l,6-naphthyridin-7-yl)-2-mo holinoacetamide [562];

N-(2-(2-methyloxazol-5-yl)-l,6-naphthyridin-7-yl)-3-mo holinopropanamide [563];

1 -methyl -N-(2 -(2 -methyloxazol -5 -yl)- 1 ,6-naphthyridin-7-yl)piperidine-4 -carboxamide [564] ; 1 -(2,2-difluoropropyl)-N-(2-(2-methyloxazol-5 -yl)- 1 ,6-naphthyridin-7-yl)piperidine-4- carboxamide [565];

N-(2-(2-methyloxazol-5-yl)- 1 ,6-naphthyridin-7-yl)-4-mo holinopiperidine- 1 -carboxamide [566] ; 4-((l,3-difluoropropan-2-yl)amino)-N-(2-(2-methyloxazol-5-yl)-l,6-naphthyridin-7-yl)

piperidine-1 -carboxamide [567];

( 1 R,3s,5 S)-3 -(( 1 ,3-difluoropropan-2-yl)amino)-N-(2-(2-methyloxazol-5 -yl)- 1 ,6-naphthyridin-7- yl)-8-azabicyclo[3.2.1] octane -8 -carboxamide [568];

( 1 R,3s,5 S)-3 -(( 1 ,3-difluoropropan-2-yl)amino)-N-(2-(2-methyloxazol-5 -yl)- 1 ,6-naphthyridin-7- yl)-8-azabicyclo[3.2.1] octane -8 -carboxamide [569];

4-(dimethylamino) -N-(2-(2 -methyloxazol -5 -yl) - 1 ,6 -naphthyridin-7 -yl)piperidine - 1 -carboxamide

[570];

4-((2,2-difluoroethyl)(methyl)amino)-N-(2-(2-methyloxazol-5-yl)-l,6-naphthyridin-7-yl)

piperidine-1 -carboxamide [571];

(3S,4S)-4-amino-3-fluoro-N-(2-(2-methyloxazol-5-yl)-l,6-naphthyridin-7-yl)piperidine-l- carboxamide [572];

(3S,4S)-3-fluoro-4-(methylamino)-N-(2-(2-methyloxazol-5-yl)-l,6-naphthyridin-7-yl)piperidine- 1 -carboxamide [573];

(3R,4R)-4-amino-3-fluoro-N-(2-(2-methyloxazol-5-yl)-l,6-naphthyridin-7-yl)piperidine-l- carboxamide [574];

(3R,4R)-3 -fluoro-4-(methylamino)-N-(2-(2-methyloxazol-5 -yl)- 1 ,6-naphthyridin-7-yl)piperidine- 1 -carboxamide [575];

4-((2-fluoroethyl)amino)-N-(2-(2-methyloxazol-5 -yl)- 1 ,6-naphthyridin-7-yl)piperidine- 1 - carboxamide [576];

4-((2,2-difluoroethyl)amino)-N-(2-(2-methyloxazol-5-yl)-l,6-naphthyridin-7-yl)piperidine-l- carboxamide [577];

(lR,3s,5S)-3-amino-N-(2-(2-methyloxazol-5-yl)-l,6-naphthyridin-7-yl)-8-azabicyclo[3.2.1] octane-8-carboxamide [578];

(lR,3r,5S)-3-amino-N-(2-(2-methyloxazol-5-yl)-l,6-naphthyridin-7-yl)-8-azabicyclo[3.2.1]

octane-8-carboxamide [579]; (lR,3r,5S)-3-((2-fluoroethyl)amino)-N-(2-(2-methyloxazol-5-yl)-l,6-naphthyridin-7-yl)-8- azabicyclo[3.2.1] octane -8 -carboxamide [580];

( 1 R,3r,5 S)-3-((2,2-difluoroethyl)amino)-N-(2-(2-methyloxazol-5-yl)- 1 ,6-naphthyridin-7-yl)-8- azabicyclo[3.2.1] octane -8 -carboxamide [581];

(lR,3s,5S)-N-(2-(2-methyloxazol-5-yl)-l,6-naphthyridin-7-yl)-3-((3,3,3-trifluoropropyl)amino)-

8 -azabicyclo [3.2.1] octane -8 -carboxamide [582] ;

(3S,4S)-3-fluoro-4-(isopropylamino)-N-(2-(2-methyloxazol-5-yl)-l,6-naphthyridin-7-yl)

piperidine-1 -carboxamide [583];

N-(2-(2-methyloxazol-5-yl)-l,6-naphthyridin-7-yl)-5,6-dihydroimidazo[l,2-a]pyrazine-7(8H)- carboxamide [584];

2-methyl-N-(2 -(2 -methyloxazol -5 -yl) - 1 ,6 -naphthyridin-7 -yl) -5 , 6-dihydroimidazo [ 1 ,2 -a] pyrazine -

7(8H)-carboxamide [585];

N-(2-(2-methyloxazol-5-yl)-l,6-naphthyridin-7-yl)-2-(mo holino-ί s)acetamide [586];

fr «5-N-(2-(2-methyloxazol-4-yl)- 1 ,6-naphthyridin-7-yl)-4-(4-methylpiperazin- 1 -yl)cyclohexane-

1 -carboxamide [587];

N-(2-(2-methyloxazol-5-yl)-l,6-naphthyridin-7-yl)-l-(l-methylpiperidin-4-yl)-lH-pyrazole-4- carboxamide [588];

2- ( lH-imidazol- 1 -yl)-N-(2-(2-methyloxazol-5-yl)-l ,6-naphthyridin-7-yl)acetamide [589] ;

4-(difluoromethoxy)-N-(2-(oxazol-5 -yl)- 1 ,6-naphthyridin-7-yl)benzamide [590] ;

3- ((l-methylpiperidin-4-yl)oxy)-N-(2-(oxazol-5-yl)-l,6-naphthyridin-7-yl)benzamide [591]; N-(2-(oxazol-5 -yl)- 1 ,6-naphthyridin-7-yl)isonicotinamide [592] ;

2-(3 -aminoazetidin-1 -yl)-N-(2-(oxazol-5 -yl)- 1 ,6-naphthyridin-7-yl)isonicotinamide [593] ;

2-(l-methylpiperidin-4-yl)-N-(2-(oxazol-5-yl)-l,6-naphthyridin-7-yl)isonicotinamide [594]; r-methyl-N-(2-(oxazol-5-yl)-l,6-naphthyridin-7-yl)-l',2',3',6'-tetrahydro-[2,4'-bipyridine]-4- carboxamide [595];

2-(4-methylpiperazin- 1 -yl)-N-(2-(oxazol-5-yl)- 1 ,6-naphthyridin-7-yl)isonicotinamide [596] ; 2-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl)-N-(2-(oxazol-5-yl)-l,6-naphthyridin-7-yl)

isonicotinamide [597];

N-(2-(oxazol-5-yl)-l,6-naphthyridin-7-yl)-2-(2,7-diazaspiro[3.5]nonan-7-yl)isonicotinamide

[598];

N-(2-(oxazol-5 -yl)- 1 ,6-naphthyridin-7-yl)-2-(piperidin-4-ylamino)isonicotinamide [599] ;

2-methyl-N-(2 -(oxazol -5 -yl) - 1 , 6-naphthyridin-7 -yl)isoindoline -5 -carboxamide [600] ;

N-(2-(oxazol-5-yl)-l,6-naphthyridin-7-yl)-l,2,3,4-tetrahydroisoquinoline-7-carboxamide [601]; N-(2-(2-methyloxazol-5-yl)-l,6-naphthyridin-7-yl)-2-(4-methylpiperazin-l-yl)isonicotinamide

[602];

N-(2-(3-methylisoxazol-5-yl)-l,6-naphthyridin-7-yl)-l-(3,3,3 rifluoropropyl)piperidine-4- carboxamide [603];

4-fluoro-l-isobutyl-N-(2-(5-methyl-l,3,4-oxadiazol-2-yl)-l,6-naphthyridin-7-yl)piperidine-4- carboxamide [604];

1 -isobutyl-N-(2-(5-methyl- 1 ,3,4-oxadiazol-2-yl)- 1 ,6-naphthyridin-7-yl)piperidine-4-carboxamide

[605];

N-(2-(5-(dimethylamino)-l,3,4-oxadiazol-2-yl)-l,6-napfa

[606];

N-(2-(5-(dimethylamino)-l,3,4-oxadiazol-2-yl)-l,6-napfa

carboxamide [607];

N-(2-(5-methyl-l,3,4-oxadiazol-2-yl)-l,6-naphthyridin-7-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [608];

3 , 3 -difluoro -N-(2 -(thiazol-5 -yl) - 1 , 6 -naphthyridin-7 -yl)cyclobutane- 1 -carboxamide [609] ;

2-methyl-N-(2-(thiazol-5-yl)-l,6-naphthyridin-7-yl)-2-azaspiro[3 ]heptane-6-carboxam

[610];

1 -fluoro-N-(2-(thiazol-5-yl)- 1 ,6-naphthyridin-7-yl)cyclohexane-l -carboxamide [611];

fra«s-4-(dimethylamino)-N-(2-(thiazol-5-yl)- 1 ,6-naphthyridin-7-yl)cyclohexane- 1 -carboxamide

[612];

trans-4-((3 -fluoroazetidin- 1 -yl)methyl)-N -(2 -(thiazol-5 -yl)- 1 ,6-naphthyridin-7-yl)cyclohexane-l - carboxamide [613];

N-(2-(thiazol-5-yl)-l,6-naphthyridin-7-yl)azetidine-3-carboxamide [614];

1- methyl-N-(2-(miazol-5-yl)-l,6-naphthyridin-7-yl)piperidine-4-carboxamide [615];

1 -(2,2-difluoropropyl)-N-(2-(thiazol-5 -yl)- 1 ,6-naphthyridin-7-yl)piperidine-4-carboxamide [616] ; 1 -(oxetan-3 -yl) -N-(2-(thiazol -5 -yl) - 1 ,6 -naphthyridin-7-yl)piperidine -4 -carboxamide [617];

1 -(2 -(pyrrolidin- 1 -yl)acetyl) -N-(2 -(thiazol-5 -yl) - 1 , 6-naphthyridin-7 -yl)piperidine -4-carboxamide

[618];

r-methyl-N-(2-(thiazol-5-yl)-l,6-naphthyridin-7-yl)-[l,4'-bipiperidine]-4-carboxamide [619];

2- (pyrrolidin- 1 -yl)-N-(2-(thiazol-5-yl)- 1 ,6-naphthyridin-7-yl)propanamide [620] ;

2-(piperidin-l-yl)-N-(2-(thiazol-5-yl)-l,6-naphthyridin-7-yl)acetamide [621];

2-(4-methylpiperazin-l -yl)-N-(2-(thiazol-5-yl)-l ,6-naphthyridin-7-yl)acetamide [622] ;

2-moφholino-N-(2-(thiazol-5-yl)-l,6-naphthyridin-7-yl)acetamide [623];

4-(piperidin-4-yloxy)-N-(2-(thiazol-5-yl)-l,6-naphthyridin-7-yl)benzamide [624]; N-(2-(thiazol-5-yl)- 1 ,6-naphthyridin-7-yl)isonicotinamide [625] ;

6-(4-methylpiperazin-l -yl)-N-(2-(thiazol-5-yl)-l ,6-naphthyridin-7-yl)nicotinamide [626] ;

l'-me l-N-(2-(thiazol-5-yl)-l,6-naph ^

carboxamide [627];

2-(3 -(dimethylamino)azetidin- 1 -yl)-N-(2-(thiazol-5 -yl)-l ,6-naphthyridin-7-yl)isonicotinamide

[628];

2-(4-(dimethylamino)piperidin-l-yl)-N-(2-(thiazol-5-yl)-l,6-naphthyridin-7-yl)isonicotinan^

[629];

2-(4-methylpiperazin-l-yl)-N-(2-(1hiazol-5-yl)-l,6-naphthyridin-7-yl)isonicotinamid [630]; 2-(( 1 -methylpiperidin-4-yl)thio)-N-(2-(thiazol-5 -yl)- 1 ,6-naphthyridin-7-yl)isonicotinamide [631] ; N-(2-(thiazol-5-yl)- 1 ,6-naphthyridin-7-yl)- 1 ,2,3,4-tetrahydroisoquinoline-7 -carboxamide [632] ; fr «5-4-((l,3-difluoropropan-2-yl)amino)-N-(2-(5-methyl-l,3,4-thiadiazol-2-yl)-l,6- naphthyridin-7 -yl)cyclohexane - 1 -carboxamide [633] ;

N-(2-(2-methylthiazol-5-yl)-l,6-naphthyridin-7-yl)mo holine-4-carboxamide [634];

N-(2-(2-methylthiazol-5-yl)-l,6-naphthyridin-7-yl)-2-(pyrrolidin-l-yl)acetamide [635];

2-((lR,4R)-2-oxa-5-azabicyclo[2.2. l]heptan-5-yl)-N-(2-(2-methylthiazol-5-yl)-l,6-naphthyridin-

7-yl)acetamide [636];

N-(2-(2-methylthiazol-5-yl)-l,6-naphthyridin-7-yl)-2-moφholinoacetamide [637];

N-(2-(2-methylthiazol-5-yl)-l,6-naphthyridin-7-yl)-2-(moφholino-ί s)acetamide [638];

2-(4-methylpiperazin- 1 -yl)-N-(2-(2-methylthiazol-5-yl)- 1 ,6-naphthyridin-7-yl)acetamide [639] ;

1- methyl-N-(2-(2-methylthiazol-5-yl)-l,6-naphthyridin-7-yl)piperidine-4-carboxamide [640]; N-(2-(2-methylthiazol-5-yl)- 1 ,6-naphthyridin-7-yl)isonicotinamide [641] ;

N-(2-(2-methylthiazol-5-yl)-l,6-naphthyridin-7-yl)nicotinamide [642];

2- (4-methylpiperazin- 1 -yl)-N-(2-(2-methylthiazol-5-yl)- 1 ,6-naphthyridin-7-yl)isonicotinamide

[643];

fr rø-N-(2-(5-methyl-l,3,4 hiadiazol-2-yl)-l,6-naphthyridin-7-yl)-4-moφholinocyclohexane-l- carboxamide [644];

fr «5-N-(2-(5-methyl-l,3,4 hiadiazol-2-yl)-l,6-naphthyridin-7-yl)-4-(4-methylpiperazin-l-yl) cyclohexane - 1 -carboxamide [645] ;

4-isopropyl-N-(2-(5-methyl-l,3,4 hiadiazol-2-yl)-l,6-naphthyridin-7-yl)piperazine-l- carboxamide [646];

4-((2-methoxyethyl)(methyl)amino)-N-(2-(5-^

piperidine-1 -carboxamide [647]; 4-(( 1 ,3 -difluoropropan-2-yl)amino)-N-(2-(5 -methyl- 1 ,3,4-thiadiazol-2-yl)- 1 ,6-naphthyridin-7-yl) piperidine-1 -carboxamide [648];

N-(2-(5-methyl-l,3,4-thiadiazol-2-yl)-l,6-naphthyridin-7-yl)-4-((3,3,3-trifluoropropyl)amino) piperidine-1 -carboxamide [649];

4-((2-fluoroethyl)amino)-N-(2-(5-methyl-l,3,4-thiadiazol-2-yl)-l,6-naphthyridin-7-yl)piperidine-

1 -carboxamide [650];

(3R,4S)-4-amino-3-fluoro-N-(2-(5-methyl-l,3,4-thiadiazol-2-yl)-l,6-naphthyridin-7-yl)

piperidine-1 -carboxamide [651];

(3R,4R)-4-amino-3-fluoro-N-(2-(5-methyl-l,3,4-thiadiazol-2-yl)-l,6-naphthyridin-7-yl)

piperidine-1 -carboxamide [652];

(3 S,4S)-3 -fluoro-N-(2-(5 -methyl- 1 ,3,4-thiadiazol-2-yl)-l ,6-naphthyridin-7-yl)-4-(methylamino) piperidine-1 -carboxamide [653];

(3R,4R)-3 -fluoro-N-(2-(5 -methyl- 1 ,3 ,4-thiadiazol-2-yl)- 1 ,6-naphthyridin-7-yl)-4-(methylamino) piperidine-1 -carboxamide [654];

4-amino-3,3-difluoro-N-(2-(5-methyl-l,3,4-thiadiazol-2-yl)-l,6-naphthyridin-7-yl)piperidine-l- carboxamide [655];

(3R,4R)-3 -fluoro-4-(isopropylamino)-N-(2-(5 -methyl- 1 ,3,4-thiadiazol-2-yl)-l ,6-naphthyridin-7- yl)piperidine-l -carboxamide [656];

(3R,4S)-3-fluoro-4-(isopropylamino)-N-(2-(5-methyl-l,3,4-thiadiazol-2-yl)-l,6-naphthyridin-7- yl)piperidine-l -carboxamide [657];

3,3-difluoro-4-(isopropylamino)-N-(2-(5-methyl-l,3,4-thiadiazol-2-yl)-l,6-naphthyridin-7-yl) piperidine-1 -carboxamide [658];

(3 S,4S)-3 -fluoro-N-(2-(5 -methyl- 1 ,3,4-thiadiazol-2-yl)-l , 6-naphthyridin-7-yl)-4-((propan-2-yl-

1, 1,1,3,3,3 -d<;)amino)piperidine - 1 -carboxamide [659] ;

(lR,3s,5S)-3-((l,3-difluoropropan-2-yl)amino)-N-(2-(5-methyl-l,3,4-thiadiazol-2-yl)-l,6- naphthyridin-7-yl)-8-azabicyclo[3.2. l]octane-8-carboxamide [660];

(lR,3s,5S)-3-((l,3-difluoropropan-2-yl)amino)-N-(2-(5-methyl-l,3,4-thiadiazol-2-yl)-l,6- naphthyridin-7-yl)-8-azabicyclo[3.2. l]octane-8-carboxamide [661];

4-(dimethylamino)-N-(2-(2-methylthiazol-5-yl)- 1 ,6-naphthyridin-7-yl)piperidine- 1 -carboxamide

[662];

4-((2,2-difluoroethyl)amino)-N-(2-(5-methyl-l,3,4-thiadiazol-2-yl)-l,6-naphthyridin-7-yl)

piperidine-1 -carboxamide [663];

4-((2,2-difluoroethyl)(methyl-£/3)amino)-N-(2-(5-methyl-l,3,4-thiadiazol-2-yl)-l,6-naphthyridin-

7-yl)piperidine-l -carboxamide [664]; N-(2-(5-methyl-l ,3,4-thiadiazol-2-yl)- 1 ,6-naphthyridin-7-yl)-4-mo holinopiperidine- 1 - carboxamide [665];

N-(2-(5-methyl-l,3,4 hiadiazol-2-yl)-l,6-naphthyridin-7-yl)-4-(4-methylpiperazin-l-yl)

piperidine-1 -carboxamide [666];

(R)-3,4-dimethyl-N-(2-(5-methyl-l,3,4 hiadiazol-2-yl)-l,6-naphthyridin-7-yl)piperazine-l^ carboxamide [667];

(S)-3,4-dimethyl-N-(2-(5-methyl-l,3,4 hiadiazol-2-yl)-l,6-naphthyridin-7-yl)piperazine-l- carboxamide [668];

(lR,3r,5S)-3-((2-fluoroethyl)amino)-N-(2-(5-methy

yl)-8-azabicyclo[3.2.1] octane -8 -carboxamide [669];

(lR,3r,5S)-3-((2,2-difluoroethyl)amino)-N-(2-(5-methyl-l,3,4-thiadiazol-2-yl)-l,6-naphthyridm

7-yl)-8-azabicyclo[3.2. l]octane-8-carboxamide [670];

( lR,3r,5 S)-3-amino-N-(2-(5-methyl- 1 ,3,4-thiadiazol-2-yl)- 1 ,6-naphthyridin-7-yl)-8-azabicyclo

[3.2.1] octane -8 -carboxamide [671];

( 1 S,4S)-5 -methyl -N-(2 -(5 -methyl-1 ,3,4-thiadiazol-2-yl)- 1 ,6-naphthyridin-7-yl)-2,5-diazabicyclo

[2.2. l]heptane-2 -carboxamide [672];

(lR,4R)-5-methyl-N-(2-(5-methyl-l,3,4-thiadiazol-2-yl)-l,6-naphthyridin-7-yl)-2,5-diazabicyclo

[2.2. l]heptane-2 -carboxamide [673];

8-methyl-N-(2-(5-methyl-l,3,4-thiadiazol-2-yl)-l,6-naphthyridin-7-yl)-3,8-diazabicyclo[3.2.1] octane-3 -carboxamide [674];

3-methyl-N-(2-(5-methyl-l,3,4-thiadiazol-2-yl)-l,6-naphthyridin-7-yl)-3,8-diazabicyclo[3.2.1] octane-8-carboxamide [675];

N-(2-(5-methyl-l,3,4-miadiazol-2-yl)-l,6-naphthyridin-7-yl)-5,6-dihydroimidazo[l,2-a]pyrazin^

7(8H)-carboxamide [676];

2-(4-methylpiperazin- 1 -yl)-N-(2-(5-methylthiazol-2-yl)- 1 ,6-naphthyridin-7-yl)isonicotinamide

[677];

2-(4-methylpiperazin-l-yl)-N-(2-(4-methylthiazol-2-yl)-l,6-naphthyridin-7-yl)isonicotinamide

[678];

N-(2-(2-(methylamino)thiazol-5-yl)-l,6-naphthyridin-7-yl)piperidine-4-carboxamide [679]; l-methyl-N-(2-(2-(methylamino)thiazol-5-yl)-l,6-naphthyridin-7-yl)piperidine-4-carboxamide

[680];

N-(2-(2-(diethylamino)thiazol-5-yl)- 1 ,6-naphthyridin-7-yl)-2-(4-fluoropiperidin- 1 -yl)acetamide

[681]; N-(2-(2-(diethylamino)thiazol-5-yl)- 1 ,6-naphthyridin-7-yl)-2-(4-methylpiperazin- 1 -yl)acetamide

[682];

N-(2-(2-aminothiazol-5-yl)-l,6-naphthyridin-7-yl)-2-(4-methylpiperazin-l-yl)isonicotinamide

[683];

N-(2-(2-(methylamino)thiazol-5-yl)-l,6-naphthyridin-7-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [684];

N-(2-(2-(dimethylamino)thiazol-5-yl)-l,6-naphthyridin-7-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [685];

2-(4 sopropylpiperazin-l-yl)-N-(2-(2-(methylamino)thiazol-5-yl)-l,6-naphthyridin-7-yl)

isonicotinamide [686];

2-(3 -(dimethylamino)azetidin- 1 -yl)-N-(2-(2-(methylamino)thiazol-5-yl)- 1 ,6-naphthyridin-7-yl) isonicotinamide [687];

2-(3 -(dimethylamino)azetidin- 1 -yl)-N-(2-(2-(dimethylamino)thiazol-5 -yl)- 1 ,6-naphthyridin-7-yl) isonicotinamide [688];

2-(3 -aminoazetidin- 1 -yl) -N-(2-(2-(dimethylamino)thiazol-5 -yl)- 1 ,6-naphthyridin-7-yl)

isonicotinamide [689];

N-(2-(5-chlorothiazol-2-yl)- 1 ,6-naphthyridin-7-yl)-2-(4-methylpiperazin- 1 -yl)isonicotinamide

[690];

2-(7-(2-(4-methylpiperazin-l-yl)isonicotinamido)-l,6-naphthyridin-2-yl)thiazole-5-carboxamide

[691];

N-(2-(isothiazol-4-yl)-l,6-naphthyridin-7-yl)-l-methylpiperidine-4-carboxamide [692];

N-(2-(l,3,4-thiadiazol-2-yl)-l,6-naphthyridin-7-yl)-4-(difluoromethoxy)benzamide [693];

N-(2-(l,3,4-thiadiazol-2-yl)-l,6-naphthyridin-7-yl)-4-(piperidin-4-yloxy)benzamide [694];

N-(2-(l,3,4-thiadiazol-2-yl)-l,6-naphthyridin-7-yl)-4-((l-methylpiperidin-4-yl)oxy)benzamide

[695];

N-(2-(l,3,4-thiadiazol-2-yl)-l,6-naphthyridin-7-yl)-3-((l-methylpiperidin-4-yl)oxy)benzamide

[696];

N⁵-(2-(l,3,4-thiadiazol-2-yl)-l,6-naphthyridin-7-yl)-N²-methylpyridine-2,5-dicarboxamide [697]; N-(2-(l,3,4-thiadiazol-2-yl)-l,6-naphthyridin-7-yl)-6-(4-methylpiperazin-l-yl)nicotinamide

[698];

N-(2-(l,3,4-thiadiazol-2-yl)-l,6-naphthyridin-7-yl)-l'-methyl-1^2',3',6'-tetrahydro-[2,4'- bipyridine] -4 -carboxamide [699] ;

N-(2-( 1 ,3,4-thiadiazol-2-yl)- 1 ,6-naphthyridin-7-yl)-2-(3-(dimethylamino)azetidin- 1 -yl)

isonicotinamide [700]; N-(2-(l,3,4 hiadiazol-2-yl)-l,6-naphthyridin-7-yl)-2-(4-methylpiperazin-l-yl)isonicotinam

[701];

N-(2-(l,3,4 hiadiazol-2-yl)-l,6-naphthyridin-7-yl)-2-(4-isopropylpiperazin-l-yl)isonicotinam

[702];

N-(2-(l,3,4 hiadiazol-2-yl)-l,6-naphthyridin-7-yl)-2-mo holinoisonicotinamide [703];

1 -fluoro-N-(2-(5-methyl- 1 ,3 ,4-thiadiazol-2-yl)- 1 ,6-naphthyridin-7-yl)cyclohexane-l - carboxamide [704];

fr «5-4-methoxy-N-(2-(5 -methyl- 1 ,3,4-thiadiazol-2-yl)-l ,6-naphthyridin-7-yl)cyclohexane- 1 - carboxamide [705];

c/5-4-methoxy-N-(2-(5-methyl- 1 ,3,4-thiadiazol-2-yl)- 1 ,6-naphthyridin-7-yl)cyclohexane- 1 - carboxamide [706];

fr «5-4-amino-N-(2-(5-methyl-l,3,4-thiadiazol-2-yl)-l,6-naphthyridin-7-yl)cyclohexane-l- carboxamide [707];

fr «5-4-(dimethylamino)-N-(2-(5-methyl-l,3,4-thiadiazol-2-yl)-l,6-naphthyridin-7-yl)

cyclohexane-1 -carboxamide [708];

fr rø-N-(2-(5-methyl-l,3,4-thiadiazol-2-yl)-l,6-naphthyridin-7-yl)-4-moφholinocyclohexane-l- carboxamide [709];

fr «5-4-(hydroxymethyl)-N-(2-(5-methyl-l,3,4-thiadiazol-2-yl)-l,6-naphthyridin-7- yl)cyclohexane - 1 -carboxamide [710];

N-(2-(5-methyl-l,3,4-thiadiazol-2-yl)-l,6-naphthyridin-7-yl)piperidine-4-carboxamide [711]; 4-fluoro-N-(2-(5-methyl- 1 ,3 ,4-thiadiazol-2-yl)- 1 ,6-naphthyridin-7-yl)piperidine-4-carboxamide

[712];

l-methyl-N-(2-(5-methyl-l,3,4-thiadiazol-2-yl)-l,6-naphthyridin-7-yl)piperidine-4-carboxamide

[713];

4-fluoro-l-methyl-N-(2-(5-methyl-l,3,4-thiadiazol-2-yl)-l,6-naphthyridin-7-yl)piperidine-4- carboxamide [714];

1 -(2-fluoroethyl)-N-(2-(5 -methyl- 1 ,3,4-thiadiazol-2-yl)- 1 ,6-naphthyridin-7-yl)piperidine-4- carboxamide [715];

1 -(2,2-difluoroethyl)-N-(2-(5-methyl- 1 ,3,4-thiadiazol-2-yl)- 1 ,6-naphthyridin-7-yl)piperidine-4- carboxamide [716];

N-(2-(5-methyl-l,3,4-thiadiazol-2-yl)-l,6-naphthyridin-7-yl)-l-(3,3,3-trifluoropropyl)piperidine- 4-carboxamide [717];

1 -(2,2-difluoropropyl)-N-(2-(5 -methyl-1 ,3,4-thiadiazol-2-yl)- 1 ,6-naphthyridin-7-yl)piperidine-4- carboxamide [718]; 1 -benzoyl -N-(2-(5 -methyl- 1 ,3,4-thiadiazol-2-yl)- 1 ,6-naphthyridin-7-yl)piperidine-4-carboxamide [719];

N-(2-(5-methyl-l ,3,4-thiadiazol-2-yl)- 1 ,6-naphthyridin-7-yl)-2-(pyrrolidin- 1 -yl)acetamide [720] ; N-(2-(5-methyl-l ,3,4-thiadiazol-2-yl)- 1 ,6-naphthyridin-7-yl)-2-(piperidin- 1 -yl)acetamide [721] ; 2-(4-methoxypiperidin- 1 -yl)-N-(2-(5-methyl- 1 ,3,4-thiadiazol-2-yl)- 1 ,6-naphthyridin-7-yl)

acetamide [722];

N-(2-(5-methyl-l,3,4-thiadiazol-2-yl)-l,6-naphthyridin-7-yl)-2-(4-methylpiperazin-l-yl)

acetamide [723];

N-(2-(5-methyl-l,3,4-thiadiazol-2-yl)-l,6-naphthyridin-7-yl)-2-mo holinoacetamide [724]; (R)-N-(2-(5-methyl-l,3,4-thiadiazol-2-yl)-l,6-naphthyridin-7-yl)-2-(3- methylmorpholino)acetamide [725];

2-(7-azabicyclo[2.2.1]heptan-7-yl)-N-(2-(5-methyl-l,3,4-thiadiazol-2-yl)-l,6-naphthyridin-7-yl) acetamide [726];

2-((lR,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(2-(5-methyl-l,3,4-thiadiazol-2-yl)-l,6- naphthyridin-7-yl)acetamide [727];

2-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-N-(2-(5-methyl-l,3,4-thiadiazol-2-yl)-l,6-naphthyridin-

7-yl)acetamide [728];

2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-N-(2-(5-methyl-l,3,4-thiadiazol-2-yl)-l,6-naphthyridin- 7-yl)acetamide [729];

N-(2-(5-methyl-l,3,4-thiadiazol-2-yl)-l,6-naphthyridin-7-yl)-2-(l,4-oxazepan-4-yl)acetamide

[730];

N-(2-(5-methyl-l,3,4-thiadiazol-2-yl)-l,6-naphthyridin-7-yl)-2-mo holinoacetamide-2,2-ί 2

[731];

N-(2-(5-methyl-l,3,4-thiadiazol-2-yl)-l,6-naphthyridin-7-yl)-2-(mo holino-ί s)acetamide [732]; 1 -methyl-3-(2-(5 -methyl-1 ,3,4-thiadiazol-2-yl)- 1 ,6-naphthyridin-7-yl)- 1 -( 1 -methylpiperidin-4- yl)urea [733];

(3S,4S)-4-amino-3-fluoro-N-(2-(5-methyl-l,3,4-thiadiazol-2-yl)-l,6-naphthyridin-7-yl)

piperidine-l-carboxamide [734];

(3 S,4S)-4-(dimethylamino)-3 -fluoro-N-(2-(5 -methyl- 1 ,3,4-thiadiazol-2-yl)-l ,6-naphthyridin-7- yl)piperidine-l-carboxamide [735];

N-(2-(5-methyl-l,3,4-thiadiazol-2-yl)-l,6-naphthyridin-7-yl)mo holine-4-carboxamide [736]; N-(2-(5-methyl-l,3,4-thiadiazol-2-yl)-l,6-naphthyridin-7-yl)-4-(methylamino)piperidine-l- carboxamide [737]; 4-(dimethylamino)-N-(2-(5 -methyl-1

carboxamide [738];

4-((2,2-difluoroethyl)(methyl)amino)-N-(2-(5 -methyl- 1 ,3,4-thiadiazol-2-yl)- 1 ,6-naphthyridin-7- yl)piperidine-l -carboxamide [739];

(3S,4S)-3-fluoro-4-(isopropylamino)-N-(2-(5-methyl-l,3,4-thiadiazol-2-yl)-l,6-naphthyridin-7- yl)piperidine-l -carboxamide [740];

2-methyl-N-(2-(5-methyl-l,3,4-thiadiazol-2-yl)-l,6-naphthyridin-7-yl)-5,6-dihydroimidazo[l,2-a] pyrazine-7(8H)-carboxamide [741];

4-methyl-N-(2-(5 -methyl-1 ,3,4-thiadiazol-2-yl)- 1 ,6-naphthyridin-7-yl)piperazine- 1 -carboxamide

[742];

N-(2-(5-methyl-l ,3,4-thiadiazol-2-yl)- 1 ,6-naphthyridin-7-yl)- 1 -( 1 -methylpiperidin-4-yl)- 1H- pyrazole -4 -carboxamide [743];

1 -( 1 -isopropylpiperidin-4-yl)-N-(2-(5 -methyl- 1 ,3,4-thiadiazol-2-yl)- 1 ,6-naphthyridin-7-yl)- 1H- pyrazole -4 -carboxamide [744];

N-(2-(5-methyl-l ,3,4-thiadiazol-2-yl)- 1 ,6-naphthyridin-7-yl)- 1 -( 1 -methylpiperidin-4-yl)- 1H- l,2,3-triazole-4-carboxamide [745];

N-(2-(5-methyl-l,3,4-thiadiazol-2-yl)-l,6-naphthyridin-7-yl)-2-(piperidin-4-yl)oxazole-4- carboxamide [746];

N-(2-(5-methyl-l,3,4-thiadiazol-2-yl)-l,6-naphthyridin-7-yl)-2-(l-methylpiperidin-4-yl)oxazole- 4-carboxamide [747];

2-(3 -(dimethylamino)azetidin- 1 -yl)-N-(2-(5-methyl- 1 ,3 ,4-thiadiazol-2-yl)-l ,6-naphthyridin-7-yl) isonicotinamide [748];

r-methyl-N-(2-(5-methyl-l,3,4-thiadiazol-2-yl)-l,6-naphthyridin-7-yl)-l',2',3',6'-tetrahydro-[2,4'- bipyridine] -4 -carboxamide [749];

N-(2-(5-methyl-l,3,4-thiadiazol-2-yl)-l,6-naphthyridin-7-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [750];

2-(methyl(l-methylpiperidin-4-yl)amino)-N-(2-(5-methyl-l,3,4-thiadiazol-2-yl)-l,6- naphthyridin-7-yl)isonicotinamide [751] ;

2-(azetidin-3-yloxy)-N-(2-(5-methyl-l,3,4-thiadiazol-2-yl)-l,6-naphthyridin-7-yl)isonicotinamide

[752];

N-(2-(5-methyl-l,3,4-thiadiazol-2-yl)-l,6-naphthyridin-7-yl)-3-((l-methylpiperidin-4-yl)oxy) benzamide [753];

N-(2-(5-methyl-l,3,4-thiadiazol-2-yl)-l,6-naphthyridin-7-yl)-2-((l-methylpiperidin-4-yl)thio) isonicotinamide [754]; 6-(4-methylpiperazin-l-yl)-N-(2-(5-(trifluoromethyl)-l,3,4 hiadiazol-2-yl)-l,6-naphthyridin-7- yl)nicotinamide [755];

2-(4-methylpiperazin-l-yl)-N-(2-(5-(trifluoromethyl)-l,3,4-thiadiazol-2-yl)-l,6-naphthyridin-7- yl)isonicotinamide [756];

N-(2-(5-amino-l,3,4 hiadiazol-2-yl)-l,6-naphthyridin-7-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [757];

N-(2-(5-(dimethylamino)-l,3,4-thiadiazol-2-yl)-l,6-napfa

yl)isonicotinamide [758];

N-(2-(3-amino-5 -fluorophenyl)- 1 ,6-naphthyridin-7-yl)-2-(4-methylpiperazin- 1 -yl)

isonicotinamide [759];

N-(2-(3-fluoro-5-(isopropylamino)phenyl)-l,6-naphthyridin-7-yl)-2-(4-methylpiperazin-l-yl) isonicotinamide [760];

1 -methyl -N-(2 -(pyridin-2 -yl) - 1 , 6-naphthyridin-7-yl)piperidine -4-carboxamide [761 ] ;

2-(4-methylpiperazin-l-yl)-N-(2-(pyridin-2-yl)-l,6-naphthyridin-7-yl)isonicotinamide [762]; 2-(4-methylpiperazin-l-yl)-N-(2-(pyridin-4-yl)-l,6-naphthyridin-7-yl)isonicotinamide [763]; N-(2-(pyridin-3 -yl)- 1 ,6-naphthyridin-7-yl)cyclopropanecarboxamide [764] ;

N-(2 -(pyridin-3 -yl) - 1 , 6 -naphthyridin-7 -yl) -2 -(pyrrolidin- 1 -yl)acetamide [765] ;

1 -methyl -N-(2 -(pyridin-3 -yl)-l ,6-naphthyridin-7-yl)piperidine-4-carboxamide [766] ;

N-(2-(pyridin-3-yl)-l,6-naphthyridin-7-yl)quinuclidine-4-carboxamide [767];

2-morpholino-N-(2-(pyridin-3 -yl)- 1 ,6-naphthyridin-7-yl)acetamide [768] ;

2-(moφholino-ί s)- -(2-(pyridin-3-yl)-l,6-naphthyridin-7-yl)acetamide [769];

2-(4-methylpiperazin-l -yl)-N-(2 -(pyridin-3 -yl)- 1 ,6-naphthyridin-7-yl)acetamide [770] ;

2-(4-methyl- 1 ,4-diazepan- 1 -yl)-N-(2-(pyridin-3-yl)- 1 ,6-naphthyridin-7-yl)acetamide [771] ; 2-(4-methylpiperazin-l -yl)-N-(2 -(pyridin-3 -yl)- 1 ,6-naphthyridin-7-yl)isonicotinamide [772] ; 2-(2 -methyl- IH-imidazol- 1 -yl)-N-(2-(pyridin-3-yl)- 1 ,6-naphthyridin-7-yl)acetamide [773] ; 2-(lH-imidazol-l-yl)-N-(2-(pyridin-3-yl)-l,6-naphthyridin-7-yl)acetamide [774];

2-(piperidin-4-yl)-N-(2-(pyridin-3-yl)-l,6-naphthyridin-7-yl)oxazole-4-carboxamide [775]; 2-(l-methylpiperidin-4-yl)-N-(2-(pyridin-3-yl)-l,6-naphthyridin-7-yl)oxazole-4-carboxamide

[776];

2-(l-isopropylpiperidin-4-yl)-N-(2-(pyridin-3-yl)-l,6-naphthyridin-7-yl)oxazole-4-carboxamide

[777];

fr rø-N-(2-(5-fluoropyridin-3-yl)-l,6-naphthyridin-7-yl)-3-moφholinocyclobutane-l- carboxamide [778]; fr «5-N-(2-(5-fluoropyridin-3-yl)-l,6-naphthyridin-7-yl)-4-((4-methylpiperazin-l-yl)methyl) cyclohexane-l-carboxamide [779];

N-(2-(5-fluoropyridin-3-yl)-l,6-naphthyridin-7-yl)-2-(pyrrolidin-l-yl)acetamide [780];

N-(2-(5-fluoropyridin-3 -yl)-l ,6-naphthyridin-7-yl)- 1 -methylpiperidine-4-carboxamide [781] ; N-(2-(5-fluoropyridin-3-yl)-l,6-naphthyridin-7-yl)-2-(4-methylpiperazin-l-yl)acetamide [782]; N-(2-(6-fluoropyridin-3-yl)-l,6-naphthyridin-7-yl)-2-(4-methylpiperazin-l-yl)acetamide [783]; N-(2-(5-fluoropyridin-3-yl)-l,6-naphthyridin-7-yl)-2-moφholinoacetamide [784];

N-(2-(5-fluoropyridin-3-yl)-l,6-naphthyridin-7-yl)-3-moφholinopropanamide [785];

N-(2-(5-fluoropyridin-3-yl)-l,6-naphthyridin-7-yl)-2-(4-methylpiperazin-l-yl)isonicotinam

[786];

N-(2-(5-fluoropyridin-3-yl)-l,6-naphthyridin-7-yl)-2-(piperidin-4-yl)oxazole-4-carboxamide

[787];

N-(2-(5-fluoropyridin-3-yl)-l,6-naphthyridin-7-yl)-2-(l-methylpiperidin-4-yl)oxazole-4- carboxamide [788];

N-(2-(5-fluoropyridin-3-yl)-l,6-naphthyridin-7-yl)-2-(l-isopropylpiperidin-4-yl)oxazole-4- carboxamide [789];

N-(2-(5-chloropyridin-3-yl)-l,6-naphthyridin-7-yl)-2-(4-methylpiperazin-l-yl)isonicotinami

[790];

N-(2-(5-methylpyridin-3-yl)-l,6-naphthyridin-7-yl)-2-moφholinoacetamide [791];

N-(2-(5-(difluoromethyl)pyridin-3-yl)-l,6-naphthyridin-7-yl)-3-(piperidin-4-yl)benzamide [792]; N-(2-(5-(difluoromethyl)pyridin-3-yl)-l,6-naphthyridin-7-yl)-3-(l-methylpiperidin-4-yl)

benzamide [793];

N-(2-(5-(difluoromethyl)pyridin-3-yl)-l,6-naphthyridin-7-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [794];

2-(4-methylpiperazin-l-yl)-N-(2-(5-(trifluoromethyl)pyridin-3-yl)-l,6-naphthyridin-7-yl)

acetamide [795];

2-(4-methylpiperazin-l-yl)-N-(2-(6-(trifluoromethyl)pyridin-3-yl)-l,6-naphthyridin-7-yl)

acetamide [796];

N-(2-(5-(hydroxymethyl)pyridin-3-yl)-l,6-naphthyridin-7-yl)-l-methylpiperidine-4-carboxamide

[797];

N-(2-(5-cyanopyridin-3 -yl)-l ,6-naphthyridin-7-yl)- 1 -methylpiperidine-4-carboxamide [798] ; N-(2-(5-methoxypyridin-3-yl)-l,6-naphthyridin-7-yl)-l-methylpiperidine-4-carboxamide [799]; N-(2-(5-methoxypyridin-3-yl)-l,6-naphthyridin-7-yl)-2-moφholinoacetamide [800]; N-(2-(5-methoxypyridin-3-yl)-l,6-naphthyridin-7-yl)-2-(4-methylpiperazin-l-yl)isonicotinamide [801];

4-fluoro-N-(2-(5-(piperidin-4-yloxy)pyridin-3-yl)-l,6-naphthyridin-7-yl)benzamide [802];

N-(2-(5-aminopyridin-3 -yl)- 1 ,6-naphthyridin-7-yl)-4-fluorobenzamide [803] ;

N-(2-(5-aminopyridin-3-yl)-l,6-naphthyridin-7-yl)-4-(piperidin-4-yloxy)benzamide [804];

N-(2-(5-aminopyridin-3 -yl)- 1 ,6-naphthyridin-7-yl)-2-(4-methylpiperazin- 1 -yl)isonicotinamide

[805];

N-(2-(5-aminopyridin-3-yl)-l,6-naphthyridin-7-yl)-2-(piperidin-4-yl)oxazole-4-carboxamide

[806];

N-(2-(6-aminopyridin-3 -yl)- 1 ,6-naphthyridin-7-yl)-2-(4-methylpiperazin- 1 -yl)isonicotinamide

[807];

N-(2-(6-(methylamino)pyridin-3-yl)-l,6-naphthyridin-7-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [808];

N-(2-(5-(isopropylamino)pyridin-3 -yl)- 1 ,6-naphthyridin-7-yl)-3 -(piperidin-4-yl)benzamide [809] ; N-(2-(5-(isopropylamino)pyridin-3 -yl)- 1 ,6-naphthyridin-7-yl)-3 -( 1 -methylpiperidin-4-yl)

benzamide [810];

N-(2-(5-(isopropylamino)pyridin-3 -yl)- 1 ,6-naphthyridin-7-yl)-2-(4-methylpiperazin- 1 -yl)

isonicotinamide [811];

N-(2-(5-(piperidin-4-ylamino)pyridin-3-yl)-l,6-naphthyridin-7-yl)cyclohexanecarboxamide

[812];

4-fluoro-N-(2-(5-(piperidin-4-ylamino)pyridin-3-yl)-l,6-naphthyridin-7-yl)benzamide [813]; 4-fluoro-N-(2-(5-(( 1 -methylpiperidin-4-yl)amino)pyridin-3 -yl)- 1 ,6-naphthyridin-7-yl)benzamide

[814];

N-(2-(5-acetamidopyridin-3-yl)-l,6-naphthyridin-7-yl)-l-methylpiperidine-4-carboxamide [815]; N-(2-(5-(dimethylamino)pyridin-3-yl)-l,6-naphthyridin-7-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [816];

N-(2-(6-(dimethylamino)pyridin-3-yl)-l,6-naphthyridin-7-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [817];

l-methyl-N-(2-(5-(pyrrolidin-l-yl)pyridin-3-yl)-l,6-naphthyridin-7-yl)piperidine-4-carboxamide

[818];

N-(2-(5-(pyrrolidin- 1 -ylmethyl)pyridin-3 -yl)- 1 ,6-naphthyridin-7-yl)cyclopropanecarboxamide

[819];

4-fluoro-N-(2-(5-(pyrrolidin- 1 -ylmethyl)pyridin-3 -yl)- 1 ,6-naphthyridin-7-yl)benzamide [820] ; N-(2-(5-((4-hydroxypiperidin-l-yl)methyl)pyridin-3-yl)-l,6-naphthyridin-7-yl) cyclopropanecarboxamide [821];

4-fluoro-N-(2-(5-((4-hydroxypiperidin-l-yl)methyl)pyridin-3-yl)-l,6-naphthyridin-7-yl)

benzamide [822];

N-(2-(5-(piperazin-l-ylmethyl)pyridin-3-yl)-l,6-naphthyridin-7-yl)cyclopropanecarboxamide

[823];

N-(2-(5 -((4-methylpiperazin- 1 -yl)methyl)pyridin-3 -yl)- 1 ,6-naphthyridin-7-yl)

cyclopropanecarboxamide [824];

N-(2-(5-(mo holinomethyl)pyridin-3-yl)-l,6-naphthyridin-7-yl)cyclopropanecarboxamide [825]; N-methyl-5-(7-(l-methylpiperidine-4-carbo [826]; N-methyl-5-(7-(2-(4-methylpiperazin-l-yl)isonicotinamido)-l,6-naphthyridin-2-yl)nicotinam

[827];

N-(2 -(pyridin-3 -yl -di) - 1 ,6 -naphthyridin-7 -yl) -2-(pyrrolidin- 1 -yl)acetamide [828] ;

2-(4-methylpiperazin- 1 -yl)-N-(2-(pyridin-3 -yl-<¾)- 1 ,6-naphthyridin-7-yl)acetamide [829] ;

2-moφholino-N-(2-(pyridin-3-yl-ί ₄()-l,6-naphthyridin-7-yl)acetamide [830];

1 -methyl -N-(2-(2-methylpyrimidin -5 -yl)- 1 ,6-naphthyridin-7-yl)piperidine-4-carboxamide [831] ; 2-(4-methylpiperazin-l-yl)-N-(2-(2-methylpyrimidin-5-yl)-l,6-naphthyridin-7-yl)isonicotinamide

[832];

N-(2 -(2-aminopyrimidin-5 -yl)- 1 , 6 -naphthyridin-7 -yl)- 1 -methylpiperidine -4 -carboxamide [833] ; 2-morpholino-N-(2-(pyridazin-3 -yl)-l ,6-naphthyridin-7-yl)acetamide [834] ;

2-moφholino-N-(2-(pyridazin-4-yl)-l,6-naphthyridin-7-yl)acetamide [835];

N-(2 -(pyridazin-4-yl) -1,6 -naphthyridin-7 -yl) -2 -(pyrrolidin- 1 -yl)acetamide [836] ;

trans -3 -ιηοφ1ιο1ίηο-Ν-(2 -(pyrazin-2-yl) - 1 ,6 -naphthyridin-7 -yl)cyclobutane - 1 -carboxamide [837] ; trans -4 -(dimethylamino) -N-(2 -(pyrazin-2-yl) - 1 , 6-naphthyridin-7-yl)cyclohexane - 1 -carboxamide

[838];

fr rø-4-moφholino-N-(2-(pyrazin-2-yl)-l,6-naphthyridin-7-yl)cyclohexane-l-carboxamide

[839];

trans-4-((3 -fluoroazetidin- 1 -yl)methyl)-N-(2-(pyrazin-2-yl)- 1 ,6-naphthyridin-7-yl)cyclohexane- 1 -carboxamide [840];

fr «5-4-((4-methylpiperazin-l-yl)methyl)-N-(2-(pyrazin-2-yl)-l,6-naphthyridin-7-yl)c

yclohexane - 1 -carboxamide [841];

N-(2-(pyrazin-2-yl)-l,6-naphthyridin-7-yl)-2-(pyrrolidin-l-yl)acetamide [842];

l-methyl-N-(2-(pyrazin-2-yl)-l,6-naphthyridin-7-yl)piperidine-4-carboxamide [843];

4-fluoro-l -methyl -N-(2-(pyrazin-2-yl)-l,6-naphthyridin-7-yl)piperidine-4-carboxamide [844]; l-(2-fluoroethyl)-N-(2-(pyrazin-2-yl)-l,6-naphthyridin-7-yl)piperidine-4-carboxamide [845];

1- (oxetan-3-yl)-N-(2-(pyrazin-2-yl)-l,6-naphthyridin-7-yl)piperidine-4-carboxamide [846];

2- moφholino-N-(2-(pyrazin-2-yl)-l,6-naphthyridin-7-yl)acetamide [847];

l-methyl-N-(2-(pyrazin-2-yl)-l,6-naphthyridin-7-yl)azepane-4-carboxamide [848];

1- isobutyl-N-(2-(pyrazin-2-yl)-l,6-naphthyridin-7-yl)azepane-4-carboxamide [849];

1 -(2-hydroxy-2-methylpropyl)-N-(2-(pyrazin-2-yl)- 1 ,6-naphthyridin-7-yl)azepane-4-carboxamide

[850];

4-(moφholinomethyl)-N-(2-(pyrazin-2-yl)- 1 ,6-naphthyridin-7-yl)benzamide [851] ;

2- (4-methylpiperazin-l-yl)-N-(2-(pyrazin-2-yl)-l,6-naphthyridin-7-yl)isonicotinamide [852]; N-(2-(6-(methylamino)pyrazin-2-yl)-l,6-naphthyridin-7-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [853];

N-(2-(6-(isopropylamino)pyrazin-2-yl)-l,6-naphthyridin-7-yl)azetidine-3-carboxamide [854]; N-(2-(6-(isopropylamino)pyrazin-2-yl)- 1 ,6-naphthyridin-7-yl)- 1 -methylpiperidine-4-carboxamide

[855];

N-(2-(6-(isopropylamino)pyrazin-2-yl)- 1 ,6-naphthyridin-7-yl)- 1 -methylpiperidine-4-carboxamide

[856];

1 -(2-fluoroethyl)-N-(2-(6-(isopropylamino)pyrazin-2-yl)- 1 ,6-naphthyridin-7-yl)piperidine-4- carboxamide [857];

l-isopropyl-N-(2-(6-(isopropylamino)pyrazin-2-yl)-l,6-naphthyridin-7-yl)piperidine-4- carboxamide [858];

l-isopentyl-N-(2-(6-(isopropylamino)pyrazin-2-yl)-l,6-naphthyridin-7-yl)piperidine-4- carboxamide [859];

N-(2-(6-(isopropylamino)pyrazin-2-yl)-l,6-naphthyridin-7-yl)-3-(piperidin-4-yl)benzamide [860]; N-(2-(6-(isopropylamino)pyrazin-2-yl)-l,6-naphthyridin-7-yl)-3-(l-methylpiperidin-4-yl)

benzamide [861];

N-(2-(6-(isopropylamino)pyrazin-2-yl)-l,6-naphthyridin-7-yl)-l-(piperidin-4-yl)-lH-l,2,3- triazole-4-carboxamide [862];

l-(l-(2-fluoroethyl)piperidin-4-yl)-N-(2-(6-(isopropylamino)pyrazin-2-yl)-l,6-naphthyridin-7- yl)- 1H- 1 ,2,3 -triazole-4-carboxamide [863] ;

N-(2-(6-(isopropylamino)pyrazin-2-yl)-l,6-naphthyridin-7-yl)-l-(l-isopropylpiperidin-4-yl)-lH- l,2,3-triazole-4-carboxamide [864];

N-(2-(6-(isopropylamino)pyrazin-2-yl)- 1 ,6-naphthyridin-7-yl)-2-(4-methylpiperazin- 1 -yl)

isonicotinamide [865]; N-(2-(6-(fer^butylamino)pyrazin-2-yl)-l,6-naphthyridin-7-yl)-2-(3-(dimethylamino)azetidin-l- yl)isonicotinamide [866];

N-(2-(6-(fert-butylamino)pyrazin-2-yl)- 1 ,6-naphthyridin-7-yl)- 1 '-methyl- 1 ',2',3 ',6'-tetrahydro-

[2,4'-bipyridine]-4-carboxamide [867];

N-(2-(6-(fer^butylamino)pyrazin-2-yl)-l,6-naphthyridin-7-yl)-2-(4-methylpiperazin-l-yl) isonicotinamide [868];

N-(2-(6-(fer^butylamino)pyrazin-2-yl)-l,6-naphthyridin-7-yl)-2-(4-isopropylpiperazin-l-yl) isonicotinamide [869];

N-(2-(6-(ferί-butylamino)pyrazin-2-yl)-l,6-naphthyridin-7-yl)-2-moφholinoisonicotinamide

[870];

N-(2-(6-(((3-fluoroazetidin-3-yl)methyl)amino)pyrazin-2-yl)-l,6-naphthyridin-7-yl)

cyclopropanecarboxamide [871];

4-fluoro-N-(2-(6-(((3-fluoroazetidin-3-yl)methyl)amino)pyrazin-2-yl)-l,6-naphthyridin-7-yl) benzamide [872];

N-(2-(6-(piperidin-4-ylamino)pyrazin-2-yl)-l,6-naphthyridin-7-yl)cyclobutanecarboxamide

[873];

3.3- difluoro-N-(2-(6-(piperidin-4-ylamino)pyrazin-2-yl)-l,6-naphthyridin-7-yl)cyclobutane-l- carboxamide [874];

N-(2-(6-(piperidin-4-ylamino)pyrazin-2-yl)-l,6-naphthyridin-7-yl)cyclopentanecarboxamide

[875];

4.4- difluoro-N-(2-(6-(piperidin-4-ylamino)pyrazin-2-yl)-l,6-naphthyridin-7-yl)cyclohexane-l- carboxamide [876];

N-(2-(6-(piperidin-4-ylamino)pyrazin-2-yl)-l,6-naphthyridin-7-yl)tetrahydro-2H-pyran-4- carboxamide [877];

4-fluoro-N-(2-(6-(piperidin-4-ylamino)pyrazin-2-yl)- 1 ,6-naphthyridin-7-yl)benzamide [878] ; N-(2-(6-(((3S,4S)-3-fluoropiperidin-4-yl)amino)pyrazin-2-yl)-l,6-naphthyridin-7-yl)

cyclopropanecarboxamide [879];

4-fluoro-N-(2-(6-(((3S,4S)-3-fluoropiperidin-4-yl)amino)pyrazin-2-yl)-l,6-naphthyridin-7-yl) benzamide [880];

N-(2-(6-((l-methylpiperidin-4-yl)amino)pyrazin-2-yl)-l,6-naphthyridin-7-yl)

cyclobutanecarboxamide [881];

N-(2-(6-((l-methylpiperidin-4-yl)amino)pyrazin-2-yl)-l,6-naphthyridin-7-yl)

cyclopentanecarboxamide [882] ; 4-fluoro-N-(2-(6-((l-methylpiperidin-4-yl)amm^

[883];

N-(2-(6-((1 sopropylpiperidin-4-yl)amino)pyrazin-2-yl)-l,6-naphthyridin-7-yl)

cyclopropanecarboxamide [884];

3,3-difluoro-N-(2-(6-((l-isopropylpiperidin-4-yl)amino)pyrazin-2-yl)-l,6-naphthyridin-7-yl) cyclobutane-l-carboxamide [885];

N-(2-(6-((1 sopropylpiperidin-4-yl)amino)pyrazin-2-yl)-l,6-naphthyridin-7-yl)

cyclopentanecarboxamide [886] ;

4-fluoro-N-(2-(6-(( 1 -isopropylpiperidin-4-yl)amino)pyrazin-2-yl)- 1 ,6-naphthyridin-7-yl) benzamide [887];

N-(2-(6-(dimethylamino)pyrazin-2-yl)-l,6-naphthyridin-7-yl)-2-(4-methylpiperazin-l-yl) isonicotinamide [888];

N-(2-(6-(diethylamino)pyrazin-2-yl)-l,6-naphthyridin-7-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [889];

N-(2-(6-(3-aminoazetidin-l-yl)pyrazin-2-yl)-l,6-naphthyridin-7-yl)-4-fluorobenzamide [890]; 2-(4-methylpiperazin- 1 -yl)-N-(2-(6-(pyrrolidin- 1 -yl)pyrazin-2-yl)- 1 ,6-naphthyridin-7-yl) isonicotinamide [891];

N-(2-(6-(azetidin-3-ylmethoxy)pyrazin-2-yl)-l,6-naphthyridin-7-yl)-4-fluorobenzamide [892]; N-(2-(6-(azetidin-3 -yloxy)pyrazin-2-yl)- 1 ,6-naphthyridin-7-yl)-4-fluorobenzamide [893] ; N-(2-(lH-pyrrolo[2,3-b]pyridin-5-yl)-l,6-naphthyridin-7-yl)-l-(l-methylpiperidin-4-yl)-lH- pyrazole-4-carboxamide [894];

N-(2-(lH-pyrrolo[3,2-b]pyridin-6-yl)-l,6-naphthyridin-7-yl)-l-(l-methylpiperidin-4-yl)-lH- pyrazole-4-carboxamide [895];

N-(2-( lH-pyrrolo[2,3 -c]pyridin-4-yl)- 1 ,6-naphthyridin-7-yl)- 1 -( 1 -methylpiperidin-4-yl)- 1H- pyrazole-4-carboxamide [896];

N-(2-(lH-pyrrolo[2,3-b]pyridin-5-yl)-l,6-naphthyridin-7-yl)-2-(4-methylpiperazin-l-yl) isonicotinamide [897];

N-(2-(lH-pyrrolo[3,2-b]pyridin-6-yl)-l,6-naphthyridin-7-yl)-2-(4-methylpiperazin-l-yl) isonicotinamide [898];

N-(2-(lH-pyrrolo[2,3-c]pyridin-4-yl)-l,6-naphthyridin-7-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [899];

2-(4-methylpiperazin-l-yl)-N-(2-(oxazolo[5,4-b]pyridin-6-yl)-l,6-naphthyridin-7-yl)

isonicotinamide [900]; N-(2-(2-methyl-lH-pyrrolo[2,3-b]pyridin-5-yl)-l,6-naphthyridin-7-yl)-2-(4-methylpiperazin-l- yl)isonicotinamide [901];

N-(2-(3-methyl-lH-pyrrolo[2,3-b]pyridin-5-yl)-l,6-naphthyridin-7-yl)-2-(4-methylpiperazin-l- yl)isonicotinamide [902];

N-(2-(2-methyl-lH-pyrrolo[3,2-b]pyridin-6-yl)-l,6-naphthyridin-7-yl)-2-(4-methylpiperazin-l- yl)isonicotinamide [903];

N-(2-(5H-pyrrolo[2,3-b]pyrazin-2-yl)-l,6-naphthyridin-7-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [904];

N-(2-(5H-pyrrolo[2,3-b]pyrazin-3-yl)-l,6-naphthyridin-7-yl)-2-(4-methylpiperazin-l- yl)isonicotinamide [905];

1 -isopropyl-N-(2-(6-(piperidin-4-ylamino)pyrazin-2-yl)- 1 ,6-naphthyridin-7-yl)- lH-pyrazole-4- carboxamide [906];

l-isopropyl-N-(2-(6-((l-methylpiperidin-4-yl)amino)pyrazin-2-yl)-l,6-naphthyridin-7-yl)-lH- pyrazole-4-carboxamide [907];

fr «5-4-((2-fluoroethyl)amino)-N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)

cyclohexane-l-carboxamide [4535];

fr «5-4-((2-methoxyethyl)amino)-N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)

cyclohexane-l-carboxamide [4536];

fert-butyl (fr «5-4-((2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)carbamoyl)cyclohexyl) carbamate [4537];

N-(2-( 1 -methyl -lH-pyrazol -4 -yl)- 1 ,6-naphthyridin-7-yl)-2-(( 1 -methylpiperidin-4-yl)amino) isonicotinamide [4538];

N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-2-(4-methylpiperazin-l-yl)thiazole-5- carboxamide [4539];

N-(2-(l-methyl-lH-pyrazol-4-yl)-l,6-naphthyridin-7-yl)-2-(4-methylpiperazin-l-yl)thiazole-5- carboxamide [4540];

N-(2-( 1 -methyl -5 -(piperidin- 1 -ylmethyl)- lH-pyrazol-4-yl)-l ,6-naphthyridin-7-yl)-2-(2,7- diazaspiro[3.5]nonan-2-yl)isonicotinamide [4541] ;

N-(2-(l-methyl-lH-l,2,3-triazol-4-yl)-l,6-naphthyridin-7-yl)-4-(piperidin-4-yloxy)benzamide

[4542];

N-(2-( 1 -methyl-lH-tetrazol-5 -yl)- 1 ,6-naphthyridin-7-yl)- 1 -(3,3,3-trifluoropropyl)piperidine-4- carboxamide [4543];

N-(2-(l,2-dimethyl-lH-imidazol-5-yl)-l,6-naphthyridin-7-yl)-2-(pyrrolidin-l-yl)propanamide

[4544]; N-(2-( 1 ,2-dimethyl- lH-imidazol-5-yl)-l ,6-naphthyridin-7-yl)-2-(piperidin- 1 -yl)propanamide

[4545];

4-isopropoxy-N-(2-(7-methyl-5,6J,8-tetrahydroim ^

yl)benzamide [4546];

trans-3 -mo holino-N-(2-(oxazol-5 -yl)- 1 ,6-naphthyridin-7-yl)cyclobutane- 1 -carboxamide

[4547];

fr «5-4-(hydroxymethyl)-N-(2-(oxazol-5-yl)-l,6-naphthyridin-7-yl)cyclohexane-l-carboxamide

[4548];

N-(2-(oxazol-5 -yl)- 1 ,6-naphthyridin-7-yl)piperidine-4-carboxamide [4549] ;

4-morpholino-N-(2-(oxazol-5 -yl)- 1 ,6-naphthyridin-7-yl)piperidine- 1 -carboxamide [4550] ; N-(2-(oxazol-5-yl)-l,6-naphthyridin-7-yl)-4-(piperidin-4-yloxy)benzamide [4551];

N-(2-(oxazol-5 -yl)- 1 ,6-naphthyridin-7-yl)-3-(piperidin-4-yloxy)benzamide [4552] ;

2-methyl-N-(2-(oxazol-5-yl)-l,6-naphthyridin-7-yl)-5,6-dihydroimidazo[l,2-a]pyrazine-7(8H)- carboxamide [4553];

2-( lH-imidazol-1 -yl)-N-(2-(oxazol-5 -yl)- 1 ,6-naphthyridin-7-yl)acetamide [4554] ;

trans -4 -(hydroxymethyl) -N-(2-(thiazol -5 -yl) - 1 ,6 -naphthyridin-7-yl)cyclohexane - 1 -carboxamide

[4555];

fr «5-4-(dimethylamino)-N-(2-(thiazol-5 -yl)- 1 ,6-naphthyridin-7-yl)cyclohexane- 1 -carboxamide

[4556];

N-(2 -(thiazol-5 -yl) - 1 , 6-naphthyridin-7 -yl) - 1 -(( 1 -(trifluoromethyl)cyclopropyl)methyl)piperidine - 4-carboxamide [4557];

fr «5-4-(hydroxymethyl)-N-(2-(2-methylthiazol-5-yl)-l,6-naphthyridin-7-yl)cyclohexane-l- carboxamide [4558];

fr «5-4-(dimethylamino)-N-(2-(2-methylthiazol-5-yl)- 1 ,6-naphthyridin-7-yl)cyclohexane- 1 - carboxamide [4559];

N-(2-(2-methylthiazol-5-yl)-l,6-naphthyridin-7-yl)-l-(oxetan-3-yl)piperidine-4 -carboxamide

[4560];

N-(2-(2-methylthiazol-5-yl)-l,6-naphthyridin-7-yl)-l-(2-(pyrrolidin-l-yl)acetyl)piperidine-4- carboxamide [4561];

2-((lS,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(2-(5-methyl-l,3,4-thiadiazol-2-yl)-l,6- naphthyridin-7-yl)acetamide [4562] ;

N-(2-(5-(cyano(4-hydroxypiperidin- 1 -yl)methyl)pyridin-3 -yl)- 1 ,6-naphthyridin-7-yl)

cyclopropanecarboxamide [4563]; 4-fluoro-N-(2-(6-(( 1 -methylazetidin-3 -yl)methoxy)pyrazin-2-yl)- 1 ,6-naphthyridin-7-yl) benzamide [4564] ;

l-isopropyl-N-(2-(6-(( l-methylpiperidin-4-yl)amino)pyrazin-2-yl)-l,6-naphthyridin-7-yl)-lH- pyrazole -4 -carboxamide [4565]; or a pharmaceutically acceptable salt thereof.

21. The compound according to any one of claims 1-19, wherein the compound of Formula I is selected from the group consisting of:

N-(7-( lH-pyrazol-4-yl)quinazolin-2-yl)-l -isobutylpiperidine-4-carboxamide [908];

N-(7 -( 1 -methyl - 1 H-pyrazol -4 -yl)quinazolin-2 -yl)cyclopropanecarboxamide [909] ;

4,4-difluoro-N-(7-( 1 -methyl-lH-pyrazol-4-yl)quinazolin-2-yl)cyclohexane- 1 -carboxamide [910] ; fr «5-4-methoxy-N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)cyclohexane- 1 -carboxamide

[911];

fr rø-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)-4-moφholinocyclohexane-l - carboxamide [912];

trans-4-((3 -fluoroazetidin- 1 -yl)methyl)-N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)

cyclohexane - 1 -carboxamide [913] ;

fr «5-N-(7-(l -methyl-lH-pyrazol-4-yl)quinazolin-2-yl)-4-((4-methylpiperazin-l -yl)methyl) cyclohexane - 1 -carboxamide [914] ;

N-(7-(l -methyl-lH-pyrazol-4-yl)quinazolin-2-yl)-2-(pyrrolidin-l -yl)acetamide [915];

(S)-2-(3 -fluoropyrrolidin- 1 -yl)-N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)acetamide [916] ; ( S) -N-(7 -( 1 -methyl - 1 H-pyrazol-4-yl)quinazolin-2-yl)tetrahydrofuran-2 -carboxamide [917]; N-(7 -( 1 -methyl - 1 H-pyrazol-4-yl)quinazolin-2 -yl)piperidine -4 -carboxamide [918];

l-methyl-N-(7-(l -methyl-lH-pyrazol-4-yl)quinazolin-2-yl)piperidine-4-carboxamide [919] ; 1 -isopropyl-N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)piperidine-4-carboxamide [920] ; 1 -(fert-butyl)-N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)piperidine-4-carboxamide [921] ; l-cyclopropyl-N-(7-(l -methyl-lH-pyrazol-4-yl)quinazolin-2-yl)piperidine-4-carboxamide [922] ; 1 -isobutyl-N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)piperidine-4-carboxamide [923] ; N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)- 1 -neopentylpiperidine-4-carboxamide [924] ; 1 -(2 -fluoroethyl) -N-(7-( 1 -methyl - 1 H-pyrazol -4 -yl)quinazolin-2 -yl)piperidine -4 -carboxamide

[925];

N-(7-(l -methyl-lH-pyrazol-4-yl)quinazolin-2-yl)-l-(3,3,3-trifluoropropyl)piperidine-4- carboxamide [926];

1 -butyl -N-(7 -( 1 -methyl - 1 H-pyrazol -4 -yl)quinazolin-2 -yl)piperidine -4 -carboxamide [927] ;

1 -benzoyl -N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)piperidine-4-carboxamide [928] ; l-(2,2-difluoropropyl)-N-(7-(l -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)piperidine-4- carboxamide [929];

N-(7 -( 1 -methyl - 1 H-pyrazol -4 -yl)quinazolin-2-yl)azetidine -3 -carboxamide [930] ;

l-(2,2-difluoroethyl)-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)piperidine-4-carboxamide

[931];

1 -(2-fluoro-2-methylpropyl)-N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)piperidine-4- carboxamide [932];

N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)- 1 -(oxetan-3-yl)piperidine-4-carboxamide

[933];

N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)- 1 -((3-methyloxetan-3 -yl)methyl)piperidine-4- carboxamide [934];

1- (2-methoxyethyl)-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)piperidine-4-carboxamide

[935];

1 -(2-isopropoxyethyl)-N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)piperidine-4- carboxamide [936];

1 , 1 -diisobutyl-4-((7-( 1 -methyl-lH-pyrazol-4-yl)quinazolin-2-yl)carbamoyl)piperidin- 1 -ium

[937];

4-fluoro-N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)piperidine-4-carboxamide [938] ; 4-fluoro- 1 -methyl -N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)piperidine-4-carboxamide

[939];

4-fluoro- 1 -isobutyl-N-(7-( 1 -methyl-lH-pyrazol-4-yl)quinazolin-2-yl)piperidine-4-carboxamide

[940];

(S)-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)piperidine-3-carboxamide [941];

(R)-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)piperidine-3-carboxamide [942];

(S)-l-isobutyl-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)piperidine-3-carboxamide [943]; (R)-l-isobutyl-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)piperidine-3-carboxamide [944]; N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)tetrahydro-2H-pyran-4-carboxamide [945] ; N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)-2-(piperidin-l-yl)acetamide [946];

2- (4-fluoropiperidin-l -yl)-N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)acetamide [947] ; trans -4 -amino -N-(7-( 1 -methyl - 1 H-pyrazol -4 -yl)quinazolin-2 -yl)cyclohexane - 1 -carboxamide

[948];

N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)-2-(4-methylpiperazin- 1 -yl)acetamide [949] ; (S)-N-(7-(l -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)piperidine-2 -carboxamide [950];

2-(4-isobutylpiperazin-l-yl)-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)acetamide [951]; 2-(3,3-dimethylazetidin-l-yl)-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)acetamide [952]; (R)-2-(3-fluoropyrrolidin- 1 -yl)-N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)acetamide [953] ; (S)-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)-2-(2-methylpyrrolidin-l-yl)acetamide

[954];

2-(3-azabicyclo[3.1.0]hexan-3-yl)-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)acetamide

[955];

2-(7-azabicyclo[2.2.1]heptan-7-yl)-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)acetamide

[956];

N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)-2-(4-methylpiperidin- 1 -yl)acetamide [957] ; N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)-2-(4-(trifluoromethyl)piperidin- 1 -yl)acetamide

[958];

2-(4-(difluoromethyl)piperidin-l-yl)-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)acetamide

[959];

N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)-2-(6-azaspiro[2.5]octan-6-yl)acetamide [960]; N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)-2-(pyrrolidin-l -yl)propanamide [961] ;

(R)-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)-2-(2-methylpyrrolidin-l-yl)acetamide

[962];

2-(cyclobutyl(methyl)amino)-N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)acetamide [963] ; 2-(diethylamino) -N-(7 -( 1 -methyl - 1 H-pyrazol -4 -yl)quinazolin-2 -yl)acetamide [964] ;

7-(2-fluoroethyl)-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)-7-azaspiro[3.5]nonane-2- carboxamide [965];

4-methyl-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)piperazine-l-carboxamide [966]; (S)-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)-2-(pyrrolidin-l-yl)propanamide [967]; (R)-N-(7-( 1 -methyl-lH-pyrazol-4-yl)quinazolin-2-yl)-2-(pyrrolidin- 1 -yl)propanamide [968] ; (R) -N-(7 -( 1 -methyl - 1 H-pyrazol-4 -yl)quinazolin-2-yl)pyrrolidine -2-carboxamide [969] ;

2-methyl-N-(7 -( 1 -methyl - 1 H-pyrazol -4 -yl)quinazolin-2-yl) -2 -azaspiro [3.3 ]heptane -6 - carboxamide [970];

N-(7-(l -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)-2-(2,2,2-trifluoroacetyl)-2-azaspiro[3.3]

heptane-6-carboxamide [971];

2-(2-fluoroethyl)-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)-2-azaspiro[3.3]heptane-6- carboxamide [972];

fr «5-4-(dimethylamino)-N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)cyclohexane- 1 - carboxamide [973];

l-acetyl-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)piperidine-4-carboxamide [974]; N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)- 1 -(( 1 -(trifluoromethyl)cyclopropyl)methyl) piperidine-4-carboxamide [975];

(S)-l-(2-fluoropropyl)-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)piperidine-4- carboxamide [976];

(R)-l-(2-fluoropropyl)-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)piperidine-4- carboxamide [977];

N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)-2-(piperidin-l-yl)propanamide [978];

N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)- 1 -(methylsulfonyl)piperidine-4-carboxamide

[979];

1 '-methyl -N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)-[ 1 ,4'-bipiperidine] -4-carboxamide

[980];

fr «5-4-(hydroxymethyl)-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)cyclohexane-l- carboxamide [981];

methyl 2 -(4-((7 -( 1 -methyl - 1 H-pyrazol -4 -yl)quinazolin-2 -yl)carbamoyl)piperidin- 1 -yl)acetate

[982];

1- benzyl-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)piperidine-4-carboxamide [983]; N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)- 1 -(2-(pyrrolidin-l -yl)acetyl)piperidine-4- carboxamide [984];

N-(7 -( 1 -methyl - 1 H-pyrazol -4 -yl)quinazolin-2-yl) -2 -morpholinoacetamide [985] ;

(S)-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)-2-(3-methylmoφholino)acetamide [986]; (R)-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)-2-(3-methylmoφholino)acetamide [987]; (S)-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)-2-(2-methylmoφholino)acetamide [988];

2- ((2R,6S)-2,6-dimethylmoφholino)-N-(7-(l -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)acetamide

[989];

2-((lS,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2- yl)acetamide [990];

2-((lR,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2- yl)acetamide [991];

2-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)

acetamide [992];

(S)-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)-2-mo holinopropanamide [993];

N-(7-(l -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)-2-(mo holin-2-yl)acetamide [994];

N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)-2-(4-methylmo holin-2-yl)acetamide [995] ; 2-(4-ethylpiperazin-l -yl)-N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)acetamide [996] ; 2-(4-isopropylpiperazin-l -yl)-N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)acetamide [997] ; 2-(4-cyclopropylpiperazin-l-yl)-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)acetamide

[998];

2-(4-(2-fluoroethyl)piperazin-l-yl)-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)acetamide

[999];

(S)-2-(2,4-dimethylpiperazin-l-yl)-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)acetamide

[1000];

1 -(2 -hydroxy ethyl) -N-(7 -( 1 -methyl - 1 H-pyrazol -4 -yl)quinazolin-2 -yl)piperidine -4-carboxamide

[1001];

N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)- 1 -(pyridin-2-ylmethyl)piperidine-4- carboxamide [1002];

N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)- 1 -(oxazol-2-ylmethyl)piperidine-4- carboxamide [1003];

(R)-N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)- 1 -oxotetrahydro-lH-pyrrolo[ 1 ,2-c]

imidazole-2(3H)-carboxamide [1004] ;

(R)-l-methyl-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)pyrrolidine-2-carboxamide

[1005];

N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)- 1 -(tetrahydro-2H-pyran-4-yl)piperidine-4- carboxamide [1006];

N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)- 1 -(pyrimidin-2-ylmethyl)piperidine-4- carboxamide [1007];

N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)- 1 -(pyrazin-2-ylmethyl)piperidine-4- carboxamide [1008];

1 -((5 -methyl- 1 ,2,4-oxadiazol-3-yl)methyl)-N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2- yl)piperidine -4 -carboxamide [1009] ;

1- (2-hydroxy-2-methylpropyl)-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)piperidine-4- carboxamide [1010];

fert-butyl 2 -(4-((7 -( 1 -methyl - 1 H-pyrazol -4 -yl)quinazolin-2 -yl)carbamoyl)piperidin- 1 -yl)acetate

[1011];

2- (4-((7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)carbamoyl)piperidin-l-yl)acetic acid [1012]; 2-(4-methyl- 1 ,4-diazepan- 1 -yl)-N-(7-( 1 -methyl-lH-pyrazol-4-yl)quinazolin-2-yl)acetamide

[1013];

tert-butyl (7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)carbamate [1014] ;

N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)but-2-ynamide [1015]; trans -4 -((7 -( 1 -methyl - 1 H-pyrazol -4 -yl)quinazolin-2 -yl)carbamoyl)cyclohexane - 1 -carboxylic acid [1016];

N-(7 -( 1 -methyl - 1 H-pyrazol -4 -yl)quinazolin-2-yl) -3 -morpholinopropanamide [1017];

fr rø-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)-3-moφholinocyclobutane-l-carboxamide

[1018];

N-(7 -( 1 -methyl - 1 H-pyrazol -4 -yl)quinazolin-2 -yl)quinuclidine -4-carboxamide [1019];

1 -isobutyl-N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)azepane-4-carboxamide [1020] ;

2-(4-methoxypiperidin- 1 -yl)-N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)acetamide [1021] ;

2- (4-hydroxypiperidin-l-yl)-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)acetamide [1022];

3- (hydroxymethyl)-N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)bicyclo[ 1.1. l]pentane- 1 - carboxamide [1023];

1 -methyl -N-(7 -( 1 -methyl - 1 H-pyrazol -4 -yl)quinazolin-2-yl)azepane -4 -carboxamide [ 1024] ;

fr «5-4-(dimethylamino)-N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)cyclohexane- 1 - carboxamide [1025];

fr «5-4-(bis(methyl-£/3)amino)-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)cyclohexane-l- carboxamide [1026];

N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)-3-((4-methylpiperazin- 1 -yl)methyl)bicyclo

[1.1. l]pentane-l -carboxamide [1027];

methyl trans-4-((7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)carbamoyl)cyclohexane- 1 - carboxylate [1028];

2-( 1 -isobutylpyrrolidin-3-yl)-N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)acetamide [1029] ; fr «5-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)-4-(4-methylpiperazine-l-carbonyl)

cyclohexane-1 -carboxamide [1030];

1 -isobutyl-N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)piperidine-4-carboxamide [1031] ; N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)- 1 -(phenylsulfonyl)piperidine-4-carboxamide

[1032];

8 -methyl -N-(7 -( 1 -methyl - 1 H-pyrazol -4 -yl)quinazolin-2-yl) -3 , 8 -diazabicyclo [3.2.1] octane -3 - carboxamide [1033];

3 -methyl -N-(7 -( 1 -methyl - 1 H-pyrazol -4 -yl)quinazolin-2-yl) -3 , 8 -diazabicyclo [3.2.1] octane -8 - carboxamide [1034];

(lR,3s,5S)-3-amino-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)-8-azabicyclo[3.2.1]octane- 8-carboxamide [1035];

(lR,3s,5S)-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)-3-((3,3,3-trifluoropropyl)amino)-8- azabicyclo[3.2.1] octane -8 -carboxamide [1036]; ( 1 R,3s,5 S)-3 -(( 1 ,3-difluoropropan-2-yl)amino)-N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2- yl)-8-azabicyclo[3.2.1] octane -8 -carboxamide [1037];

N-(7 -( 1 -methyl - 1 H-pyrazol -4 -yl)quinazolin-2-yl)morpholine -4 -carboxamide [ 1038] ;

4-(dimethylamino)-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)piperidine-l-carboxamide

[1039];

(S)-2,4-dimethyl-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)piperazine-l -carboxamide

[1040];

1 -methyl-3-(7-( 1 -methyl-lH-pyrazol-4-yl)quinazolin-2-yl)- 1 -( 1 -methylpiperidin-4-yl)urea

[1041];

1 -(7-( 1 -methyl-lH-pyrazol-4-yl)quinazolin-2-yl)-3 -( 1 -methylpiperidin-4-yl)urea [1042] ;

4-isopropyl-N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)piperazine-l -carboxamide [1043] ; (R)-3,4-dimethyl-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)piperazine-l -carboxamide

[1044];

N-(7-(lH-pyrazol-4-yl)quinazolin-2-yl)-2-(4-methylpiperazin-l-yl)isonicotinamide [1045]; N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)-3-(piperazin-l-yl)benzamide [1046];

N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)-3-(4-methylpiperazin- 1 -yl)benzamide [1047] ; N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)-3-(pyrrolidin-l-ylmethyl)benzamide [1048]; N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)-3-(piperidin-4-yloxy)benzamide [1049]; N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)-3-(( 1 -methylpiperidin-4-yl)oxy)benzamide

[1050];

N-(7-(l -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)-4-(piperidin-4-yloxy)benzamide [1051]; N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)-4-(( 1 -methylpiperidin-4-yl)oxy)benzamide

[1052];

N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)-2-(piperazin-l-yl)isonicotinamide [1053];

[1054];

2-(4-isopropylpiperazin-l-yl)-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)isonicotinamide

[1055];

2-(4-cyclopropylpiperazin-l-yl)-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)

isonicotinamide [1056];

2-(4-(2-fluoroethyl)piperazin-l-yl)-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)

isonicotinamide [1057];

N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)-6-(4-methylpiperazin- 1 -yl)nicotinamide

[1058];

N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)-5-(piperidin-4-yloxy)nicotinamide [1059]; N-(7-(l -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)-2-(piperidin-4-yloxy)isonicotinamide [1060]; N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)-2-(( 1 -methylpiperidin-4-yl)oxy)

isonicotinamide [1061];

N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)-5-(piperidin-4-ylamino)nicotinamide [1062]; N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)-5-(( 1 -methylpiperidin-4-yl)amino)nicotinamide

[1063];

2-(4-aminopiperidin-l-yl)-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)isonicotinamide

[1064];

N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)-2-(4-(methylamino)piperidin- 1 -yl)

isonicotinamide [1065];

2-(4-(dimethylamino)piperidin-l-yl)-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)

isonicotinamide [1066];

2-(( 1 -isopropylpiperidin-4-yl)oxy)-N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)

isonicotinamide [1067];

2-(3 -aminoazetidin- 1 -yl)-N-(7-( 1 -methyl-lH-pyrazol-4-yl)quinazolin-2-yl)isonicotinamide

[1068];

2-(3-(dimethylamino)azetidin-l-yl)-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)

isonicotinamide [1069];

N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)-2-mo holinoisonicotinamide [1070];

2-((2-(dimethylamino)ethyl)amino)-N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)

isonicotinamide [1071];

2-(2-(dimethylamino)ethoxy)-N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)isonicotinamide

[1072];

2-(4-isobutylpiperazin-l-yl)-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)isonicotinamide

[1073];

2-(azetidin-3-yloxy)-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)isonicotinamide [1074]; N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)-2-(( 1 -methylazetidin-3 -yl)oxy)isonicotinamide

[1075];

2-(4-ethylpiperazin-l-yl)-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)isonicotinamide

[1076];

4-((dimethylamino)methyl)-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)benzamide [1077]; N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)-3-(l-methylpiperidin-4-yl)benzamide [1078]; N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)-3-((4-methylpiperazin- 1 -yl)methyl)benzamide

[1079]; N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)isonicotinamide [1080];

2-hydroxy-N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)isonicotinamide [1081] ;

2-isopropoxy-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)isonicotinamide [1082];

N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)-2-( 1 -methylpiperidin-4-yl)isonicotinamide

[1083];

r-methyl-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)-l',2',3',6'-tetrahydro-[2,4'- bipyridine]-4-carboxamide [1084];

N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)-2-(4-(6-(4-methylpiperazin- 1 -yl)

nicotinoyl)piperazin- 1 -yl)isonicotinamide [1085] ;

2-(4-hydroxy-4-methyl-4 ⁴-piperazin-l-yl)-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl) isonicotinamide [1086];

2-methyl-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)-6-(4-methylpiperazin-l-yl)

isonicotinamide [1087];

3 -methyl -N-(7 -( 1 -methyl - 1 H-pyrazol -4 -yl)quinazolin-2-yl) -2-(4 -methylpiperazin- 1 -yl)

isonicotinamide [1088];

2-(4-methyl- 1 ,4-diazepan- 1 -yl)-N-(7-( 1 -methyl-lH-pyrazol-4-yl)quinazolin-2-yl)isonicotinamide

[1089];

2-((2S,6R)-2,6-dimethylmo holino)-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)

isonicotinamide [1090];

N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)-2-(2,7-diazaspiro[3.5]nonan-2-yl)

isonicotinamide [1091];

N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)-2-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl) isonicotinamide [1092];

N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)-2-(2,7-diazaspiro[3.5]nonan-7-yl)

isonicotinamide [1093];

N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)-2-(2-methyl-2,7-diazaspiro[3.5]nonan-7-yl) isonicotinamide [1094];

2-(methyl( 1 -methylpiperidin-4-yl)amino)-N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl) isonicotinamide [1095];

N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)-2-(( 1 -methylpiperidin-4-yl)thio)

isonicotinamide [1096];

N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)-2-(4-methylpiperazin- 1 -yl)pyrimidine-4- carboxamide [1097]; N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)-6-(4-methylpiperazin- 1 -yl)pyridazine-4- carboxamide [1098];

N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)-6-(4-methylpiperazin- 1 -yl)pyrimidine-4- carboxamide [1099];

N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)-2-phenylacetamide [1100] ;

N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)-3-phenylpropanamide [1101];

N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)-2-(pyridin-3 -yl)acetamide [1102] ;

N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)-3-(pyridin-3 -yl)propanamide [1103] ;

N-(7-(l -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)-2-(pyridin-4-yl)acetamide [1104];

N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)-3-(pyridin-4-yl)propanamide [1105];

N-(7 -( 1 -methyl - 1 H-pyrazol -4 -yl)quinazolin-2 -yl)isoindoline -5 -carboxamide [1106] ;

2-methyl-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)isoindoline-5-carboxamide [1107]; N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)-l,2,3,4-tetrahydroisoquinoline-7 -carboxamide

[1108];

2-methyl-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)-l,2,3,4-tetrahydroisoquinoline-7- carboxamide [1109];

2-methyl-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)-l,2,3,4-tetrahydroisoquinoline-6- carboxamide [1110];

N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)-l,2,3,4-tetrahydroisoquinoline-6-carboxamide

[1111];

N-(7-(l-methyl-lH-pyrazol-4-yl quinazolin-2-yl) - 1 H-indole -5 -carboxamide [1112];

N-(7-(l-methyl-lH-pyrazol-4-yl quinazolin-2 -yl)benzofuran-5 -carboxamide [1113];

N-(7-( 1 -methyl- 1 H-pyrazol -4 -yl quinazolin-2 -yl)furo [2,3 -c]pyridine-5 -carboxamide [1114]; N-(7-(l-methyl-lH-pyrazol-4-yl quinazolin-2-yl)benzo[b]thiophene-5 -carboxamide [1115]; N-(7-(l-methyl-lH-pyrazol-4-yl quinazolin-2 -yl)benzofuran-6-carboxamide [1116];

N-(7-(l-methyl-lH-pyrazol-4-yl quinazolin-2 -yl)benzo [d] oxazole -6 -carboxamide [111 ]; N-(7-(l-methyl-lH-pyrazol-4-yl quinazolin-2 -yl)benzo [d]thiazole -6-carboxamide [1118]; N-(7-(l-methyl-lH-pyrazol-4-yl quinazolin-2 -yl)benzo [d] oxazole -5 -carboxamide [1119]; N-(7-(l-methyl-lH-pyrazol-4-yl quinazolin-2 -yl)benzo [d]thiazole -5 -carboxamide [1120]; N-(7-(l-methyl-lH-pyrazol-4-yl quinazolin-2 -yl)quinoline -3 -carboxamide [1121];

N-(7-(l-methyl-lH-pyrazol-4-yl quinazolin-2 -yl)quinoline-6-carboxamide [1122] ;

N-(7-(l-methyl-lH-pyrazol-4-yl quinazolin-2 -yl )quinoxaline -6 -carboxamide [1123];

5-chloro-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [1124]; 3-chloro-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)-2-(4-methylpiperazin-l-yl) isonicotinamide [1125];

2- (2,5-diazabicyclo[2.2.1]heptan-2-yl)-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)

isonicotinamide [1126];

N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)-2-(5-methyl-2,5-diazabicyclo[2.2.1]heptan-2- yl)isonicotinamide [1127];

3- fluoro-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [1128];

N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)-2-((4-methylpiperazin- 1 -yl)methyl)

isonicotinamide [1129];

N-(7-(l -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)-2-(mo holinomethyl)isonicotinamide [1130]; N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)-2-(pyrrolidin-l-ylmethyl)isonicotinamide

[1131];

N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)-2-(2-(4-methylpiperazin-l-yl)pyridin-4-yl) acetamide [1132];

1 -methyl -N-(7 -( 1 -methyl - 1 H-pyrazol -4 -yl)quinazolin-2-yl) - 1 H-indazole -5 -carboxamide [1133]; 1 -methyl -N-(7 -( 1 -methyl - 1 H-pyrazol -4 -yl)quinazolin-2-yl) - 1 H-benzo [d] imidazole-5 - carboxamide [1134];

N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)- 1 -(piperidin-4-yl)-lH-pyrazole-4-carboxamide

[1135];

N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)- 1 -( 1 -methylpiperidin-4-yl)- lH-pyrazole-4- carboxamide [1136];

1 -( 1 -ethylpiperidin-4-yl)-N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)-lH-pyrazole-4- carboxamide [1137];

l-(l-(2-fluoroethyl)piperidin-4-yl)-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)-lH- pyrazole -4 -carboxamide [1138];

1 -( 1 -isopropylpiperidin-4-yl)-N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)- lH-pyrazole-4- carboxamide [1139];

1 -( 1 -cyclopropylpiperidin-4-yl)-N-(7-( 1 -methyl-lH-pyrazol-4-yl)quinazolin-2-yl)- lH-pyrazole- 4-carboxamide [1140];

isopropyl 4-(4-((7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)carbamoyl)-lH-pyrazol-l- yl)piperidine-l -carboxylate [1141];

N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)-l-(piperidin-4-yl)-lH-l,2,3-triazole-4- carboxamide [1142]; N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)- 1 -( 1 -methylpiperidin-4-yl)- 1H- 1 ,2,3-triazole-4- carboxamide [1143];

l-(l-(2-fluoroethyl)piperidin-4-yl)-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)-lH-l,2,3- triazole-4-carboxamide [1144];

1- (l-isopropylpiperidin-4-yl)-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)-lH-l,2,3- triazole-4-carboxamide [1145];

N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)-2-(4-methylpiperazin- 1 -yl)oxazole-5 - carboxamide [1146];

2- (3 -(dimethylamino)azetidin- 1 -yl)-N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)oxazole-4- carboxamide [1147];

N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)-2-(piperidin-4-yl)oxazole-4-carboxamide

[1148];

N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)-2-( 1 -methylpiperidin-4-yl)oxazole-4- carboxamide [1149];

2-(l-(2-fluoroethyl)piperidin-4-yl)-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)oxazole-4- carboxamide [1150];

2-(l-isopropylpiperidin-4-yl)-N-(7-(l -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)oxazole-4- carboxamide [1151];

N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)-2-(4-methylpiperazin- 1 -yl)oxazole-4- carboxamide [1152];

2-(3 -(dimethylamino)azetidin- 1 -yl)-N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)thiazole-5 - carboxamide [1153];

N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)-2-(piperidin-4-yl)thiazole-4-carboxamide

[1154];

N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)-2-(4-methylpiperazin- 1 -yl)thiazole-4- carboxamide [1155];

2-(l-(2-fluoroethyl)piperidin-4-yl)-N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)thiazole-4- carboxamide [1156];

2-( 1 -isopropylpiperidin-4-yl)-N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)thiazole-4- carboxamide [1157];

N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)- 1 -(2-(methyl- 3)propyl- 1 , 1 ,2,3, 3,3-£/e)

piperidine-4-carboxamide [1158];

N-(7-(l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)-2-(pyrrolidin-l-yl -2,2,5, 5-<¾)acetamide [1159]; N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)-2-(4-(methyl-£/3)piperazin-l-yl)acetamide [1160];

N-(7-(l -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)-2-(mo holino-ί s)acetamide [1161];

( S) -N-(7 -( 1 -(methyl -ds) - 1 H-pyrazol -4 -yl)quinazolin-2 -yl)-2 -(pyrrolidin- 1 -yl)propanamide

[1162];

l-isobutyl-N-(7-(l-(methyl- 3)-lH-pyrazol-4-yl)quinazolin-2-yl)piperidine-4-carboxamide

[1163];

N-(7-(l-(methyl-£/3)-lH-pyrazol-4-yl)quinazolin-2-yl)-2-(4-methylpiperazin-l-yl)acetamide

[1164];

N-(7-( 1 -(methyl -<¾)- lH-pyrazol-4-yl)quinazolin-2-yl)-2-(pyrrolidin- 1 -yl)acetamide [1165] ; N-(7-(l-(methyl-£/3)-lH-pyrazol-4-yl)quinazolin-2-yl)-2-(piperidin-l-yl)acetamide [1166];

N-(7-( 1 -(methyl -<¾)- lH-pyrazol-4-yl)quinazolin-2-yl)- 1 -(3,3,3 -trifluoropropyl)piperidine-4- carboxamide [1167];

N-(7-(lH-pyrazol-4-yl)quinazolin-2-yl)-2-(4-(methyl-£/3)piperazin-l-yl)isonicotinamide [1168]; N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)-2-(4-(methyl- 3)piperazin- 1 -yl)isonicotinamide

[1169];

N-(7-(l-(methyl- 3)-lH-pyrazol-4-yl)quinazolin-2-yl)-2-(4-methylpiperazin-l-yl)isonicotinamide

[1170];

N-(7-( 1 -(methyl-^)- lH-pyrazol-4-yl)quinazolin-2-yl)-2-(4-(methyl-£/3)piperazin-l -yl)

isonicotinamide [1171];

N-(7-( 1 -(methyl -<¾)- lH-pyrazol-4-yl)quinazolin-2-yl)- 1 -(piperidin-4-yl)- lH-pyrazole-4- carboxamide [1172];

N-(7-( 1 -(methyl -<¾)- 1 H-pyrazol -4 -yl)quinazolin -2 -yl)- 1 -( 1 -methylpiperidin-4-yl)- lH-pyrazole-4- carboxamide [1173];

N-(7-(l -(methyl-^)- 1 H-pyrazol -4 -yl)quinazolin -2 -yl)-2-(piperidin-4-yl)oxazole-4-carboxamide

[1174];

N-(7-( 1 -(methyl -<¾)- 1 H-pyrazol -4 -yl)quinazolin -2 -yl)-2-( 1 -methylpiperidin-4-yl)oxazole-4- carboxamide [1175];

N-(7-( 1 -ethyl- lH-pyrazol-4-yl)quinazolin-2-yl)-2-(pyrrolidin-l -yl)acetamide [1176] ;

N-(7-(l-cyclopropyl-lH-pyrazol-4-yl)quinazolin-2-yl)-2-(pyrrolidin-l-yl)acetamide [1177]; N-(7-(l-cyclopropyl-lH-pyrazol-4-yl)quinazolin-2-yl)-l-(3,3,3-trifluoropropyl)piperidine-4- carboxamide [1178];

N-(7-( 1 -( 1 -methylpiperidin-4-yl)- lH-pyrazol-4-yl)quinazolin-2-yl)cyclohexanecarboxamide

[1179]; 2-(pyrrolidin- 1 -yl)-N-(7-(5-(trifluoromethyl)- lH-pyrazol-4-yl)quinazolin-2-yl)acetamide [1180] ; N-(7-(5-(hydroxymethyl)- 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)- 1 -methylpiperidine-4- carboxamide [1181];

N-(7-(5-(hydroxymethyl)-l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)tetrahydro-2H-pyran-4- carboxamide [1182];

N-(7-(5-(azetidin-l-ylmethyl)-l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)-4,4- difluorocyclohexane- 1 -carboxamide [1183] ;

4,4-difluoro-N-(7-( 1 -methyl -5 -(pyrrolidin-1 -ylmethyl)- lH-pyrazol-4-yl)quinazolin-2-yl)

cyclohexane-1 -carboxamide [1184];

4,4-difluoro-N-(7-( 1 -methyl -5 -(piperidin-1 -ylmethyl)- lH-pyrazol-4-yl)quinazolin-2-yl)

cyclohexane-1 -carboxamide [1185];

2-(2 -fluoroethyl) -N-(7 -( 1 -methyl -5 -(piperidin- 1 -ylmethyl) - 1 H-pyrazol -4 -yl)quinazolin-2 -yl) -2 - azaspiro [3.3] heptane -6 -carboxamide [1186];

fert-butyl 6-((7-(l-methyl-5-(piperidin-l-ylmethyl)-lH-pyrazol-4-yl)quinazolin-2-yl)carbamoyl)-

2-azaspiro [3.3] heptane -2 -carboxylate [1187];

2-fluoro-2 -methyl -N-(7-( 1 -methyl-5 -(piperidin- 1 -ylmethyl)- lH-pyrazol-4-yl)quinazolin-2-yl) propanamide [1188];

2-(diethylamino)-N-(7-( 1 -methyl-5 -(piperidin- 1 -ylmethyl)-lH-pyrazol-4-yl)quinazolin-2-yl) acetamide [1189];

fr «5-4-methoxy-N-(7-( 1 -methyl-5 -(piperidin-1 -ylmethyl)- lH-pyrazol-4-yl)quinazolin-2-yl) cyclohexane-1 -carboxamide [1190];

fr «5-4-(hydroxymethyl)-N-(7-( 1 -methyl-5 -(piperidin- 1 -ylmethyl)- lH-pyrazol-4-yl)quinazolin-2- yl)cyclohexane - 1 -carboxamide [1191];

(R)-N-(7-(l-methyl-5-(piperidin-l-ylmethyl)-lH-pyrazol-4-yl)quinazolin-2-yl)pyrrolidine-2- carboxamide [1192];

l-isobutyl-N-(7-(l-methyl-5-(piperidin-l-ylmethyl)-lH-pyrazol-4-yl)quinazolin-2-yl)piperidine-

4-carboxamide [1193];

N-(7-( 1 -methyl-5 -(piperidin- 1 -ylmethyl)- lH-pyrazol-4-yl)quinazolin-2-yl)- 1 -(oxetan-3 -yl)

piperidine-4-carboxamide [1194];

l-benzoyl-N-(7-(l-methyl-5-(piperidin-l-ylmethyl)-lH-pyrazol-4-yl)quinazolin-2-yl)piperidine-

4-carboxamide [1195];

N-(7-( 1 -methyl-5 -(piperidin- 1 -ylmethyl)- lH-pyrazol-4-yl)quinazolin-2-yl)tetrahydro-2H-pyran- 4-carboxamide [1196]; N-(7-( 1 -methyl -5 -(piperidin- 1 -ylmethyl)- lH-pyrazol-4-yl)quinazolin-2-yl)-2-(4-methylpiperidin- l-yl)acetamide [1197];

N-(7-(l-(difluoromethyl)-lH-pyrazol-4-yl)quinazolin-2-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [1198];

N-(7-( 1 -ethyl- lH-pyrazol-4-yl)quinazolin-2-yl)-2-(4-methylpiperazin- 1 -yl)isonicotinamide

[1199];

N-(7-(l-isopropyl-lH-pyrazol-4-yl)quinazolin-2-yl)-3 -(piperidin -4-yloxy)benzamide [1200]; N-(7-( 1 -isopropyl- lH-pyrazol-4-yl)quinazolin-2-yl)-3 -(( 1 -methylpiperidin-4-yl)oxy)benzamide

[1201];

N-(7-(l -isopropyl- lH-pyrazol-4-yl)quinazolin-2-yl)-4-(piperidin-4-yloxy)benzamide [1202]; N-(7-(l-cyclopropyl-lH-pyrazol-4-yl)quinazolin-2-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [1203];

4-fluoro-N-(7-( 1 -( 1 -methylpiperidin-4-yl)- lH-pyrazol-4-yl)quinazolin-2-yl)benzamide [1204] ;

4- (difluoromethoxy)-N-(7-( 1 -( 1 -methylpiperidin-4-yl)- lH-pyrazol-4-yl)quinazolin-2-yl)

benzamide [1205];

5- fluoro-N-(7-( 1 -( 1 -methylpiperidin-4-yl)- lH-pyrazol-4-yl)quinazolin-2-yl)nicotinamide [1206] ; N² -methyl -N⁵-(7-( 1 -( 1 -methylpiperidin-4-yl)- lH-pyrazol-4-yl)quinazolin-2-yl)pyridine-2,5- dicarboxamide [1207];

1 -isopropyl -N-(7-( 1 -( 1 -methylpiperidin-4-yl)-lH-pyrazol-4-yl)quinazolin-2-yl)- lH-pyrazole-4- carboxamide [1208];

2-methyl-N-(7-( 1 -( 1 -methylpiperidin-4-yl)- lH-pyrazol-4-yl)quinazolin-2-yl)thiazole-5 - carboxamide [1209];

N-(7-(5 -amino- 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)-2-(4-methylpiperazin-l -yl)

isonicotinamide [1210];

4-(difluoromethoxy)-N-(7-(5-(hydroxymethyl)-l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)

benzamide [1211];

N-(7-(5-(hydroxymethyl)- 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)-2-(4-methylpiperazin- 1 -yl) isonicotinamide [1212];

N-(7-(5-(hydroxymethyl)-l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)-2-(7-methyl-2,7-diazaspiro

[3.5]nonan-2-yl)isonicotinamide [1213];

4-fluoro-N-(7-(l-methyl-5-(pyrrolidin-l-ylmethyl)-lH-pyrazol-4-yl)quinazolin-2-yl)benzamide

[1214];

4-fluoro-N-(7-(l-methyl-5-(piperidin-l-ylmethyl)-lH-pyrazol-4-yl)quinazolin-2-yl)benzamide

[1215]; 4-(difluoromethoxy)-N-(7-( 1 -methyl-5 -(pi

benzamide [1216];

N-(7-( 1 -methyl-5 -(piperidin- 1 -ylmethyl)- lH-pyrazol-4-yl)quinazolin-2-yl)-3-(pyrrolidin-l - ylmethyl)benzamide [1217];

N-(7-( 1 -methyl-5 -(piperidin- 1 -ylmethyl)- lH-pyrazol-4-yl)quinazolin-2-yl)-2-(7-methyl -2,7- diazaspiro[3.5]nonan-2-yl)isonicotinamide [1218] ;

N-(7-( 1 -methyl-5 -(piperidin- 1 -ylmethyl)- lH-pyrazol-4-yl)quinazolin-2-yl)-2- moφholinoisonicotinamide [1219];

N-(7-( 1 -methyl-5 -(morpholinomethyl)- lH-pyrazol-4-yl)quinazolin-2-yl)-2- moφholinoisonicotinamide [1220];

N-(7-(4,5,6,7-tetrahydropyrazolo[ 1 ,5-a]pyrazin-3 -yl)quinazolin-2-yl)- 1 -(( 1 -(trifluoromethyl) cyclopropyl)methyl)piperidine-4-carboxamide [1221] ;

3,3-difluoro-N-(7-(5-methyl-4,5,6,7-tetrahydropyrazolo[l,5-a]pyrazin-3-yl)quinazolin-2-yl) cyclobutane-l-carboxamide [1222];

N-((4,4-difluorocyclohexyl)methyl)-7-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[l,5-a]

pyrazin-3 -yl)quinazolin-2 -amine [1223] ;

N-(7-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[l,5-a]pyrazin-3-yl)quinazolin-2-yl)-l-((l-

(trifluoromethyl)cyclopropyl)methyl)piperidine -4 -carboxamide [ 1224] ;

N-(7-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[l,5-a]pyrazin-3-yl)quinazolin-2-yl)-2-

(pyrrolidin- 1 -yl)acetamide [1225];

2-(7-azabicyclo[2.2.1]heptan-7-yl)-N-(7-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[l,5-a] pyrazin-3 -yl)quinazolin-2-yl)acetamide [1226] ;

(R)-N-(7-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[ 1 ,5 -a]pyrazin-3 -yl)quinazolin-2-yl)- 1 - isobutylpiperidine-3 -carboxamide [1227] ;

N-(7-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[l,5-a]pyrazin-3-yl)quinazolin-2-yl)piperidine-

4-carboxamide [1228];

4-fluoro-N-(7-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[l,5-a]pyrazin-3-yl)quinazolin-2-yl)-

1 -isobutylpiperidine -4-carboxamide [1229];

N-(7-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[l,5-a]pyrazin-3-yl)quinazolin-2-yl)-2-(4- methylpiperazin- 1 -yl)acetamide [1230] ;

4-fluoro-N-(7-(4,5,6,7-tetrahydropyrazolo[l,5-a]pyrazin-3-yl)quinazolin-2-yl)benzamide [1231]; N-(7-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[l,5-a]pyrazin-3-yl)quinazolin-2-yl)-3-(4- methylpiperazin- 1 -yl)benzamide [1232]; N⁵-(7-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[l,5-a]pyrazin-3-yl)quinazolin-2-yl)-N²- methylpyridine-2,5 -dicarboxamide [1233] ;

N-(7-(5-(2-fluoroethyl)-4,5,6J-tetrahydropyrazolo[l,5-a]pyrazin-3-yl)quinazolin-2-yl)-6-(4- methylpiperazin- 1 -yl)nicotinamide [1234];

2-(azetidin-3-yloxy)-N-(7-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[l,5-a]pyrazin-3-yl) quinazolin-2-yl)isonicotinamide [1235];

N-(7-( 1 -methyl- lH-pyrazol-5 -yl)quinazolin-2-yl)- 1 -(3,3,3-trifluoropropyl)piperidine-4- carboxamide [1236];

1- methyl-N-(7-(l-methyl-lH-pyrazol-3-yl)quinazolin-2-yl)piperidine-4-carboxamide [1237]; N-(7-( 1 -methyl- lH-pyrazol -3 -yl)quinazolin-2-yl)-2-(4-methylpiperazin- 1 -yl)isonicotinamide

[1238];

2- fluoro-2 -methyl -N-(7-( 1 -methyl-lH- 1 ,2,3 -triazol-4-yl)quinazolin-2-yl)propanamide [1239] ; 2,2,3, 3-tetramethyl-N-(7-(l-methyl-lH-l,2,3-triazol-4-yl)quinazolin-2-yl)cyclopropane-l- carboxamide [1240];

fr «5-N-(7-(l-methyl-lH-l,2,3-triazol-4-yl)quinazolin-2-yl)-4-(pyrrolidin-l-yl)cyclohexane-l- carboxamide [1241];

trans-N-(7-( 1 -methyl- lH-1 ,2,3-triazol-4-yl)quinazolin-2-yl)-4-mo holinocyclohexane- 1 - carboxamide [1242];

N-(7-(l-methyl-lH-l,2,3-triazol-4-yl)quinazolin-2-yl)-2-(piperidin-l-yl)acetamide [1243]; 1 -ethyl -4-fluoro-N-(7-( 1 -methyl- 1H- 1 ,2,3 -triazol-4-yl)quinazolin-2-yl)piperidine-4-carboxamide

[1244];

4-fluoro- 1 -isobutyl-N-(7-( 1 -methyl- 1H- 1 ,2,3 -triazol-4-yl)quinazolin-2-yl)piperidine-4- carboxamide [1245];

N-(7-(l-methyl-lH-l,2,3-triazol-4-yl)quinazolin-2-yl)-l-(3,3,3-trifluoropropyl)piperidine-4- carboxamide [1246];

N-(7-(l-methyl-lH-l,2,3-triazol-4-yl)quinazolin-2-yl)cyclopropanecarboxamide [1247];

4,4-difluoro-N-(7-(l-methyl-lH-l,2,3-triazol-4-yl)quinazolin-2-yl)cyclohexane-l -carboxamide

[1248];

trans -4 -(dimethylamino) -N-(7-( 1 -methyl- 1H- 1 ,2,3-triazol-4-yl)quinazolin-2-yl)cyclohexane- 1 - carboxamide [1249];

fr «5-N-(7-(l-methyl-lH-l,2,3-triazol-4-yl)quinazolin-2-yl)-4-((4-methylpiperazin-l-yl)methyl) cyclohexane-1 -carboxamide [1250];

N-(7-(l-methyl-lH-l,2,3-triazol-4-yl)quinazolin-2-yl)piperidine-4-carboxamide [1251]; 1- isobutyl-N-(7-(l-methyl-lH-l,2,3 riazol-4-yl)quinazolin-2-yl)piperidine-4-carboxamide

[1252];

N-(7-(l-methyl-lH-l,2,3-triazol-4-yl)quinazolin-2-yl)-l-((l-(trifluoromethyl)cyclopropyl)

methyl)piperidine -4 -carboxamide [1253];

N-(7-(l-methyl-lH-l,2,3-triazol-4-yl)quinazolin-2-yl)-l-((3-methyloxetan-3-yl)methyl)

piperidine-4-carboxamide [1254];

N-(7-(l-methyl-lH-l,2,3 riazol-4-yl)quinazolin-2-yl)-l-(2-(pyrrolidin-l-yl)acetyl)piperidine-4- carboxamide [1255];

1 '-methyl-N-(7-( 1 -methyl- 1H- 1,2,3 -triazol-4-yl)quinazolin-2-yl)-[ 1 ,4'-bipiperidine] -4- carboxamide [1256];

(R)-N-(7-( 1 -methyl-lH- 1 ,2,3-triazol-4-yl)quinazolin-2-yl)piperidine-3 -carboxamide [1257] ; (R)-l-isobutyl-N-(7-(l-methyl-lH-l,2,3-triazol-4-yl)quinazolin-2-yl)piperidine-3-carboxamide

[1258];

N-(7-(l-methyl-lH-l,2,3-triazol-4-yl)quinazolin-2-yl)-2-(pyrrolidin-l-yl)acetamide [1259]; N-(7-(l-methyl-lH-l,2,3-triazol-4-yl)quinazolin-2-yl)-2-(4-methylpiperazin-l-yl)acetamide

[1260];

2- (7-azabicyclo[2.2.1]heptan-7-yl)-N-(7-(l-methyl-lH-l,2,3-triazol-4-yl)quinazolin-2-yl)

acetamide [1261];

1 -(2-hydroxy-2-methylpropyl)-N-(7-( 1 -methyl- 1H- 1 ,2,3-triazol-4-yl)quinazolin-2-yl)piperidine-

4-carboxamide [1262];

N-(7-(l-methyl-lH-l,2,3-triazol-4-yl)quinazolin-2-yl)-2-moφholinoacetamide [1263];

2-(4-methoxypiperidin-l-yl)-N-(7-(l-methyl-lH-l,2,3-triazol-4-yl)quinazolin-2-yl)acetamide

[1264];

N-(7-(l-methyl-lH-l,2,3-triazol-4-yl)quinazolin-2-yl)mo holine-4-carboxamide [1265];

N-(7-(l-methyl-lH-l,2,3-triazol-4-yl)quinazolin-2-yl)-l-(piperidin-4-yl)-lH-pyrazole-4- carboxamide [1266];

N-(7-(l-methyl-lH-l,2,3-triazol-4-yl)quinazolin-2-yl)-l-(l-methylpiperidin-4-yl)-lH-pyrazole-4- carboxamide [1267];

1 -( 1 -ethylpiperidin-4-yl)-N-(7-( 1 -methyl- 1H- 1 ,2,3 -triazol-4-yl)quinazolin-2-yl)- lH-pyrazole-4- carboxamide [1268];

l-(l-isopropylpiperidin-4-yl)-N-(7-(l-methyl-lH-l,2,3-triazol-4-yl)quinazolin-2-yl)-lH- pyrazole-4-carboxamide [1269];

N-(7-(l-methyl-lH-l,2,3-triazol-4-yl)quinazolin-2-yl)-l-(piperidin-4-yl)-lH-l,2,3-triazole-4- carboxamide [1270]; l-(l-(2-fluoroethyl)piperidin-4-yl)-N-(7-(l-methyl-lH-l,2,3-triazol-4-yl)quinazolin-2-yl)-lH- l,2,3-triazole-4-carboxamide [1271];

1- (l-isopropylpiperidin-4-yl)-N-(7-(l-methyl-lH-l,2,3 riazol-4-yl)quinazolin-2-yl)-lH-l,2,3- triazole-4-carboxamide [1272];

N-(7-(l-methyl-lH-l,2,3 riazol-4-yl)quinazolin-2-yl)-2-(piperidin-4-yl)oxazole-4-carboxamide

[1273];

N-(7-(l-methyl-lH-l,2,3-triazol-4-yl)quinazolin-2-yl)-2-(l-methylpiperidin-4-yl)oxazole-4- carboxamide [1274];

2- (1 sopropylpiperidin-4-yl)-N-(7-(l-methyl-lH-l,2,3-triazol-4-yl)quinazolin-2-yl)oxazole-4- carboxamide [1275];

2-fluoro-N-(7-(l-methyl-lH-l,2,3-triazol-4-yl)quinazolin-2-yl)benzamide [1276];

N-(7-(l-methyl-lH-l,2,3 riazol-4-yl)quinazolin-2-yl)-3-((l-methylpiperidin-4-yl)oxy)benzamide

[1277];

N² -methyl -N⁵-(7-(l-methyl-lH-l,2,3 riazol-4-yl)quinazolin-2-yl)pyridine-2,5-dicarboxamide

[1278];

N-(7-(l-methyl-lH-l,2,3-triazol-4-yl)quinazolin-2-yl)-6-(4-methylpiperazin-l-yl)nicotinamide

[1279];

2-(3 -(dimethylamino)azetidin- 1 -yl)-N-(7-( 1 -methyl- 1H- 1 ,2,3-triazol-4-yl)quinazolin-2-yl)

isonicotinamide [1280];

N-(7-(l-methyl-lH-l,2,3-triazol-4-yl)quinazolin-2-yl)-2-(l-methylpiperidin-4-yl)isonicotinamide

[1281];

2-(4-(dimethylamino)piperidin-l-yl)-N-(7-(l-methyl-lH-l,2,3-triazol-4-yl)quinazolin-2-yl) isonicotinamide [1282];

N-(7-(l-methyl-lH-l,2,3-triazol-4-yl)quinazolin-2-yl)-2-moφholinoisonicotinamide [1283]; N-(7-(l-methyl-lH-l,2,3-triazol-4-yl)quinazolin-2-yl)-2-(4-methylpiperazin-l-yl)isonicotinamide

[1284];

2-(4-methyl- 1 ,4-diazepan- 1 -yl)-N-(7-( 1 -methyl-lH-1 ,2,3-triazol-4-yl)quinazolin-2-yl)

isonicotinamide [1285];

2-(4-isopropylpiperazin-l -yl)-N-(7-( 1 -methyl- 1H- 1 ,2,3-triazol-4-yl)quinazolin-2-yl)

isonicotinamide [1286];

N-(7-(l-methyl-lH-l,2,3-triazol-4-yl)quinazolin-2-yl)-2-(piperidin-4-ylamino)isonicotinamide

[1287];

2-(methyl( 1 -methylpiperidin-4-yl)amino)-N-(7-( 1 -methyl- 1H- 1 ,2,3 -triazol-4-yl)quinazolin-2-yl) isonicotinamide [1288]; N-(7-(l-methyl-lH-l,2,3 riazol-4-yl)quinazolin-2-yl)-2-((l-methylpiperidin-4-yl)thio) isonicotinamide [1289];

2-methyl-N-(7-(l-methyl-lH-l,2,3 riazol-4-yl)quinazolin-2-yl)-l,2,3,4 etrahydroisoquinoline- 6-carboxamide [1290];

N-(7-(l-methyl-lH-l,2,3 riazol-4-yl)quinazolin-2-yl)-2-(piperazin-l-yl)isonicotinamide [1291]; N-(7-(l-methyl-lH-l,2,3 riazol-4-yl)quinazolin-2-yl)-2-(2-(4-methylpiperazin-l-yl)pyridin-4-yl) acetamide [1292];

1 , 1 -bis(methyl-£¾)-4-(4-((7-( 1 -methyl- 1H- 1,2,3 -triazol-4-yl)quinazolin-2-yl)carbamoyl)pyridin-

2-yl)piperazin-l-ium [1293];

N-(7-(l-methyl-lH-l,2,3-triazol-4-yl)quinazolin-2-yl)-2-(4-(methyl-£/3)piperazin-l-yl)

isonicotinamide [1294];

N-(7-(l-methyl-lH-l,2,3-triazol-5-yl)quinazolin-2-yl)-l-(3,3,3-trifluoropropyl)piperidine-4- carboxamide [1295];

N-(7-(4-methyl-4H-l,2,4-triazol-3-yl)quinazolin-2-yl)-2-moφholinoacetamide [1296];

N-(7-(4-methyl-4H-l,2,4-triazol-3-yl)quinazolin-2-yl)-l-(3,3,3-trifluoropropyl)piperidine-4- carboxamide [1297];

4-fluoro- 1 -isobutyl-N-(7-(4-methyl-4H- 1 ,2,4-triazol-3 -yl)quinazolin-2-yl)piperidine-4- carboxamide [1298];

N-(7-(4,5-dimethyl-4H-l,2,4-triazol-3-yl)quinazolin-2-yl)-2-mo holinoacetamide [1299];

N-(7-(4,5-dimethyl-4H-l,2,4-triazol-3-yl)quinazolin-2-yl)-l-(3,3,3-trifluoropropyl)piperidine-4- carboxamide [1300];

N-(7-( 1H- 1 ,2,3 -triazol- 1 -yl)quinazolin-2-yl)-4-fluoro- 1 -isobutylpiperidine-4 -carboxamide

[1301];

N-(7-(2H- 1 ,2,3 -triazol-2-yl)quinazolin-2-yl)-4-fluoro- 1 -isobutylpiperidine-4 -carboxamide

[1302];

N-(7-(lH-l,2,4-triazol-l-yl)quinazolin-2-yl)-2-(4-methylpiperazin-l-yl)isonicotinamide [1303]; 1 -isobutyl-N-(7-( 1 -methyl- lH-tetrazol-5-yl)quinazolin-2-yl)piperidine-4-carboxamide [1304] ; 2,2,3, 3-tetramethyl-N-(7-(l-methyl-lH-imidazol-5-yl)quinazolin-2-yl)cyclopropane-l- carboxamide [1305];

4,4-difluoro-N-(7-( 1 -methyl-lH-imidazol-5 -yl)quinazolin-2-yl)cyclohexane- 1 -carboxamide

[1306];

N-(7 -( 1 -methyl - 1 H-imidazol-5 -yl)quinazolin-2 -yl) -2 -(piperidin- 1 -yl)acetamide [ 1307] ;

2-fluoro-2 -methyl -N-(7-( 1 -methyl- lH-imidazol-5-yl)quinazolin-2-yl)propanamide [1308] ;

1 -fluoro-N-(7-( 1 -methyl- lH-imidazol-5-yl)quinazolin-2-yl)cyclopropane-l -carboxamide [1309] ; 2-methyl-N-(7-(l-methyl-lH-imidazol-5-yl)quinazolin-2-yl)-2-azaspiro[3.3]heptane-6- carboxamide [1310];

1 -fluoro-N-(7-( 1 -methyl- lH-imidazol-5-yl)quinazolin-2-yl)cyclohexane-l -carboxamide [1311]; fr «5-4-methoxy-N-(7-( 1 -methyl- lH-imidazol-5 -yl)quinazolin-2-yl)cyclohexane-l -carboxamide

[1312];

trans -4 -(hydroxymethyl) -N-(7-( 1 -methyl - 1 H-imidazol -5 -yl)quinazolin-2 -yl)cyclohexane - 1 - carboxamide [1313];

N-(7-(l-methyl-lH-imidazol-5-yl)quinazolin-2-yl)azetidine-3-carboxamide [1314];

(R)-N-(7-(l-methyl-lH-imidazol-5-yl)quinazolin-2-yl)tetrahydrofuran-2 -carboxamide [1315]; l-(2-methoxyethyl)-N-(7-(l-methyl-lH-imidazol-5-yl)quinazolin-2-yl)piperidine-4-carboxamide

[1316];

N-(7-(l-methyl-lH-imidazol-5-yl)quinazolin-2-yl)-l-(3,3,3-trifluoropropyl)piperidine-4- carboxamide [1317];

1- isobutyl-N-(7-(l-methyl-lH-imidazol-5-yl)quinazolin-2-yl)piperidine-4-carboxamide [1318]; N-(7-(l-methyl-lH-imidazol-5-yl)quinazolin-2-yl)-l-(methylsulfonyl)piperidine-4-carboxamide

[1319];

N-(7-(l-methyl-lH-imidazol-5-yl)quinazolin-2-yl)-2-(pyrrolidin-l-yl)propanamide [1320];

2- isopropoxy-N-(7 -( 1 -methyl - 1 H-imidazol -5 -yl)quinazolin-2 -yl)acetamide [1321];

3 -isopropoxy-N-(7 -( 1 -methyl - 1 H-imidazol -5 -yl)quinazolin-2 -yl)propanamide [ 1322] ;

N-(7-(l,2-dimethyl-lH-imidazol-5-yl)quinazolin-2-yl)cyclopropanecarboxamide [1323];

N-(7-(l,2-dimethyl-lH-imidazol-5-yl)quinazolin-2-yl)cyclohexanecarboxamide [1324];

N-(7-( 1 ,2-dimethyl- lH-imidazol-5-yl)quinazolin-2-yl)-4,4-difluorocyclohexane- 1 -carboxamide

[1325];

(S)-N-(7-(l,2-dimethyl-lH-imidazol-5-yl)quinazolin-2-yl)tetrahydrofuran-2 -carboxamide [1326]; N-(7-(l,2-dimethyl-lH-imidazol-5-yl)quinazolin-2-yl)-3,3-difluorocyclobutane-l -carboxamide

[1327];

N-(7-( 1 ,2-dimethyl- lH-imidazol-5-yl)quinazolin-2-yl)- 1 -fluorocyclopropane- 1 -carboxamide

[1328];

N-(7-(l,2-dimethyl-lH-imidazol-5-yl)quinazolin-2-yl)mo holine-4-carboxamide [1329];

N-(7-(l,2-dimethyl-lH-imidazol-5-yl)quinazolin-2-yl)mo holine-ί s-4-carboxamide [1330]; l-methyl-N-(7-(l-methyl-lH-imidazol-5-yl)quinazolin-2-yl)-lH-pyrazole-4-carboxamide [1331]; 1 -ethyl -N-(7-( 1 -methyl- lH-imidazol-5-yl)quinazolin-2-yl)- lH-pyrazole -4 -carboxamide [1332] ; l-isopropyl-N-(7-(l-methyl-lH-imidazol-5-yl)quinazolin-2-yl)-lH-pyrazole-4 -carboxamide

[1333]; l-cyclopropyl-N-(7-(l-methyl-lH midazol-5-yl)quinazolin-2-yl)-lH-pyrazole-4-carboxamide

[1334];

1 -isobutyl-N-(7-( 1 -methyl- lH-imidazol-5-yl)quinazolin-2-yl)- lH-pyrazole-4 -carboxamide

[1335];

1 -methyl -N-(7 -( 1 -methyl - 1 H-imidazol-5 -yl)quinazolin-2-yl) - 1 H-pyrazole -3 -carboxamide [1336]; N-(7-(l-methyl-lH-imidazol-5-yl)quinazolin-2-yl)-2-(l-methyl-lH-pyrazol-4-yl)acetamide

[1337];

l-methyl-N-(7-(l-methyl-lH-imidazol-5-yl)quinazolin-2-yl)-lH-imidazole-4-carboxamide

[1338];

l-isopropyl-N-(7-(l-methyl-lH-imidazol-5-yl)quinazolin-2-yl)-lH-imidazole-4 -carboxamide

[1339];

N-(7-(l-methyl-lH-imidazol-5-yl)quinazolin-2-yl)-l-(tetrahydro-2H-pyran-4-yl)-lH-imidazole- 4-carboxamide [1340];

1 ,2-dimethyl -N-(7 -( 1 -methyl - 1 H-imidazol -5 -yl)quinazolin-2 -yl) - 1 H-imidazole -5 -carboxamide

[1341];

1- methyl-N-(7-(l-methyl-lH-imidazol-5-yl)quinazolin-2-yl)-lH-l,2,4-triazole-3-carboxamide

[1342];

2- methyl-N-(7-(l-methyl-lH-imidazol-5-yl)quinazolin-2-yl)oxazole-4-carboxamide [1343]; 2-isopropyl-N-(7-(l-methyl-lH-imidazol-5-yl)quinazolin-2-yl)oxazole-4-carboxamide [1344]; 4-methyl-N-(7-(l-methyl-lH-imidazol-5-yl)quinazolin-2-yl)oxazole-2 -carboxamide [1345];

4- methyl-N-(7-(l-methyl-lH-imidazol-5-yl)quinazolin-2-yl)thiazole-2 -carboxamide [1346]; 2-methyl-N-(7-(l-methyl-lH-imidazol-5-yl)quinazolin-2-yl)thiazole-4-carboxamide [1347];

5 -methyl -N-(7 -( 1 -methyl - 1 H-imidazol-5 -yl)quinazolin-2-yl) -1,3,4 -oxadiazole -2 -carboxamide

[1348];

5- methyl-N-(7-(l-methyl-lH-imidazol-5-yl)quinazolin-2-yl)-l,3,4-thiadiazole-2 -carboxamide

[1349];

l-isopropyl-N-(7-(l-isopropyl-lH-imidazol-5-yl)quinazolin-2-yl)-lH-pyrazole-4-carboxamide

[1350];

N-(7-( 1 ,2-dimethyl- lH-imidazol-5-yl)quinazolin-2-yl)- 1 -methyl- lH-pyrazole-4 -carboxamide

[1351];

N-(7-( 1 ,2-dimethyl- lH-imidazol-5-yl)quinazolin-2-yl)- 1 -isopropyl- lH-pyrazole-4-carboxamide

[1352];

N-(7-( 1 ,2-dimethyl- lH-imidazol-5-yl)quinazolin-2-yl)-2-methylthiazole-5 -carboxamide [1353] ; 4-fluoro-N-(7-(l -methyl- lH-imidazol-5-yl)quinazolin-2-yl)benzamide [1354]; 4-(difluoromethoxy)-N-(7-( 1 -methyl- lH-imidazol-5 -yl)quinazolin-2-yl)benzamide [1355] ;

N-(7-(l-methyl-lH-imidazol-5-yl)quinazolin-2-yl)-3-(pyrrolidin-l-ylmethyl)benzamide [1356]; 2-fluoro-N-(7-(l-methyl-lH-imidazol-5-yl)quinazolin-2-yl)benzamide-3,4,5,6-£/4 [1357];

4-fluoro-N-(7-(l-methyl-lH-imidazol-5-yl)quinazolin-2-yl)benzamide-2,3,5,6-£/4 [1358];

2-chloro-N-(7-(l-methyl-lH-imidazol-5-yl)quinazolin-2-yl)benzamide-3,4,5,6-£/4 [1359];

4-chloro-N-(7-(l-methyl-lH-imidazol-5-yl)quinazolin-2-yl)benzamide-2,3,5,6-£/4 [1360];

4-(methyl-£/3)-N-(7-(l-methyl-lH-imidazol-5-yl)quinazolin-2-yl)benzamide [1361];

4-methyl-N-(7-(l-methyl-lH-imidazol-5-yl)quinazolin-2-yl)benzamide-2,3,5,6-£/4 [1362];

4-(methyl-£/3)-N-(7-(l-methyl-lH-imidazol-5-yl)quinazolin-2-yl)benzamide-2,3,5,6-£/4 [1363]; 4-(methoxy-< 3) -N-(7 -( 1 -methyl- 1 H-imidazol -5 -yl)quinazolin-2 -yl)benzamide [ 1364] ;

4-(methoxy-£/3)-N-(7-(l-methyl-lH-imidazol-5-yl)quinazolin-2-yl)benzamide-2,3, 5,6-<¾ [1365]; 4-methoxy-N-(7-(l-methyl-lH-imidazol-5-yl)quinazolin-2-yl)benzamide-2,3, [1366]; (E)-N-(7-(l,2-dimethyl-lH-imidazol-5-yl)quinazolin-2-yl)-3-(phenyl-2,3,4,5,6-£/j)acrylamide

[1367];

(E)-N-(7-(l,2-dimethyl-lH-imidazol-5-yl)quinazolin-2-yl)-3-(phenyl-2,3,4,5,6-£/j)acrylamide- 2,2-d₂ [1368];

N-(7-(l,2-dimethyl-lH-imidazol-5-yl)quinazolin-2-yl)-2-(4-fluorophenyl)acetamide-2,2-£/2

[1369];

(E)-N-(7-(l-methyl-lH-imidazol-5-yl)quinazolin-2-yl)-3-(phenyl-2,3,4,5,6-£/j acrylamide [1370]; (E)-N-(7-(l-methyl-lH-imidazol-5-yl)quinazolin-2-yl)-3-(phenyl-2,3,4,5,6-£/j)acrylamide-2,3-£/2

[1371];

2-(4-fluorophenyl)-N-(7-(l-methyl-lH-imidazol-5-yl)quinazolin-2-yl)acetamide-2,2-d2 [1372]; N-(7 -( 1 -methyl - 1 H-imidazol-5 -yl)quinazolin-2 -yl) -2 -(4-methylpiperazin- 1 -yl)isonicotinamide

[1373];

2-(dimethylamino)-N-(7-(l-methyl-lH-imidazol-5-yl)quinazolin-2-yl)isonicotinamide [1374]; 2-(3 -aminoazetidin- 1 -yl) -N-(7 -( 1 -methyl - 1 H-imidazol -5 -yl)quinazolin-2 -yl)isonicotinamide

[1375];

N-(7-(l-methyl-lH-imidazol-5-yl)quinazolin-2-yl)-2-(pyrrolidin-l-yl)isonicotinamide [1376]; N-(7-(l-methyl-lH-imidazol-5-yl)quinazolin-2-yl)-2-(piperidin-l-yl)isonicotinamide [1377]; N-(7-(l-methyl-lH-imidazol-5-yl)quinazolin-2-yl)-2-moφholinoisonicotinamide [1378];

2-(4-isopropylpiperazin- 1 -yl)-N-(7-( 1 -methyl- lH-imidazol-5 -yl)quinazolin-2-yl)isonicotinamide

[1379];

2-(4-cyclopropylpiperazin- 1 -yl)-N-(7-( 1 -methyl- lH-imidazol-5 -yl)quinazolin-2-yl)

isonicotinamide [1380]; N-(7-(l-methyl-lH-imidazol-5-yl)quinazolin-2-yl)-2-(2,7-diazaspiro[3.5]nonan-2-yl) isonicotinamide [1381];

N-(7-(l-methyl-lH midazol-5-yl)quinazolin-2-yl)-2-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl) isonicotinamide [1382];

N-(7-(l-methyl-lH-imidazol-5-yl)quinazolin-2-yl)isoindoline-5-carboxamide [1383] ;

2-methyl-N-(7-(l-methyl-lH-imidazol-5-yl)quinazolin-2-yl)isoindoline-5-carboxamide [1384]; 2-(azetidin-l-yl)-N-(7-(l-methyl-lH midazol-5-yl)quinazolin-2-yl)isonicotinamide [1385]; 2-methoxy-N-(7-( 1 -methyl- lH-imidazol -5 -yl)quinazolin-2-yl)isonicotinamide [1386] ;

2-methyl-N-(7-(l-methyl-lH-imidazol-5-yl)quinazolin-2-yl)isonicotinamide [1387];

2-cyano-N-(7-(l-methyl-lH-imidazol-5-yl)quinazolin-2-yl)isonicotinamide [1388];

2-(3,3-difluoroazetidin-l-yl)-N-(7-(l-methyl-lH-imidazol-5-yl)quinazolin-2-yl)isonicotinamide

[1389] ;

2-(4,4-difluoropiperidin-l-yl)-N-(7-(l-methyl-lH-imidazol-5-yl)quinazolin-2-yl)isonicotinam

[1390] ;

2-isopropoxy-N-(7 -( 1 -methyl - 1 H-imidazol -5 -yl)quinazolin-2 -yl)isonicotinamide [1391];

N-(7-(l-methyl-lH-imidazol-5-yl)quinazolin-2-yl^

[1392] ;

N-(7-(l-methyl-lH-imidazol-5-yl)quinazolin-2-yl)-2-(pyrrolidin-l-yl-iis)isonicotinamide [1393]; N-(7 -( 1 -methyl - 1 H-imidazol-5 -yl)quinazolin-2 -yl) -2 -(piperidin- 1 -yl -di o)isonicotinamide [1394] ; N-(7-(l-methyl-lH-imidazol-5-yl)quinazolin-2-yl)-2-(moφholino-ί s)isonicotinamide [1395]; N-(7-(l,2-dimethyl-lH-imidazol-5-yl)quinazolin-2-yl)-4-isopropoxybenzamide [1396] ;

N-(7-(l,2-dimethyl-lH-imidazol-5-yl)quinazolin-2-yl)-4-(piperidin-4-yloxy)benzamide [1397]; 4-(benzyloxy) -N-(7 -( 1 ,2 -dimethyl - 1 H-imidazol -5 -yl)quinazolin-2 -yl)benzamide [1398];

N-(7-(l,2-dimethyl-lH-imidazol-5-yl)quinazolin-2-yl)-2-fluorobenzamide-3,4,5,6-£/4 [1399]; N-(7-(l,2-dimethyl-lH-imidazol-5-yl)quinazolin-2-yl)-4-fluorobenzamide-2,3,5,6-£/4 [1400]; 2-chloro-N-(7-(l,2-dimethyl-lH-imidazol-5-yl)quinazolin-2-yl)benzamide-3,4,5,6-£/4 [1401]; 4-chloro-N-(7-(l,2-dimethyl-lH-imidazol-5-yl)quinazolin-2-yl)benzamide-2,3,5,6-£/4 [1402]; N-(7-(l,2-dimethyl-lH-imidazol-5-yl)quinazolin-2-yl)-4-(methyl-£/3)benzamide [1403];

N-(7-(l,2-dimethyl-lH-imidazol-5-yl)quinazolin-2-yl)-4-methylbenzamide-2,3,5,6-£/4 [1404]; N-(7-(l,2-dimethyl-lH-imidazol-5-yl)quinazolin-2-yl)-4-(methyl-£/3)benzamide-2,3,5,6-£/4

[1405] ;

N-(7-(l,2-dimethyl-lH-imidazol-5-yl)quinazolin-2-yl)-4-(methoxy-£/3)benzamide [1406] ;

N-(7-(l,2-dimethyl-lH-imidazol-5-yl)quinazolin-2-yl)-4-(methoxy-£/3)benzamide-2,3,5,6-£/4

[1407] ; N-iT-il^-dimethyl-lH-imidazol-S-y^quinazolin^-y^^-methoxybenzamide^^^^-^ [1408]; N-(7-( 1 ,2-dimethyl- lH-imidazol-5-yl)quinazolin-2-yl)-2-(4-methylpiperazin- 1 -yl)

isonicotinamide [1409];

N-(7-(l,2-dimethyl-lH-imidazol-5-yl)quinazolin-2-yl)-2-moφholinoisonicotinamide [1410]; N-(7-(l,2-dimethyl-lH-imidazol-5-yl)quinazolin-2-yl)-2-(pyrrolidin-l-yl)isonicotinam [1411]; N-(7-(l,2-dimethyl-lH-imidazol-5-yl)quinazolin-2-yl)-2-(dimethylamino)isonicotm^ [1412]; N-(7-(l,2-dimethyl-lH-imidazol-5-yl)quinazolin-2-yl)-2-(pyrrolidin-l-yl -2,2,5, 5-aV)

isonicotinamide [1413];

N-(7-( 1 ,2-dimethyl- lH-imidazol-5 -yl)quinazolin -2 -yl)-2 -(pyrrolidin-1 -yl-a's)isonicotinamide

[1414];

N-(7-(l,2-dimethyl-lH-imidazol-5-yl)quinazolm^

[1415];

N-(7-(l,2-dimethyl-lH-imidazol-5-yl)quinazolin-2-yl)-2-(moφholino-α's)isonicotinamide [1416]; N-(7-(5,6,7,8-tetrahydroimidazo[l,2-a]pyrazin-3-yl)quinazolin-2-yl)cyclopropanecarboxamide

[1417];

N-(7-(7-methyl-5,6,7,8-tetrahydroimidazo[l,2-a]pyrazin-3-yl)quinazolin-2-yl)

cyclopropanecarboxamide [1418];

3,3-difluoro-N-(7-(5,6,7,8-tetrahydroimidazo[l,2-a]pyrazin-3-yl)quinazolin-2-yl)cyclobutane-l- carboxamide [1419];

(R)-N-(7-(5,6,7,8-tetrahydroimidazo[l,2-a]pyrazin-3-yl)quinazolin-2-yl)pyrrolidine-2- carboxamide [1420];

(R)-N-(7-(5,6,7,8-tetrahydroimidazo[l,2-a]pyrazin-3-yl)quinazolin-2-yl)piperidine-3- carboxamide [1421];

l-methyl-N-(7-(5,6,7,8-tetrahydroimidazo[l,2-a]pyrazin-3-yl)quinazolin-2-yl)piperidine-4- carboxamide [1422];

N-(7-(5 ,6,7, 8-tetrahydroimidazo [ 1 ,2-a]pyrazin-3 -yl)quinazolin-2-yl)- 1 -(( 1 -(trifluoromethyl) cyclopropyl)methyl)piperidine-4-carboxamide [1423] ;

l-benzoyl-N-(7-(5,6,7,8-tetrahydroimidazo[l,2-a]pyrazin-3-yl)quinazolin-2-yl)piperidine-4- carboxamide [1424];

4-fluoro-l-isobutyl-N-(7-(5,6,7,8-tetrahydroimidazo[l,2-a]pyrazin-3-yl)quinazolin-2-yl)

piperidine-4-carboxamide [1425];

(R)-2-(2-methylpyrrolidin-l-yl)-N-(7-(5,6,7,8-tetrahydroimidazo[l,2-a]pyrazin-3-yl)quinazolin-

2-yl)acetamide [1426]; 2-(cyclobutyl(methyl)amino)-N-(7- yl)acetamide [1427];

4-fluoro-N-(7-(5,6,7,8 etrahydroimidazo[l,2-a]pyrazin-3-yl)quinazolin-2-yl)benzamide [1428]; 4-isopropoxy-N-(7-(5,6,7,8 etrahydroimidazo[l,2-a]pyrazin-3-yl)quinazolin-2-yl)benzamide

[1429];

4-(difluoromethoxy)-N-(7-(5,6J,8 etrahydroimidazo[l,2-a]pyrazin-3-yl)quinazolin-2-yl)

benzamide [1430];

2-((2-(dimethylamino)ethyl)amino)-N-(7-(^_^

quinazolin-2-yl)isonicotinamide [1431];

2-((1 sopropylpiperidin-4-yl)oxy)-N-(7-(5,6,7,8 etrahydroimidazo[l,2-a]pyrazin-3-yl)

quinazolin-2-yl)isonicotinamide [1432];

N-(7-(oxazol-5-yl)quinazolin-2-yl)-l-(3,3,3-trifluoropropyl)piperidine-4-carboxamide [1433]; N-(7-(oxazol-5-yl)quinazolin-2-yl)cyclopropanecarboxamide [1434];

(R)-N-(7-(oxazol-5-yl)quinazolin-2-yl)tetrahydrofuran-2 -carboxamide [1435];

(R)-N-(7-(oxazol-5-yl)quinazolin-2-yl)piperidine-3-carboxamide [1436];

N-(7-(oxazol-5 -yl)quinazolin-2-yl)tetrahydro-2H-pyran-4-carboxamide [1437] ;

N-(7 -(oxazol-5 -yl)quinazolin-2-yl) - 1 -(2 -(pyrrolidin- 1 -yl)acetyl)piperidine -4 -carboxamide [ 1438] ; r-methyl-N-(7-(oxazol-5-yl)quinazolin-2-yl)-[l,4'-bipiperidine]-4-carboxamide [1439];

c/. ·-4-moφholino-N-(7-(oxazol-5-yl)quinazolin-2-yl)cyclohexane-l -carboxamide [1440] ;

2-(cyclobutyl(methyl)amino)-N-(7-(oxazol-5-yl)quinazolin-2-yl)acetamide [1441];

N-(7-(oxazol-5-yl)quinazolin-2-yl)-2-(pyrrolidin-l-yl)acetamide [1442];

(R)-2-(2-methylpyrrolidin- 1 -yl)-N-(7 -(oxazol-5 -yl)quinazolin-2-yl)acetamide [1443] ;

2-(4 -methylpiperazin- 1 -yl) -N-(7 -(oxazol -5 -yl)quinazolin-2 -yl)acetamide [ 1444] ;

fr «5-4-((4-methylpiperazin-l-yl)methyl)-N-(7-(oxazol-5-yl)quinazolin-2-yl)cyclohexane-l- carboxamide [1445];

l-(2,2-difluoropropyl)-N-(7-(oxazol-5-yl)quinazolin-2-yl)piperidine-4-carboxamide [1446]; fra«s-4-(hydroxymethyl)-N-(7-(2-methyloxazol-5 -yl)quinazolin-2-yl)cyclohexane- 1 -carboxamide

[1447];

fra«s-4-(methylamino)-N-(7-(2-methyloxazol-5 -yl)quinazolin-2-yl)cyclohexane- 1 -carboxamide

[1448];

trans-4-(( 1 ,3 -difluoropropan-2-yl)amino)-N-(7-(2-methyloxazol-5 -yl)quinazolin-2-yl)

cyclohexane-1 -carboxamide [1449];

fr «5-N-(7-(2-methyloxazol-5 -yl)quinazolin-2-yl)-4-((propan-2-yl- 1,1, 1 ,3,3,3-£¾;)amino)

cyclohexane-1 -carboxamide [1450]; trans -4 -((2,2 -difluoroethyl)amino)-N-(7 -(2-methyloxazol -5 -yl)quinazolin-2 -yl)cyclohexane - 1 - carboxamide [1451];

fr «5-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)-4-((3,3,3-trifluoropropyl)amino)cyclohexane- 1 -carboxamide [1452];

fr «5-4-((2-methoxyethyl)amino)-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)cyclohexane-l- carboxamide [1453];

trans -4 -(dimethylamino)-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)cyclohexane-l -carboxamide

[1454];

fr «5-4-(bis(methyl- 3)amino)-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)cyclohexane-l- carboxamide [1455];

c/5-4-(dimethylamino)-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)cyclohexane-l-carboxamide

[1456];

fr «5-4-((2,2-difluoroethyl)(methyl)amino)-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)

cyclohexane-1 -carboxamide [1457];

fr «5-4-(methyl(oxetan-3-yl)amino)-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)cyclohexane-l- carboxamide [1458];

fr «5-4-((2-fluoroethyl)amino)-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)cyclohexane-l- carboxamide [1459];

fr «5-4-(2-(fluoromethyl)aziridin-l-yl)-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)cyclohexane- 1 -carboxamide [1460];

trans-4-((3 -fluoroazetidin- 1 -yl)methyl)-N-(7-(2-methyloxazol-5 -yl)quinazolin-2-yl)cyclohexane- 1 -carboxamide [1461];

fr rø-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)-3-mo holinocyclobutane-l -carboxamide

[1462];

fr rø-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)-4-mo holinocyclohexane-l-carboxamide

[1463];

N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)-2-(piperidin-l-yl)acetamide [1464];

2-(4-methoxypiperidin-l-yl)-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)acetamide [1465]; N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)-2-(4-methylpiperazin-l-yl)acetamide [1466];

N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)moφholine-4-carboxamide [1467];

N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)-2-mo holinoacetamide [1468];

N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)-3-moφholinopropanamide [1469];

1 -methyl -N-(7-(2-methyloxazol-5 -yl)quinazolin-2-yl)piperidine-4-carboxamide [1470] ; l-(2,2-difluoropropyl)-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)piperidine-4 -carboxamide

[1471];

N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)-4-moφholinopiperidine-l -carboxamide [1472]; 4-(( 1 ,3 -difluoropropan-2-yl)amino)-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)piperidine- 1 - carboxamide [1473];

(lR,3s,5S)-3-((l,3-difluoropropan-2-yl)amino)-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)-8- azabicyclo[3.2.1] octane -8 -carboxamide [1474];

(lR,3s,5S)-3-((l,3-difluoropropan-2-yl)amino)-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)-8- azabicyclo[3.2.1] octane -8 -carboxamide [1475];

4-(dimethylamino)-N-(7-(2-methyloxazol-5 -yl)quinazolin-2-yl)piperidine- 1 -carboxamide [1476] ; 4-((2,2-difluoroethyl)(methyl)amino)-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)piperidine-l- carboxamide [1477];

(3S,4S)-4-amino-3-fluoro-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)piperidine-l-carboxamide

[1478];

(3 S,4S)-3 -fluoro-4-(methylamino)-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)piperidine- 1 - carboxamide [1479];

(3R,4R)-4-amino-3-fluoro-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)piperidine-l-carboxamide

[1480];

(3R,4R)-3-fluoro-4-(methylamino)-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)piperidine-l- carboxamide [1481];

4-((2-fluoroethyl)amino)-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)piperidine-l-carboxamide

[1482];

4-((2,2-difluoroethyl)amino)-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)piperidine-l- carboxamide [1483];

(lR,3s,5S)-3-amino-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)-8-azabicyclo[3.2.1]octane-8- carboxamide [1484];

(lR,3r,5S)-3-amino-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)-8-azabicyclo[3.2.1]octane-8- carboxamide [1485];

(lR,3r,5S)-3-((2-fluoroethyl)amino)-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)-8-azabicyclo

[3.2.1] octane -8 -carboxamide [I486];

(lR,3r,5S)-3-((2,2-difluoroethyl)amino)-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)-8- azabicyclo[3.2.1] octane -8 -carboxamide [1487];

(lR,3s,5S)-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)-3-((3,3,3-trifluoropropyl)amino)-8- azabicyclo[3.2.1] octane -8 -carboxamide [1488]; (3S,4S)-3-fluoro-4-(isopropylamino)-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)piperidine-l- carboxamide [1489];

N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)-5,6-dihydroimidazo[l,2-a]pyrazine-7(8H)- carboxamide [1490];

2-methyl-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)-5,6-dihydroimidazo[l,2-a]pyrazine-7(8H)- carboxamide [1491];

N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)-2-(moφholino-ί s)acetamide [1492];

fr «5-N-(7-(2-methyloxazol-4-yl)quinazolin-2-yl)-4-(4-methylpiperazin-l-yl)cyclohexane-l- carboxamide [1493];

N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)-l-(l-methylpiperidin-4-yl)-lH-pyrazole-4- carboxamide [1494];

2- (lH-imidazol-l-yl)-N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)acetamide [1495];

4-(difluoromethoxy)-N-(7-(oxazol-5-yl)quinazolin-2-yl)benzamide [1496];

3- ((l-methylpiperidin-4-yl)oxy)-N-(7-(oxazol-5-yl)quinazolin-2-yl)benzamide [1497];

N-(7-(oxazol-5-yl)quinazolin-2-yl)isonicotinamide [1498];

2-(3 -aminoazetidin- 1 -yl)-N-(7-(oxazol-5 -yl)quinazolin-2-yl)isonicotinamide [1499] ;

2-( 1 -methylpiperidin-4-yl)-N-(7-(oxazol-5 -yl)quinazolin-2-yl)isonicotinamide [1500] ;

r-methyl-N-(7-(oxazol-5-yl)quinazolin-2-yl)-r,2',3',6'-tetrahydro-[2,4'-bipyridine]-4- carboxamide [1501];

2-(4-methylpiperazin-l -yl)-N-(7-(oxazol-5-yl)quinazolin-2-yl)isonicotinamide [1502] ;

2-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl)-N-(7-(oxazol-5-yl)quinazolin-2-yl)isonicotinamide

[1503];

N-(7-(oxazol-5-yl)quinazolin-2-yl)-2-(2,7-diazaspiro[3.5]nonan-7-yl)isonicotinamide [1504]; N-(7-(oxazol-5-yl)quinazolin-2-yl)-2-(piperidin-4-ylamino)isonicotinamide [1505];

2-methyl-N-(7-(oxazol-5 -yl)quinazolin-2-yl)isoindoline-5 -carboxamide [1506] ;

N-(7-(oxazol-5-yl)quinazolin-2-yl)-l,2,3,4-tetrahydroisoquinoline-7-carboxamide [1507];

N-(7-(2-methyloxazol-5-yl)quinazolin-2-yl)-2-(4-methylpiperazin-l-yl)isonicotinamide [1508]; N-(7-(3-methylisoxazol-5-yl)quinazolin-2-yl)-l-(3,3,3 rifluoropropyl)piperidine-4-carboxamide

[1509];

4- fluoro-l-isobutyl-N-(7-(5 -methyl- 1,3, 4-oxadiazol-2-yl)quinazolin-2-yl)piperidine-4- carboxamide [1510];

l-isobutyl-N-(7-(5-methyl-l,3,4-oxadiazol-2-yl)quinazolin-2-yl)piperidine-4 -carboxamide

[1511];

N-(7-(5-(dimethylamino)-l,3,4-oxadiazol-2-yl)quinazolin-2-yl)piperidine-4-carboxamide [1512]; N-(7-(5-(dimethylamino)-l,3,4-oxadiazol-2-yl)quinazolin-2-yl)-l-methylpiperidine-4^ carboxamide [1513];

N-(7-(5-methyl-l,3,4-oxadiazol-2-yl)quinazolin-2-yl)-2-(4-methylpiperazin-l-yl)isonicotinami

[1514];

3,3-difluoro-N-(7-(thiazol-5-yl)quinazolin-2-yl)cyclobutane-l-carboxamide [1515];

2-methyl-N-(7-(thiazol-5-yl)quinazolin-2-yl)-2-azaspiro[3.3]heptane-6-carboxamide [1516]; 1 -fluoro -N-(7 -(thiazol-5 -yl)quinazolin-2 -yl)cyclohexane - 1 -carboxamide [1517];

trans -4 -(dimethylamino) -N-(7 -(thiazol-5 -yl)quinazolin-2-yl)cyclohexane - 1 -carboxamide [1518]; trans-4-((3 -fluoroazetidin- 1 -yl)methyl)-N-(7-(thiazol-5 -yl)quinazolin-2-yl)cyclohexane- 1 - carboxamide [1519];

N-(7-(thiazol-5-yl)quinazolin-2-yl)azetidine-3-carboxamide [1520];

l-methyl-N-(7-(thiazol-5-yl)quinazolin-2-yl)piperidine-4-carboxamide [1521];

l-(2,2-difluoropropyl)-N-(7-(thiazol-5-yl)quinazolin-2-yl)piperidine-4-carboxamide [1522]; l-(oxetan-3-yl)-N-(7-(thiazol-5-yl)quinazolin-2-yl)piperidine-4-carboxamide [1523];

1- (2-(pyrrolidin-l-yl)acetyl)-N-(7-(thiazol-5-yl)quinazolin-2-yl)piperidine-4-carboxamide [1524]; r-methyl-N-(7-(thiazol-5-yl)quinazolin-2-yl)-[l,4'-bipiperidine]-4-carboxamide [1525];

2- (pyrrolidin-l-yl)-N-(7-(thiazol-5-yl)quinazolin-2-yl)propanamide [1526];

2-(piperidin-l-yl)-N-(7-(thiazol-5-yl)quinazolin-2-yl)acetamide [1527];

2-(4-methylpiperazin-l-yl)-N-(7-(thiazol-5-yl)quinazolin-2-yl)acetamide [1528];

2-moφholino-N-(7-(thiazol-5-yl)quinazolin-2-yl)acetamide [1529];

4-(piperidin-4-yloxy)-N-(7-(thiazol-5-yl)quinazolin-2-yl)benzamide [1530];

N-(7-(thiazol-5-yl)quinazolin-2-yl)isonicotinamide [1531];

6-(4-methylpiperazin-l-yl)-N-(7-(thiazol-5-yl)quinazolin-2-yl)nicotinamide [1532];

r-methyl-N-(7-(miazol-5-yl)quinazolin-2-yl)-l',2',3',6'-tetrahydro-[2,4'-bipyridine]-4- carboxamide [1533];

2-(3 -(dimethylamino)azetidin- 1 -yl)-N-(7-(thiazol-5 -yl)quinazolin-2-yl)isonicotinamide [1534] ; 2-(4-(dimethylamino)piperidin-l -yl)-N-(7-(thiazol-5-yl)quinazolin-2-yl)isonicotinamide [1535] ; 2-(4-methylpiperazin-l-yl)-N-(7-(thiazol-5-yl)quinazolin-2-yl)isonicotinamide [1536];

2-((l-memylpiperidin-4-yl)thio)-N-(7-(thiazol-5-yl)quinazolin-2-yl)isonicotinamide [1537]; N-(7-(thiazol-5-yl)quinazolin-2-yl)-l,2,3,4-tetrahydroisoquinoline-7-carboxamide [1538];

trans-4-(( 1 ,3 -difluoropropan-2-yl)amino)-N-(7-(5 -methyl- 1 ,3,4-thiadiazol-2-yl)quinazolin-2-yl) cyclohexane-1 -carboxamide [1539];

N-(7-(2-methylthiazol-5-yl)quinazolin-2-yl)mo holine-4-carboxamide [1540];

N-(7-(2-methylthiazol-5-yl)quinazolin-2-yl)-2-(pyrrolidin-l-yl)acetamide [1541]; 2-((lR,4R)-2-oxa-5-azabicyclo[2.2 ]heptan-5-yl)-N-(7-(2-methylthiazol-5-yl)quinazolin-2-yl) acetamide [1542];

N-(7-(2-methylthiazol-5-yl)quinazolin-2-yl)-2-moφholinoacetamide [1543];

N-(7-(2-methylthiazol-5 -yl)quinazolin-2-yl)-2-(mo holino-ί s)acetamide [1544] ;

2-(4-methylpiperazin-l-yl)-N-(7-(2-methylthiazol-5-yl)quinazolin-2-yl)acetamide [1545];

1 -methyl -N-(7 -(2 -methylthiazol-5 -yl)quinazolin-2-yl)piperidine -4 -carboxamide [1546];

N-(7-(2-methylthiazol-5-yl)quinazolin-2-yl)isonicotinamide [1547];

N-(7-(2-methylthiazol-5 -yl)quinazolin-2-yl)nicotinamide [1548] ;

2-(4-methylpiperazin-l-yl)-N-(7-(2-methylthiazol-5-yl)quinazolin-2-yl)isonicotinamide [1549]; fr rø-N-(7-(5-methyl-l,3,4 hiadiazol-2-yl)quinazolin-2-yl)-4-moφholinocyclohexane-l- carboxamide [1550];

fr «5-N-(7-(5-methyl-l,3,4 hiadiazol-2-yl)quinazolin-2-yl)-4-(4-methylpiperazin-l-yl)

cyclohexane-1 -carboxamide [1551];

4-isopropyl-N-(7-(5-methyl-l,3,4 hiadiazol-2-yl)quinazolin-2-yl)piperazine-l-carboxamide

[1552];

4-((2-methoxyethyl)(methyl)amino)-N-(7-(5-methyl-l,3,4-thiadiazol-2-yl)quinazolin-2-yl)

piperidine-1 -carboxamide [1553];

4-(( 1 ,3 -difluoropropan-2-yl)amino)-N-(7-(5 -methyl- 1 ,3 ,4-thiadiazol-2-yl)quinazolin-2-yl)

piperidine-1 -carboxamide [1554];

N-(7-(5-methyl-l,3,4-thiadiazol-2-yl)quinazolin-2-yl)-4-((3,3,3-trifluoropropyl)amino)piperidine-

1 -carboxamide [1555];

4-((2-fluoroethyl)amino)-N-(7-(5 -methyl- 1 ,3,4-thiadiazol-2-yl)quinazolin-2-yl)piperidine- 1 - carboxamide [1556];

(3R,4S)-4-amino-3-fluoro-N-(7-(5-methyl-l,3,4-thiadiazol-2-yl)quinazolin-2-yl)piperidine-l- carboxamide [1557];

(3R,4R)-4-amino-3-fluoro-N-(7-(5-methyl-l,3,4-thiadiazol-2-yl)quinazolin-2-yl)piperidine-l- carboxamide [1558];

(3S,4S)-3-fluoro-N-(7-(5-methyl-l,3,4-thiadiazol-2-yl)quinazolin-2-yl)-4-(methylamino)

piperidine-1 -carboxamide [1559];

(3R,4R)-3 -fluoro-N-(7-(5 -methyl- 1 ,3,4-thiadiazol-2-yl)quinazolin-2-yl)-4-(methylamino)

piperidine-1 -carboxamide [1560];

4-amino-3,3 -difluoro-N-(7-(5-methyl- 1 ,3,4-thiadiazol-2-yl)quinazolin-2-yl)piperidine- 1 - carboxamide [1561]; (3R,4R)-3-fluoro-4-(isopropylamino)-N-(7-(5-methyl-l,3,4 hiadiazol-2-yl)quinazolin-2-yl) piperidine-l-carboxamide [1562];

(3R,4S)-3-fluoro-4-(isopropylamino)-N-(7-(5-methyl-l,3,4-1hiadiazol-2-yl)quinazolin-2-yl) piperidine-l-carboxamide [1563];

3,3-difluoro-4-(isopropylamino)-N-(7-(5-methyl-l,3,4-miadiazol-2-yl)quinazolin-2-yl)pi^

1- carboxamide [1564];

(3S,4S)-3-fluoro-N-(7-(5-methyl-l,3,4-thiadiazol-2-yl)quinazolin-2-yl)-4-((propan-2-yl-

1, 1,1,3,3,3 -d<;)amino)piperidine - 1 -carboxamide [1565];

( 1 R,3s,5 S)-3 -(( 1 ,3-difluoropropan-2-yl)amino)-N-(7-(5-methyl- 1 ,3,4-thiadiazol-2-yl)quinazolin-

2- yl) -8 -azabicyclo [3.2.1] octane -8 -carboxamide [1566];

( 1 R,3s,5 S)-3 -(( 1 ,3-difluoropropan-2-yl)amino)-N-(7-(5 -methyl-1 ,3,4-thiadiazol-2-yl)quinazolin-

2-yl) -8 -azabicyclo [3.2.1] octane -8 -carboxamide [1567];

4-(dimethylamino)-N-(7-(2-methylthiazol-5-yl)quinazolin-2-yl)piperidine-l -carboxamide [1568]; 4-((2,2-difluoroethyl)amino)-N-(7-(5-methyl-l,3,4-thiadiazol-2-yl)quinazolin-2-yl)piperidine carboxamide [1569];

4-((2,2-difluoroethyl)(methyl-£/3)amino)-N-(7-(5-methyl-l,3,4-thiadiazol-2-yl)quinazolin-2-yl) piperidine-l-carboxamide [1570];

N-(7-(5-methyl-l,3,4-thiadiazol-2-yl)quinazolin-2-yl)-4-moφholinopiperidine-l -carboxamide

[1571];

N-(7-(5-methyl-l,3,4-thiadiazol-2-yl)quinazolin-2-yl)-4-(4-methylpiperazin-l-yl)piperidine-l- carboxamide [1572];

(R)-3,4-dimethyl-N-(7-(5-methyl-l,3,4-thiadiazol-2-yl)quinazolin-2-yl)piperazine-l-carboxamide

[1573];

(S)-3,4-dimethyl-N-(7-(5-methyl-l,3,4-thiadiazol-2-yl)quinazolin-2-yl)piperazine-l-carboxamide

[1574];

(lR,3r,5S)-3-((2-fluoroethyl)amino)-N-(7-(5-methyl-l,3,4-thiadiazol-2-yl)quinazolin-2-yl)-8- azabicyclo[3.2.1] octane -8 -carboxamide [1575];

(lR,3r,5S)-3-((2,2-difluoroethyl)amino)-N-(7-(5-methyl-l,3,4-thiadiazol-2-yl)quinazolin-2-yl)-8- azabicyclo[3.2.1] octane -8 -carboxamide [1576];

(lR,3r,5S)-3-amino-N-(7-(5-methyl-l,3,4-thiadiazol-2-yl)quinazolin-2-yl)-8-azabicyclo[3.2.1] octane-8-carboxamide [1577];

(lS,4S)-5-methyl-N-(7-(5-methyl-l,3,4-thiadiazol-2-yl)quinazolin-2-yl)-2,5-diazabicyclo[2.2.1

]heptane-2 -carboxamide [1578]; (lR,4R)-5-methyl-N-(7-(5-methyl-l,3,4 hiadiazol-2-yl)quinazolin-2-yl)-2,5-diazabicycloP heptane-2-carboxamide [1579];

8-methyl-N-(7-(5-methyl-l,3,4 hiadiazol-2-yl)quinazolin-2-yl)-3,8-diazabicyclo[3.2.1]octane-3- carboxamide [1580];

3-methyl-N-(7-(5-methyl-l,3,4 hiadiazol-2-yl)quinazolin-2-yl)-3,8-diazabicyclo[3.2.1]octane-8- carboxamide [1581];

N-(7-(5-methyl-l,3,4 hiadiazol-2-yl)quinazolin-2-yl)-5,6-dihydroimidazo[l,2-a]pyrazine^

carboxamide [1582];

2-(4-methylpiperazin-l-yl)-N-(7-(5-methylthiazol-2-yl)quinazolin-2-yl)isonicotinamide [1583]; 2-(4-methylpiperazin- 1 -yl)-N-(7-(4-methylthiazol-2-yl)quinazolin-2-yl)isonicotinamide [1584] ; N-(7-(2-(methylamino)thiazol-5-yl)quinazolin-2-yl)piperidine-4-carboxamide [1585];

1 -methyl -N-(7-(2-(methylamino)thiazol-5 -yl)quinazolin-2-yl)piperidine-4-carboxamide [1586] ; N-(7-(2-(diethylamino)thiazol-5-yl)quinazolin-2-yl)-2-(4-fluoropiperidin-l-yl)acetamide [1587]; N-(7-(2-(diemylamino)thiazol-5-yl)quinazolin-2-yl)-2-(4-methylpiperazin-l-yl)acetam [1588]; N-(7-(2-aminothiazol-5 -yl)quinazolin-2-yl)-2-(4-methylpiperazin- 1 -yl)isonicotinamide [1589] ; N-(7-(2-(methylamino)thiazol-5-yl)quinazolin-2-yl)-2-(4-methylpiperazin-l-yl)isonicotinam

[1590];

N-(7-(2-(dimethylamino)thiazol-5-yl)quinazolin-2-yl)-2-(4-methylpiperazin-l-yl)isonicotinami

[1591];

2-(4-isopropylpiperazin-l-yl)-N-(7-(2-(methylamino)thiazol-5-yl)quinazolin-2-yl)

isonicotinamide [1592];

2-(3-(dimethylamino)azetidin-l-yl)-N-(7-(2-(methylamino)thiazol-5-yl)quinazolin-2-yl)

isonicotinamide [1593];

2-(3 -(dimethylamino)azetidin- 1 -yl)-N-(7-(2-(dimethylamino)thiazol-5 -yl)quinazolin-2-yl)

isonicotinamide [1594];

2-(3 -aminoazetidin- 1 -yl)-N-(7-(2-(dimethylamino)thiazol-5 -yl)quinazolin-2-yl)isonicotinamide

[1595];

N-(7-(5-chloromiazol-2-yl)quinazolin-2-yl)-2-(4-methylpiperazin-l-yl)isonicotinamide [1596]; 2-(2-(2-(4-methylpiperazin-l-yl)isonicotinamido)quinazolin-7-yl)thiazole-5-carboxamide [1597]; N-(7-(isothiazol-4-yl)quinazolin-2-yl)-l-methylpiperidine-4-carboxamide [1598];

N-(7-( 1 ,3 ,4-thiadiazol-2-yl)quinazolin-2-yl)-4-(difluoromethoxy)benzamide [1599] ;

N-(7-(l,3,4-thiadiazol-2-yl)quinazolin-2-yl)-4-(piperidin-4-yloxy)benzamide [1600];

N-(7-(l,3,4-thiadiazol-2-yl)quinazolin-2-yl)-4-((l-methylpiperidin-4-yl)oxy)benzamide [1601]; N-(7-(l,3,4-thiadiazol-2-yl)quinazolin-2-yl)-3-((l-methylpiperidin-4-yl)oxy)benzamide [1602]; N⁵-(7-(l,3,4-thiadiazol-2-yl)quinazolin-2-yl)-N²-^ [1603]; N-(7-(l,3,4 hiadiazol-2-yl)quinazolin-2-yl)-6-(4-methylpiperazin-l-yl)nicotinamide [1604]; N-(7-(l,3,4-thiadiazol-2-yl)quin^

carboxamide [1605];

N-(7-(l,3,4-thiadiazol-2-yl)quinazolin-2-yl)-2-(3-(dm

[1606];

N-(7-(l,3,4 hiadiazol-2-yl)quinazolin-2-yl)-2-(4-methylpiperazin-l-yl)isonicotinami [1607]; N-(7-(l,3,4 hiadiazol-2-yl)quinazolin-2-yl)-2-(4 sopropylpiperazin-l-yl)isonicotinamide [1608]; N-(7-(l,3,4 hiadiazol-2-yl)quinazolin-2-yl)-2-moφholinoisonicotinamide [1609];

1 -fluoro-N-(7-(5-methyl- 1 ,3,4-thiadiazol-2-yl)quinazolin-2-yl)cyclohexane- 1 -carboxamide

[1610];

fr «5-4-methoxy-N-(7-(5 -methyl- 1 ,3,4-thiadiazol-2-yl)quinazolin-2-yl)cyclohexane- 1 - carboxamide [1611];

c/5-4-methoxy-N-(7-(5-methyl-l,3,4-thiadiazol-2-yl)quinazolin-2-yl)cyclohexane-l-carboxamide

[1612];

fr «5-4-amino-N-(7-(5-methyl-l,3,4-thiadiazol-2-yl)quinazolin-2-yl)cyclohexane-l-carboxamide

[1613];

trans -4 -(dimethylamino) -N-(7 -(5 -methyl -1,3,4 -thiadiazol-2-yl)quinazolin-2 -yl)cyclohexane - 1 - carboxamide [1614];

fr rø-N-(7-(5-methyl-l,3,4-thiadiazol-2-yl)quinazolin-2-yl)-4-moφholinocyclohexane-l- carboxamide [1615];

fr «5-4-(hydroxymethyl)-N-(7-(5-methyl-l,3,4-thiadiazol-2-yl)quinazolin-2-yl)cyclohexane-l- carboxamide [1616];

N-(7-(5-methyl-l,3,4-thiadiazol-2-yl)quinazolin-2-yl)piperidine-4-carboxamide [1617];

4-fluoro-N-(7-(5-methyl-l,3,4-thiadiazol-2-yl)quinazolin-2-yl)piperidine-4-carboxamide [1618]; l-methyl-N-(7-(5-methyl-l,3,4-thiadiazol-2-yl)quinazolin-2-yl)piperidine-4-carboxamide [1619]; 4-fluoro-l-methyl-N-(7-(5-methyl-l,3,4-thiadiazol-2-yl)quinazolin-2-yl)piperidine-4- carboxamide [1620];

1 -(2-fluoroethyl)-N-(7-(5 -methyl- 1 ,3,4-thiadiazol-2-yl)quinazolin-2-yl)piperidine-4-carboxamide

[1621];

l-(2,2-difluoroethyl)-N-(7-(5-methyl-l,3,4-thiadiazol-2-yl)quinazolin-2-yl)piperidine-4- carboxamide [1622];

N-(7-(5-methyl-l,3,4-thiadiazol-2-yl)quinazolin-2-yl)-l-(3,3,3-trifluoropropyl)piperidine-4- carboxamide [1623]; 1- (2,2-difluoropropyl)-N-(7-(5-methyl-l,3,4 hiadiazol-2-yl)quinazolin-2-yl)piperidine-4- carboxamide [1624];

1 -benzoyl -N-(7-(5 -methyl- 1 ,3,4-thiadiazol-2-yl)quinazolin-2-yl)piperidine-4-carboxamide

[1625];

N-(7-(5-methyl-l,3,4-thiadiazol-2-yl)quinazolin-2-yl)-2-(pyrrolidin-l-yl)acetamide [1626]; N-(7-(5-methyl-l,3,4-thiadiazol-2-yl)quinazolin-2-yl)-2-(piperidin-l-yl)acetamide [1627];

2- (4-methoxypiperidin-l-yl)-N-(7-(5-methyl-l,3,4-thiadiazol-2-yl)quinazolin-2-yl)acetamid^

[1628];

N-(7-(5-methyl-l,3,4-thiadiazol-2-yl)quinazolin-2-yl)-2-(4-methylpiperazin-l-yl)acetamide

[1629];

N-(7-(5-methyl-l,3,4-thiadiazol-2-yl)quinazolin-2-yl)-2-moφholinoacetamide [1630];

(R)-N-(7-(5-methyl-l,3,4-thiadiazol-2-yl)quinazolin-2-yl)-2-(3-methylmoφholino)acetamide

[1631];

2-(7-azabicyclo[2.2.1]heptan-7-yl)-N-(7-(5-methyl-l,3,4-thiadiazol-2-yl)quinazolin-2-yl)

acetamide [1632];

2-((lR,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(7-(5-methyl-l,3,4-thiadiazol-2-yl)

quinazolin-2-yl)acetamide [1633];

2-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-N-(7-(5-methyl-l,3,4-thiadiazol-2-yl)quinazolin-2-yl) acetamide [1634];

2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-N-(7-(5-methyl-l,3,4-thiadiazol-2-yl)quinazolin-2-yl) acetamide [1635];

N-(7-(5-methyl-l,3,4-thiadiazol-2-yl)quinazolin-2-yl)-2-(l,4-oxazepan-4-yl)acetamide [1636]; N-(7-(5-methyl-l,3,4-thiadiazol-2-yl)quinazolin-2-yl)-2-moφholinoacetamide-2,2-ί 2 [1637]; N-(7-(5-methyl-l,3,4-thiadiazol-2-yl)quinazolin-2-yl)-2-(moφholino-ί s)acetamide [1638]; 1 -methyl-3 -(7-(5 -methyl- 1 ,3 ,4-thiadiazol-2-yl)quinazolin-2-yl)- 1 -( 1 -methylpiperidin-4-yl)urea

[1639];

(3S,4S)-4-amino-3-fluoro-N-(7-(5-methyl-l,3,4-thiadiazol-2-yl)quinazolin-2-yl)piperidine-l- carboxamide [1640];

(3 S,4S)-4-(dimethylamino)-3 -fluoro-N-(7-(5 -methyl- 1 ,3,4-thiadiazol-2-yl)quinazolin-2-yl) piperidine-l-carboxamide [1641];

N-(7-(5-methyl-l,3,4-thiadiazol-2-yl)quinazolin-2-yl)moφholine-4-carboxamide [1642];

N-(7-(5-methyl-l,3,4-thiadiazol-2-yl)quinazolin-2-yl)-4-(methylamino)piperidine-l-carboxamide

[1643]; 4-(dimethylamino) -N-(7-(5 -methyl -1,3,4 -thiadiazol -2 -yl)quinazolin-2 -yl)piperidine - 1 - carboxamide [1644];

4-((2,2-difluoroethyl)(methyl)amino)-N-(7-(5-m

piperidine-1 -carboxamide [1645];

(3S,4S)-3-fluoro-4-(isopropylamino)-N-(7-(5-methyl-l,3,4-thiadiazol-2-yl)quinazolin-2-yl)

piperidine-1 -carboxamide [1646];

2-methyl-N-(7-(5-methyl-l,3,4 hiadiazol-2-yl)quinazolin-2-yl)-5,6-dihydroimidazo[l,2-a]

pyrazine-7(8H)-carboxamide [1647];

4-methyl-N-(7-(5-methyl-l,3,4 hiadiazol-2-yl)quinazolin-2-yl)piperazine-l-carboxamide [1648]; N-(7-(5-methyl-l,3,4 hiadiazol-2-yl)quinazolin-2-yl)-l-(l-methylpiperidin-4-yl)-lH-pyrazole-^ carboxamide [1649];

1 -( 1 -isopropylpiperidin-4-yl)-N-(7-(5 -methyl- 1 ,3,4-thiadiazol-2-yl)quinazolin-2-yl)- lH-pyrazole- 4-carboxamide [1650];

N-(7-(5-methyl-l,3,4-thiadiazol-2-yl)quinazolin-2-yl)-l-(l-methylpiperidin-4-yl)-lH-l,2,3- triazole -4 -carboxamide [1651];

N-(7-(5-methyl-l,3,4-thiadiazol-2-yl)quinazolin-2-yl)-2-(piperidin-4-yl)oxazole-4-carboxamide

[1652];

N-(7-(5-methyl-l,3,4-thiadiazol-2-yl)quinazolin-2-yl)-2-(l-methylpiperidin-4-yl)oxazole-4- carboxamide [1653];

2-(3 -(dimethylamino)azetidin- 1 -yl)-N-(7-(5-methyl- 1 ,3 ,4-thiadiazol-2-yl)quinazolin-2-yl)

isonicotinamide [1654];

r-methyl-N-(7-(5-methyl-l,3,4-thiadiazol-2-yl)quinazolin-2-yl)-l',2',3',6'-tetrahydro-[2,4'- bipyridine] -4 -carboxamide [1655];

N-(7-(5-methyl-l,3,4-thiadiazol-2-yl)quinazolin-2-yl)-2-(4-methylpiperazin-l-yl)isonicotinamide

[1656];

2-(methyl( 1 -methylpiperidin-4-yl)amino)-N-(7-(5-methyl- 1 ,3 ,4-thiadiazol-2-yl)quinazolin-2-yl) isonicotinamide [1657];

2-(azetidin-3-yloxy)-N-(7-(5-methyl-l,3,4-thiadiazol-2-yl)quinazolin-2-yl)isonicotinamide

[1658];

N-(7-(5-methyl-l,3,4-thiadiazol-2-yl)quinazolin-2-yl)-3-((l-methylpiperidin-4-yl)oxy)benzamide

[1659];

N-(7-(5-methyl-l,3,4-thiadiazol-2-yl)quinazolin-2-yl)-2-((l-methylpiperidin-4-yl)thio)

isonicotinamide [1660]; 6-(4-methylpiperazin-l-yl)-N-(7-(5-(trifluoromethyl)-l,3,4 hiadiazol-2-yl)quinazolin-2-yl) nicotinamide [1661];

2-(4-methylpiperazin-l-yl)-N-(7-(5-(trifluoromethyl)-l,3,4 hiadiazol-2-yl)quinazolin-2-yl) isonicotinamide [1662];

N-(7-(5-amino-l,3,4 hiadiazol-2-yl)quinazolin-2-yl)-2-(4-methylpiperazin-l-yl)isonicotina^

[1663];

N-(7-(5-(dimethylamino)-l,3,4-miadiazol-2-yl)qum^

isonicotinamide [1664];

N-(7-(3-amino-5-fluorophenyl)quinazolin-2-yl)-2-(4-methylpiperazin-l-yl)isonicotinamide

[1665];

N-(7-(3-fluoro-5-(isopropylamino)phenyl)quinazolin-2-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [1666];

1 -methyl -N-(7-(pyridin-2-yl)quinazolin-2-yl)piperidine-4-carboxamide [1667] ;

2-(4-methylpiperazin-l-yl)-N-(7-(pyridin-2-yl)quinazolin-2-yl)isonicotinamide [1668];

2-(4-methylpiperazin-l-yl)-N-(7-(pyridin-4-yl)quinazolin-2-yl)isonicotinamide [1669];

N-(7-(pyridin-3 -yl)quinazolin-2-yl)cyclopropanecarboxamide [1670] ;

N-(7-(pyridin-3-yl)quinazolin-2-yl)-2-(pyrrolidin-l-yl)acetamide [1671];

1 -methyl -N-(7-(pyridin-3 -yl)quinazolin-2-yl)piperidine-4-carboxamide [1672] ;

N-(7 -(pyridin-3 -yl)quinazolin-2-yl)quinuclidine -4 -carboxamide [ 1673] ;

2-moφholino-N-(7-(pyridin-3-yl)quinazolin-2-yl)acetamide [1674];

2-(moφholino-ί s)- -(7-(pyridin-3-yl)quinazolin-2-yl)acetamide [1675];

2-(4-methylpiperazin-l-yl)-N-(7-(pyridin-3-yl)quinazolin-2-yl)acetamide [1676];

2-(4-methyl- 1 ,4-diazepan-l -yl)-N-(7-(pyridin-3 -yl)quinazolin-2-yl)acetamide [1677] ;

2-(4-methylpiperazin-l-yl)-N-(7-(pyridin-3-yl)quinazolin-2-yl)isonicotinamide [1678];

2-(2-methyl-lH-imidazol-l-yl)-N-(7-(pyridin-3-yl)quinazolin-2-yl)acetamide [1679];

2-(lH-imidazol-l-yl)-N-(7-(pyridin-3-yl)quinazolin-2-yl)acetamide [1680];

2-(piperidin-4-yl)-N-(7-(pyridin-3-yl)quinazolin-2-yl)oxazole-4-carboxamide [1681];

2-(l-methylpiperidin-4-yl)-N-(7-(pyridin-3-yl)quinazolin-2-yl)oxazole-4-carboxamide [1682]; 2-(l-isopropylpiperidin-4-yl)-N-(7-(pyridin-3-yl)quinazolin-2-yl)oxazole-4-carboxamide [1683]; fr rø-N-(7-(5-fluoropyridin-3-yl)quinazolin-2-yl)-3-mo holinocyclobutane-l -carboxamide

[1684];

fr «5-N-(7-(5-fluoropyridin-3-yl)quinazolin-2-yl)-4-((4-methylpiperazin-l-yl)methyl)

cyclohexane-1 -carboxamide [1685];

N-(7-(5-fluoropyridin-3-yl)quinazolin-2-yl)-2-(pyrrolidin-l-yl)acetamide [1686]; N-(7-(5-fluoropyridin-3-yl)quinazolin-2-yl)-l-methylpiperidine-4-carboxamide [1687];

N-(7-(5-fluoropyridin-3 -yl)quinazolin-2-yl)-2-(4-methylpiperazin- 1 -yl)acetamide [1688] ;

N-(7-(6-fluoropyridin-3-yl)quinazolin-2-yl)-2-(4-methylpiperazin-l-yl)acetamide [1689];

N-(7-(5-fluoropyridin-3-yl)quinazolin-2-yl)-2-mo holinoacetamide [1690];

N-(7 -(5 -fluoropyridin-3 -yl)quinazolin-2 -yl) -3 -mo holinopropanamide [1691];

N-(7-(5-fluoropyridin-3-yl)quinazolin-2-yl)-2-(4-methylpiperazin-l-yl)isonicotinamide [1692]; N-(7-(5-fluoropyridin-3-yl)quinazolin-2-yl)-2-(piperidin-4-yl)oxazole-4-carboxamide [1693]; N-(7-(5-fluoropyridin-3-yl)quinazolin-2-yl)-2-(l-methylpiperidin-4-yl)oxazole-4-carboxamide

[1694];

N-(7-(5-fluoropyridin-3-yl)quinazolin-2-yl)-2-(l-isopropylpiperidin-4-yl)oxazole-4-carboxamide

[1695];

N-(7-(5-chloropyridin-3-yl)quinazolin-2-yl)-2-(4-methylpiperazin-l-yl)isonicotinamide [1696]; N-(7-(5-methylpyridin-3-yl)quinazolin-2-yl)-2-mo holinoacetamide [1697];

N-(7-(5-(difluoromethyl)pyridin-3-yl)quinazolin-2-yl)-3-(piperidin-4-yl)benzamide [1698]; N-(7-(5-(difluoromethyl)pyridin-3-yl)quinazolin-2-yl)-3-(l-methylpiperidin-4-yl)benzamide

[1699];

N-(7-(5-(difluoromethyl)pyridin-3-yl)quinazolin-2-yl)-2-(4-methylpiperazin-l-yl)isonicotinamid

[1700];

2-(4-methylpiperazin- 1 -yl)-N-(7-(5 -(trifluoromethyl)pyridin-3 -yl)quinazolin-2-yl)acetamide

[1701];

2-(4-methylpiperazin-l-yl)-N-(7-(6-(trifluoromethyl)pyridin-3-yl)quinazolin-2-yl)acetamide

[1702];

N-(7-(5-(hydroxymethyl)pyridin-3-yl)quinazolin-2-yl)-l-methylpiperidine-4-carboxamide

[1703];

N-(7-(5-cyanopyridin-3-yl)quinazolin-2-yl)-l-methylpiperidine-4-carboxamide [1704];

N-(7-(5-methoxypyridin-3-yl)quinazolin-2-yl)-l-methylpiperidine-4-carboxamide [1705];

N-(7-(5-methoxypyridin-3-yl)quinazolin-2-yl)-2-moφholinoacetamide [1706];

N-(7-(5-methoxypyridin-3-yl)quinazolin-2-yl)-2-(4-methylpiperazin-l-yl)isonicotinam [1707]; 4-fluoro-N-(7-(5-(piperidin-4-yloxy)pyridin-3-yl)quinazolin-2-yl)benzamide [1708];

N-(7 -(5 -aminopyridin-3 -yl)quinazolin-2 -yl) -4 -fluorobenzamide [ 1709] ;

N-(7-(5-aminopyridin-3-yl)quinazolin-2-yl)-4-(piperidin-4-yloxy)benzamide [1710];

N-(7-(5-aminopyridin-3-yl)quinazolin-2-yl)-2-(4-methylpiperazin-l-yl)isonicotinamide [1711]; N-(7-(5-aminopyridin-3-yl)quinazolin-2-yl)-2-(piperidin-4-yl)oxazole-4-carboxamide [1712]; N-(7-(6-aminopyridin-3-yl)quinazolin-2-yl)-2-(4-methylpiperazin-l-yl)isonicotinamide [1713]; N-(7-(6-(methylamino)pyridin-3-yl)quinazolin-2-yl)-2-(4-methylpiperazin-l-yl)isonicotinamide [1714];

N-(7-(5-(isopropylamino)pyridin-3-yl)quinazolin-2-yl)-3-(piperidin-4-yl)benzamide [1715]; N-(7-(5-(isopropylamino)pyridin-3-yl)quinazolin-2-yl)-3-(l-methylpiperidin-4-yl)benzamide

[1716];

N-(7-(5-(isopropylamino)pyridin-3-yl)quinazolin-2-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [1717];

N-(7-(5-(piperidin-4-ylamino)pyridin-3-yl)quinazolin-2-yl)cyclohexanecarboxamide [1718]; 4-fluoro-N-(7-(5-(piperidin-4-ylamino)pyridin-3-yl)quinazolin-2-yl)benzamide [1719];

4-fluoro-N-(7-(5-((l-methylpiperidin-4-yl)amino)pyridin-3-yl)quinazolin-2-yl)benzamide [1720]; N-(7 -(5 -acetamidopyridin-3 -yl)quinazolin-2 -yl)- 1 -methylpiperidine -4 -carboxamide [ 1721 ] ; N-(7-(5-(dimethylamino)pyridin-3-yl)quinazolin-2-yl)-2-(4-methylpiperazin-l-yl)isonicotinami

[1722];

N-(7-(6-(dimethylamino)pyridin-3 -yl)quinazolin-2-yl)-2-(4-methylpiperazin- 1 -yl)isonicotinamide

[1723];

1- methyl-N-(7-(5-(pyrrolidin-l-yl)pyridin-3-yl)quinazolin-2-yl)piperidine-4-carboxamide [1724]; N-(7-(5-(pyrrolidin-l-ylmethyl)pyridin-3-yl)quinazolin-2-yl)cyclopropanecarboxamide [1725]; 4-fluoro-N-(7-(5-(pyrrolidin-l -ylmethyl)pyridin-3-yl)quinazolin-2-yl)benzamide [1726] ;

N-(7-(5 -((4-hydroxypiperidin- 1 -yl)methyl)pyridin-3 -yl)quinazolin-2-yl)

cyclopropanecarboxamide [1727];

4-fluoro-N-(7-(5-((4-hydroxypiperidin-l-yl)methyl)pyridin-3-yl)quinazolin-2-yl)benzamide

[1728];

N-(7-(5-(piperazin-l-ylmethyl)pyridin-3-yl)quinazolin-2-yl)cyclopropanecarboxamide [1729]; N-(7-(5-((4-methylpiperazin-l-yl)methyl)pyridin-3-yl)quinazolin-2-yl)cyclopropanecarboxamide

[1730];

N-(7-(5-(mo holinomethyl)pyridin-3-yl)quinazolin-2-yl)cyclopropanecarboxamide [1731]; N-methyl-5-(2-(l-methylpiperidine-4-carboxamido)quinazolin-7-yl)nicotinamide [1732];

N-methyl-5-(2-(2-(4-methylpiperazin-l-yl)isonicotinamido)quinazolin-7-yl)nicotinamide [1733]; N-(7-(pyridin-3-yl-£/4)quinazolin-2-yl)-2-(pyrrolidin-l-yl)acetamide [1734];

2- (4-methylpiperazin- 1 -yl)-N-(7-(pyridin-3 -yl-d4)quinazolin-2-yl)acetamide [1735] ;

2-moφholino-N-(7-(pyridin-3-yl-ί ₄()quinazolin-2-yl)acetamide [1736];

1 -methyl -N-(7 -(2 -methylpyrimidin-5 -yl)quinazolin-2 -yl)piperidine -4 -carboxamide [1737] ;

2-(4-methylpiperazin-l-yl)-N-(7-(2-methylpyrimidin-5-yl)quinazolin-2-yl)isonicotinamide

[1738]; N-(7-(2-aminopyrimidin-5-yl)quinazolin-2-yl)-l -methylpiperidine-4-carboxamide [1739] ;

2-moφholino-N-(7-(pyridazin-3-yl)quinazolin-2-yl)acetamide [1740];

2-moφholino-N-(7-(pyridazin-4-yl)quinazolin-2-yl)acetamide [1741];

N-(7-(pyridazin-4-yl)quinazolin-2-yl)-2-(pyrrolidin-l-yl)acetamide [1742];

trans-3 -mo holino-N-(7-(pyrazin-2-yl)quinazolin-2-yl)cyclobutane- 1 -carboxamide [1743] ; fr «5-4-(dimethylamino)-N-(7-(pyrazin-2-yl)quinazolin-2-yl)cyclohexane-l -carboxamide [1744]; fr rø-4-mo holino-N-(7-(pyrazin-2-yl)quinazolin-2-yl)cyclohexane-l -carboxamide [1745]; fr «5-4-((3-fluoroazetidin- 1 -yl)methyl)-N-(7-(pyrazin-2-yl)quinazolin-2-yl)cyclohexane- 1 - carboxamide [1746];

fr «5-4-((4-methylpiperazin- 1 -yl)methyl)-N-(7-(pyrazin-2-yl)quinazolin-2-yl)cyclohexane- 1 - carboxamide [1747];

N-(7-(pyrazin-2-yl)quinazolin-2-yl)-2-(pyrrolidin- 1 -yl)acetamide [1748] ;

1 -methyl -N-(7-(pyrazin -2 -yl)quinazolin-2-yl)piperidine-4-carboxamide [1749] ;

4-fluoro-l-methyl-N-(7-(pyrazin-2-yl)quinazolin-2-yl)piperidine-4-carboxamide [1750];

l-(2-fluoroethyl)-N-(7-(pyrazin-2-yl)quinazolin-2-yl)piperidine-4-carboxamide [1751];

1- (oxetan-3-yl)-N-(7-(pyrazin-2-yl)quinazolin-2-yl)piperidine-4-carboxamide [1752];

2- moφholino-N-(7-(pyrazin-2-yl)quinazolin-2-yl)acetamide [1753];

l-methyl-N-(7-(pyrazin-2-yl)quinazolin-2-yl)azepane-4-carboxamide [1754];

l-isobutyl-N-(7-(pyrazin-2-yl)quinazolin-2-yl)azepane-4-carboxamide [1755];

1- (2-hydroxy-2-methylpropyl)-N-(7-(pyrazin-2-yl)quinazolin-2-yl)azepane-4-carboxamide

[1756];

4-(moφholinomethyl)-N-(7-(pyrazin-2-yl)quinazolin-2-yl)benzamide [1757];

2- (4-methylpiperazin- 1 -yl)-N-(7-(pyrazin-2-yl)quinazolin-2-yl)isonicotinamide [1758] ;

N-(7-(6-(methylamino)pyrazin-2-yl)quinazolin-2-yl)-2-(4-methylpiperazin-l-yl)isonicotinamide

[1759];

N-(7-(6-(isopropylamino)pyrazin-2-yl)quinazolin-2-yl)azetidine-3-carboxamide [1760];

N-(7-(6-(isopropylamino)pyrazin-2-yl)quinazolin-2-yl)piperidine-4-carboxamide [1761];

N-(7-(6-(isopropylamino)pyrazin-2-yl)quinazolin-2-yl)-l-methylpiperidine-4 -carboxamide

[1762];

l-(2-fluoroethyl)-N-(7-(6-(isopropylamino)pyrazin-2-yl)quinazolin-2-yl)piperidine-4- carboxamide [1763];

l-isopropyl-N-(7-(6-(isopropylamino)pyrazin-2-yl)quinazolin-2-yl)piperidine-4-carboxamide

[1764]; l-isopentyl-N-(7-(6-(isopropylamino)pyrazin-2-yl)quinazolin-2-yl)piperidine-4-carboxamide

[1765];

N-(7-(6-(isopropylamino)pyrazin-2-yl)quinazolin-2-yl)-3-(piperidin-4-yl)benzamide [1766]; N-(7-(6-(isopropylamino)pyrazin-2-yl)quinazolin-2-yl)-3 -( 1 -methylpiperidin-4-yl)benzamide

[1767];

N-(7-(6-(isopropylamino)pyrazin-2-yl)quinazolin-2^

carboxamide [1768];

l-(l-(2-fluoroethyl)piperidin-4-yl)-N-(7-(6-(isopropylamino)pyrazin-2-yl)quinazolin-2-yl)-lH- l,2,3-triazole-4-carboxamide [1769];

N-(7-(6-(isopropylamino)pyrazin-2-yl)quinazolin-2-yl)-l-(l-isopropylpiperidin-4-yl)-lH-l,2,3- triazole -4 -carboxamide [1770];

N-(7-(6-(isopropylamino)pyrazin-2-yl)quinazolin-2-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [1771];

N-(7-(6-(fer^butylamino)pyrazin-2-yl)quinazolin-2-yl)-2-(3-(dimethylamino)azetidin-l-yl) isonicotinamide [1772];

N-(7-(6-(fer^butylamino)pyrazin-2-yl)quinazolin-2-yl)-r-methyl-r,2',3',6'-tetrahydro-[2,4'- bipyridine] -4 -carboxamide [1773];

N-(7-(6-(feri-butylamino)pyrazin-2-yl)quinazolin-2-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [1774];

N-(7-(6-(feri-butylamino)pyrazin-2-yl)quinazolin-2-yl)-2-(4-isopropylpiperazin-l-yl)

isonicotinamide [1775];

N-(7-(6-(ferί-butylamino)pyrazin-2-yl)quinazolin-2-yl)-2-moφholinoisonicotinamide [1776]; N-(7-(6-(((3-fluoroazetidin-3-yl)methyl)amino)pyrazin-2-yl)quinazolin-2-yl)

cyclopropanecarboxamide [1777];

4-fluoro-N-(7-(6-(((3-fluoroazetidin-3-yl)methyl)amino)pyrazin-2-yl)quinazolin-2-yl)benzamide

[1778];

N-(7-(6-(piperidin-4-ylamino)pyrazin-2-yl)quinazolin-2-yl)cyclobutanecarboxamide [1779];

3.3- difluoro-N-(7-(6-(piperidin-4-ylamino)pyrazin-2-yl)quinazolin-2-yl)cyclobutane-l- carboxamide [1780];

N-(7-(6-(piperidin-4-ylamino)pyrazin-2-yl)quinazolin-2-yl)cyclopentanecarboxamide [1781];

4.4- difluoro-N-(7-(6-(piperidin-4-ylamino)pyrazin-2-yl)quinazolin-2-yl)cyclohexane-l- carboxamide [1782];

N-(7-(6-(piperidin-4-ylamino)pyrazin-2-yl)quinazolin-2-yl)tetrahydro-2H-pyran-4-carboxamide

[1783]; 4-fluoro-N-(7-(6-(piperidin-4-ylamino)pyrazin-2-yl)quinazolin-2-yl)benzamide [1784];

N-(7-(6-(((3S,4S)-3-fluoropiperidin-4-yl)amino)pyrazin-2-yl)quinazolin-2-yl)

cyclopropanecarboxamide [1785];

4-fluoro-N-(7-(6-(((3S,4S)-3-fluoropiperidin-4-yl)amino)pyrazin-2-yl)quinazolin-2-yl)benzamide

[1786];

N-(7-(6-((l-methylpiperidin-4-yl)amino)pyrazin-2-yl)quinazolin-2-yl)cyclobutanecarboxamide

[1787];

N-(7-(6-((l-methylpiperidin-4-yl)amino)pyrazin-2-yl)quinazolin-2-yl)cyclopentanecarboxamide

[1788];

4-fluoro-N-(7-(6-((l-methylpiperidin-4-yl)amino)pyrazin-2-yl)quinazolin-2-yl)benzamide [1789]; N-(7-(6-((l-isopropylpiperidin-4-yl)amino)pyrazin-2-yl)quinazolin-2-yl)

cyclopropanecarboxamide [1790];

3,3-difluoro-N-(7-(6-((l-isopropylpiperidin-4-yl)amino)pyrazin-2-yl)quinazolin-2-yl)

cyclobutane-l-carboxamide [1791];

N-(7-(6-((l-isopropylpiperidin-4-yl)amino)pyrazin-2-yl)quinazolin-2-yl)

cyclopentanecarboxamide [1792];

4-fluoro-N-(7-(6-((l-isopropylpiperidin-4-yl)amino)pyrazin-2-yl)quinazolin-2-yl)benzamide

[1793];

N-(7-(6-(dimethylamino)pyrazin-2-yl)quinazolin-2-yl)-2-(4-methylpiperazin-l- yl)isonicotinamide [1794];

N-(7-(6-(diethylamino)pyrazin-2-yl)quinazolin-2-yl)-2-(4-methylpiperazin-l-yl)isonicotinami

[1795];

N-(7-(6-(3-aminoazetidin-l-yl)pyrazin-2-yl)quinazolin-2-yl)-4-fluorobenzamide [1796];

2-(4-methylpiperazin- 1 -yl)-N-(7-(6-(pyrrolidin- 1 -yl)pyrazin-2-yl)quinazolin-2-yl)isonicotinamide

[1797];

N-(7-(6-(azetidin-3-ylmethoxy)pyrazin-2-yl)quinazolin-2-yl)-4-fluorobenzamide [1798];

N-(7-(6-(azetidin-3-yloxy)pyrazin-2-yl)quinazolin-2-yl)-4-fluorobenzamide [1799];

N-(7-(lH-pyrrolo[2,3-b]pyridin-5-yl)quinazolin-2-yl)-l-(l-methylpiperidin-4-yl)-lH-pyrazole-4- carboxamide [1800];

N-(7-(lH-pyrrolo[3,2-b]pyridin-6-yl)quinazolin-2-yl)-l-(l-methylpiperidin-4-yl)-lH-pyrazole-4- carboxamide [1801];

N-(7-(lH-pyrrolo[2,3-c]pyridin-4-yl)quinazolin-2-yl)-l-(l-methylpiperidin-4-yl)-lH-pyrazole-4- carboxamide [1802]; N-(7-( lH-pyrrolo[2,3-b]pyridin-5-yl)quinazo^

[1803] ;

N-(7-( lH-pyrrolo[3,2-b]pyridin-6-yl)quinazolm^

[1804] ;

N-(7 -( 1 H-pyrrolo [2,3 -c] pyridin-4 -yl)quinazolin-2-yl)-2-(4-methylpiperazin-l -yl)isonicotinamide

[1805] ;

2-(4-methylpiperazin-l -yl)-N-(7-(oxazolo[5,4-b]pyridin-6-yl)quinazolin-2-yl)isonicotinamide

[1806] ;

N-(7-(2-methyl-lH-pyrrolo[2,3-b]pyridin-5-yl)quinazolin-2-yl)-2-(4-methylpiperazin-l -yl)

isonicotinamide [1807];

N-(7-(3-methyl-lH-pyrrolo[2,3-b]pyridin-5-yl)quinazolin-2-yl)-2-(4-methylpiperazin-l -yl)

isonicotinamide [1808];

N-(7-(2-methyl-lH-pyrrolo[3,2-b]pyridin-6-yl)quinazolin-2-yl)-2-(4-methylpiperazin-l -yl)

isonicotinamide [1809];

N-(7-(5H-pyrrolo[2,3-b]pyrazin-2-yl)quinazolin-2-yl)-2-(4-methylpiperazin-l -yl)isonicotinamide

[1810] ;

N-(7-(5H-pyrrolo[2,3-b]pyrazin-3-yl)quinazolin-2-yl)-2-(4-methylpiperazin-l -yl)isonicotinamide

[1811] ;

l-isopropyl-N-(7-(6-(piperidin-4-ylamino)pyrazin-2-yl)quinazolin-2-yl)-lH-pyrazole-4- carboxamide [1812];

l-isopropyl-N-(7-(6-(( l-methylpiperidin-4-yl)amino)pyrazin-2-yl)quinazolin-2-yl)-lH-pyrazole- 4-carboxamide [1813];

fr «5-4-((2-fluoroethyl)amino)-N-(7-( l-methyl-lH-pyrazol-4-yl)quinazolin-2-yl)cyclohexane-l - carboxamide [4566];

fra«s-4-((2-methoxyethyl)amino)-N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)cyclohexane- 1 -carboxamide [4567];

fert-butyl (trans-4-((7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)carbamoyl)cyclohexyl) carbamate [4568];

N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)-2-(( 1 -methylpiperidin-4-yl)amino)

isonicotinamide [4569];

N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)-2-(4-methylpiperazin- 1 -yl)thiazole-5 - carboxamide [4570];

N-(7-( 1 -methyl- lH-pyrazol-4-yl)quinazolin-2-yl)-2-(4-methylpiperazin- 1 -yl)thiazole-5 - carboxamide [4571]; N-(7-( 1 -methyl -5 -(piperidin- 1 -ylmethyl)- lH-pyrazol-4-yl)quinazolin-2-yl)-2-(2,7-diazaspiro[3.5] nonan-2-yl)isonicotinamide [4572] ;

N-(7-(l-methyl-lH-l,2,3-triazol-4-yl)quinazolin-2-yl)-4-(piperidin-4-yloxy)benzamide [4573]; N-(7-( 1 -methyl- lH-tetrazol-5 -yl)quinazolin-2-yl)- 1 -(3,3,3-trifluoropropyl)piperidine-4- carboxamide [4574];

N-(7-(l,2-dimethyl-lH-imidazol-5-yl)quinazolin-2-yl)-2-(pyrrolidin-l-yl)propanamide [4575]; N-(7-(l,2-dimethyl-lH-imidazol-5-yl)quinazolin-2-yl)-2-(piperidin-l-yl)propanamide [4576]; 4-isopropoxy-N-(7-(7-methyl-5,6,7,8-tetrahydroimidazo[l,2-a]pyrazin-3-yl)quinazolin-2-yl) benzamide [4577];

trans-3 -morpholino-N-(7-(oxazol-5 -yl)quinazolin-2-yl)cyclobutane- 1 -carboxamide [4578] ; fr «5-4-(hydroxymethyl)-N-(7-(oxazol-5-yl)quinazolin-2-yl)cyclohexane-l -carboxamide [4579]; N-(7-(oxazol-5-yl)quinazolin-2-yl)piperidine-4-carboxamide [4580];

4-moφholino-N-(7-(oxazol-5-yl)quinazolin-2-yl)piperidine-l -carboxamide [4581];

N-(7-(oxazol-5-yl)quinazolin-2-yl)-4-(piperidin-4-yloxy)benzamide [4582];

N-(7-(oxazol-5-yl)quinazolin-2-yl)-3-(piperidin-4-yloxy)benzamide [4583];

2-methyl-N-(7-(oxazol-5-yl)quinazolin-2-yl)-5,6-dihydroimidazo[l,2-a]pyrazine-7(8H)- carboxamide [4584];

2-(lH-imidazol-l-yl)-N-(7-(oxazol-5-yl)quinazolin-2-yl)acetamide [4585];

fr «5-4-(hydroxymethyl)-N-(7-(thiazol-5-yl)quinazolin-2-yl)cyclohexane-l-carboxamide [4586]; fr «5-4-(dimethylamino)-N-(7-(thiazol-5-yl)quinazolin-2-yl)cyclohexane-l -carboxamide [4587]; N-(7-(thiazol-5-yl)quinazolin-2-yl)-l-((l-(trifluoromethyl)cyclopropyl)methyl)piperidine-4- carboxamide [4588];

fr «5-4-(hydroxymethyl)-N-(7-(2-methylthiazol-5-yl)quinazolin-2-yl)cyclohexane-l- carboxamide [4589];

fr «5-4-(dimethylamino)-N-(7-(2-methylthiazol-5 -yl)quinazolin-2-yl)cyclohexane- 1 -carboxamide

[4590];

N-(7-(2-methylthiazol-5-yl)quinazolin-2-yl)-l-(oxetan-3-yl)piperidine-4-carboxamide [4591]; N-(7-(2-methylthiazol-5 -yl)quinazolin-2-yl)- 1 -(2-(pyrrolidin- 1 -yl)acetyl)piperidine-4- carboxamide [4592];

2-((lS,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(7-(5-methyl-l,3,4-thiadiazol-2-yl)

quinazolin-2-yl)acetamide [4593];

N-(7-(5-(cyano(4-hydroxypiperidin-l-yl)methyl)pyridin-3-yl)quinazolin-2-yl)

cyclopropanecarboxamide [4594]; 4-fluoro-N-(7-(6-(( 1 -methylazetidin-3 -yl)methoxy)pyrazin-2-yl)quinazolin-2-yl)benzamide

[4595] ;

l-isopropyl-N-(7-(6-((l-methylpiperidin-4-yl)amino)pyrazin-2-yl)quinazolin-2-yl)-lH-pyrazole- 4-carboxamide [4596]; or a pharmaceutically acceptable salt thereof.

22. The compound according to any one of claims 1-19, wherein the compound of Formula I is selected from the group consisting of:

N-(6-( lH-pyrazol-4-yl)cinnolin-3-yl)-l -isobutylpiperidine-4-carboxamide [1814];

N-(6-( l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)cyclopropanecarboxamide [1815];

4,4-difluoro-N-(6-( l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)cyclohexane-l -carboxamide [1816] ; fr «5-4-methoxy-N-(6-( 1 -methyl- lH-pyrazol-4-yl)cinnolin -3 -yl)cyclohexane- 1 -carboxamide

[1817] ;

trans -N-(6-( 1 -methyl - 1 H-pyrazol -4 -yl)cinnolin-3 -yl) -4 -morpholinocyclohexane - 1 -carboxamide

[1818] ;

trans-4-((3 -fluoroazetidin- 1 -yl)methyl)-N-(6-( 1 -methyl- lH-pyrazol-4-yl)cinnolin-3-yl)

cyclohexane-1 -carboxamide [1819];

fr «5-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-4-((4-methylpiperazin-l-yl)methyl)

cyclohexane-1 -carboxamide [1820];

N-(6 -( 1 -methyl - 1 H-pyrazol -4 -yl)cinnolin-3 -yl) -2 -(pyrrolidin- 1 -yl)acetamide [1821] ;

(S)-2-(3 -fluoropyrrolidin- 1 -yl)-N-(6-( 1 -methyl- lH-pyrazol-4-yl)cinnolin-3 -yl)acetamide [1822] ; (S)-N-(6-( l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)tetrahydrofuran-2 -carboxamide [1823];

N-(6 -( 1 -methyl - 1 H-pyrazol -4 -yl)cinnolin-3 -yl)piperidine -4 -carboxamide [1824] ;

1 -methyl -N-(6 -( 1 -methyl - 1 H-pyrazol -4 -yl)cinnolin-3 -yl)piperidine -4 -carboxamide [ 1825] ;

1 -isopropyl-N-(6-( 1 -methyl- lH-pyrazol-4-yl)cinnolin-3-yl)piperidine-4-carboxamide [1826] ; 1 -(fert-butyl)-N-(6-( 1 -methyl- lH-pyrazol-4-yl)cinnolin-3 -yl)piperidine-4-carboxamide [1827] ; l-cyclopropyl-N-(6-(l -methyl-lH-pyrazol-4-yl)cinnolin-3-yl)piperidine-4-carboxamide [1828]; 1 -isobutyl-N-(6-( 1 -methyl- lH-pyrazol-4-yl)cinnolin-3 -yl)piperidine-4-carboxamide [1829] ; N-(6-( l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-l -neopentylpiperidine-4-carboxamide [1830] ; 1 -(2 -fluoroethyl) -N-(6-( 1 -methyl - 1 H-pyrazol -4 -yl)cinnolin-3 -yl)piperidine -4 -carboxamide

[1831] ;

N-(6 -( 1 -methyl - 1 H-pyrazol -4 -yl)cinnolin-3 -yl) - 1 -(3 ,3 , 3 -trifluoropropyl)piperidine -4 - carboxamide [1832];

1 -butyl -N-(6 -( 1 -methyl - 1 H-pyrazol -4 -yl)cinnolin-3 -yl)piperidine -4 -carboxamide [1833];

1 -benzoyl -N-(6-( 1 -methyl - 1 H-pyrazol -4 -yl)cinnolin-3 -yl)piperidine -4 -carboxamide [ 1834] ; l-(2,2-difluoropropyl)-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)piperidine-4-carboxam

[1835];

N-(6 -( 1 -methyl - 1 H-pyrazol -4 -yl)cinnolin-3 -yl)azetidine -3 -carboxamide [1836];

1 -(2,2-difluoroethyl)-N-(6 -(1 -methyl - 1 H-pyrazol -4 -yl)cinnolin-3 -yl)piperidine -4 -carboxamide

[1837];

1 -(2 -fluoro-2 -methylpropyl)-N-(6 -( 1 -methyl- 1 H-pyrazol -4 -yl)cinnolin-3 -yl)piperidine -4 - carboxamide [1838];

N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-l-(oxetan-3-yl)piperidine-4-carboxamide [1839]; N-(6-( 1 -methyl -1 H-pyrazol -4 -yl)cinnolin-3 -yl)- 1 -((3-methyloxetan-3 -yl)methyl)piperidine-4- carboxamide [1840];

1- (2-methoxyethyl)-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)piperidine-4 -carboxamide

[1841];

1 -(2-isopropoxyethyl)-N-(6-( 1 -methyl- lH-pyrazol-4-yl)cinnolin -3 -yl)piperidine-4-carboxamide

[1842];

1 , 1 -diisobutyl-4-((6-( 1 -methyl- lH-pyrazol-4-yl)cinnolin-3 -yl)carbamoyl)piperidin-l -ium [1843] ; 4-fluoro-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)piperidine-4-carboxamide [1844];

4-fluoro- 1 -methyl -N-(6-( 1 -methyl-lH-pyrazol-4-yl)cinnolin-3 -yl)piperidine-4-carboxamide

[1845];

4-fluoro- 1 -isobutyl-N-(6-( 1 -methyl- lH-pyrazol-4-yl)cinnolin-3 -yl)piperidine-4-carboxamide

[1846];

(S)-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)piperidine-3-carboxamide [1847];

(R)-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)piperidine-3-carboxamide [1848];

(S)- 1 -isobutyl-N-(6-( 1 -methyl -1 H-pyrazol -4 -yl)cinnolin-3-yl)piperidine -3 -carboxamide [1849] ; (R)-l-isobutyl-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)piperidine-3-carboxamide [1850]; N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)tetrahydro-2H-pyran-4-carboxamide [1851]; N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-2-(piperidin-l-yl)acetamide [1852];

2- (4-fluoropiperidin-l-yl)-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)acetamide [1853]; trans -4 -amino -N-(6-( 1 -methyl - 1 H-pyrazol -4 -yl)cinnolin-3 -yl)cyclohexane - 1 -carboxamide

[1854];

N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-2-(4-methylpiperazin-l-yl)acetamide [1855]; (S)-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)piperidine-2 -carboxamide [1856];

2-(4-isobutylpiperazin-l-yl)-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)acetamide [1857]; 2-(3,3-dimethylazetidin-l-yl)-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)acetamide [1858]; (R)-2-(3-fluoropyrrolidin- 1 -yl)-N-(6-( 1 -methyl- lH-pyrazol-4-yl)cinnolin-3 -yl)acetamide [1859] ; (S)-N-(6-( 1 -methyl-lH-pyrazol-4-yl)cinnolin-3 -yl)-2-(2-methylpyrrolidin- 1 -yl)acetamide [1860] ; 2-(3-azabicyclo[3.1.0]hexan-3-yl)-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)acetamide

[1861];

2-(7-azabicyclo[2.2.1]heptan-7-yl)-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)acetamide

[1862];

N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-2-(4-methylpiperidin-l-yl)acetamide [1863]; N-(6-( 1 -methyl -1 H-pyrazol -4 -yl)cinnolin-3 -yl)-2-(4-(trifluoromethyl)piperidin- 1 -yl)acetamide

[1864];

2-(4-(difluoromethyl)piperidin-l-yl)-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)acetamide

[1865];

N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-2-(6-azaspiro[2.5]octan-6-yl)acetamide [1866]; N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-2-(pyrrolidin-l-yl)propanamide [1867];

(R)-N-(6-( 1 -methyl- lH-pyrazol-4-yl)cinnolin-3-yl)-2-(2-methylpyrrolidin- 1 -yl)acetamide [1868] ; 2-(cyclobutyl(methyl)amino)-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)acetamide [1869]; 2-(diethylamino)-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)acetamide [1870];

7-(2-fluoroethyl)-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-7-azaspiro[3.5]nonane-2- carboxamide [1871];

4-methyl-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)piperazine-l-carboxamide [1872];

(S)-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-2-(pyrrolidin-l-yl)propanamide [1873]; (R)-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-2-(pyrrolidin-l-yl)propanamide [1874]; (R)-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)pyrrolidine-2-carboxamide [1875];

2-methyl -N-(6 -( 1 -methyl - 1 H-pyrazol -4 -yl)cinnolin-3 -yl) -2 -azaspiro [3.3] heptane -6-carboxamide

[1876];

N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-2-(2,2,2-trifluoroacetyl)-2-azaspiro[3.3]heptane- 6-carboxamide [1877];

2-(2-fluoroethyl)-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-2-azaspiro[3.3]heptane-6- carboxamide [1878];

trans -4 -(dimethylamino) -N-(6 -( 1 -methyl - 1 H-pyrazol-4 -yl)cinnolin-3 -yl)cyclohexane - 1 - carboxamide [1879];

1 -acetyl -N-(6 -( 1 -methyl - 1 H-pyrazol -4 -yl)cinnolin-3 -yl)piperidine -4 -carboxamide [ 1880] ;

N-(6 -( 1 -methyl - 1 H-pyrazol -4 -yl)cinnolin-3 -yl) - 1 -(( 1 -(trifluoromethyl)cyclopropyl)methyl)

piperidine-4-carboxamide [1881];

(S)- 1 -(2-fluoropropyl)-N-(6-( 1 -methyl-lH-pyrazol-4-yl)cinnolin-3 -yl)piperidine -4 -carboxamide

[1882]; (R)-l-(2-fluoropropyl)-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)piperidine-4-carboxamide

[1883];

N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-2-(piperidin-l-yl)propanamide [1884];

N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-l-(methylsulfonyl)piperidine-4 -carboxamide

[1885];

1 '-methyl -N-(6-( 1 -methyl- lH-pyrazol-4-yl)cinnolin-3 -yl)-[ 1 ,4'-bipiperidine] -4-carboxamide

[1886];

fr «5-4-(hydroxymethyl)-N-(6-( 1 -methyl- lH-pyrazol-4-yl)cinnolin-3 -yl)cyclohexane- 1 - carboxamide [1887];

methyl 2-(4-((6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)carbamoyl)piperidin-l-yl)acetate

[1888];

1 -benzyl -N-(6 -( 1 -methyl - 1 H-pyrazol -4 -yl)cinnolin-3 -yl)piperidine -4 -carboxamide [ 1889] ;

N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-l-(2-(pyrrolidin-l-yl)acetyl)piperidine-4- carboxamide [1890];

N-(6 -( 1 -methyl - 1 H-pyrazol -4 -yl)cinnolin-3 -yl)-2-morpholinoacetamide [1891];

(S)-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-2-(3-methylmo holino)acetamide [1892]; (R)-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-2-(3-methylmo holino)acetamide [1893]; (S)-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-2-(2-methylmo holino)acetamide [1894]; 2-((2R,6S)-2,6-dimethylmoφholino)-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)acetamide

[1895];

2-((lS,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3- yl)acetamide [1896];

2-((lR,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3- yl)acetamide [1897];

2-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)acetamide

[1898];

(S)-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-2-moφholinopropanamide [1899];

N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-2-(moφholin-2-yl)acetamide [1900];

N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-2-(4-methylmoφholin-2-yl)acetamide [1901]; 2-(4-ethylpiperazin-l-yl)-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)acetamide [1902];

2-(4-isopropylpiperazin-l -yl)-N-(6-( 1 -methyl- lH-pyrazol-4-yl)cinnolin-3 -yl)acetamide [1903] ; 2-(4-cyclopropylpiperazin- 1 -yl)-N-(6-( 1 -methyl-lH-pyrazol-4-yl)cinnolin-3 -yl)acetamide [1904] ; 2-(4-(2-fluoroethyl)piperazin- 1 -yl)-N-(6-( 1 -methyl-lH-pyrazol-4-yl)cinnolin-3 -yl)acetamide

[1905]; (S)-2-(2,4-dimethylpiperazin-l-yl)-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)acetamide

[1906];

1 -(2-hydroxyethyl)-N-(6-( 1 -methyl- lH-pyrazol-4-yl)cinnolin-3 -yl)piperidine-4-carboxamide

[1907];

N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-l-(pyridin-2-ylmethyl)piperidine-4-carboxamide

[1908];

N-(6-( 1 -methyl -IH-pyrazol -4 -yl)cinnolin-3 -yl)- 1 -(oxazol-2-ylmethyl)piperidine-4-carboxamide

[1909];

(R)-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-l-oxotetrahydro-lH-pyrrolo[l,2-c]imidazole-

2(3H)-carboxamide [1910];

(R)-l -methyl -N-(6-( 1 -methyl- lH-pyrazol-4-yl)cinnolin-3 -yl)pyrrolidine-2-carboxamide [1911]; N-(6 -( 1 -methyl - 1 H-pyrazol -4 -yl)cinnolin-3 -yl) - 1 -(tetrahydro -2H-pyran-4 -yl)piperidine -4 - carboxamide [1912];

N-(6 -( 1 -methyl - 1 H-pyrazol -4 -yl)cinnolin-3 -yl) - 1 -(pyrimidin-2-ylmethyl)piperidine -4- carboxamide [1913];

N-(6-( 1 -methyl -1 H-pyrazol -4 -yl)cinnolin-3 -yl)- 1 -(pyrazin-2-ylmethyl)piperidine-4-carboxamide

[1914];

1 -((5 -methyl- 1 ,2,4-oxadiazol-3-yl)methyl)-N-(6-( 1 -methyl- lH-pyrazol-4-yl)cinnolin-3 -yl)

piperidine-4-carboxamide [1915];

1- (2-hydroxy-2-methylpropyl)-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)piperidine-4- carboxamide [1916];

tert-butyl 2-(4-((6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)carbamoyl)piperidin-l-yl)acetate

[1917];

2- (4-((6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)carbamoyl)piperidin-l-yl)acetic acid [1918]; 2-(4-methyl-l,4-diazepan-l-yl)-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)acetamide [1919]; tert-butyl (6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)carbamate [1920];

N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)but-2-ynamide [1921];

fr «5-4-((6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)carbamoyl)cyclohexane-l-carboxylic acid

[1922];

N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-3-moφholinopropanamide [1923];

trans-N-(6-( 1 -methyl -1 H-pyrazol -4 -yl)cinnolin-3 -yl)-3 -mo holinocyclobutane- 1 -carboxamide

[1924];

N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)quinuclidine-4-carboxamide [1925];

l-isobutyl-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)azepane-4-carboxamide [1926]; 2-(4-methoxypiperidin- 1 -yl)-N-(6-( 1 -methyl- lH-pyrazol-4-yl)cinnolin-3 -yl)acetamide [1927] ;

2- (4-hydroxypiperidin-l-yl)-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)acetamide [1928];

3- (hydroxymethyl)-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)bicyclo[l . l . l]pentane-l- carboxamide [1929];

1 -methyl -N-(6-( 1 -methyl-lH-pyrazol-4-yl)cinnolin-3 -yl)azepane-4-carboxamide [1930] ;

trans -4 -(dimethylamino) -N-(6 -( 1 -methyl - 1 H-pyrazol-4 -yl)cinnolin-3 -yl)cyclohexane - 1 - carboxamide [1931];

fr «5-4-(bis(methyl-d3)amino)-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)cyclohexane-l- carboxamide [1932];

N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-3-((4-methylpiperazin-l-yl)methyl)bicyclo[ 1.1.1] pentane-1 -carboxamide [1933];

methyl fr «5-4-((6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)carbamoyl)cyclohexane-l- carboxylate [1934];

2-(l-isobutylpyrrolidin-3-yl)-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)acetamide [1935]; fr «5-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-4-(4-methylpiperazine-l-carbonyl)

cyclohexane-1 -carboxamide [1936];

1 -isobutyl-N-(6-( 1 -methyl- lH-pyrazol-4-yl)cinnolin-3 -yl)piperidine-4-carboxamide [1937] ; N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-l-(phenylsulfonyl)piperidine-4-carboxamide

[1938];

8 -methyl -N-(6 -( 1 -methyl - 1 H-pyrazol -4 -yl)cinnolin-3 -yl) -3 , 8 -diazabicyclo [3.2.1] octane -3 - carboxamide [1939];

3 -methyl -N-(6 -( 1 -methyl - 1 H-pyrazol -4 -yl)cinnolin-3 -yl) -3 , 8 -diazabicyclo [3.2.1] octane -8 - carboxamide [1940];

(lR,3s,5S)-3-amino-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-8-azabicyclo[3.2.1]octane-8- carboxamide [1941];

(lR,3s,5S)-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-3-((3,3,3-trifluoropropyl)amino)-8- azabicyclo[3.2.1] octane -8 -carboxamide [1942];

(lR,3s,5S)-3-((l,3-difluoropropan-2-yl)amino)-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-8- azabicyclo[3.2.1] octane -8 -carboxamide [1943];

N-(6 -( 1 -methyl - 1 H-pyrazol -4 -yl)cinnolin-3 -yl)mo holine -4-carboxamide [1944];

4- (dimethylamino) -N-(6-( 1 -methyl - 1 H-pyrazol -4 -yl)cinnolin-3 -yl)piperidine - 1 -carboxamide

[1945];

(S)-2,4-dimethyl-N-(6-( 1 -methyl- lH-pyrazol-4-yl)cinnolin-3 -yl)piperazine- 1 -carboxamide

[1946]; 1 -methyl -3 -(6 -( 1 -methyl - 1 H-pyrazol -4 -yl)cinnolin-3 -yl) - 1 -( 1 -methylpiperidin-4 -yl)urea [1947]; 1 -(6-( 1 -methyl-lH-pyrazol-4-yl)cinnolin-3 -yl)-3 -( 1 -methylpiperidin-4-yl)urea [1948] ;

4-isopropyl-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)piperazine-l -carboxamide [1949]; (R)-3 ,4-dimethyl-N-(6-( 1 -methyl- lH-pyrazol-4-yl)cinnolin-3 -yl)piperazine- 1 -carboxamide

[1950];

N-(6-(lH-pyrazol-4-yl)cinnolin-3-yl)-2-(4-methylpiperazin-l-yl)isonicotinamide [1951];

N-(6 -( 1 -methyl - 1 H-pyrazol -4 -yl)cinnolin-3 -yl) -3 -(piperazin- 1 -yl)benzamide [ 1952] ;

N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-3-(4-methylpiperazin-l-yl)benzamide [1953]; N-(6-( 1 -methyl-lH-pyrazol-4-yl)cinnolin-3 -yl)-3 -(pyrrolidin- 1 -ylmethyl)benzamide [1954] ; N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-3-(piperidin-4-yloxy)benzamide [1955];

N-(6-( 1 -methyl- lH-pyrazol-4-yl)cinnolin-3 -yl)-3 -(( 1 -methylpiperidin-4-yl)oxy)benzamide

[1956];

N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-4-(piperidin-4-yloxy)benzamide [1957];

N-(6-( 1 -methyl -1 H-pyrazol -4 -yl)cinnolin-3 -yl)-4-(( 1 -methylpiperidin-4-yl)oxy)benzamide

[1958];

N-(6 -( 1 -methyl - 1 H-pyrazol -4 -yl)cinnolin-3 -yl) -2 -(piperazin- 1 -yl)isonicotinamide [1959];

N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-2-(4-methylpiperazin-l-yl)isonicotinamide

[I960];

2-(4-isopropylpiperazin-l -yl)-N-(6-( 1 -methyl- lH-pyrazol-4-yl)cinnolin-3 -yl)isonicotinamide

[1961];

2-(4-cyclopropylpiperazin- 1 -yl)-N-(6-( 1 -methyl-lH-pyrazol-4-yl)cinnolin-3 -yl)isonicotinamide

[1962];

2-(4-(2-fluoroethyl)piperazin- 1 -yl)-N-(6-( 1 -methyl-lH-pyrazol-4-yl)cinnolin-3 -yl)

isonicotinamide [1963];

N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-6-(4-methylpiperazin-l-yl)nicotinamide [1964]; N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-5-(piperidin-4-yloxy)nicotinamide [1965];

N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-2-(piperidin-4-yloxy)isonicotinamide [1966]; N-(6-( 1 -methyl -1 H-pyrazol -4 -yl)cinnolin-3 -yl)-2-(( 1 -methylpiperidin-4-yl)oxy)isonicotinamide

[1967];

N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-5-(piperidin-4-ylamino)nicotinamide [1968]; N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-5-((l-methylpiperidin-4-yl)amino)nicotinamide

[1969];

2-(4-aminopiperidin-l-yl)-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)isonicotinamide [1970]; N-(6 -( 1 -methyl - 1 H-pyrazol -4 -yl)cinnolin-3 -yl)-2-(4 -(methylamino)piperidin- 1 -yl)

isonicotinamide [1971];

2-(4-(dimethylamino)piperidin-l -yl)-N-(6-( 1 -methyl- lH-pyrazol-4-yl)cinnolin-3 -yl)

isonicotinamide [1972];

2-(( 1 -isopropylpiperidin-4-yl)oxy)-N-(6-( 1 -methyl- lH-pyrazol-4-yl)cinnolin-3-yl)

isonicotinamide [1973];

2-(3 -aminoazetidin- 1 -yl)-N-(6-( 1 -methyl -1 H-pyrazol -4 -yl)cinnolin-3 -yl)isonicotinamide [1974] ; 2-(3 -(dimethylamino)azetidin- 1 -yl)-N-(6-( 1 -methyl- lH-pyrazol-4-yl)cinnolin-3-yl)

isonicotinamide [1975];

N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-2-moφholinoisonicotinamide [1976];

2-((2-(dimethylamino)ethyl)amino)-N-(6-( 1 -methyl- lH-pyrazol-4-yl)cinnolin-3 -yl)

isonicotinamide [1977];

2-(2-(dimethylamino)ethoxy)-N-(6-( 1 -methyl- lH-pyrazol-4-yl)cinnolin-3 -yl)isonicotinamide

[1978];

2-(4-isobutylpiperazin-l-yl)-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)isonicotinamide

[1979];

2-(azetidin-3 -yloxy)-N-(6-( 1 -methyl- lH-pyrazol-4-yl)cinnolin -3 -yl)isonicotinamide [1980] ; N-(6-( 1 -methyl -1 H-pyrazol -4 -yl)cinnolin-3 -yl)-2-(( 1 -methylazetidin-3 -yl)oxy)isonicotinamide

[1981];

2-(4-ethylpiperazin-l-yl)-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)isonicotinamide [1982]; 4-((dimethylamino)methyl)-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)benzamide [1983]; N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-3-(l-methylpiperidin-4-yl)benzamide [1984]; N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-3-((4-methylpiperazin-l-yl)methyl)benzamide

[1985];

N-(6 -( 1 -methyl - 1 H-pyrazol -4 -yl)cinnolin-3 -yl)isonicotinamide [ 1986] ;

2-hydroxy-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)isonicotinamide [1987];

2-isopropoxy-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)isonicotinamide [1988];

N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-2-(l-methylpiperidin-4-yl)isonicotinamide

[1989];

r-methyl-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-l',2',3',6'-tetrahydro-[2,4'-bipyridine]-

4-carboxamide [1990];

N-(6 -( 1 -methyl - 1 H-pyrazol -4 -yl)cinnolin-3 -yl) -2 -(4-(6 -(4-methylpiperazin- 1 -yl)

nicotinoyl)piperazin- 1 -yl)isonicotinamide [1991] ; 2-(4-hydroxy-4-methyl-4 ⁴-piperazin-l-yl)-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl) isonicotinamide [1992];

2-methyl -N-(6 -( 1 -methyl - 1 H-pyrazol -4 -yl)cinnolin-3 -yl) -6 -(4-methylpiperazin- 1 -yl)

isonicotinamide [1993];

3 -methyl -N-(6 -( 1 -methyl - 1 H-pyrazol -4 -yl)cinnolin-3 -yl) -2 -(4-methylpiperazin- 1 -yl)

isonicotinamide [1994];

2-(4-methyl- 1 ,4-diazepan- 1 -yl)-N-(6-( 1 -methyl-lH-pyrazol-4-yl)cinnolin-3-yl)isonicotinamide

[1995];

2-((2S,6R)-2,6-dimethylmo holino)-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)

isonicotinamide [1996];

N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-2-(2,7-diazaspiro[3.5]nonan-2-yl)isonicotinamide

[1997];

N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-2-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl) isonicotinamide [1998];

N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-2-(2,7-diazaspiro[3.5]nonan-7-yl)isonicotinamide

[1999];

N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-2-(2-methyl-2,7-diazaspiro[3.5]nonan-7-yl) isonicotinamide [2000];

2-(methyl( 1 -methylpiperidin-4-yl)amino)-N-(6-( 1 -methyl- lH-pyrazol-4-yl)cinnolin-3-yl)

isonicotinamide [2001];

N-(6-( 1 -methyl -1 H-pyrazol -4 -yl)cinnolin-3 -yl)-2-(( 1 -methylpiperidin-4-yl)thio)isonicotinamide

[2002];

N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-2-(4-methylpiperazin-l-yl)pyrimidine-4- carboxamide [2003];

N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-6-(4-methylpiperazin-l-yl)pyridazine-4- carboxamide [2004];

N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-6-(4-methylpiperazin-l-yl)pyrimidine-4- carboxamide [2005];

N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-2-phenylacetamide [2006];

N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-3-phenylpropanamide [2007];

N-(6 -( 1 -methyl - 1 H-pyrazol -4 -yl)cinnolin-3 -yl) -2 -(pyridin-3 -yl)acetamide [2008] ;

N-(6 -( 1 -methyl - 1 H-pyrazol -4 -yl)cinnolin-3 -yl) -3 -(pyridin-3 -yl)propanamide [2009] ;

N-(6 -( 1 -methyl - 1 H-pyrazol -4 -yl)cinnolin-3 -yl) -2 -(pyridin-4-yl)acetamide [2010];

N-(6 -( 1 -methyl - 1 H-pyrazol -4 -yl)cinnolin-3 -yl) -3 -(pyridin-4-yl)propanamide [2011]; N-(6 -( 1 -methyl - 1 H-pyrazol -4 -yl)cinnolin-3 -yl)isoindoline -5 -carboxamide [2012] ;

2-methyl-N-(6 -( 1 -methyl - 1 H-pyrazol -4 -yl)cinnolin-3 -yl)isoindoline -5 -carboxamide [2013]; N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-l,2,3,4-tetrahydroisoquinoline-7-carboxamide

[2014];

2-methyl-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-l,2,3,4-tetrahydroisoquinoline-7- carboxamide [2015];

2-methyl-N-(6 -( 1 -methyl - 1 H-pyrazol -4 -yl)cinnolin-3 -yl) - 1 ,2, 3 ,4 -tetrahydroisoquinoline -6 - carboxamide [2016];

N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-l,2,3,4-tetrahydroisoquinoline-6-carboxamide

[2017];

N-(6 ■( 1 -methyl - 1 H-pyrazol -4 -y ll))cinnolin-3 -yl) - 1 H-indole -5 -carboxamide [2018];

N-(6■(l-methyl-lH-pyrazol-4-yll))cinnolin-3-yl)benzofuran-5 -carboxamide [2019];

N-(6■( 1 -methyl - 1 H-pyrazol -4 -y ll))cinnolin-3-yl)furo[2,3-c]pyridine-5-carboxamide [2020]; N-(6■(l-methyl-lH-pyrazol-4-yll))cinnolin-3 -yl)benzo [b]thiophene-5 -carboxamide [2021 ] ; N-(6■(l-methyl-lH-pyrazol-4-yll))cinnolin-3-yl)benzofuran-6-carboxamide [2022];

N-(6■(l-methyl-lH-pyrazol-4-yll))cinnolin-3 -yl)benzo [d] oxazole -6-carboxamide [2023] ; N-(6■( 1 -methyl - 1 H-pyrazol -4 -y ll))cinnolin-3-yl)benzo[d]thiazole-6-carboxamide [2024]; N-(6■(l-methyl-lH-pyrazol-4-yll))cinnolin-3 -yl)benzo [d] oxazole -5 -carboxamide [2025] ; N-(6■( 1 -methyl - 1 H-pyrazol -4 -y ll))cinnolin-3-yl)benzo[d]thiazole-5-carboxamide [2026]; N-(6■( 1 -methyl - 1 H-pyrazol -4 -y ll))cinnolin-3 -yl)quinoline-3 -carboxamide [2027] ;

N-(6■( 1 -methyl - 1 H-pyrazol -4 -y ll))cinnolin-3 -yl)quinoline -6 -carboxamide [2028] ;

N-(6■( 1 -methyl - 1 H-pyrazol -4 -y ll))cinnolin-3 -yl)quinoxaline-6-carboxamide [2029] ;

5-chloro-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [2030];

3-chloro-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [2031];

2- (2,5-diazabicyclo[2.2.1]heptan-2-yl)-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)

isonicotinamide [2032];

N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-2-(5-methyl-2,5-diazabicyclo[2.2.1]heptan-2- yl)isonicotinamide [2033];

3- fluoro-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [2034];

N-(6-( 1 -methyl -1 H-pyrazol -4 -yl)cinnolin-3 -yl)-2-((4-methylpiperazin- 1 -yl)methyl)

isonicotinamide [2035]; N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-2-(mo holinomethyl)isonicotinamide [2036]; N-(6-( 1 -methyl-lH-pyrazol-4-yl)cinnolin-3 -yl)-2-(pyrrolidin- 1 -ylmethyl)isonicotinamide [2037] ; N-(6-( 1 -methyl -1 H-pyrazol -4 -yl)cinnolin-3 -yl)-2-(2-(4-methylpiperazin- 1 -yl)pyridin-4-yl)

acetamide [2038];

1 -methyl -N-(6-( 1 -methyl -1 H-pyrazol -4 -yl)cinnolin-3 -yl)- lH-indazole -5 -carboxamide [2039] ; 1 -methyl -N-(6 -( 1 -methyl - 1 H-pyrazol -4 -yl)cinnolin-3 -yl)- 1 H-benzo [d] imidazole -5 -carboxamide

[2040];

N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-l-(piperidin-4-yl)-lH-pyrazole-4 -carboxamide

[2041];

N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-l-(l-methylpiperidin-4-yl)-lH-pyrazole-4- carboxamide [2042];

1 -( 1 -ethylpiperidin-4-yl)-N-(6-( 1 -methyl- lH-pyrazol-4-yl)cinnolin-3-yl)- lH-pyrazole-4- carboxamide [2043];

1 -( 1 -(2-fluoroethyl)piperidin-4-yl)-N-(6-( 1 -methyl-lH-pyrazol-4-yl)cinnolin-3 -yl)- lH-pyrazole- 4-carboxamide [2044];

1 -( 1 -isopropylpiperidin-4-yl)-N-(6-( 1 -methyl- lH-pyrazol-4-yl)cinnolin-3 -yl)- lH-pyrazole-4- carboxamide [2045];

l-(l-cyclopropylpiperidin-4-yl)-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-lH-pyrazole-4- carboxamide [2046];

isopropyl 4-(4-((6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)carbamoyl)-lH-pyrazol-l-yl) piperidine-l-carboxylate [2047];

N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-l-(piperidin-4-yl)-lH-l,2,3-triazole-4- carboxamide [2048];

N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-l-(l-methylpiperidin-4-yl)-lH-l,2,3-triazole-4- carboxamide [2049];

1- (l-(2-fluoroethyl)piperidin-4-yl)-N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-lH-l,2,3- triazole -4 -carboxamide [2050];

1 -( 1 -isopropylpiperidin-4-yl)-N-(6-( 1 -methyl- lH-pyrazol-4-yl)cinnolin-3 -yl)- 1H- 1 ,2,3 -triazole-4- carboxamide [2051];

N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-2-(4-methylpiperazin-l-yl)oxazole-5- carboxamide [2052];

2- (3 -(dimethylamino)azetidin- 1 -yl)-N-(6-( 1 -methyl- lH-pyrazol-4-yl)cinnolin-3-yl)oxazole-4- carboxamide [2053];

N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-2-(piperidin-4-yl)oxazole-4-carboxamide [2054]; N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-2-(l-methylpiperidin-4-yl)oxazole-4- carboxamide [2055];

2-( 1 -(2-fluoroethyl)piperidin-4-yl)-N-(6-( 1 -methyl-lH-pyrazol-4-yl)cinnolin-3 -yl)oxazole-4- carboxamide [2056];

2-( 1 -isopropylpiperidin-4-yl)-N-(6-( 1 -methyl- lH-pyrazol-4-yl)cinnolin-3 -yl)oxazole-4- carboxamide [2057];

N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-2-(4-methylpiperazin-l-yl)oxazole-4- carboxamide [2058];

2-(3 -(dimethylamino)azetidin- 1 -yl)-N-(6-( 1 -methyl- lH-pyrazol-4-yl)cinnolin-3-yl)thiazole-5- carboxamide [2059];

N-(6 -( 1 -methyl - 1 H-pyrazol -4 -yl)cinnolin-3 -yl) -2 -(piperidin-4-yl)thiazole -4 -carboxamide [2060] ; N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-2-(4-methylpiperazin-l-yl)thiazole-4- carboxamide [2061];

2-( 1 -(2-fluoroethyl)piperidin-4-yl)-N-(6-( 1 -methyl-lH-pyrazol-4-yl)cinnolin-3 -yl)thiazole-4- carboxamide [2062];

2-( 1 -isopropylpiperidin-4-yl)-N-(6-( 1 -methyl- lH-pyrazol-4-yl)cinnolin-3 -yl)thiazole-4- carboxamide [2063];

1 -methyl -N-(6 -( 1 -methyl - 1 H-pyrazol -4 -yl)cinnolin-3 -yl -4 - )piperidine-4-carboxamide [2064] ; N-(6-( l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-l-(2 -(methyl -d3)propyl-l, 1,2,3, 3,3-£¾;)piperidine- 4-carboxamide [2065];

N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-2-(pyrrolidin-l-yl-2,2,5,5-£/4)acetamide [2066]; N-(6-( 1 -methyl -1 H-pyrazol -4 -yl)cinnolin-3 -yl)-2-(4-(methyl-<i3)piperazin- 1 -yl)acetamide [2067] ; N-(6-(l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-2-(mo holino-ί s)acetamide [2068];

( S) -N-(6 -( 1 -(methyl -ds)-\ H-pyrazol -4 -yl)cinnolin-3 -yl)-2-(pyrrolidin- 1 -yl)propanamide [2069] ; l-isobutyl-N-(6-(l-(methyl-£/3)-lH-pyrazol-4-yl)cinnolin-3-yl)piperidine-4-carboxamide [2070]; N-(6-( 1 -(methyl -<¾)- lH-pyrazol-4-yl)cinnolin-3 -yl)-2-(4-methylpiperazin-l -yl)acetamide [2071] ; N-(6-( 1 -(methyl -<¾)- lH-pyrazol-4-yl)cinnolin-3 -yl)-2-(pyrrolidin- 1 -yl)acetamide [2072] ;

N-(6-( 1 -(methyl -<¾)- lH-pyrazol-4-yl)cinnolin-3-yl)-2-(piperidin- 1 -yl)acetamide [2073] ;

N-(6-( 1 -(methyl -ds)- lH-pyrazol-4-yl)cinnolin-3 -yl)- 1 -(3,3, 3-trifluoropropyl)piperidine-4- carboxamide [2074];

N-(6-(lH-pyrazol-4-yl)cinnolin-3-yl)-2-(4-(methyl-£/3)piperazin-l-yl)isonicotinamide [2075]; N-(6-( 1 -methyl -1 H-pyrazol -4 -yl)cinnolin-3 -yl)-2-(4-(methyl-<i3)piperazin- 1 -yl)isonicotinamide

[2076]; N-(6-( 1 -(methyl -<¾)- lH-pyrazol-4-yl)cinnolin-3 -yl)-2-(4-methylpiperazin- 1 -yl)isonicotinamide

[2077];

N-(6-( 1 -(methyl - 3)- lH-pyrazol-4-yl)cinnolin-3 -yl)-2-(4-(methyl-£/3)piperazin- 1 -yl)

isonicotinamide [2078];

N-(6-(l-(methyl-£/3)-lH-pyrazol-4-yl)cinnolin-3-yl)-l-(piperidin-4-yl)-lH-pyrazole-4- carboxamide [2079];

N-(6-( 1 -(methyl -<¾)- lH-pyrazol-4-yl)cinnolin-3 -yl)- 1 -( 1 -methylpiperidin-4-yl)- lH-pyrazole-4- carboxamide [2080];

N-(6-( 1 -(methyl - 3)- lH-pyrazol-4-yl)cinnolin-3 -yl)-2-(piperidin-4-yl)oxazole-4-carboxamide

[2081];

N-(6-( 1 -(methyl -<¾)- lH-pyrazol-4-yl)cinnolin-3 -yl)-2-( 1 -methylpiperidin-4-yl)oxazole-4- carboxamide [2082];

N-(6-( 1 -ethyl- lH-pyrazol-4-yl)cinnolin-3-yl)-2-(pyrrolidin- 1 -yl)acetamide [2083] ;

N-(6-(l-cyclopropyl-lH-pyrazol-4-yl)cinnolin-3-yl)-2-(pyrrolidin-l-yl)acetamide [2084];

N-(6-(l-cyclopropyl-lH-pyrazol-4-yl)cinnolin-3-yl)-l-(3,3,3-trifluoropropyl)piperidine-4- carboxamide [2085];

N-(6-( 1 -( 1 -methylpiperidin-4-yl)- lH-pyrazol-4-yl)cinnolin-3-yl)cyclohexanecarboxamide [2086] ; 2-(pyrrolidin-l-yl)-N-(6-(5-(trifluoromethyl)-lH-pyrazol-4-yl)cinnolin-3-yl)acetamide [2087]; N-(6-(5-(hydroxymethyl)-l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-l-methylpiperidine-4- carboxamide [2088];

N-(6-(5-(hydroxymethyl)-l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)tetrahydro-2H-pyran-4- carboxamide [2089];

N-(6-(5-(azetidin-l-ylmethyl)-l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-4,4-difluorocyclohexane-

1-carboxamide [2090];

4,4-difluoro-N-(6-(l-methyl-5-(pyrrolidin-l-ylmethyl)-lH-pyrazol-4-yl)cinnolin-3-yl)

cyclohexane-l-carboxamide [2091];

4,4-difluoro-N-(6-(l-methyl-5-(piperidin-l-ylmethyl)-lH-pyrazol-4-yl)cinnolin-3-yl)

cyclohexane-l-carboxamide [2092];

2-(2 -fluoroethyl) -N-(6 -( 1 -methyl -5 -(piperidin- 1 -ylmethyl) - 1 H-pyrazol -4 -yl)cinnolin-3 -yl) -2 - azaspiro [3.3] heptane -6 -carboxamide [2093] ;

fert-butyl 6-((6 -( 1 -methyl -5 -(piperidin- 1 -ylmethyl) - 1 H-pyrazol -4 -yl)cinnolin-3 -yl)carbamoyl) -2 - azaspiro [3.3] heptane -2 -carboxylate [2094] ;

2-fluoro-2-methyl-N-(6-(l-methyl-5-(piperidin-l-ylmethyl)-lH-pyrazol-4-yl)cinnolin-3-yl)

propanamide [2095]; 2-(diethylamino)-N-(6-( 1 -methyl-5 -(piperidin- 1 -ylmethyl)-lH-pyrazol-4-yl)cinnolin-3 -yl) acetamide [2096];

fr «5-4-methoxy-N-(6-(l-methyl-5-(piperidin-l-ylmethyl)-lH-pyrazol-4-yl)cinnolin-3-yl)

cyclohexane-l-carboxamide [2097];

fra«s-4-(hydroxymethyl)-N-(6-( 1 -methyl-5 -(piperidin- 1 -ylmethyl)- lH-pyrazol-4-yl)cinnolin-3- yl)cyclohexane - 1 -carboxamide [2098] ;

(R)-N-(6-(l-methyl-5-(piperidin-l-ylmethyl)-lH-pyrazol-4-yl)cinnolin-3-yl)pyrrolidine-2- carboxamide [2099];

l-isobutyl-N-(6-(l-methyl-5-(piperidin-l-ylmethyl)-lH-pyrazol-4-yl)cinnolin-3-yl)piperidine-4- carboxamide [2100];

N-(6-( 1 -methyl-5 -(piperidin- 1 -ylmethyl)- lH-pyrazol-4-yl)cinnolin-3-yl)- 1 -(oxetan-3 -yl)

piperidine-4-carboxamide [2101];

l-benzoyl-N-(6-(l-methyl-5-(piperidin-l-ylmethyl)-lH-pyrazol-4-yl)cinnolin-3-yl)piperidine-4- carboxamide [2102];

N-(6-( 1 -methyl-5 -(piperidin- 1 -ylmethyl)- lH-pyrazol-4-yl)cinnolin-3-yl)tetrahydro-2H-pyran-4- carboxamide [2103];

N-(6-( 1 -methyl-5 -(piperidin- 1 -ylmethyl)- lH-pyrazol-4-yl)cinnolin-3-yl)-2-(4-methylpiperidin- 1 - yl)acetamide [2104];

N-(6-( 1 -(difluoromethyl)- lH-pyrazol-4-yl)cinnolin-3-yl)-2-(4-methylpiperazin- 1 -yl)

isonicotinamide [2105];

N-(6-( 1 -ethyl- lH-pyrazol-4-yl)cinnolin-3 -yl)-2-(4-methylpiperazin- 1 -yl)isonicotinamide [2106] ; N-(6-(l-isopropyl-lH-pyrazol-4-yl)cinnolin-3-yl)-3-(piperidin-4-yloxy)benzamide [2107]; N-(6-(l-isopropyl-lH-pyrazol-4-yl)cinnolin-3-yl)-3-((l-methylpiperidin-4-yl)oxy)benzamide

[2108];

N-(6-(l-isopropyl-lH-pyrazol-4-yl)cinnolin-3-yl)-4-(piperidin-4-yloxy)benzamide [2109]; N-(6-(l-cyclopropyl-lH-pyrazol-4-yl)cinnolin-3-yl)-2-(4-methylpiperazin-l-yl)isonicotinamide

[2110];

4-fluoro-N-(6-( 1 -( 1 -methylpiperidin-4-yl)- lH-pyrazol-4-yl)cinnolin-3-yl)benzamide [2111];

4- (difluoromethoxy)-N-(6-( 1 -( 1 -methylpiperidin-4-yl)- lH-pyrazol-4-yl)cinnolin-3-yl)benzamide

[2112];

5- fluoro-N-(6-( 1 -( 1 -methylpiperidin-4-yl)- lH-pyrazol-4-yl)cinnolin-3-yl)nicotinamide [2113]; N² -methyl -N⁵-(6-(l-(l-methylpiperidin-4-yl)-lH-pyrazol-4-yl)cinnolin-3-yl)pyridine-2,5- dicarboxamide [2114]; 1- isopropyl-N-(6-(l-(l-methylpiperidin-4-yl)-lH-pyrazol-4-yl)cinnolin-3-yl)-lH-pyrazole-4- carboxamide [2115];

2- methyl-N-(6-( 1 -( 1 -methylpiperidin-4-yl)- lH-pyrazol-4-yl)cinnolin-3 -yl)thiazole-5 - carboxamide [2116];

N-(6-(5 -amino- 1 -methyl- lH-pyrazol-4-yl)cinnolin-3-yl)-2-(4-methylpiperazin- 1 -yl)

isonicotinamide [2117];

4-(difluoromethoxy)-N-(6-(5-(hydroxymethyl)-l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl) benzamide [2118];

N-(6-(5-(hydroxymethyl)-l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-2-(4-methylpiperazin-l-yl) isonicotinamide [2119];

N-(6-(5-(hydroxymethyl)-l-methyl-lH-pyrazol-4-yl)cinnolin-3-yl)-2-(7-methyl-2,7-diazaspiro

[3.5]nonan-2-yl)isonicotinamide [2120];

4-fluoro-N-(6-(l -methyl -5-(pyrrolidin-l-ylmethyl)-lH-pyrazol-4-yl)cinnolin-3-yl)benzamide

[2121];

4-fluoro-N-(6-(l-methyl-5-(piperidin-l-ylmethyl)-lH-pyrazol-4-yl)cinnolin-3-yl)benzamide

[2122];

4-(difluoromethoxy)-N-(6-(l-methyl-5-(piperidin-l-ylmethyl)-lH-pyrazol-4-yl)cinnolin-3- yl)benzamide [2123];

N-(6-( 1 -methyl -5 -(piperidin- 1 -ylmethyl)- lH-pyrazol-4-yl)cinnolin-3-yl)-3-(pyrrolidin- 1 - ylmethyl)benzamide [2124];

N-(6-( 1 -methyl -5 -(piperidin- 1 -ylmethyl)- lH-pyrazol-4-yl)cinnolin-3-yl)-2-(7-methyl -2,7- diazaspiro[3.5]nonan-2-yl)isonicotinamide [2125] ;

N-(6-( 1 -methyl -5 -(piperidin- 1 -ylmethyl)- lH-pyrazol-4-yl)cinnolin-3-yl)-2- moφholinoisonicotinamide [2126];

N-(6-( 1 -methyl -5 -(morpholinomethyl)- lH-pyrazol-4-yl)cinnolin-3 -yl)-2- moφholinoisonicotinamide [2127];

N-(6-(4,5,6,7-tetrahydropyrazolo[l,5-a]pyrazin-3-yl)cinnolin-3-yl)-l-((l-(trifluoromethyl) cyclopropyl)methyl)piperidine-4-carboxamide [2128] ;

3 ,3 -difluoro-N-(6-(5 -methyl-4,5 ,6,7-tetrahydropyrazolo [ 1 ,5 -a]pyrazin-3 -yl)cinnolin-3 - yl)cyclobutane - 1 -carboxamide [2129];

N-((4,4-difluorocyclohexyl)methyl)-6-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[l,5- a]pyrazin-3 -yl)cinnolin-3 -amine [2130];

N-(6-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[l,5-a]pyrazin-3-yl)cinnolin-3-yl)-l-((l-

(trifluoromethyl)cyclopropyl)methyl)piperidine -4 -carboxamide [2131]; N-(6-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[l,5-a]pyrazin-3-yl)cinnolin-3-yl)-2-

(pyrrolidin- 1 -yl)acetamide [2132] ;

2-(7-azabicyclo[2.2.1]heptan-7-yl)-N-(6-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[ l,5- a]pyrazin-3 -yl)cinnolin-3 -yl)acetamide [2133];

(R)-N-(6-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[ l,5-a]pyrazin-3-yl)cinnolin-3-yl)-l - isobutylpiperidine-3 -carboxamide [2134] ;

N-(6-(5-(2-fluoroethyl)-4,5,6j etrahydropyrazolo[l,5-a]pyrazin-3-yl)cinnolin-3-yl)piperidine-4- carboxamide [2135];

4-fluoro-N-(6-(5-(2-fluoroethyl)-4,5,6j etrahydropyrazolo[ l,5-a]pyrazin-3-yl)cinnolin-3-yl)-l - isobutylpiperidine-4-carboxamide [2136] ;

N-(6-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[l,5-a]pyrazin-3-yl)cinnolin-3-yl)-2-(4- methylpiperazin- 1 -yl)acetamide [2137] ;

4-fluoro-N-(6-(4,5,6,7-tetrahydropyrazolo[l,5-a]pyrazin-3-yl)cinnolin-3-yl)benzamide [2138]; N-(6-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[l,5-a]pyrazin-3-yl)cinnolin-3-yl)-3-(4- methylpiperazin- 1 -yl)benzamide [2139];

N⁵-(6-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[l,5-a]pyrazin-3-yl)cinnolin-3-yl)-N²- methylpyridine-2,5 -dicarboxamide [2140] ;

N-(6-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[l,5-a]pyrazin-3-yl)cinnolin-3-yl)-6-(4- methylpiperazin- 1 -yl)nicotinamide [2141] ;

2-(azetidin-3-yloxy)-N-(6-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[l,5-a]pyrazin-3- yl)cinnolin-3 -yl)isonicotinamide [2142] ;

N-(6 -( 1 -methyl - 1 H-pyrazol -5 -yl)cinnolin-3 -yl) - 1 -(3 ,3 , 3 -trifluoropropyl)piperidine -4 - carboxamide [2143];

1 -methyl -N-(6 -( 1 -methyl - 1 H-pyrazol -3 -yl)cinnolin-3 -yl)piperidine -4 -carboxamide [2144] ;

N-(6-( l-methyl-lH-pyrazol-3-yl)cinnolin-3-yl)-2-(4-methylpiperazin-l -yl)isonicotinamide

[2145] ;

2-fluoro-2 -methyl -N-(6-( l-methyl-lH-l,2,3-triazol-4-yl)cinnolin-3-yl)propanamide [2146]; 2,2,3, 3-tetramethyl-N-(6-(l -methyl-lH-l,2,3-triazol-4-yl)cinnolin-3-yl)cyclopropane-l - carboxamide [2147];

trans-N-(6-( 1 -methyl-lH-1 ,2,3-triazol-4-yl)cinnolin-3 -yl)-4-(pyrrolidin- 1 -yl)cyclohexane-l - carboxamide [2148];

trans-N-(6-( 1 -methyl-lH-1 ,2,3-triazol-4-yl)cinnolin-3 -yl)-4-moφholinocyclohexane- 1 - carboxamide [2149];

N-(6-( l-methyl-lH-l,2,3-triazol-4-yl)cinnolin-3-yl)-2-(piperidin-l-yl)acetamide [2150]; 1 -ethyl -4-fluoro-N-(6-( 1 -methyl- 1H- 1 ,2,3 -triazol-4-yl)cinnolin-3 -yl)piperidine-4-carboxamide [2151];

4-fluoro- 1 -isobutyl-N-(6-( 1 -methyl- 1H- 1 ,2,3-triazol-4-yl)cinnolin-3 -yl)piperidine-4-carboxamide

[2152];

N-(6-(l-methyl-lH-l,2,3-triazol-4-yl)cinnolin-3-yl)-l-(3,3,3-trifluoropropyl)piperidine-4- carboxamide [2153];

N-(6-(l-methyl-lH-l,2,3-triazol-4-yl)cinnolin-3-yl)cyclopropanecarboxamide [2154];

4,4-difluoro-N-(6-( 1 -methyl-lH-1 ,2,3 -triazol-4-yl)cinnolin-3-yl)cyclohexane- 1 -carboxamide

[2155];

trans -4 -(dimethylamino) -N-(6 -( 1 -methyl - 1 H- 1 ,2, 3 -triazol -4 -yl)cinnolin-3 -yl)cyclohexane - 1 - carboxamide [2156];

fr «5-N-(6-(l-methyl-lH-l,2,3-triazol-4-yl)cinnolin-3-yl)-4-((4-methylpiperazin-l-yl)methyl) cyclohexane-1 -carboxamide [2157];

N-(6-(l-methyl-lH-l,2,3-triazol-4-yl)cinnolin-3-yl)piperidine-4-carboxamide [2158];

1- isobutyl-N-(6-(l-methyl-lH-l,2,3-triazol-4-yl)cinnolin-3-yl)piperidine-4-carboxamide [2159]; N-(6-(l-methyl-lH-l,2,3-triazol-4-yl)cinnolin-3-yl)-l-((l-(trifluoromethyl)cyclopropyl)methyl) piperidine-4-carboxamide [2160];

N-(6-(l-methyl-lH-l,2,3-triazol-4-yl)cinnolin-3-yl)-l-((3-methyloxetan-3-yl)methyl)piperidine- 4-carboxamide [2161];

N-(6-(l-methyl-lH-l,2,3-triazol-4-yl)cinnolin-3-yl)-l-(2-(pyrrolidin-l-yl)acetyl)piperidine-4- carboxamide [2162];

1 '-methyl -N-(6-( 1 -methyl- lH-1 ,2,3 -triazol-4-yl)cinnolin-3-yl)-[ 1 ,4'-bipiperidine]-4-carboxamide

[2163];

(R)-N-(6-(l-methyl-lH-l,2,3-triazol-4-yl)cinnolin-3-yl)piperidine-3-carboxamide [2164];

(R)-l-isobutyl-N-(6-(l-methyl-lH-l,2,3-triazol-4-yl)cinnolin-3-yl)piperidine-3-carboxamide

[2165];

N-(6-(l-methyl-lH-l,2,3-triazol-4-yl)cinnolin-3-yl)-2-(pyrrolidin-l-yl)acetamide [2166];

N-(6-(l-methyl-lH-l,2,3-triazol-4-yl)cinnolin-3-yl)-2-(4-methylpiperazin-l-yl)acetamide [2167];

2- (7-azabicyclo[2.2.1]heptan-7-yl)-N-(6-(l-methyl-lH-l,2,3-triazol-4-yl)cinnolin-3-yl)acetamide

[2168];

1 -(2-hydroxy-2-methylpropyl)-N-(6-( 1 -methyl- 1H- 1 ,2,3-triazol-4-yl)cinnolin-3 -yl)piperidine-4- carboxamide [2169];

N-(6-(l-methyl-lH-l,2,3-triazol-4-yl)cinnolin-3-yl)-2-moφholinoacetamide [2170]; 2-(4-methoxypiperidin-l-yl)-N-(6-(l-methyl-lH-l,2,3 riazol-4-yl)cinnolin-3-yl)acetamide

[2171];

N-(6-(l-methyl-lH-l,2,3-triazol-4-yl)cinnolin-3-yl)mo holine-4-carboxamide [2172];

N-(6-(l-methyl-lH-l,2,3-triazol-4-yl)cinnolin-3-yl)-l-(piperidin-4-yl)-lH-pyrazole-4- carboxamide [2173];

N-(6-(l-methyl-lH-l,2,3 riazol-4-yl)cinnolin-3-yl)-l-(l-methylpiperidin-4-yl)-lH-pyrazole-4- carboxamide [2174];

1 -( 1 -ethylpiperidin-4-yl)-N-(6-( 1 -methyl- 1H- 1 ,2,3 -triazol-4-yl)cinnolin-3 -yl)-lH-pyrazole-4- carboxamide [2175];

l-(l-isopropylpiperidin-4-yl)-N-(6-(l-methyl-lH-l,2,3-triazol-4-yl)cinnolin-3-yl)-lH-pyrazole-4- carboxamide [2176];

N-(6-(l-methyl-lH-l,2,3-triazol-4-yl)cinnolin-3-yl)-l-(piperidin-4-yl)-lH-l,2,3-triazole-4- carboxamide [2177];

l-(l-(2-fluoroethyl)piperidin-4-yl)-N-(6-(l-methyl-lH-l,2,3-triazol-4-yl)cinnolin-3-yl)-lH-l,2,3- triazole -4 -carboxamide [2178] ;

1- (l-isopropylpiperidin-4-yl)-N-(6-(l-methyl-lH-l,2,3-triazol-4-yl)cinnolin-3-yl)-lH-l,2,3- triazole -4 -carboxamide [2179] ;

N-(6-(l-methyl-lH-l,2,3-triazol-4-yl)cinnolin-3-yl)-2-(piperidin-4-yl)oxazole-4 -carboxamide

[2180];

N-(6-(l-methyl-lH-l,2,3-triazol-4-yl)cinnolin-3-yl)-2-(l-methylpiperidin-4-yl)oxazole-4- carboxamide [2181];

2- (l-isopropylpiperidin-4-yl)-N-(6-(l-methyl-lH-l,2,3-triazol-4-yl)cinnolin-3-yl)oxazole-4- carboxamide [2182];

2-fluoro-N-(6-( 1 -methyl- 1H- 1 ,2,3 -triazol-4-yl)cinnolin-3-yl)benzamide [2183] ;

N-(6-( 1 -methyl-lH-1 ,2,3-triazol-4-yl)cinnolin-3 -yl)-3 -(( 1 -methylpiperidin-4-yl)oxy)benzamide

[2184];

N² -methyl -N⁵-(6-(l-methyl-lH-l,2,3-triazol-4-yl)cinnolin-3-yl)pyridine-2,5-dicarboxamide

[2185];

N-(6-(l-methyl-lH-l,2,3-triazol-4-yl)cinnolin-3-yl)-6-(4-methylpiperazin-l-yl)nicotinamide

[2186];

2-(3 -(dimethylamino)azetidin- 1 -yl)-N-(6-( 1 -methyl- 1H- 1 ,2,3-triazol-4-yl)cinnolin-3 -yl)

isonicotinamide [2187];

N-(6-(l-methyl-lH-l,2,3-triazol-4-yl)cinnolin-3-yl)-2-(l-methylpiperidin-4-yl)isonicotinamide

[2188]; 2-(4-(dimethylamino)piperidin-l-yl)-N-(6-(l-methyl-lH-l,2,3 riazol-4-yl)cinnolin-3-yl) isonicotinamide [2189];

N-(6-(l-methyl-lH-l,2,3 riazol-4-yl)cinnolin-3-yl)-2-moφholinoisonicotinamide [2190];

N-(6-(l-methyl-lH-l,2,3 riazol-4-yl)cinnolin-3-yl)-2-(4-methylpiperazin-l-yl)isonicotinam

[2191];

2-(4-methyl- 1 ,4-diazepan- 1 -yl)-N-(6-( 1 -methyl-lH-1 ,2,3-triazol-4-yl)cinnolin-3-yl)

isonicotinamide [2192];

2-(4-isopropylpiperazin-l-yl)-N-(6-(l-methyl-lH-l,2,3-triazol-4-yl)cinnolin-3-yl)isonicotinamide

[2193];

N-(6-(l-methyl-lH-l,2,3-triazol-4-yl)cinnolin-3-yl)-2-(piperidin-4-ylamino)isonicotinamide

[2194];

2-(methyl( 1 -methylpiperidin-4-yl)amino)-N-(6-( 1 -methyl- IH- 1 ,2,3 -triazol-4-yl)cinnolin-3 - yl)isonicotinamide [2195];

N-(6-(l-methyl-lH-l,2,3-triazol-4-yl)cinnolin-3-yl)-2-((l-methylpiperidin-4-yl)thio)

isonicotinamide [2196];

2-methyl-N-(6-(l-methyl-lH-l,2,3-triazol-4-yl)cinnolin-3-yl)-l,2,3,4-tetrahydroisoquinoline-6- carboxamide [2197];

N-(6-(l-methyl-lH-l,2,3-triazol-4-yl)cinnolin-3-yl)-2-(piperazin-l-yl)isonicotinamide [2198]; N-(6-(l-methyl-lH-l,2,3-triazol-4-yl)cinnolin-3-yl)-2-(2-(4-methylpiperazin-l-yl)pyridin-4- yl)acetamide [2199];

1 , 1 -bis(methyl-£/3)-4-(4-((6-( 1 -methyl- IH- 1 ,2,3 -triazol-4-yl)cinnolin-3 -yl)carbamoyl)pyridin-2- yl)piperazin-l-ium [2200];

N-(6-(l-methyl-lH-l,2,3-triazol-4-yl)cinnolin-3-yl)-2-(4-(methyl-£/₃)piperazin-l-yl)

isonicotinamide [2201];

N-(6-(l-methyl-lH-l,2,3-triazol-5-yl)cinnolin-3-yl)-l-(3,3,3-trifluoropropyl)piperidine-4- carboxamide [2202];

N-(6-(4-methyl-4H-l,2,4-triazol-3-yl)cinnolin-3-yl)-2-moφholinoacetamide [2203];

N-(6-(4-methyl-4H-l,2,4-triazol-3-yl)cinnolin-3-yl)-l-(3,3,3-trifluoropropyl)piperidine-4- carboxamide [2204];

4-fluoro- 1 -isobutyl-N-(6-(4-methyl-4H- 1 ,2,4-triazol-3 -yl)cinnolin-3 -yl)piperidine-4-carboxamide

[2205];

N-(6-(4,5 -dimethyl -4H- 1 ,2,4-triazol-3 -yl)cinnolin-3 -yl)-2-moφholinoacetamide [2206] ;

N-(6-(4,5 -dimethyl -4H- 1 ,2,4-triazol-3 -yl)cinnolin-3 -yl)- 1 -(3 ,3 ,3 -trifluoropropyl)piperidine-4- carboxamide [2207]; N-(6-( 1H- 1 ,2,3 -triazol- 1 -yl)cinnolin-3 -yl)-4-fluoro-l -isobutylpiperidine-4 -carboxamide [2208] ; N-(6-(2H- 1 ,2,3 -triazol-2-yl)cinnolin-3 -yl)-4-fluoro-l -isobutylpiperidine-4 -carboxamide [2209] ; N-(6-(lH-l,2,4-triazol-l-yl)cirmolin-3-yl)-2-(4-methylpiperazin-l-yl)isonicotinamide [2210]; 1 -isobutyl-N-(6-( 1 -methyl- lH-tetrazol-5-yl)cinnolin-3-yl)piperidine-4-carboxamide [2211] ; 2,2,3, 3-tetramethyl-N-(6-(l-methyl-lH-imidazol-5-yl)cinnolin-3-yl)cyclopropane-l-carboxamide

[2212];

4,4-difluoro-N-(6-(l-methyl-lH-imidazol-5-yl)cinnolin-3-yl)cyclohexane-l-carboxamide [2213]; N-(6 -( 1 -methyl - 1 H-imidazol-5 -yl)cinnolin-3 -yl) -2-(piperidin- 1 -yl)acetamide [2214];

2-fluoro-2 -methyl -N-(6-(l-methyl-lH-imidazol-5-yl)cinnolin-3-yl)propanamide [2215];

1 -fluoro-N-(6-( 1 -methyl- lH-imidazol-5-yl)cinnolin-3-yl)cyclopropane- 1 -carboxamide [2216] ; 2-methyl-N-(6-(l-methyl-lH-imidazol-5-yl)cinnolin-3-yl)-2-azaspiro[3.3]heptane-6 -carboxamide

[2217];

1 -fluoro-N-(6-( 1 -methyl- lH-imidazol-5 -yl)cinnolin-3-yl)cyclohexane- 1 -carboxamide [2218] ; fr «5-4-methoxy-N-(6-( 1 -methyl- lH-imidazol-5-yl)cinnolin-3 -yl)cyclohexane- 1 -carboxamide

[2219];

fr «5-4-(hydroxymethyl)-N-(6-( 1 -methyl -lH-imidazol -5 -yl)cinnolin-3 -yl)cyclohexane- 1 - carboxamide [2220];

N-(6-( 1 -methyl- lH-imidazol-5-yl)cinnolin-3 -yl)azetidine-3 -carboxamide [2221] ;

(R)-N-(6-(l-methyl-lH-imidazol-5-yl)cinnolin-3-yl)tetrahydrofuran-2 -carboxamide [2222]; l-(2-methoxyethyl)-N-(6-(l-methyl-lH-imidazol-5-yl)cinnolin-3-yl)piperidine-4 -carboxamide

[2223];

N-(6-(l-methyl-lH-imidazol-5-yl)cinnolin-3-yl)-l-(3,3,3-trifluoropropyl)piperidine-4- carboxamide [2224];

1- isobutyl-N-(6-(l-methyl-lH-imidazol-5-yl)cinnolin-3-yl)piperidine-4-carboxamide [2225]; N-(6 -( 1 -methyl - 1 H-imidazol-5 -yl)cinnolin-3 -yl) - 1 -(methylsulfonyl)piperidine -4 -carboxamide

[2226];

N-(6-( 1 -methyl-lH-imidazol-5-yl)cinnolin-3 -yl)-2-(pyrrolidin- 1 -yl)propanamide [2227] ;

2- isopropoxy-N-(6-( 1 -methyl- lH-imidazol-5 -yl)cinnolin-3-yl)acetamide [2228] ;

3- isopropoxy-N-(6-(l-methyl-lH-imidazol-5-yl)cinnolin-3-yl)propanamide [2229];

N-(6-(l,2-dimethyl-lH-imidazol-5-yl)cinnolin-3-yl)cyclopropanecarboxamide [2230];

N-(6-(l,2-dimethyl-lH-imidazol-5-yl)cinnolin-3-yl)cyclohexanecarboxamide [2231];

N-(6-( 1 ,2-dimethyl- lH-imidazol-5 -yl)cinnolin-3-yl)-4,4-difluorocyclohexane- 1 -carboxamide

[2232];

(S)-N-(6-(l,2-dimethyl-lH-imidazol-5-yl)cinnolin-3-yl)tetrahydrofuran-2 -carboxamide [2233]; N-(6-(l,2-dimethyl-lH-imidazol-5-yl)cinnolin-3-yl)-3,3-difluorocyclobutane-l-carboxami

[2234] ;

N-(6-(l,2-dimethyl-lH-imidazol-5-yl)cinnolin-3-yl)-l-fluorocyclopropane-l -carboxamide

[2235] ;

N-(6-(l,2-dimethyl-lH-imidazol-5-yl)cinnolin-3-yl)moφholine-4-carboxamide [2236];

N-(6-(l,2-dimethyl-lH-imidazol-5-yl)cinnolin-3-yl)moφholine-ί s-4-carboxamide [2237];

1 -methyl -N-(6 -( 1 -methyl - 1 H-imidazol-5 -yl)cinnolin-3 -yl) - 1 H-pyrazole -4-carboxamide [2238] ; 1 -ethyl -N-(6-( 1 -methyl- lH-imidazol-5 -yl)cinnolin-3 -yl)- 1 H-pyrazole-4-carboxamide [2239] ; 1 -isopropyl-N-(6-( 1 -methyl- lH-imidazol-5-yl)cinnolin-3 -yl)- 1 H-pyrazole -4 -carboxamide [2240] ;

1- cyclopropyl-N-(6-(l-methyl-lH-imidazol-5-yl)cinnolin-3-yl)-lH-pyrazole-4 -carboxamide

[2241] ;

1 -isobutyl-N-(6-( 1 -methyl- lH-imidazol-5-yl)cinnolin-3-yl)- lH-pyrazole-4-carboxamide [2242] ; 1 -methyl -N-(6 -( 1 -methyl - 1 H-imidazol-5 -yl)cinnolin-3 -yl) - 1 H-pyrazole -3 -carboxamide [2243] ; N-(6-( 1 -methyl-lH-imidazol-5-yl)cinnolin-3 -yl)-2-( 1 -methyl- lH-pyrazol-4-yl)acetamide [2244] ; 1 -methyl -N-(6 -( 1 -methyl - 1 H-imidazol-5 -yl)cinnolin-3 -yl) - 1 H-imidazole -4 -carboxamide [2245] ; 1 -isopropyl-N-(6-( 1 -methyl- lH-imidazol-5-yl)cinnolin-3 -yl)- 1 H-imidazole -4 -carboxamide

[2246] ;

N-(6-( 1 -methyl-lH-imidazol-5-yl)cinnolin-3 -yl)- 1 -(tetrahydro-2H-pyran-4-yl)- 1 H-imidazole -4- carboxamide [2247];

1 ,2-dimethyl-N-(6 -( 1 -methyl - 1 H-imidazol -5 -yl)cinnolin-3 -yl) - 1 H-imidazole -5 -carboxamide

[2248] ;

1 -methyl -N-(6-( 1 -methyl-lH-imidazol-5 -yl)cinnolin-3-yl)- 1H- 1 ,2,4-triazole-3-carboxamide

[2249] ;

2- methyl-N-(6-(l-methyl-lH-imidazol-5-yl)cinnolin-3-yl)oxazole-4-carboxamide [2250];

2-isopropyl-N-(6-( 1 -methyl- lH-imidazol-5-yl)cinnolin-3 -yl)oxazole -4 -carboxamide [2251] ; 4-methyl-N-(6-(l-methyl-lH-imidazol-5-yl)cinnolin-3-yl)oxazole-2 -carboxamide [2252];

4- methyl-N-(6-(l-methyl-lH-imidazol-5-yl)cinnolin-3-yl)thiazole-2 -carboxamide [2253] ;

2-methyl-N-(6-(l-methyl-lH-imidazol-5-yl)cinnolin-3-yl)thiazole-4-carboxamide [2254] ;

5- methyl-N-(6-(l-methyl-lH-imidazol-5-yl)cinnolin-3-yl)-l,3,4-oxadiazole-2 -carboxamide

[2255] ;

5-methyl-N-(6-(l-methyl-lH-imidazol-5-yl)cinnolin-3-yl)-l,3,4-thiadiazole-2 -carboxamide

[2256] ;

l-isopropyl-N-(6-(l-isopropyl-lH-imidazol-5-yl)cinnolin-3-yl)-lH-pyrazole-4 -carboxamide

[2257] ; N-(6-(l,2-dimethyl-lH-imidazol-5-yl)cinnolin-3-yl)-l-methyl-lH-pyrazole-4-carboxamid^

[2258];

N-(6-(l,2-dimethyl-lH-imidazol-5-yl)cinnolin-3-yl)-l-isopropyl-lH-pyrazole-4-carboxamide

[2259];

N-(6-(l,2-dimethyl-lH-imidazol-5-yl)cinnolin-3-yl)-2-methylthiazole-5-carboxamide [2260]; 4-fluoro-N-(6-( 1 -methyl-lH-imidazol-5 -yl)cinnolin-3-yl)benzamide [2261] ;

4-(difluoromethoxy)-N-(6-(l-methyl-lH-imidazol-5-yl)cinnolin-3-yl)benzamide [2262];

N-(6 -( 1 -methyl - 1 H-imidazol-5 -yl)cinnolin-3 -yl) -3 -(py rrolidin- 1 -ylmethyl)benzamide [2263] ; 2-fluoro-N-(6-(l-methyl-lH-imidazol-5-yl)cinnolin-3-yl)benzamide-3,4,5,6-£/4 [2264];

4-fluoro-N-(6-(l-methyl-lH-imidazol-5-yl)cinnolin-3-yl)benzamide-2,3,5,6-£/4 [2265];

2-chloro-N-(6-(l-methyl-lH-imidazol-5-yl)cinnolin-3-yl)benzamide-3,4,5,6-£/4 [2266];

4-chloro-N-(6-(l-methyl-lH-imidazol-5-yl)cinnolin-3-yl)benzamide-2,3,5,6-£/4 [2267];

4-(methyl-<i3)-N-(6-( 1 -methyl- lH-imidazol-5-yl)cinnolin -3 -yl)benzamide [2268] ;

4-methyl-N-(6-(l-methyl-lH-imidazol-5-yl)cinnolin-3-yl)benzamide-2,3,5,6-£/4 [2269];

4-(methyl-£/3)-N-(6-(l-methyl-lH-imidazol-5-yl)cinnolin-3-yl)benzamide-2,3,5,6-£/4 [2270]; 4-(methoxy-£/3)-N-(6-(l-methyl-lH-imidazol-5-yl)cinnolin-3-yl)benzamide [2271];

4-(methoxy- 3)-N-(6-(l-methyl-lH-imidazol-5-yl)cinnolin-3-yl)benzamide-2,3,5,6-ii4 [2272]; 4-methoxy-N-(6-(l-methyl-lH-imidazol-5-yl)cinnolin-3-yl)benzamide-2,3,5,6-£/4 [2273];

(E)-N-(6-(l,2-dimethyl-lH-imidazol-5-yl)cinnolin-3-yl)-3-(phenyl-2,3,4,5,6-£/j)acrylamide

[2274];

(E)-N-(6-(l,2-dimethyl-lH-imidazol-5-yl)cinnolin-3-yl)-3-(phenyl-2,3,4,5,6- j)acrylamide-2,3-£/2

[2275];

N-(6-(l,2-dimethyl-lH-imidazol-5-yl)cinnolin-3-yl)-2-(4-fluorophenyl)acetamide-2,2-£/2 [2276]; (E)-N-(6-(l-methyl-lH-imidazol-5-yl)cinnolin-3-yl)-3-(phenyl-2,3,4,5,6-£/j)acrylamide [2277]; (E)-N-(6-(l-methyl-lH-imidazol-5-yl)cinnolin-3-yl)-3-(phenyl-2,3,4,5,6-£/j)acrylamide-2,3-£/2

[2278];

2-(4-fluorophenyl)-N-(6-(l-methyl-lH-imidazol-5-yl)cinnolin-3-yl)acetamide-2,2-£/2 [2279]; N-(6-(l-methyl-lH-imidazol-5-yl)cinnolin-3-yl)-2-(4-methylpiperazin-l-yl)isonicotinamide

[2280];

2-(dimethylamino)-N-(6 -(1 -methyl - 1 H-imidazol -5 -yl)cinnolin-3 -yl)isonicotinamide [2281]; 2-(3 -aminoazetidin- 1 -yl) -N-(6 -( 1 -methyl - 1 H-imidazol -5 -yl)cinnolin-3 -yl)isonicotinamide [2282] ; N-(6-( 1 -methyl-lH-imidazol-5-yl)cinnolin-3 -yl)-2-(pyrrolidin- 1 -yl)isonicotinamide [2283] ; N-(6-(l-methyl-lH-imidazol-5-yl)cinnolin-3-yl)-2-(piperidin-l-yl)isonicotinamide [2284];

N-(6-(l-methyl-lH-imidazol-5-yl)cinnolin-3-yl)-2-mo holinoisonicotinamide [2285]; 2-(4-isopropylpiperazin- 1 -yl)-N-(6-( 1 -methyl- lH-imidazol-5 -yl)cinnolin-3 -yl)isonicotinamide [2286];

2-(4-cyclopropylpiperazin- 1 -yl)-N-(6-( 1 -methyl- lH-imidazol-5 -yl)cinnolin-3-yl)isonicotinamide

[2287];

N-(6-(l-methyl-lH-imidazol-5-yl)cinnolin-3-yl)-2-(2,7-diazaspiro[3.5]nonan-2-yl)

isonicotinamide [2288];

N-(6-(l-methyl-lH-imidazol-5-yl)cinnolin-3-yl)-2-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl) isonicotinamide [2289];

N-(6-( 1 -methyl-lH-imidazol-5-yl)cinnolin-3 -yl)isoindoline-5 -carboxamide [2290] ;

2-methyl-N-(6-(l-methyl-lH-imidazol-5-yl)cinnolin-3-yl)isoindoline-5-carboxamide [2291]; 2-(azetidin-l-yl)-N-(6-(l-methyl-lH-imidazol-5-yl)cinnolin-3-yl)isonicotinamide [2292];

2-methoxy-N-(6-(l-methyl-lH-imidazol-5-yl)cinnolin-3-yl)isonicotinamide [2293];

2-methyl-N-(6-( 1 -methyl- 1 H-imidazol-5 -yl)cinnolin-3 -yl)isonicotinamide [2294] ;

2-cyano-N-(6-( 1 -methyl- 1 H-imidazol-5 -yl)cinnolin-3 -yl)isonicotinamide [2295] ;

2-(3,3-difluoroazetidin-l-yl)-N-(6-(l-methyl-lH-imidazol-5-yl)cinnolin-3-yl)isonicotinamide

[2296];

2-(4,4-difluoropiperidin-l -yl)-N-(6-( 1 -methyl- lH-imidazol-5 -yl)cinnolin-3 -yl)isonicotinamide

[2297];

2-isopropoxy-N-(6-(l-methyl-lH-imidazol-5-yl)cinnolin-3-yl)isonicotinamide [2298];

N-(6-(l-methyl-lH-imidazol-5-yl)cinnolin-3-yl)-2-(pyrrolidin-l-yl-2,2,5,5-^)isonicotinamide

[2299];

N-(6-( 1 -methyl-lH-imidazol-5-yl)cinnolin-3 -yl)-2-(pyrrolidin- 1 -yl-<¾)isonicotinamide [2300] ; N-(6-(l-methyl-lH-imidazol-5-yl)cinnolin-3-yl)-2-(piperidin-l-yl-£/;o)isonicotinamide [2301]; N-(6-(l-methyl-lH-imidazol-5-yl)cinnolin-3-yl)-2-(mo holino-ί s)isonicotinamide [2302]; N-(6-(l,2-dimethyl-lH-imidazol-5-yl)cinnolin-3-yl)-4-isopropoxybenzamide [2303];

N-(6-(l,2-dimethyl-lH-imidazol-5-yl)cinnolin-3-yl)-4-(piperidin-4-yloxy)benzamide [2304]; 4-(benzyloxy)-N-(6-(l,2-dimethyl-lH-imidazol-5-yl)cinnolin-3-yl)benzamide [2305];

N-(6-(l,2-dimethyl-lH-imidazol-5-yl)cinnolin-3-yl)-2-fluorobenzamide-3,4,5,6-£/4 [2206]; N-(6-(l,2-dimethyl-lH-imidazol-5-yl)cinnolin-3-yl)-4-fluorobenzamide-2,3,5,6-£/4 [2307]; 2-chloro-N-(6-(l,2-dimethyl-lH-imidazol-5-yl)cinnolin-3-yl)benzamide-3,4,5,6-£/4 [2308]; 4-chloro-N-(6-(l,2-dimethyl-lH-imidazol-5-yl)cinnolin-3-yl)benzamide-2,3,5,6-£/4 [2309]; N-(6-(l,2-dimethyl-lH-imidazol-5-yl)cinnolin-3-yl)-4-(methyl-£/3)benzamide [2310];

N-(6-(l,2-dimethyl-lH-imidazol-5-yl)cinnolin-3-yl)-4-methylbenzamide-2,3,5,6-£/4 [2311]; N-(6-(l,2-dimethyl-lH-imidazol-5-yl)cinnolin-3-yl)-4-(methyl-£/3)benzamide-2,3,5,6-£/4 [2312]; N-(6-(l,2-dimethyl-lH-imidazol-5-yl)cinnolin-3-yl)-4-(methoxy-£/3)benzamide [2313];

N-(6-(l,2-dimethyl-lH-imidazol-5-yl)cinnolin-3-yl)-4-(methoxy-£/3)benzamide-2,3, 5,6-<¾ [2314]; N-(6-(l,2-dimethyl-lH-imidazol-5-yl)cinnolin-3-yl)-4-methoxybenzamide-2,3,5,6-£/4 [2315]; N-(6-(l,2-dimethyl-lH-imidazol-5-yl)cinnolin-3-yl)-2-(4-methylpiperazin-l-yl)isonicotm

[2316];

N-(6-(l,2-dimethyl-lH-imidazol-5-yl)cinnolin-3-yl)-2-mo holinoisonicotinamide [2317];

N-(6-( 1 ,2-dimethyl- lH-imidazol-5-yl)cinnolin-3-yl)-2-(pyrrolidin- 1 -yl)isonicotinamide [2318] ; N-(6-(l,2-dimethyl-lH-imidazol-5-yl)cinno [2319]; N-(6-( 1 ,2-dimethyl- lH-imidazol-5-yl)cinnolin-3-yl)-2-(pyrrolidin- 1 -yl -2,2,5,5 -dj)

isonicotinamide [2320];

N-(6-(l,2-dimethyl-lH-imidazol-5-yl)cinnolin-3-yl)-2-(pyrrolidin-l-yl- s)isonicotinamide

[2321];

N-(6-(l,2-dimethyl-lH-imidazol-5-yl)cinnolin-3-yl)-2-(piperidin-l-yl- ;o)isonicotinamide

[2322];

N-(6-(l,2-dimethyl-lH-imidazol-5-yl)cinnolin-3-yl)-2-(moφholino-ί s)isonicotinamide [2323]; N-(6-(5,6,7,8-tetrahydroimidazo[l,2-a]pyrazin-3-yl)cinnolin-3-yl)cyclopropanecarboxamide

[2324];

N-(6-(7-methyl-5,6,7,8-tetrahydroimidazo[l,2-a]pyrazin-3-yl)cinnolin-3-yl)

cyclopropanecarboxamide [2325];

3,3-difluoro-N-(6-(5,6,7,8-tetrahydroimidazo[l,2-a]pyrazin-3-yl)cinnolin-3-yl)cyclobutane-l- carboxamide [2326];

(R)-N-(6-(5,6,7,8-tetrahydroimidazo[l,2-a]pyrazin-3-yl)cinnolin-3-yl)pyrrolidine-2-carboxamide

[2327];

(R)-N-(6-(5,6,7,8-tetrahydroimidazo[l,2-a]pyrazin-3-yl)cinnolin-3-yl)piperidine-3-carboxamide

[2328];

l-methyl-N-(6-(5,6,7,8-tetrahydroimidazo[l,2-a]pyrazin-3-yl)cinnolin-3-yl)piperidine-4- carboxamide [2329];

N-(6-(5,6,7,8-tetrahydroimidazo[ 1 ,2-a]pyrazin-3 -yl)cinnolin-3 -yl)- 1 -(( 1 -(trifluoromethyl)

cyclopropyl)methyl)piperidine-4-carboxamide [2330] ;

l-benzoyl-N-(6-(5,6,7,8-tetrahydroimidazo[l,2-a]pyrazin-3-yl)cinnolin-3-yl)piperidine-4- carboxamide [2331];

4-fluoro-l-isobutyl-N-(6-(5,6,7,8-tetrahydroimidazo[l,2-a]pyrazin-3-yl)cinnolin-3-yl)piperidine- 4-carboxamide [2332]; (R)-2-(2-methylpyrrolidin-l-yl)-N-(6-(5,6,7,8 etra

yl)acetamide [2333];

2-(cyclobutyl(methyl)amino)-N-(6-(5,6J,8 etrahydroimidazo[l,2-a]pyrazin-3-yl)cinnolin-3 yl)acetamide [2334];

4-fluoro-N-(6-(5,6,7,8 etrahydroimidazo[l,2-a]pyrazin-3-yl)cinnolin-3-yl)benzamide [2335]; 4-isopropoxy-N-(6-(5,6,7,8 etrahydroimidazo[l,2-a]pyrazin-3-yl)cinnolin-3-yl)benzamide

[2336];

4-(difluoromethoxy)-N-(6-(5,6,7,8 etrahydroimidazo[l,2-a]pyrazin-3-yl)cinnolin-3-yl)

benzamide [2337];

2-((2-(dimethylamino)ethyl)amino)-N^

3-yl)isonicotinamide [2338];

2-((1 sopropylpiperidin-4-yl)oxy)-N-(6-(5,6,7,8 etrahydroimidazo[l,2-a]pyrazin-3-yl)cinnolin-

3-yl)isonicotinamide [2339];

N-(6-(oxazol-5-yl)cinnolin-3-yl)-l-(3,3,3-trifluoropropyl)piperidine-4-carboxamide [2340]; N-(6-(oxazol-5-yl)cinnolin-3-yl)cyclopropanecarboxamide [2341];

(R)-N-(6-(oxazol-5-yl)cinnolin-3-yl)tetrahydrofuran-2-carboxamide [2342];

(R)-N-(6-(oxazol-5-yl)cinnolin-3-yl)piperidine-3-carboxamide [2343];

N-(6-(oxazol-5-yl)cinnolin-3-yl)tetrahydro-2H-pyran-4-carboxamide [2344];

N-(6-(oxazol-5-yl)cinnolin-3-yl)-l-(2-(pyrrolidin-l-yl)acetyl)piperidine-4-carboxamide [2345]; r-methyl-N-(6-(oxazol-5-yl)cinnolin-3-yl)-[l,4'-bipiperidine]-4-carboxamide [2346];

cz^'s -4-morpholino-N-(6-(oxazol-5 -yl)cinnolin-3 -yl)cyclohexane- 1 -carboxamide [2347] ;

2-(cyclobutyl(methyl)amino)-N-(6-(oxazol-5-yl)cinnolin-3-yl)acetamide [2348];

N-(6-(oxazol-5 -yl)cinnolin-3-yl)-2-(pyrrolidin- 1 -yl)acetamide [2349] ;

(R)-2-(2-methylpyrrolidin-l-yl)-N-(6-(oxazol-5-yl)cinnolin-3-yl)acetamide [2350];

2-(4-methylpiperazin- 1 -yl)-N-(6-(oxazol-5 -yl)cinnolin-3-yl)acetamide [2351] ;

fr «5-4-((4-methylpiperazin-l-yl)methyl)-N-(6-(oxazol-5-yl)cinnolin-3-yl)cyclohexane-l- carboxamide [2352];

l-(2,2-difluoropropyl)-N-(6-(oxazol-5-yl)cinnolin-3-yl)piperidine-4-carboxamide [2353];

trans -4 -(hydroxymethyl)-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)cyclohexane-l -carboxamide

[2354];

trans -4 -(methylamino)-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)cyclohexane-l -carboxamide

[2355];

trans-4-(( 1 ,3 -difluoropropan-2-yl)amino)-N-(6-(2-methyloxazol-5 -yl)cinnolin-3 -yl)cyclohexane- 1 -carboxamide [2356]; fr «5-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)-4-((propan-2-yl-l, l, l,3,3,3-£/6)amino) cyclohexane-1 -carboxamide [2357];

fra«s-4-((2,2-difluoroemyl)amino)-N-(6-(2^

carboxamide [2358];

fr «5-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)-4-((3,3,3-trifluoropropyl)amino)cyclohexane-l- carboxamide [2359];

trans -4 -((2-methoxyethyl)amino) -N-(6 -(2 -methyloxazol-5 -yl)cinnolin-3 -yl)cyclohexane - 1 - carboxamide [2360];

trans -4 -(dimethylamino) -N-(6 -(2-methyloxazol -5 -yl)cinnolin-3 -yl)cyclohexane- 1 -carboxamide

[2361];

fr «5-4-(bis(methyl-£/3)amino)-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)cyclohexane-l- carboxamide [2362];

c/5-4-(dimethylamino)-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)cyclohexane-l-carboxamide

[2363];

fr «5-4-((2,2-difluoroethyl)(methyl)amino)-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)

cyclohexane-1 -carboxamide [2364];

fr «5-4-(methyl(oxetan-3-yl)amino)-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)cyclohexane-l- carboxamide [2365];

trans -4 -((2-fluoroethyl)amino) -N-(6 -(2-methyloxazol -5 -yl)cinnolin-3 -yl)cyclohexane - 1 - carboxamide [2366];

fr «5-4-(2-(fluoromethyl)aziridin-l-yl)-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)cyclohexane-l- carboxamide [2367];

fr «5-4-((3-fluoroazetidin-l-yl)methyl)-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)cyclohexane-l- carboxamide [2368];

fr rø-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)-3-mo holinocyclobutane-l -carboxamide [2369]; fr rø-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)-4-mo holinocyclohexane-l-carboxamide

[2370];

N-(6-(2-methyloxazol-5 -yl)cinnolin-3 -yl)-2-(piperidin-l -yl)acetamide [2371] ;

2-(4-methoxypiperidin- 1 -yl)-N-(6-(2-methyloxazol-5-yl)cinnolin-3 -yl)acetamide [2372] ;

N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)-2-(4-methylpiperazin-l-yl)acetamide [2373];

N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)moφholine-4-carboxamide [2374];

N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)-2-mo holinoacetamide [2375];

N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)-3-moφholinopropanamide [2376];

1 -methyl -N-(6-(2 -methyloxazol-5 -yl)cinnolin-3 -yl)piperidine-4-carboxamide [2377] ; l-(2,2-difluoropropyl)-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)piperidine-4-carboxamide

[2378];

N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)-4-mo holinopiperidine-l-carboxamide [2379]; 4-((l,3-difluoropropan-2-yl)amino)-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)piperidine-l- carboxamide [2380];

( lR,3s,5 S)-3 -(( 1 ,3-difluoropropan-2-yl)amino)-N-(6-(2-methyloxazol-5 -yl)cinnolin-3 -yl)-8- azabicyclo[3.2.1] octane -8 -carboxamide [2381];

( lR,3s,5 S)-3 -(( 1 ,3-difluoropropan-2-yl)amino)-N-(6-(2-methyloxazol-5 -yl)cinnolin-3 -yl)-8- azabicyclo[3.2.1] octane -8 -carboxamide [2382];

4-(dimethylamino)-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)piperidine-l -carboxamide [2383]; 4-((2,2-difluoroethyl)(methyl)amino)-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)piperidine-l- carboxamide [2384];

(3 S,4S)-4-amino-3-fluoro-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)piperidine-l -carboxamide

[2385];

(3S,4S)-3-fluoro-4-(methylamino)-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)piperidine-l- carboxamide [2386];

(3 R,4R)-4-amino-3-fluoro-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)piperidine-l -carboxamide

[2387];

(3R,4R)-3-fluoro-4-(methylamino)-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)piperidine-l- carboxamide [2388];

4-((2-fluoroethyl)amino)-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)piperidine-l -carboxamide

[2389];

4-((2,2-difluoroethyl)amino)-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)piperidine-l-carboxamide

[2390];

(lR,3s,5S)-3-amino-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)-8-azabicyclo[3.2.1]octane-8- carboxamide [2391];

(lR,3r,5S)-3-amino-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)-8-azabicyclo[3.2.1]octane-8- carboxamide [2392];

(lR,3r,5S)-3-((2-fluoroethyl)amino)-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)-8- azabicyclo[3.2.1] octane -8 -carboxamide [2393];

(lR,3r,5S)-3-((2,2-difluoroethyl)amino)-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)-8- azabicyclo[3.2.1] octane -8 -carboxamide [2394];

(lR,3s,5S)-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)-3-((3,3,3-trifluoropropyl)amino)-8- azabicyclo [3.2.1] octane -8 -carboxamide [2395]; (3S,4S)-3-fluoro-4-(isopropylamino)-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)piperidine-l- carboxamide [2396];

N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)-5,6-dihydroimidazo[l,2-a]pyrazine-7(8H)-carboxamide

[2397];

2-methyl-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)-5,6-dihydroimidazo[l,2-a]pyrazine-7(8H)- carboxamide [2398];

N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)-2-(moφholino-ί s)acetamide [2399];

fr «5-N-(6-(2-methyloxazol-4-yl)cinnolin-3-yl)-4-(4-methylpiperazin-l-yl)cyclohexane-l- carboxamide [2400];

N-(6-(2-methyloxazol-5 -yl)cinnolin-3 -yl)-l -( 1 -methylpiperidin-4-yl)-lH-pyrazole-4- carboxamide [2401];

2- (lH-imidazol-l-yl)-N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)acetamide [2402];

4-(difluoromethoxy)-N-(6-(oxazol-5-yl)cinnolin-3-yl)benzamide [2403];

3- ((l-methylpiperidin-4-yl)oxy)-N-(6-(oxazol-5-yl)cinnolin-3-yl)benzamide [2404];

N-(6-(oxazol-5-yl)cinnolin-3-yl)isonicotinamide [2405];

2-(3 -aminoazetidin- 1 -yl)-N-(6-(oxazol-5 -yl)cinnolin-3-yl)isonicotinamide [2406] ;

2-(l-methylpiperidin-4-yl)-N-(6-(oxazol-5-yl)cinnolin-3-yl)isonicotinamide [2407];

r-methyl-N-(6-(oxazol-5-yl)cinnolin-3-yl)-r,2',3',6' etrahydro-[2,4'-bipyridine]-4-carboxamide

[2408];

2-(4-methylpiperazin- 1 -yl)-N-(6-(oxazol-5 -yl)cinnolin-3 -yl)isonicotinamide [2409] ;

2-(7-methyl-2 -diazaspiro[3.5]nonan-2-yl)-N-(6-(oxazol-5-yl)cinnolin-3-yl)isonicotinamide

[2410];

N-(6-(oxazol-5-yl)cinnolin-3-yl)-2-(2,7-diazaspiro[3.5]nonan-7-yl)isonicotinamide [2411]; N-(6-(oxazol-5-yl)cinnolin-3-yl)-2-(piperidin-4-ylamino)isonicotinamide [2412];

2-methyl-N-(6-(oxazol-5-yl)cinnolin-3-yl)isoindoline-5-carboxamide [2413];

N-(6-(oxazol-5-yl)cinnolin-3-yl)-l,2,3,4-tetrahydroisoquinoline-7-carboxamide [2414];

N-(6-(2-methyloxazol-5-yl)cinnolin-3-yl)-2-(4-methylpiperazin-l-yl)isonicotinamide [2415]; N-(6-(3-methylisoxazol-5-yl)cinnolin-3-yl)-l-(3,3,3 rifluoropropyl)piperidine-4-carboxamide

[2416];

4- fluoro- 1 -isobutyl-N-(6-(5 -methyl- 1 ,3 ,4-oxadiazol-2-yl)cinnolin-3 -yl)piperidine-4-carboxamide

[2417];

l-isobutyl-N-(6-(5-methyl-l,3,4-oxadiazol-2-yl)cinnolin-3-yl)piperidine-4-carboxamide [2418]; N-(6-(5-(dimethylamino)-l,3,4-oxadiazol-2-yl)cinnolin-3-yl)piperidine-4-carboxamide [2419]; N-(6-(5-(dimethylamino)- 1 ,3,4-oxadiazol-2-yl)cinnolin-3 -yl)- 1 -methylpiperidine-4-carboxamide

[2420];

N-(6-(5-methyl-l,3,4-oxadiazol-2-yl)cinnolin-3-yl)-2-(4-m

[2421];

3 , 3 -difluoro -N-(6 -(thiazol-5 -yl)cinnolin-3 -yl)cyclobutane - 1 -carboxamide [2422] ;

2-methyl-N-(6-(thiazol-5-yl)cinnolin-3-yl)-2-azaspiro[3.3]heptane-6-carboxamide [2423]; 1 -fluoro-N-(6-(thiazol-5-yl)cinnolin-3 -yl)cyclohexane- 1 -carboxamide [2424] ;

trans -4 -(dimethylamino) -N-(6 -(thiazol-5 -yl)cinnolin-3 -yl)cyclohexane - 1 -carboxamide [2425] ; trans -4 -((3 -fluoroazetidin- 1 -yl)methyl) -N-(6 -(thiazol -5 -yl)cinnolin-3 -yl)cyclohexane - 1 - carboxamide [2426];

N-(6-(thiazol-5-yl)cinnolin-3-yl)azetidine-3-carboxamide [2427];

l-methyl-N-(6-(thiazol-5-yl)cinnolin-3-yl)piperidine-4-carboxamide [2428];

1 -(2,2-difluoropropyl)-N-(6-(thiazol-5 -yl)cinnolin-3 -yl)piperidine-4-carboxamide [2429] ;

l-(oxetan-3-yl)-N-(6-(thiazol-5-yl)cinnolin-3-yl)piperidine-4-carboxamide [2430];

1- (2-(pyrrolidin-l-yl)acetyl)-N-(6-(thiazol-5-yl)cinnolin-3-yl)piperidine-4-carboxamide [2431]; 1 '-methyl -N-(6-(thiazol-5-yl)cinnolin-3 -yl)-[ 1 ,4'-bipiperidine] -4-carboxamide [2432] ;

2- (pyrrolidin- 1 -yl) -N-(6-(thiazol-5 -yl)cinnolin-3 -yl)propanamide [2433] ;

2-(piperidin- 1 -yl)-N-(6-(thiazol-5 -yl)cinnolin-3 -yl)acetamide [2434] ;

2-(4-methylpiperazin-l-yl)-N-(6-(thiazol-5-yl)cinnolin-3-yl)acetamide [2435];

2-moφholino-N-(6-(thiazol-5-yl)cinnolin-3-yl)acetamide [2436];

4-(piperidin-4-yloxy)-N-(6-(thiazol-5-yl)cinnolin-3-yl)benzamide [2437];

N-(6-(thiazol-5-yl)cinnolin-3-yl)isonicotinamide [2438] ;

6-(4-methylpiperazin-l-yl)-N-(6-(thiazol-5-yl)cinnolin-3-yl)nicotinamide [2439];

r-methyl-N-(6-(miazol-5-yl)cinnolin-3-yl)-r,2',3',6'-tetrahydro-[2,4'-bipyridine]-4-carboxamide

[2440];

2-(3 -(dimethylamino)azetidin- 1 -yl)-N-(6-(thiazol-5 -yl)cinnolin-3-yl)isonicotinamide [2441] ; 2-(4-(dimethylamino)piperidin-l-yl)-N-(6-(miazol-5-yl)cinnolin-3-yl)isonicotinamide [2442]; 2-(4-methylpiperazin-l-yl)-N-(6-(thiazol-5-yl)cinnolin-3-yl)isonicotinamide [2443];

2-((l-methylpiperidin-4-yl)thio)-N-(6-(miazol-5-yl)cinnolin-3-yl)isonicotinamide [2444];

N-(6-(thiazol-5-yl)cinnolin-3-yl)-l,2,3,4-tetrahydroisoquinoline-7 -carboxamide [2445];

fr «5-4-((l,3-difluoropropan-2-yl)amino)-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)cinnolin-3-yl) cyclohexane-1 -carboxamide [2446];

N-(6-(2-methylthiazol-5-yl)cinnolin-3-yl)moφholine-4-carboxamide [2447];

N-(6 -(2-methylthiazol-5 -yl)cinnolin-3 -yl) -2 -(pyrrolidin- 1 -yl)acetamide [2448] ; 2-(( 1 R,4R)-2-oxa-5 -azabicyclo [2.2.1 ]heptan-5 -yl) -N-(6-(2-methylthiazol-5 -yl)cinnolin-3 - yl)acetamide [2449];

N-(6-(2-methylthiazol-5-yl)cinnolin-3-yl)-2-mo holinoacetamide [2450];

N-(6-(2-methylthiazol-5-yl)cinnolin-3-yl)-2-(mo holino-ί s)acetamide [2451];

2-(4-methylpiperazin- 1 -yl)-N-(6-(2-methylthiazol-5 -yl)cinnolin-3-yl)acetamide [2452] ;

1- methyl-N-(6-(2-methylthiazol-5-yl)cinnolin-3-yl)piperidine-4-carboxamide [2453];

N-(6-(2-methylthiazol-5-yl)cinnolin-3-yl)isonicotinamide [2454];

N-(6-(2-methylthiazol-5-yl)cinnolin-3-yl)nicotinamide [2455] ;

2- (4-methylpiperazin- 1 -yl)-N-(6-(2-methylthiazol-5 -yl)cinnolin-3-yl)isonicotinamide [2456] ; fr rø-N-(6-(5-methyl-l,3,4 hiadiazol-2-yl)cinnolin-3-yl)-4-moφholinocyclohexane-l- carboxamide [2457];

fr «5-N-(6-(5-methyl-l,3,4 hiadiazol-2-yl)cinnolin-3-yl)-4-(4-methylpiperazin-l-yl)

cyclohexane-1 -carboxamide [2458];

4-isopropyl-N-(6-(5 -methyl- 1 ,3 ,4-thiadiazol-2-yl)cinnolin-3 -yl)piperazine- 1 -carboxamide [2459] ; 4-((2-methoxyethyl)(methyl)amino)-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)cinnolin-3-yl)

piperidine-1 -carboxamide [2460];

4-(( 1 ,3 -difluoropropan-2-yl)amino)-N-(6-(5 -methyl- 1 ,3,4-thiadiazol-2-yl)cinnolin-3 -yl)

piperidine-1 -carboxamide [2461];

N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)cinnolin-3-yl)-4-((3,3,3-trifluoropropyl)amino)piperidine-l- carboxamide [2462];

4-((2-fluoroethyl)amino)-N-(6-(5 -methyl- 1 ,3 ,4-thiadiazol-2-yl)cinnolin-3 -yl)piperidine- 1 - carboxamide [2463];

(3R,4S)-4-amino-3-fluoro-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)cinnolin-3-yl)piperidine-l- carboxamide [2464];

(3R,4R)-4-amino-3-fluoro-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)cinnolin-3-yl)piperidine-l- carboxamide [2465];

(3S,4S)-3-fluoro-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)cinnolin-3-yl)-4-(methylamino)piperidine-

1 -carboxamide [2466];

(3R,4R)-3-fluoro-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)cinnolin-3-yl)-4-(methylamino)

piperidine-1 -carboxamide [2467];

4-amino-3,3-difluoro-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)cinnolin-3-yl)piperidine-l- carboxamide [2468];

(3R,4R)-3 -fluoro-4-(isopropylamino)-N-(6-(5 -methyl- 1 ,3,4-thiadiazol-2-yl)cinnolin-3 -yl)

piperidine-1 -carboxamide [2469]; (3R,4S)-3-fluoro-4-(isopropylamino)-N-(6-(5-methyl-l,3,4-1hiadiazol-2-yl)cinnolin-3-yl) piperidine-l-carboxamide [2470];

3,3-difluoro-4-(isopropylamino)-N-(6-(5-methy^

carboxamide [2471];

(3S,4S)-3-fluoro-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)cinnolin-3-yl)-4-((propan-2-yl-l, 1,1,3,3,3-

£/e)amino)piperidine- 1 -carboxamide [2472] ;

(lR,3s,5S)-3-((l,3-difluoropropan-2-yl)amino)-N-(6-(5-m

yl)-8-azabicyclo[3.2.1] octane -8 -carboxamide [2473];

(lR,3s,5S)-3-((l,3-difluoropropan-2-yl)amino)-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)cinnolin-3- yl)-8-azabicyclo[3.2. l]octane-8-carboxamide [2474];

4-(dimethylamino)-N-(6-(2-methylthiazol-5-yl)cinnolin-3 -yl)piperidine- 1 -carboxamide [2475] ; 4-((2,2-difluoroethyl)amino)-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)cinnolin-3-yl)piperidine-l- carboxamide [2476];

4-((2,2-difluoroethyl)(methyl- 3)amino)-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)cirmolin-3- yl)piperidine-l -carboxamide [2477];

N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)cinnolin-3-yl)-4-moφholinopiperidine-l -carboxamide

[2478];

N-(6-(5-methyl-l ,3,4-thiadiazol-2-yl)cinnolin-3 -yl)-4-(4-methylpiperazin- 1 -yl)piperidine- 1 - carboxamide [2479];

(R)-3,4-dimethyl-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)cinnolin-3-yl)piperazine-l -carboxamide

[2480];

(S)-3 ,4-dimethyl-N-(6-(5 -methyl- 1 ,3 ,4-thiadiazol-2-yl)cinnolin-3 -yl)piperazine- 1 -carboxamide

[2481];

(lR,3r,5S)-3-((2-fluoroethyl)amino)-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)cinnolin-3-yl)-8- azabicyclo[3.2.1] octane -8 -carboxamide [2482];

(lR,3r,5S)-3-((2,2-difluoroethyl)amino)-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)cinnolin-3-yl)-8- azabicyclo[3.2.1] octane -8 -carboxamide [2483];

(lR,3r,5S)-3-amino-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)cinnolin-3-yl)-8-azabicyclo[3.2.1] octane-8-carboxamide [2484];

(l S,4S)-5-methyl-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)cinnolin-3-yl)-2,5-diazabicyclo[2.2.1] heptane-2 -carboxamide [2485] ;

(lR,4R)-5-methyl-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)cinnolin-3-yl)-2,5-diazabicyclo[2.2.1] heptane-2 -carboxamide [2486] ; 8-methyl-N-(6-(5-methyl-l,3,4 hiadiazol-2-yl)cinnolin-3-yl)-3,8-diazabicyclo[3.2.1]octane-3- carboxamide [2487];

3-methyl-N-(6-(5-methyl-l,3,4 hiadiazol-2-yl)cinnolin-3-yl)-3,8-diazabicyclo[3.2.1]octane-8- carboxamide [2488];

N-(6-(5-methyl-l,3,4 hiadiazol-2-yl)cinnolin-3-yl)-5,6-dihydroimidazo[l,2-a]pyrazine-7(8H^ carboxamide [2489];

2-(4-methylpiperazin- 1 -yl)-N-(6-(5 -methylthiazol-2-yl)cinnolin-3 -yl)isonicotinamide [2490] ; 2-(4-methylpiperazin-l-yl)-N-(6-(4-methylmiazol-2-yl)cinnolin-3-yl)isonicotinam [2491]; N-(6-(2-(methylamino)thiazol-5-yl)cinnolin-3-yl)piperidine-4-carboxamide [2492];

1- methyl-N-(6-(2-(methylamino)thiazol-5-yl)cinnolin-3-yl)piperidine-4-carboxamide [2493]; N-(6-(2-(diethylamino)thiazol-5-yl)cinnolin-3-yl)-2-(4-fluoropiperidin-l-yl)acetam [2494]; N-(6-(2-(diethylamino)thiazol-5-yl)cinnolin-3-yl)-2-(4-methylpiperazin-l-yl)acetami [2495]; N-(6-(2-aminothiazol-5-yl)cinnolin-3-yl)-2-(4-methylpiperazin-l-yl)isonicotinamid [2496]; N-(6-(2-(methylamino)thiazol-5-yl)cinnolin-3-yl)-2-(4-methylpiperazin-l-yl)isonicotinam

[2497];

N-(6-(2-(dimethylamino)thiazol-5-yl)cinnolin-3-yl)-2-(4-methylpiperazin-l-yl)isonicotinam

[2498];

2- (4 sopropylpiperazin-l-yl)-N-(6-(2-(methylamino)thiazol-5-yl)cinnolin-3-yl)isonicotinamide

[2499];

2-(3 -(dimethylamino)azetidin- 1 -yl)-N-(6-(2-(methylamino)thiazol-5 -yl)cinnolin-3 -yl)

isonicotinamide [2500];

2-(3 -(dimethylamino)azetidin- 1 -yl)-N-(6-(2-(dimethylamino)thiazol-5 -yl)cinnolin-3-yl)

isonicotinamide [2501];

2-(3 -aminoazetidin- 1 -yl)-N-(6-(2-(dimethylamino)thiazol-5 -yl)cinnolin-3-yl)isonicotinamide

[2502];

N-(6-(5-chlorothiazol-2-yl)cinnolin-3 -yl)-2-(4-methylpiperazin- 1 -yl)isonicotinamide [2503] ; 2-(3 -(2-(4-methylpiperazin- 1 -yl)isonicotinamido)cinnolin-6-yl)thiazole-5 -carboxamide [2504] ; N-(6-(isothiazol-4-yl)cinnolin-3-yl)-l-methylpiperidine-4-carboxamide [2505];

N-(6-(l,3,4-thiadiazol-2-yl)cinnolin-3-yl)-4-(difluoromethoxy)benzamide [2506];

N-(6-(l,3,4-thiadiazol-2-yl)cinnolin-3-yl)-4-(piperidin-4-yloxy)benzamide [2507];

N-(6-(l,3,4-thiadiazol-2-yl)cinnolin-3-yl)-4-((l-methylpiperidin-4-yl)oxy)benzamide [2508]; N-(6-( 1 ,3,4-thiadiazol-2-yl)cinnolin-3-yl)-3 -(( 1 -methylpiperidin-4-yl)oxy)benzamide [2509] ; N⁵-(6-(l,3,4-thiadiazol-2-yl)cinnolin-3-yl)-N²-methylpyridine-2,5-dicarboxamide [2510]; N-(6-(l,3,4-thiadiazol-2-yl)cinnolin-3-yl)-6-(4-methylpiperazin-l-yl)nicotinamide [2511]; N-(6-(l,3,4-thiadiazol-2-yl)cinnolin-3-yl)-l'^

carboxamide [2512];

N-(6 -( 1 , 3 ,4-thiadiazol -2 -yl)cinnolin-3 -yl) -2 -(3 -(dimethylamino)azetidin- 1 -yl)isonicotinamide

[2513];

N-(6-(l,3,4 hiadiazol-2-yl)cinnolin-3-yl)-2-(4-methylpiperazin-l-yl)isonicotinamide [2514]; N-(6-(l,3,4 hiadiazol-2-yl)cinnolin-3-yl)-2-(4 sopropylpiperazin-l-yl)isonicotinamide [2515]; N-(6-(l,3,4 hiadiazol-2-yl)cinnolin-3-yl)-2-moφholinoisonicotinamide [2516];

1 -fluoro-N-(6-(5-methyl- 1 ,3 ,4-thiadiazol-2-yl)cinnolin-3 -yl)cyclohexane-l -carboxamide [2517] ; fr «5-4-methoxy-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)cinnolin-3-yl)cyclohexane-l -carboxamide

[2518];

cz^'s -4-methoxy-N-(6-(5 -methyl- 1 ,3 ,4-thiadiazol-2-yl)cinnolin-3 -yl)cyclohexane- 1 -carboxamide

[2519];

trans -4 -amino -N-(6-(5 -methyl -1,3,4 -thiadiazol -2 -yl)cinnolin-3 -yl)cyclohexane - 1 -carboxamide

[2520];

fr «5-4-(dimethylamino)-N-(6-(5 -methyl-1 ,3,4-thiadiazol-2-yl)cinnolin-3 -yl)cyclohexane- 1 - carboxamide [2521];

fr rø-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)cinnolin-3-yl)-4-moφholinocyclohexane-l- carboxamide [2522];

fr «5-4-(hydroxymethyl)-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)cinnolin-3-yl)cyclohexane-l- carboxamide [2523];

N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)cinnolin-3-yl)piperidine-4-carboxamide [2524];

4-fluoro-N-(6-(5-methyl- 1 ,3 ,4-thiadiazol-2-yl)cinnolin-3 -yl)piperidine-4-carboxamide [2525] ; l-methyl-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)cinnolin-3-yl)piperidine-4-carboxamide [2526]; 4-fluoro-l-methyl-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)cinnolin-3-yl)piperidine-4-carboxamide

[2527];

1 -(2-fluoroethyl)-N-(6-(5 -methyl- 1 ,3 ,4-thiadiazol-2-yl)cinnolin-3-yl)piperidine-4-carboxamide

[2528];

l-(2,2-difluoroethyl)-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)cinnolin-3-yl)piperidine-4- carboxamide [2529];

N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)cinnolin-3-yl)-l-(3,3,3-trifluoropropyl)piperidine-4- carboxamide [2530];

l-(2,2-difluoropropyl)-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)cinnolin-3-yl)piperidine-4- carboxamide [2531];

l-benzoyl-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)cinnolin-3-yl)piperidine-4-carboxamide [2532]; N-(6-(5-methyl-l,3,4 hiadiazol-2-yl)cinnolin-3-yl)-2-(pyrrolidin-l-yl)acetamide [2533];

N-(6-(5-methyl-l,3,4 hiadiazol-2-yl)cinnolin-3-yl)-2-(piperidin-l-yl)acetamide [2534];

2-(4-methoxypiperidin- 1 -yl)-N-(6-(5-methyl- 1 ,3,4-thiadiazol-2-yl)cinnolin-3 -yl)acetamide

[2535];

N-(6-(5-methyl-l,3,4 hiadiazol-2-yl)cinnolin-3-yl)-2-(4-methylpiperazin-l-yl)acetamide [2536]; N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)cinnolin-3-yl)-2-moφholinoacetamide [2537];

(R)-N-(6-(5-methyl-l,3,4 hiadiazol-2-yl)cinnolin-3-yl)-2-(3-methylmoφholino)acetamide

[2538];

2-(7-azabicyclo[2.2 ]heptan-7-yl)-N-(6-(5-methyl-l,3,4-th^

[2539];

2-((lR,4R)-2-oxa-5-azabicyclo[2.2. l]heptan-5-yl)-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)cinnolin-

3-yl)acetamide [2540];

2-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)cinnolin-3- yl)acetamide [2541];

2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)cinnolin-3- yl)acetamide [2542];

N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)cinnolin-3-yl)-2-(l,4-oxazepan-4-yl)acetamide [2543]; N-(6-(5-methyl-l,3,4 hiadiazol-2-yl)cinnolin-3-yl)-2-moφholinoacetamide-2,2-ί 2 [2544]; N-(6-(5-methyl-l,3,4 hiadiazol-2-yl)cinnolin-3-yl)-2-(moφholino-ί s)acetamide [2545];

l-methyl-3-(6-(5-methyl-l,3,4-thiadiazol-2-yl)cinnoh^

[2546];

(3S,4S)-4-amino-3-fluoro-N-(6-(5-methyl-l,3,4 hiadiazol-2-yl)cinnolin-3-yl)piperidine-l- carboxamide [2547];

(3 S,4S)-4-(dimethylamino)-3 -fluoro-N-(6-(5 -methyl- 1 ,3,4-thiadiazol-2-yl)cinnolin-3 -yl)

piperidine-l-carboxamide [2548];

N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)cinnolin-3-yl)mo holine-4-carboxamide [2549];

N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)cinnolin-3-yl)-4-(methylamino)piperidine-l-carboxam

[2550];

4-(dimethylamino)-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)cinnolin-3-yl)piperidine-l-carbox

[2551];

4-((2,2-difluoroethyl)(methyl)amino)-N-(6-(5 -methyl- 1 ,3,4-thiadiazol-2-yl)cinnolin-3 -yl)

piperidine-l-carboxamide [2552];

(3S,4S)-3-fluoro-4-(isopropylamino)-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)cinnolin-3-yl)

piperidine-l-carboxamide [2553]; 2-methyl-N-(6-(5-methyl-l,3,4 hiadiazol-2-yl)cinnolin-3-yl)-5,6-dihydroimidazo[l,2-a]

7(8H)-carboxamide [2554];

4-methyl-N-(6-(5-methyl-l,3,4 hiadiazol-2-yl)cinnolin-3-yl)piperazine-l-carboxamide [2555]; N-(6-(5-methyl-l,3,4 hiadiazol-2-yl)cinnolin-3-yl)-l-(l-methylpiperidin-4-yl)-lH-pyrazole-4- carboxamide [2556];

1 -( 1 -isopropylpiperidin-4-yl)-N-(6-(5 -methyl- 1 ,3 ,4-thiadiazol-2-yl)cinnolin-3 -yl)- lH-pyrazole-4- carboxamide [2557];

N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)cinnolin-3-yl)-l-(l-methylpiperidin-4-yl)-lH-l,2,3-triazo 4-carboxamide [2558];

N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)cinnolin-3-yl)-2-(piperidin-4-yl)oxazole-4-carboxamide

[2559];

N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)cinnolin-3-yl)-2-(l-methylpiperidin-4-yl)oxazole-4- carboxamide [2560];

2-(3 -(dimethylamino)azetidin- 1 -yl)-N-(6-(5 -methyl- 1 ,3 ,4-thiadiazol-2-yl)cinnolin-3 - yl)isonicotinamide [2561];

r-methyl-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)cinnolin-3-yl)-r,2',3',6'-tetrahydro-[2,4'- bipyridine] -4 -carboxamide [2562] ;

N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)cinnolin-3-yl)-2-(4-methylpiperazin-l-yl)isonicotinamide

[2563];

2-(methyl( 1 -methylpiperidin-4-yl)amino)-N-(6-(5-methyl- 1 ,3 ,4-thiadiazol-2-yl)cinnolin-3 -yl) isonicotinamide [2564];

2-(azetidin-3-yloxy)-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)cinnolin-3-yl)isonicotinamide [2565]; N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)cinnolin-3-yl)-3-((l-methylpiperidin-4-yl)oxy)benzamide

[2566];

N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)cinnolin-3-yl)-2-((l-methylpiperidin-4-yl)thio)

isonicotinamide [2567];

6-(4-methylpiperazin-l-yl)-N-(6-(5-(trifluoromethyl)-l,3,4-thiadiazol-2-yl)cinnolin-3-yl)

nicotinamide [2568];

2-(4-methylpiperazin-l-yl)-N-(6-(5-(trifluoromethyl)-l,3,4-thiadiazol-2-yl)cinnolin-3-yl)

isonicotinamide [2569];

N-(6-(5-amino-l,3,4-thiadiazol-2-yl)cinnolin-3-yl)-2-(4-methylpiperazin-l-yl)isonicotinamide

[2570];

N-(6-(5-(dimethylamino)-l,3,4-thiadiazol-2-yl)cinnolin-3-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [2571]; N-(6-(3-amino-5 -fluorophenyl)cinnolin-3 -yl)-2-(4-methylpiperazin- 1 -yl)isonicotinamide [2572] ; N-(6-(3-fluoro-5-(isopropylamino)phenyl)cinnolin-3-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [2573];

1 -methyl -N-(6-(pyridin-2-yl)cinnolin-3 -yl)piperidine-4-carboxamide [2574] ;

2-(4-methylpiperazin-l-yl)-N-(6-(pyridin-2-yl)cinnolin-3-yl)isonicotinamide [2575];

2-(4-methylpiperazin-l-yl)-N-(6-(pyridin-4-yl)cinnolin-3-yl)isonicotinamide [2576];

N-(6-(pyridin-3-yl)cinnolin-3-yl)cyclopropanecarboxamide [2577];

N-(6-(pyridin-3 -yl)cinnolin-3-yl)-2-(pyrrolidin- 1 -yl)acetamide [2578] ;

1 -methyl -N-(6-(pyridin-3 -yl)cinnolin-3 -yl)piperidine-4-carboxamide [2579] ;

N-(6-(pyridin-3-yl)cinnolin-3-yl)quinuclidine-4-carboxamide [2580];

2-moφholino-N-(6-(pyridin-3-yl)cinnolin-3-yl)acetamide [2581] ;

2-(moφholino-ί s)- -(6-(pyridin-3-yl)cinnolin-3-yl)acetamide [2582];

2-(4-methylpiperazin- 1 -yl)-N-(6-(pyridin-3 -yl)cinnolin-3 -yl)acetamide [2583] ;

2-(4-methyl- 1 ,4-diazepan-l -yl)-N-(6-(pyridin-3 -yl)cinnolin-3-yl)acetamide [2584] ;

2-(4-methylpiperazin- 1 -yl)-N-(6-(pyridin-3 -yl)cinnolin-3 -yl)isonicotinamide [2585] ;

2-(2-methyl-lH-imidazol-l-yl)-N-(6-(pyridin-3-yl)cinnolin-3-yl)acetamide [2586];

2-(lH-imidazol-l-yl)-N-(6-(pyridin-3-yl)cinnolin-3-yl)acetamide [2587];

2-(piperidin-4-yl)-N-(6-(pyridin-3-yl)cinnolin-3-yl)oxazole-4-carboxamide [2588];

2-( 1 -methylpiperidin-4-yl)-N-(6-(pyridin-3 -yl)cinnolin-3 -yl)oxazole-4-carboxamide [2589] ; 2-(l-isopropylpiperidin-4-yl)-N-(6-(pyridin-3-yl)cinnolin-3-yl)oxazole-4-carboxamide [2590]; fr rø-N-(6-(5-fluoropyridin-3-yl)cinnolin-3-yl)-3-mo holinocyclobutane-l-carboxamide [2591]; fr «5-N-(6-(5-fluoropyridin-3-yl)cinnolin-3-yl)-4-((4-methylpiperazin-l-yl)methyl)cyclohexane-

1-carboxamide [2592];

N-(6-(5-fluoropyridin-3-yl)cinnolin-3-yl)-2-(pyrrolidin-l-yl)acetamide [2593];

N-(6-(5-fluoropyridin-3-yl)cinnolin-3-yl)-l-methylpiperidine-4-carboxamide [2594];

N-(6-(5-fluoropyridin-3-yl)cinnolin-3-yl)-2-(4-methylpiperazin-l-yl)acetamide [2595];

N-(6-(6-fluoropyridin-3-yl)cinnolin-3-yl)-2-(4-methylpiperazin-l-yl)acetamide [2596];

N-(6-(5-fluoropyridin-3-yl)cinnolin-3-yl)-2-moφholinoacetamide [2597];

N-(6-(5-fluoropyridin-3-yl)cinnolin-3-yl)-3-moφholinopropanamide [2598];

N-(6-(5-fluoropyridin-3-yl)cinnolin-3-yl)-2-(4-methylpiperazin-l-yl)isonicotinamide [2599]; N-(6-(5-fluoropyridin-3-yl)cinnolin-3-yl)-2-(piperidin-4-yl)oxazole-4-carboxamide [2600]; N-(6-(5-fluoropyridin-3-yl)cinnolin-3-yl)-2-(l-methylpiperidin-4-yl)oxazole-4-carboxamide

[2601]; N-(6-(5-fluoropyridin-3-yl)cinnolin-3-yl)-2-(l-isopropylpiperidin-4-yl)oxazole-4-carboxamide

[2602];

N-(6-(5-chloropyridin-3-yl)cinnolin-3-yl)-2-(4-methylpiperazin-l-yl)isonicotinamide [2603]; N-(6-(5-methylpyridin-3-yl)cinnolin-3-yl)-2-mo holinoacetamide [2604];

N-(6-(5-(difluoromethyl)pyridin-3-yl)cinnolin-3-yl)-3-(piperidin-4-yl)benzamide [2605];

N-(6-(5-(difluoromethyl)pyridin-3-yl)cinnolin-3-yl)-3-(l-methylpiperidin-4-yl)benzamide [2606]; N-(6-(5-(difluoromethyl)pyridin-3-yl)cinnolin-3-yl)-2-(4-methylpiperazin-l-yl)isonicotinamide

[2607];

2-(4-methylpiperazin-l-yl)-N-(6-(5-(trifluoromethyl)pyridin-3-yl)cinnolin-3-yl)acetamide [2608]; 2-(4-methylpiperazin-l-yl)-N-(6-(6-(trifluoromethyl)pyridin-3-yl)cinnolin-3-yl)acetamide [2609]; N-(6-(5-(hydroxymethyl)pyridin-3-yl)cinnolin-3-yl)-l-methylpiperidine-4-carboxamide [2610]; N-(6-(5-cyanopyridin-3-yl)cinnolin-3-yl)-l-methylpiperidine-4-carboxamide [2611];

N-(6-(5-methoxypyridin-3-yl)cinnolin-3-yl)-l-methylpiperidine-4-carboxamide [2612];

N-(6 -(5 -methoxypyridin-3 -yl)cinnolin-3 -yl) -2 -morpholinoacetamide [2613];

N-(6-(5-methoxypyridin-3-yl)cinnolin-3-yl)-2-(4-methylpiperazin-l-yl)isonicotinamide [2614]; 4-fluoro-N-(6-(5-(piperidin-4-yloxy)pyridin-3-yl)cinnolin-3-yl)benzamide [2615];

N-(6-(5-aminopyridin-3-yl)cinnolin-3-yl)-4-fluorobenzamide [2616];

N-(6-(5-aminopyridin-3-yl)cinnolin-3-yl)-4-(piperidin-4-yloxy)benzamide [2617];

N-(6 -(5 -aminopyridin-3 -yl)cinnolin-3 -yl) -2 -(4 -methylpiperazin- 1 -yl)isonicotinamide [2618]; N-(6-(5-aminopyridin-3-yl)cinnolin-3-yl)-2-(piperidin-4-yl)oxazole-4-carboxamide [2619];

N-(6-(6-aminopyridin-3 -yl)cinnolin-3-yl) -2 -(4 -methylpiperazin- 1 -yl)isonicotinamide [2620] ; N-(6-(6-(methylamino)pyridin-3-yl)cinnolin-3-yl)-2-(4-methylpiperazin-l-yl)isonicotinamide

[2621];

N-(6-(5-(isopropylamino)pyridin-3-yl)cinnolin-3-yl)-3-(piperidin-4-yl)benzamide [2622];

N-(6-(5 -(isopropylamino)pyridin-3 -yl)cinnolin-3 -yl)-3 -( 1 -methylpiperidin-4-yl)benzamide

[2623];

N-(6-(5-(isopropylamino)pyridin-3-yl)cinnolin-3-yl)-2-(4-methylpiperazin-l-yl)isonicotinamide

[2624];

N-(6-(5-(piperidin-4-ylamino)pyridin-3-yl)cinnolin-3-yl)cyclohexanecarboxamide [2625];

4-fluoro-N-(6-(5-(piperidin-4-ylamino)pyridin-3-yl)cinnolin-3-yl)benzamide [2626];

4-fluoro-N-(6-(5 -(( 1 -methylpiperidin-4-yl)amino)pyridin-3 -yl)cinnolin-3 -yl)benzamide [2627] ; N-(6-(5-acetamidopyridin-3-yl)cinnolin-3-yl)-l-methylpiperidine-4-carboxamide [2628];

N-(6-(5-(dimethylamino)pyridin-3-yl)cinnolin-3-yl)-2-(4-methylpiperazin-l-yl)isonicotinamide

[2629]; N-(6-(6-(dimethylamino)pyridin-3-yl)cinnolin-3-yl)-2-(4-methylpiperazin-l-yl)isonicotinamide

[2630];

1- methyl-N-(6-(5-(pyrrolidin-l-yl)pyridin-3-yl)cinnolin-3-yl)piperidine-4-carboxamide [2631]; N-(6 -(5 -(pyrrolidin- 1 -ylmethyl)pyridin-3 -yl)cinnolin-3 -yl)cyclopropanecarboxamide [2632] ; 4-fluoro-N-(6-(5-(pyrrolidin-l-ylmethyl)pyridin-3-yl)cinnolin-3-yl)benzamide [2633];

N-(6-(5-((4-hydroxypiperidin-l-yl)methyl)pyridin-3-yl)cinnolin-3-yl)cyclopropanecarboxamide

[2634];

4-fluoro-N-(6-(5-((4-hydroxypiperidin-l-yl)methyl)pyridin-3-yl)cinnolin-3-yl)benzamide [2635]; N-(6-(5 -(piperazin- 1 -ylmethyl)pyridin-3 -yl)cinnolin-3 -yl)cyclopropanecarboxamide [2636] ; N-(6-(5 -((4-methylpiperazin- 1 -yl)methyl)pyridin-3 -yl)cinnolin-3 -yl)cyclopropanecarboxamide

[2637];

N-(6-(5-(mo holinomethyl)pyridin-3-yl)cinnolin-3-yl)cyclopropanecarboxamide [2638];

N-methyl-5-(3-(l-methylpiperidine-4-carboxamido)cinnolin-6-yl)nicotinamide [2639];

N-methyl-5 -(3 -(2 -(4-methylpiperazin- 1 -yl)isonicotinamido)cinnolin-6-yl)nicotinamide [2640] ; N-(6-(pyridin-3-yl-£/₄()cinnolin-3-yl)-2-(pyrrolidin-l-yl)acetamide [2641];

2- (4-methylpiperazin- 1 -yl)-N-(6-(pyridin-3 -yl-d.i)cinnolin-3-yl)acetamide [2642] ;

2-morpholino-N-(6-(pyridin-3 -yl-<¾)cinnolin-3 -yl)acetamide [2643] ;

1- methyl-N-(6-(2-methylpyrimidin-5-yl)cinnolin-3-yl)piperidine-4-carboxamide [2644];

2- (4-methylpiperazin-l-yl)-N-(6-(2-methylpyrimidin-5-yl)cinnolin-3-yl)isonicotinamide [2645]; N-(6-(2-aminopyrimidin-5-yl)cinnolin-3-yl)-l-methylpiperidine-4-carboxamide [2646];

2-moφholino-N-(6-(pyridazin-3 -yl)cinnolin-3 -yl)acetamide [2647] ;

2-moφholino-N-(6-(pyridazin-4-yl)cinnolin-3 -yl)acetamide [2648] ;

N-(6-(pyridazin -4 -yl)cinnolin-3-yl) -2 -(pyrrolidin- 1 -yl)acetamide [2649] ;

fr rø-3-mo holino-N-(6-(pyrazin-2-yl)cinnolin-3-yl)cyclobutane-l -carboxamide [2650];

trans -4 -(dimethylamino) -N-(6 -(pyrazin-2-yl)cinnolin-3 -yl)cyclohexane - 1 -carboxamide [2651]; trans -4 -Γηοφηο1ίηο-Ν-(6 -(pyrazin-2-yl)cinnolin-3 -yl)cyclohexane - 1 -carboxamide [2652] ;

fr «5-4-((3-fluoroazetidin-l-yl)methyl)-N-(6-(pyrazin-2-yl)cinnolin-3-yl)cyclohexane-l- carboxamide [2653];

trans-4-( (4-methylpiperazin- 1 -yl)methyl)-N-(6-(pyrazin-2-yl)cinnolin-3-yl)cyclohexane- 1 - carboxamide [2654];

N-(6-(pyrazin-2-yl)cinnolin-3-yl)-2-(pyrrolidin-l-yl)acetamide [2655];

1 -methyl -N-(6-(pyrazin -2 -yl)cinnolin-3 -yl)piperidine-4-carboxamide [2656] ;

4-fluoro-l -methyl-N-(6-(pyrazin-2-yl)cinnolin-3-yl)piperidine-4-carboxamide [2657] ;

1 -(2-fluoroethyl)-N-(6-(pyrazin-2-yl)cinnolin-3 -yl)piperidine-4-carboxamide [2658] ; 1- (oxetan-3-yl)-N-(6-(pyrazin-2-yl)cinnolin-3-yl)piperidine-4-carboxamide [2659];

2- moφholino-N-(6-(pyrazin-2-yl)cinnolin-3-yl)acetamide [2660] ;

1 -methyl -N-(6-(pyrazin -2 -yl)cinnolin-3 -yl)azepane-4-carboxamide [2661] ;

1 -isobutyl-N-(6-(pyrazin-2-yl)cinnolin-3 -yl)azepane-4-carboxamide [2662] ;

1- (2 -hydroxy -2 -methylpropyl)-N-(6-(pyrazin-2-yl)cinnolin-3-yl)azepane-4-carboxamide [2663]; 4-(moφholinomethyl)-N-(6-(pyrazin-2-yl)cinnolin-3-yl)benzamide [2664];

2- (4-methylpiperazin-l-yl)-N-(6-(pyrazin-2-yl)cinnolin-3-yl)isonicotinamide [2665];

N-(6-(6-(methylamino)pyrazin-2-yl)cinnolin-3-yl)-2-(4-methylpiperazin-l-yl)isonicotinamide

[2666];

N-(6-(6-(isopropylamino)pyrazin-2-yl)cinnolin-3-yl)azetidine-3-carboxamide [2667];

N-(6-(6-(isopropylamino)pyrazin-2-yl)cinnolin-3-yl)piperidine-4-carboxamide [2668];

N-(6-(6-(isopropylamino)pyrazin-2-yl)cinnolin-3-yl)-l-methylpiperidine-4-carboxamide [2669]; l-(2-fluoroethyl)-N-(6-(6-(isopropylamino)pyrazin-2-yl)cinnolin-3-yl)piperidine-4-carboxamide

[2670];

l-isopropyl-N-(6-(6-(isopropylamino)pyrazin-2-yl)cinnolin-3-yl)piperidine-4-carboxamide

[2671];

l-isopentyl-N-(6-(6-(isopropylamino)pyrazin-2-yl)cinnolin-3-yl)piperidine-4-carboxamide

[2672];

N-(6-(6-(isopropylamino)pyrazin-2-yl)cinnolin-3-yl)-3-(piperidin-4-yl)benzamide [2673]; N-(6-(6-(isopropylamino)pyrazin-2-yl)cinnolin-3-yl)-3-(l-methylpiperidin-4-yl)benzamide

[2674];

N-(6-(6-(isopropylamino)pyrazin-2-yl)cinnolin-3-yl)-l-(piperidin-4-yl)-lH-l,2,3-triazole-4- carboxamide [2675];

l-(l-(2-fluoroethyl)piperidin-4-yl)-N-(6-(6-(isopropylamino)pyrazin-2-yl)cinnolin-3-yl)-lH- l,2,3-triazole-4-carboxamide [2676];

N-(6-(6-(isopropylamino)pyrazin-2-yl)cinnolin-3-yl)-l-(l-isopropylpiperidin-4-yl)-lH-l,2,3- triazole-4-carboxamide [2677];

N-(6-(6-(isopropylamino)pyrazin-2-yl)cinnolin-3-yl)-2-(4-methylpiperazin-l-yl)isonicotinamide

[2678];

N-(6-(6-(feri-butylamino)pyrazin-2-yl)cinnolin-3-yl)-2-(3-(dimethylamino)azetidin-l-yl)

isonicotinamide [2679];

N-(6-(6-(fer^butylamino)pyrazin-2-yl)cinnolin-3-yl)-r-methyl-r,2',3',6'-tetrahydro-[2,4'- bipyridine] -4 -carboxamide [2680] ; N-(6-(6-(fer^butylamino)pyrazin-2-yl)cinnolin-3-yl)-2-(4-methylpiperazin-l-yl)isonicotinamide

[2681];

N-(6-(6-(fer^butylamino)pyrazin-2-yl)cinnolin-3-yl)-2-(4-isopropylpiperazin-l-yl)

isonicotinamide [2682];

N-(6-(6-(feri-butylamino)pyrazin-2-yl)cinnolin-3 -yl)-2-mo holinoisonicotinamide [2683] ; N-(6-(6-(((3-fluoroazetidin-3-yl)methyl)amino)pyrazin-2-yl)cinnolin-3-yl)

cyclopropanecarboxamide [2684];

4-fluoro-N-(6-(6-(((3-fluoroazetidin-3-yl)methyl)amino)pyrazin-2-yl)cinnolin-3-yl)benzami

[2685];

N-(6-(6-(piperidin-4-ylamino)pyrazin-2-yl)cinnolin-3 -yl)cyclobutanecarboxamide [2686] ;

3.3- difluoro-N-(6-(6-(piperidin-4-ylamino)pyrazin-2-yl)cinnolin-3-yl)cyclobutane-l-carboxami

[2687];

N-(6-(6-(piperidin-4-ylamino)pyrazin-2-yl)cinnolin-3 -yl)cyclopentanecarboxamide [2688] ;

4.4- difluoro-N-(6-(6-(piperidin-4-ylamino)pyrazin-2-yl)cinnolin-3-yl)cyclohexane-l- carboxamide [2689];

N-(6-(6-(piperidin-4-ylamino)pyrazin-2-yl)cinnolin-3-yl)tetrahydro-2H-pyran-4-carboxamide

[2690];

4-fluoro-N-(6-(6-(piperidin-4-ylamino)pyrazin-2-yl)cinnolin-3-yl)benzamide [2691];

N-(6-(6-(((3S,4S)-3-fluoropiperidin-4-yl)amino)pyrazin-2-yl)cinnolin-3-yl)

cyclopropanecarboxamide [2692];

4-fluoro-N-(6-(6-(((3S,4S)-3-fluoropiperidin-4-yl)amino)pyrazin-2-yl)cinnolin-3-yl)benzamide

[2693];

N-(6-(6-(( 1 -methylpiperidin-4-yl)amino)pyrazin-2-yl)cinnolin-3 -yl)cyclobutanecarboxamide

[2694];

N-(6-(6-(( 1 -methylpiperidin-4-yl)amino)pyrazin-2-yl)cinnolin-3 -yl)cyclopentanecarboxamide

[2695];

4-fluoro-N-(6-(6-((l-methylpiperidin-4-yl)amino)pyrazin-2-yl)cinnolin-3-yl)benzamide [2696]; N-(6-(6-((l-isopropylpiperidin-4-yl)amino)pyrazin-2-yl)cinnolin-3-yl)cyclopropanecarboxamide

[2697];

3,3-difluoro-N-(6-(6-((l-isopropylpiperidin-4-yl)amino)pyrazin-2-yl)cinnolin-3-yl)cyclobutane- 1-carboxamide [2698];

N-(6-(6-((l-isopropylpiperidin-4-yl)amino)pyrazin-2-yl)cinnolin-3-yl)cyclopentanecarboxamide

[2699]; 4-fluoro-N-(6-(6-(( 1 -isopropylpiperidin-4-yl)amino)pyrazin-2-yl)cinnolin-3 -yl)benzamide

[2700];

N-(6-(6-(dimethylamino)pyrazin-2-yl)cinnolin-3 -yl)-2-(4-methylpiperazin- 1 -yl)isonicotinamide

[2701];

N-(6-(6-(diethylamino)pyrazin-2-yl)cinnolin-3-yl)-2-(4-methylpiperazin-l-yl)isonicotinamide

[2702];

N-(6-(6-(3-aminoazetidin-l-yl)pyrazin-2-yl)cinnolin-3-yl)-4-fluorobenzamide [2703];

2-(4-methylpiperazin- 1 -yl)-N-(6-(6-(pyrrolidin- 1 -yl)pyrazin-2-yl)cinnolin-3 -yl)isonicotinamide

[2704];

N-(6-(6-(azetidin-3-ylmethoxy)pyrazin-2-yl)cinnolin-3-yl)-4-fluorobenzamide [2705];

N-(6-(6-(azetidin-3-yloxy)pyrazin-2-yl)cinnolin-3-yl)-4-fluorobenzamide [2706];

N-(6-( lH-pyrrolo[2,3 -b]pyridin-5 -yl)cinnolin-3-yl)- 1 -( 1 -methylpiperidin-4-yl)- lH-pyrazole-4- carboxamide [2707];

N-(6-(lH-pyrrolo[3,2-b]pyridin-6-yl)cinnolin-3-yl)-l-(l-methylpiperidin-4-yl)-lH-pyrazole-4- carboxamide [2708];

N-(6-(lH-pyrrolo[2,3-c]pyridin-4-yl)cinnolin-3-yl)-l-(l-methylpiperidin-4-yl)-lH-pyrazole-4- carboxamide [2709];

N-(6-( IH-pyrrolo [2,3 -b]pyridin-5 -yl)cinnolin-3 -yl)-2-(4-methylpiperazin- 1 -yl)isonicotinamide

[2710];

N-(6-(lH-pyrrolo[3,2-b]pyridin-6-yl)cinnolin-3-yl)-2-(4-methylpiperazin-l-yl)isonicotinami

[2711];

N-(6-(lH-pyrrolo[2,3-c]pyridin-4-yl)cinnolin-3-yl)-2-(4-methylpiperazin-l-yl)isonicotinami

[2712];

2-(4-methylpiperazin-l-yl)-N-(6-(oxazolo[5,4-b]pyridin-6-yl)cinnolin-3-yl)isonicotinamide

[2713];

N-(6-(2-methyl-lH-pyrrolo[2,3-b]pyridin-5-yl)cinnolin-3-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [2714];

N-(6-(3-methyl-lH-pyrrolo[2,3-b]pyridin-5-yl)cinnolin-3-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [2715];

N-(6-(2-methyl-lH-pyrrolo[3,2-b]pyridin-6-yl)cinnolin-3-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [2716];

N-(6-(5H-pyrrolo[2,3-b]pyrazin-2-yl)cinnolin-3-yl)-2-(4-methylpiperazin-l-yl)isonicotinamide

[2717]; N-(6-(5H-pyrrolo[2,3-b]pyrazin-3-yl)cinnolin-3-yl)-2-(4-methylpiperazin-l-yl)isonicotinamid^

[2718] ;

l-isopropyl-N-(6-(6-(piperidin-4-ylamino)pyrazin-2-yl)cinnolin-3-yl)-lH-pyrazole-4- carboxamide [2719];

l-isopropyl-N-(6-(6-(( l-methylpiperidin-4-yl)amino)pyrazin-2-yl)cinnolin-3-yl)-lH-pyrazole-4- carboxamide [2720]; or a pharmaceutically acceptable salt thereof.

23. The compound according to any one of claims 1-19, wherein the compound of Formula I is selected from the group consisting of:

N-(3 -( lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl)- 1 -isobutylpiperidine-4-carboxamide [2721] ; N-(3-( l-methyl-lH-pyrazol-4-yl)-l ,7-naphthyridin-6-yl)cyclopropanecarboxamide [2722];

4,4-difluoro-N-(3-( l-methyl-lH-pyrazol-4-yl)-l ,7-naphthyridin-6-yl)cyclohexane-l-carboxamide

[2723] ;

fr «5-4-methoxy-N-(3-(l -methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)cyclohexane-l - carboxamide [2724];

trans-N-(3-( 1 -methyl- lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl)-4-morpholinocyclohexane- 1 - carboxamide [2725];

trans-4-((3 -fluoroazetidin- 1 -yl)methyl)-N-(3-( 1 -methyl- lH-pyrazol-4-yl)-l ,7-naphthyridin-6-yl) cyclohexane-1 -carboxamide [2726];

trans-N-(3-( 1 -methyl-lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl)-4-((4-methylpiperazin- 1 -yl)

methyl)cyclohexane- 1 -carboxamide [2727] ;

N-(3 -( 1 -methyl -lH-pyrazol -4 -yl)- 1 ,7-naphthyridin-6-yl)-2-(pyrrolidin- 1 -yl)acetamide [2728] ; (S)-2-(3 -fluoropyrrolidin- 1 -yl)-N-(3-( 1 -methyl- lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl)

acetamide [2729];

(S)-N-(3 -( 1 -methyl-lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl)tetrahydrofuran -2 -carboxamide

[2730] ;

N-(3 -( 1 -methyl -lH-pyrazol -4 -yl)- 1 ,7-naphthyridin-6-yl)piperidine-4-carboxamide [2731] ;

1 -methyl -N-(3 -( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 ,7 -naphthyridin-6-yl)piperidine -4 -carboxamide

[2732] ;

1 -isopropyl-N-(3-( 1 -methyl- lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl)piperidine-4-carboxamide

[2733] ;

1 -(fert-butyl)-N-(3-( 1 -methyl- 1 H-pyrazol -4 -yl)- 1 ,7-naphthyridin-6-yl)piperidine-4-carboxamide

[2734] ;

l-cyclopropyl-N-(3-(l -methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)piperidine-4-carboxamide

[2735] ; 1 -isobutyl-N-(3-( 1 -methyl- lH-pyrazol-4-yl)-l ,7-naphthyridin-6-yl)piperidine-4-carboxamide

[2736];

N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)-l-neopentylpiperidine-4-carboxamide

[2737];

l-(2-fluoroethyl)-N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)piperidine-4- carboxamide [2738];

N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)-l-(3,3,3-trifluoropropyl)piperidine-4- carboxamide [2739];

1 -butyl -N-(3 -( 1 -methyl- lH-pyrazol-4-yl)-l ,7-naphthyridin-6-yl)piperidine-4-carboxamide

[2740];

1 -benzoyl -N-(3-( 1 -methyl- lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl)piperidine-4-carboxamide

[2741];

l-(2,2-difluoropropyl)-N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)piperidine-4- carboxamide [2742];

N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)azetidine-3-carboxamide [2743];

1 -(2,2-difluoroethyl)-N-(3-( 1 -methyl- lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl)piperidine-4- carboxamide [2744];

1 -(2-fluoro-2-methylpropyl)-N-(3 -( 1 -methyl- lH-pyrazol-4-yl)-l ,7-naphthyridin-6-yl)piperidine-

4-carboxamide [2745];

N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)-l-(oxetan-3-yl)piperidine-4- carboxamide [2746];

N-(3 -( 1 -methyl -lH-pyrazol -4 -yl)- 1 ,7-naphthyridin-6-yl)- 1 -((3-methyloxetan-3 -yl)methyl) piperidine-4-carboxamide [2747];

1 -(2-methoxyethyl)-N-(3 -( 1 -methyl-lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl)piperidine-4- carboxamide [2748];

l-(2-isopropoxyethyl)-N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)piperidine-4- carboxamide [2749];

1 , 1 -diisobutyl-4-((3-( 1 -methyl- lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl)carbamoyl)piperidin- 1 - ium [2750];

4-fluoro-N-(3 -( 1 -methyl- lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl)piperidine-4-carboxamide

[2751];

4-fluoro- 1 -methyl -N-(3 -( 1 -methyl-lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl)piperidine-4- carboxamide [2752]; 4-fluoro- 1 -isobutyl-N-(3-( 1 -methyl- lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl)piperidine-4- carboxamide [2753];

(S)-N-(3 -( 1 -methyl-lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl)piperidine-3-carboxamide [2754] ; (R)-N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)piperidine-3-carboxamide [2755]; (S)- 1 -isobutyl-N-(3 -( 1 -methyl- lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl)piperidine-3 -carboxamide

[2756];

(R)-l-isobutyl-N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)piperidine-3-carboxamide

[2757];

N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)tetrahydro-2H-pyran-4-carboxamide

[2758];

N-(3 -( 1 -methyl-lH-pyrazol-4-yl)-l ,7-naphthyridin-6-yl)-2-(piperidin- 1 -yl)acetamide [2759] ; 2-(4-fluoropiperidin-l-yl)-N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)acetamide

[2760];

fr «5-4-amino-N-(3-( 1 -methyl-lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl)cyclohexane- 1 - carboxamide [2761];

N-(3 -( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 ,7 -naphthyridin-6 -yl)-2-(4 -methylpiperazin- 1 -yl)acetamide

[2762];

(S)-N-(3 -( 1 -methyl-lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl)piperidine-2 -carboxamide [2763] ; 2-(4-isobutylpiperazin-l-yl)-N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)acetamide

[2764];

2-(3,3-dimethylazetidin- 1 -yl)-N-(3 -( 1 -methyl-lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl)acetamide

[2765];

(R)-2-(3-fluoropyrrolidin- 1 -yl)-N-(3 -( 1 -methyl- lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl)

acetamide [2766];

(S)-N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)-2-(2-methylpyrrolidin-l-yl)

acetamide [2767];

2-(3-azabicyclo[3.1.0]hexan-3 -yl)-N-(3 -( 1 -methyl- lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl) acetamide [2768];

2-(7-azabicyclo[2.2.1]heptan-7-yl)-N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl) acetamide [2769];

N-(3 -( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 ,7 -naphthyridin-6 -yl)-2-(4 -methylpiperidin- 1 -yl)acetamide

[2770];

N-(3 -( 1 -methyl -1 H-pyrazol -4 -yl)- 1 ,7-naphthyridin-6-yl)-2-(4-(trifluoromethyl)piperidin- 1 -yl) acetamide [2771]; 2-(4-(difluoromethyl)piperidin-l-yl)-N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl) acetamide [2772];

N-(3-(l-methyl-lH-pyrazol-4-yl)-l ,7-naphthyridin-6-yl)-2-(6-azaspiro[2.5]octan-6-yl)acetamide

[2773];

N-(3 -( 1 -methyl -lH-pyrazol -4 -yl)- 1 ,7-naphthyridin-6-yl)-2-(pyrrolidin-l -yl)propanamide [2774] ; (R)-N-(3-( 1 -methyl- lH-pyrazol-4-yl)-l ,7-naphthyridin-6-yl)-2-(2-methylpyrrolidin- 1 -yl)

acetamide [2775];

2-(cyclobutyl(methyl)amino)-N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)acetamide

[2776];

2-(diethylamino)-N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)acetamide [2777]; 7-(2-fluoroethyl)-N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)-7-azaspiro[3.5]

nonane-2-carboxamide [2778] ;

4-methyl-N-(3 -( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 ,7 -naphthyridin-6-yl)piperazine - 1 -carboxamide

[2779];

(S)-N-(3 -( 1 -methyl-lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl)-2-(pyrrolidin- 1 -yl)propanamide

[2780];

(R)-N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)-2-(pyrrolidin-l-yl)propanamide

[2781];

(R)-N-(3 -( 1 -methyl-lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl)pyrrolidine-2 -carboxamide [2782] ; 2-methyl-N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)-2-azaspiro[3.3]heptane-6- carboxamide [2783];

N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)-2-(2,2,2-trifluoroacetyl)-2-azaspiro[3.3] heptane-6-carboxamide [2784] ;

2-(2-fluoroethyl)-N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)-2-azaspiro[3.3]

heptane-6-carboxamide [2785] ;

trans -4 -(dimethylamino) -N-(3 -( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 ,7 -naphthyridin-6-yl)cyclohexane - 1 - carboxamide [2786];

1 -acetyl -N-(3 -( 1 -methyl -1 H-pyrazol -4 -yl)- 1 ,7-naphthyridin-6-yl)piperidine-4 -carboxamide

[2787];

N-(3 -( 1 -methyl -1 H-pyrazol -4 -yl)- 1 ,7-naphthyridin-6-yl)- 1 -(( 1 -(trifluoromethyl)cyclopropyl) methyl)piperidine -4 -carboxamide [2788] ;

(S)-l-(2-fluoropropyl)-N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)piperidine-4- carboxamide [2789]; (R)-l-(2-fluoropropyl)-N-(3-(l-methyl-lH-pyrazol-4-yl)-l ,7-naphthyridin-6-yl)piperidine-4- carboxamide [2790];

N-(3 -( 1 -methyl-lH-pyrazol-4-yl)-l ,7-naphthyridin-6-yl)-2-(piperidin- 1 -yl)propanamide [2791] ; N-(3 -( 1 -methyl - 1 H-pyrazol -4-yl) - 1 ,7 -naphthyridin-6-yl) - 1 -(methylsulfonyl)piperidine -4 - carboxamide [2792];

1 '-methyl -N-(3 -( 1 -methyl- lH-pyrazol-4-yl)-l ,7-naphthyridin-6-yl)-[ 1 ,4'-bipiperidine] -4- carboxamide [2793];

fr «5-4-(hydroxymethyl)-N-(3-( 1 -methyl- lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl)cyclohexane- 1 - carboxamide [2794];

methyl 2 -(4 -((3 -( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 , 7-naphthyridin-6 -yl)carbamoyl)piperidin- 1 -yl) acetate [2795];

1 -benzyl -N-(3 -( 1 -methyl -1 H-pyrazol -4-yl)- 1 ,7-naphthyridin-6-yl)piperidine-4 -carboxamide

[2796];

N-(3 -( 1 -methyl -1 H-pyrazol -4-yl)- 1 ,7-naphthyridin-6-yl)- 1 -(2-(pyrrolidin-l -yl)acetyl)piperidine-

4-carboxamide [2797];

N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)-2-moφholinoacetamide [2798];

(S)-N-(3 -( 1 -methyl-lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl)-2-(3 -methylmorpholino)acetamide

[2799];

(R)-N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)-2-(3-methylmo holino)acetamide

[2800];

(S)-N-(3 -( 1 -methyl-lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl)-2-(2-methylmo holino)acetamide

[2801];

2-((2R,6S)-2,6-dimethylmoφholino)-N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl) acetamide [2802];

2-((lS,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7- naphthyridin-6-yl)acetamide [2803] ;

2-((lR,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7- naphthyridin-6-yl)acetamide [2804] ;

2-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl) acetamide [2805];

(S)-N-(3 -( 1 -methyl-lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl)-2-moφholinopropanamide [2806] ; N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)-2-(moφholin-2-yl)acetamide [2807]; N-(3 -( 1 -methyl -1 H-pyrazol -4-yl)- 1 ,7-naphthyridin-6-yl)-2-(4-methylmoφholin-2-yl)acetamide

[2808]; 2-(4-ethylpiperazin-l-yl)-N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)acetamide

[2809];

2-(4-isopropylpiperazin-l-yl)-N-(3-(l-methyl-lH-pyrazol-4-yl)-l ,7-naphthyridin-6-yl)acetamide

[2810];

2-(4-cyclopropylpiperazin- 1 -yl)-N-(3 -( 1 -methyl-lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl)

acetamide [2911];

2-(4-(2-fluoroethyl)piperazin- 1 -yl)-N-(3-( 1 -methyl-lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl) acetamide [2812];

(S)-2-(2,4-dimethylpiperazin-l-yl)-N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl) acetamide [2813];

1 -(2-hydroxyethyl)-N-(3 -( 1 -methyl- lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl)piperidine-4- carboxamide [2814];

N-(3 -( 1 -methyl -1 H-pyrazol -4 -yl)- 1 ,7-naphthyridin-6-yl)- 1 -(pyridin-2-ylmethyl)piperidine-4- carboxamide [2815];

N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)-l-(oxazol-2-ylmethyl)piperidine-4- carboxamide [2816];

(R)-N-(3 -( 1 -methyl-lH-pyrazol-4-yl)-l ,7-naphthyridin-6-yl)- 1 -oxotetrahydro- lH-pyrrolo[ 1 ,2-c] imidazole-2(3H)-carboxamide [2817] ;

(R) - 1 -methyl -N-(3 -( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 ,7 -naphthyridin-6 -yl)pyrrolidine-2 -carboxamide

[2818];

N-(3 -( 1 -methyl -1 H-pyrazol -4 -yl)- 1 ,7-naphthyridin-6-yl)- 1 -(tetrahydro-2H-pyran-4-yl)piperidine- 4-carboxamide [2819];

N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)-l-(pyrimidin-2-ylmethyl)piperidine-4- carboxamide [2820];

N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)-l-(pyrazin-2-ylmethyl)piperidine-4- carboxamide [2821];

1 -((5 -methyl- 1 ,2,4-oxadiazol-3-yl)methyl)-N-(3-( 1 -methyl- 1 H-pyrazol -4 -yl)- 1 ,7-naphthyridin-6- yl)piperidine -4 -carboxamide [2822] ;

1- (2-hydroxy-2-methylpropyl)-N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)

piperidine-4-carboxamide [2823];

fert-butyl 2-(4-((3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)carbamoyl)piperidin-l-yl) acetate [2824];

2- (4-((3-( 1 -methyl- lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl)carbamoyl)piperidin-l -yl)acetic acid

[2825]; 2-(4-methyl- 1 ,4-diazepan- 1 -yl)-N-(3-( 1 -methyl-lH-pyrazol-4-yl)-l ,7-naphthyridin-6-yl) acetamide [2826];

fert-butyl (3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)carbamate [2827];

N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)but-2-ynamide [2828];

trans-4-((3 -( 1 -methyl -lH-pyrazol -4 -yl)-l ,7-naphthyridin-6-yl)carbamoyl)cyclohexane- 1 - carboxylic acid [2829];

N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)-3-moφholinopropanamide [2830]; trans-N-(3-( 1 -methyl- lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl)-3-moφholinocyclobutane- 1 - carboxamide [2831];

N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)quinuclidine-4-carboxamide [2832]; 1 -isobutyl-N-(3-( 1 -methyl- lH-pyrazol-4-yl)-l ,7-naphthyridin-6-yl)azepane-4-carboxamide

[2833];

2-(4-methoxypiperidin- 1 -yl)-N-(3 -( 1 -methyl- lH-pyrazol-4-yl)-l ,7-naphthyridin-6-yl)acetamide

[2834];

2- (4-hydroxypiperidin-l -yl)-N-(3 -( 1 -methyl- lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl)acetamide

[2835];

3- (hydroxymethyl)-N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)bicyclo[l . l . l]

pentane-1 -carboxamide [2836];

1- methyl-N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)azepane-4-carboxamide [2837]; fr «5-4-(dimethylamino)-N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)cyclohexane-l- carboxamide [2838];

fr «5-4-(bis(methyl-£/3)amino)-N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)

cyclohexane-1 -carboxamide [2839];

N-(3 -( 1 -methyl -lH-pyrazol -4 -yl)- 1 ,7-naphthyridin-6-yl)-3-((4-methylpiperazin- 1 -yl)methyl) bicyclo[l .1. l]pentane-l -carboxamide [2840];

methyl trans A-((3-( 1 -methyl- lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl)carbamoyl)cyclohexane- 1 - carboxylate [2841];

2- ( 1 -isobutylpyrrolidin-3 -yl)-N-(3-( 1 -methyl- lH-pyrazol-4-yl)-l ,7-naphthyridin-6-yl)acetamide

[2842];

trans -N-(3 -( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 , 7-naphthyridin-6-yl) -4 -(4 -methylpiperazine - 1 - carbonyl)cyclohexane- 1 -carboxamide [2843] ;

1 -isobutyl-N-(3-( 1 -methyl- lH-pyrazol-4-yl)-l ,7-naphthyridin-6-yl)piperidine-4-carboxamide

[2844]; N-(3-(l-methyl-lH-pyrazol-4-yl)-l ,7-naphthyridin-6-yl)-l-(phenylsulfonyl)piperidine-4- carboxamide [2845];

8 -methyl -N-(3 -( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 ,7 -naphthyridin-6-yl) -3 , 8 -diazabicyclo [3.2.1] octane - 3-carboxamide [2846];

3 -methyl -N-(3 -( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 ,7 -naphthyridin-6-yl) -3 , 8 -diazabicyclo [3.2.1] octane - 8-carboxamide [2847];

(lR,3s,5S)-3-amino-N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)-8-azabicyclo[3.2.1] octane-8-carboxamide [2848];

(lR,3s,5S)-N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)-3-((3,3,3-trifluoropropyl) amino)-8 -azabicyclo [3.2.1 ]octane-8 -carboxamide [2849] ;

(lR,3s,5S)-3-((l,3-difluoropropan-2-yl)amino)-N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7- naphthyridin-6 -yl) -8 -azabicyclo [3.2.1] octane-8 -carboxamide [2850] ;

N-(3 -( 1 -methyl -1 H-pyrazol -4 -yl)- 1 ,7-naphthyridin-6-yl)mo holine-4-carboxamide [2851] ; 4-(dimethylamino)-N-(3-( 1 -methyl-lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl)piperidine- 1 - carboxamide [2852];

(S)-2,4-dimethyl-N-(3-( 1 -methyl- lH-pyrazol-4-yl)-l ,7-naphthyridin-6-yl)piperazine- 1 - carboxamide [2853];

1 -methyl-3 -(3 -( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 ,7 -naphthyridin-6-yl) - 1 -( 1 -methylpiperidin-4 -yl)urea

[2854];

1 -(3 -( 1 -methyl- lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl)-3 -( 1 -methylpiperidin-4-yl)urea [2855] ; 4-isopropyl-N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)piperazine-l -carboxamide

[2856];

(R)-3,4-dimethyl-N-(3-( 1 -methyl- lH-pyrazol-4-yl)-l ,7-naphthyridin-6-yl)piperazine- 1 - carboxamide [2857];

N-(3 -( lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl)-2-(4-methylpiperazin-l -yl)isonicotinamide

[2858];

N-(3 -( 1 -methyl-lH-pyrazol-4-yl)-l ,7-naphthyridin-6-yl)-3 -(piperazin- 1 -yl)benzamide [2859] ; N-(3 -( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 ,7 -naphthyridin-6 -yl)-3 -(4 -methylpiperazin- 1 -yl)benzamide

[2860];

N-(3 -( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 ,7 -naphthyridin-6 -yl)-3 -(pyrrolidin- 1 -ylmethyl)benzamide

[2861];

N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)-3-(piperidin-4-yloxy)benzamide [2862]; N-(3 -( 1 -methyl -1 H-pyrazol -4 -yl)- 1 ,7-naphthyridin-6-yl)-3-(( 1 -methylpiperidin-4-yl)oxy)

benzamide [2863]; N-(3-(l-methyl-lH-pyrazol-4-yl)-l ,7-naphthyridin-6-yl)-4-(piperidin-4-yloxy)benzamide [2864]; N-(3 -( 1 -methyl -lH-pyrazol -4 -yl)- 1 ,7-naphthyridin-6-yl)-4-(( 1 -methylpiperidin-4-yl)oxy)

benzamide [2865];

N-(3 -( 1 -methyl - 1 H-pyrazol -4-yl) - 1 ,7 -naphthyridin-6-y 1) -2 -(piperazin- 1 -yl)isonicotinamide

[2866];

N-(3 -( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 ,7 -naphthyridin-6 -yl)-2-(4 -methylpiperazin- 1 -yl)

isonicotinamide [2867];

2-(4-isopropylpiperazin-l-yl)-N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)

isonicotinamide [2868];

2-(4-cyclopropylpiperazin- 1 -yl)-N-(3 -( 1 -methyl-lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl)

isonicotinamide [2869];

2-(4-(2-fluoroethyl)piperazin- 1 -yl)-N-(3-( 1 -methyl-lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl) isonicotinamide [2870];

N-(3 -( 1 -methyl -1 H-pyrazol -4-yl)- 1 ,7-naphthyridin-6-yl)-6-(4-methylpiperazin- 1 -yl)nicotinamide

[2871];

N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)-5-(piperidin-4-yloxy)nicotinamide

[2872];

N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)-2-(piperidin-4-yloxy)isonicotinamide

[2873];

N-(3 -( 1 -methyl -1 H-pyrazol -4-yl)- 1 ,7-naphthyridin-6-yl)-2-(( 1 -methylpiperidin-4-yl)oxy)

isonicotinamide [2874];

N-(3 -( 1 -methyl - 1 H-pyrazol -4-yl) - 1 ,7 -naphthyridin-6-yl) -5 -(piperidin-4-ylamino)nicotinamide

[2875];

N-(3 -( 1 -methyl -1 H-pyrazol -4-yl)- 1 ,7-naphthyridin-6-yl)-5-(( 1 -methylpiperidin-4-yl)amino) nicotinamide [2876];

2-(4-aminopiperidin- 1 -yl)-N-(3 -( 1 -methyl-lH-pyrazol-4-yl)-l ,7-naphthyridin-6-yl)

isonicotinamide [2877];

N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)-2-(4-(methylamino)piperidin-l-yl) isonicotinamide [2878];

2-(4-(dimethylamino)piperidin-l-yl)-N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl) isonicotinamide [2879];

2-((l-isopropylpiperidin-4-yl)oxy)-N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl) isonicotinamide [2880]; 2-(3 -aminoazetidin- 1 -yl)-N-(3 -( 1 -methyl -1 H-pyrazol -4 -yl)- 1 ,7-naphthyridin-6-yl)

isonicotinamide [2881];

2-(3 -(dimethylamino)azetidin- 1 -yl)-N-(3-( 1 -methyl- lH-pyrazol-4-yl)-l ,7-naphthyridin-6-yl) isonicotinamide [2882];

N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)-2-moφholinoisonicotinamide [2883]; 2-((2-(dimethylamino)ethyl)amino)-N-(3-( 1 -methyl- lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl) isonicotinamide [2884];

2-(2-(dimethylamino)ethoxy)-N-(3 -( 1 -methyl- lH-pyrazol-4-yl)-l ,7-naphthyridin-6-yl)

isonicotinamide [2885];

2-(4-isobutylpiperazin-l-yl)-N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)

isonicotinamide [2886];

2-(azetidin-3-yloxy)-N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)isonicotinamide

[2887];

N-(3 -( 1 -methyl -1 H-pyrazol -4 -yl)- 1 ,7-naphthyridin-6-yl)-2-(( 1 -methylazetidin-3 -yl)oxy)

isonicotinamide [2888];

2-(4-ethylpiperazin-l-yl)-N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)

isonicotinamide [2889];

4-((dimethylamino)methyl)-N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)benzamide

[2890];

N-(3 -( 1 -methyl -1 H-pyrazol -4 -yl)- 1 ,7-naphthyridin-6-yl)-3-( 1 -methylpiperidin-4-yl)benzamide

[2891];

N-(3 -( 1 -methyl -1 H-pyrazol -4 -yl)- 1 ,7-naphthyridin-6-yl)-3-((4-methylpiperazin- 1 -yl)methyl) benzamide [2892];

N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)isonicotinamide [2893];

2-hydroxy-N-(3-( 1 -methyl- lH-pyrazol-4-yl)-l ,7-naphthyridin-6-yl)isonicotinamide [2894] ; 2-isopropoxy-N-(3 -( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 , 7-naphthyridin-6 -yl)isonicotinamide [2895] ; N-(3 -( 1 -methyl -1 H-pyrazol -4 -yl)- 1 ,7-naphthyridin-6-yl)-2-( 1 -methylpiperidin-4-yl)

isonicotinamide [2896];

r-methyl-N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)-r,2',3',6'-tetrahydro-[2,4'- bipyridine]-4-carboxamide [2897];

N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)-2-(4-(6-(4-methylpiperazin-l-yl) nicotinoyl)piperazin- 1 -yl)isonicotinamide [2898] ;

2-(4-hydroxy-4-methyl-4 4-piperazin-l-yl)-N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-

6-yl)isonicotinamide [2899]; 2-methyl-N-(3-(l-methyl-lH-pyrazol-4-yl)-l ,7-naphthyridin-6-yl)-6-(4-methylpiperazin-l-yl) isonicotinamide [2900];

3 -methyl -N-(3 -( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 ,7 -naphthyridin-6-yl) -2 -(4-methylpiperazin- 1 -yl) isonicotinamide [2901];

2-(4-methyl- 1 ,4-diazepan- 1 -yl)-N-(3-( 1 -methyl-lH-pyrazol-4-yl)-l ,7-naphthyridin-6-yl)

isonicotinamide [2902];

2-((2S,6R)-2,6-dimethylmo holino)-N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6- yl)isonicotinamide [2903];

N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)-2-(2,7-diazaspiro[3.5]nonan-2-yl)

isonicotinamide [2904];

N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)-2-(7-methyl-2,7-diazaspiro[3.5]nonan-

2-yl)isonicotinamide [2905];

N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)-2-(2,7-diazaspiro[3.5]nonan-7-yl)

isonicotinamide [2906];

N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)-2-(2-methyl-2,7-diazaspiro[3.5]nonan-

7-yl)isonicotinamide [2907];

2-(methyl( 1 -methylpiperidin-4-yl)amino)-N-(3 -( 1 -methyl- lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6- yl)isonicotinamide [2908];

N-(3 -( 1 -methyl -1 H-pyrazol -4 -yl)- 1 ,7-naphthyridin-6-yl)-2-(( 1 -methylpiperidin-4-yl)thio)

isonicotinamide [2909];

N-(3 -( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 ,7 -naphthyridin-6 -yl)-2-(4 -methylpiperazin- 1 -yl)pyrimidine - 4-carboxamide [2910];

N-(3 -( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 ,7 -naphthyridin-6 -yl)-6-(4 -methylpiperazin- 1 -yl)pyridazine -4 - carboxamide [2911];

N-(3 -( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 ,7 -naphthyridin-6 -yl)-6-(4 -methylpiperazin- 1 -yl)pyrimidine -

4-carboxamide [2912];

N-(3 -( 1 -methyl - 1 H-pyrazol -4-yl) - 1 ,7 -naphthyridin-6-yl) -2 -phenylacetamide [2913];

N-(3 -( 1 -methyl-lH-pyrazol-4-yl)-l ,7-naphthyridin-6-yl)-3 -phenylpropanamide [2914] ;

N-(3 -( 1 -methyl -1 H-pyrazol -4-yl)- 1 ,7-naphthyridin-6-yl)-2-(pyridin-3-yl)acetamide [2915] ; N-(3 -( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 ,7 -naphthyridin-6 -yl)-3 -(pyridin-3 -yl)propanamide [2916]; N-(3 -( 1 -methyl -1 H-pyrazol -4-yl)- 1 ,7-naphthyridin-6-yl)-2-(pyridin-4-yl)acetamide [2917] ; N-(3 -( 1 -methyl -1 H-pyrazol -4-yl)- 1 ,7-naphthyridin-6-yl)-3-(pyridin-4-yl)propanamide [2918] ; N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)isoindoline-5-carboxamide [2919]; 2-methyl-N-(3 -( 1 -methyl -1 H-pyrazol -4 -yl)- 1 ,7-naphthyridin-6-yl)isoindoline-5 -carboxamide

[2920];

N-(3 -( 1 -methyl -1 H-pyrazol -4 -yl)- 1 ,7-naphthyridin-6-yl)-l ,2,3,4-tetrahydroisoquinoline-7- carboxamide [2921];

2-methyl-N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)-l,2,3,4- tetrahydroisoquinoline-7 -carboxamide [2922] ;

2- methyl-N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)-l,2,3,4- tetrahydroisoquinoline-6-carboxamide [2923] ;

N-(3 -( 1 -methyl -1 H-pyrazol -4 -yl)- 1 ,7-naphthyridin-6-yl)-l ,2,3,4-tetrahydroisoquinoline-6- carboxamide [2924];

N-(3 -( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 ,7 -naphthyridin-6-yl) - 1 H-indole-5 -carboxamide [2925] ; N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)benzofuran-5-carboxamide [2926]; N-(3-(l-methyl-lH-pyrazol-4-yl)-l ,7-naphthyridin-6-yl)furo[2,3-c]pyridine-5-carboxamide

[2927];

N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)benzo[b]thiophene-5-carboxamide

[2928];

N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)benzofuran-6-carboxamide [2929]; N-(3 -( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 ,7 -naphthyridin-6 -yl)benzo [d] oxazole -6 -carboxamide [2930] ; N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)benzo[d]thiazole-6-carboxamide [2931]; N-(3 -( 1 -methyl -1 H-pyrazol -4 -yl) - 1 ,7 -naphthyridin-6 -yl)benzo[d] oxazole -5 -carboxamide [2932] ; N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)benzo[d]thiazole-5-carboxamide [2933]; N-(3 -( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 ,7 -naphthyridin-6 -yl)quinoline -3 -carboxamide [2934] ;

N-(3 -( 1 -methyl -1 H-pyrazol -4 -yl)- 1 ,7-naphthyridin-6-yl)quinoline-6-carboxamide [2935] ;

N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)quinoxaline-6-carboxamide [2936]; 5-chloro-N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)-2-(4-methylpiperazin-l-yl) isonicotinamide [2937];

3- chloro-N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)-2-(4-methylpiperazin-l-yl) isonicotinamide [2938];

2- (2,5-diazabicyclo[2.2.1]heptan-2-yl)-N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl) isonicotinamide [2939];

N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)-2-(5-methyl-2,5-diazabicyclo[2.2.1] heptan-2-yl)isonicotinamide [2940] ;

3- fluoro-N-(3 -( 1 -methyl- 1 H-pyrazol -4 -yl)- 1 ,7-naphthyridin-6-yl)-2-(4-methylpiperazin- 1 -yl) isonicotinamide [2941]; N-(3 -( 1 -methyl -1 H-pyrazol -4 -yl)- 1 ,7-naphthyridin-6-yl)-2-((4-methylpiperazin- 1 -yl)methyl) isonicotinamide [2942];

N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)-2-(moφholinomethyl)isonicotinamide

[2943];

N-(3 -( 1 -methyl -1 H-pyrazol -4 -yl)- 1 ,7-naphthyridin-6-yl)-2-(pyrrolidin- 1 -ylmethyl)

isonicotinamide [2944];

N-(3 -( 1 -methyl -1 H-pyrazol -4 -yl)- 1 ,7-naphthyridin-6-yl)-2-(2-(4-methylpiperazin- 1 -yl)pyridin-4- yl)acetamide [2945];

1 -methyl -N-(3 -( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 ,7 -naphthyridin-6-yl) - 1 H-indazole -5 -carboxamide

[2946];

1 -methyl -N-(3 -( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 ,7 -naphthyridin-6-yl) - 1 H-benzo [d] imidazole-5 - carboxamide [2947];

N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)-l-(piperidin-4-yl)-lH-pyrazole-4- carboxamide [2948];

N-(3 -( 1 -methyl-lH-pyrazol-4-yl)-l ,7-naphthyridin-6-yl)- 1 -( 1 -methylpiperidin-4-yl)- 1H- pyrazole -4 -carboxamide [2949];

1 -( 1 -ethylpiperidin-4-yl)-N-(3-( 1 -methyl- lH-pyrazol-4-yl)-l ,7-naphthyridin-6-yl)- lH-pyrazole-

4-carboxamide [2950];

l-(l-(2-fluoroethyl)piperidin-4-yl)-N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)-lH- pyrazole -4 -carboxamide [2951];

1 -( 1 -isopropylpiperidin-4-yl)-N-(3 -( 1 -methyl-lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl)-lH- pyrazole -4 -carboxamide [2952];

1 -( 1 -cyclopropylpiperidin-4-yl)-N-(3-( 1 -methyl-lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl)- 1H- pyrazole -4 -carboxamide [2953];

isopropyl 4-(4-((3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)carbamoyl)-lH-pyrazol-l- yl)piperidine-l-carboxylate [2954];

N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)-l-(piperidin-4-yl)-lH-l,2,3-triazole-4- carboxamide [2955];

N-(3 -( 1 -methyl-lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl)- 1 -( 1 -methylpiperidin-4-yl)- 1H- 1,2,3- triazole -4 -carboxamide [2956];

l-(l-(2-fluoroethyl)piperidin-4-yl)-N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)-lH- l,2,3-triazole-4-carboxamide [2957];

1 -( 1 -isopropylpiperidin-4-yl)-N-(3 -( 1 -methyl- lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl) - 1H- 1 ,2,3 - triazole -4 -carboxamide [2958]; N-(3 -( 1 -methyl -lH-pyrazol -4 -yl)- 1 ,7-naphthyridin-6-yl)-2-(4-methylpiperazin-l -yl)oxazole-5 - carboxamide [2959];

2-(3 -(dimethylamino)azetidin- 1 -yl)-N-(3-( 1 -methyl- lH-pyrazol-4-yl)-l ,7-naphthyridin-6-yl) oxazole -4 -carboxamide [2960] ;

N-(3 -( 1 -methyl -lH-pyrazol -4 -yl)- 1 ,7-naphthyridin-6-yl)-2-(piperidin-4-yl)oxazole-4- carboxamide [2961];

N-(3 -( 1 -methyl -lH-pyrazol -4 -yl)- 1 ,7-naphthyridin-6-yl)-2-( 1 -methylpiperidin-4-yl)oxazole-4- carboxamide [2962];

2-(l-(2-fluoroethyl)piperidin-4-yl)-N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl) oxazole -4 -carboxamide [2963] ;

2-( 1 -isopropylpiperidin-4-yl)-N-(3 -( 1 -methyl-lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl)oxazole-4- carboxamide [2964];

N-(3 -( 1 -methyl - 1 H-pyrazol -4 -yl) - 1 ,7 -naphthyridin-6 -yl)-2-(4 -methylpiperazin- 1 -yl)oxazole -4 - carboxamide [2965];

2-(3 -(dimethylamino)azetidin- 1 -yl)-N-(3-( 1 -methyl- lH-pyrazol-4-yl)-l ,7-naphthyridin-6-yl) thiazole-5 -carboxamide [2966] ;

N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)-2-(piperidin-4-yl)thiazole-4- carboxamide [2967];

N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)-2-(4-methylpiperazin-l-yl)thiazole-4- carboxamide [2968];

2-(l-(2-fluoroethyl)piperidin-4-yl)-N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl) thiazole-4-carboxamide [2969] ;

2-(l-isopropylpiperidin-4-yl)-N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)thiazole-4- carboxamide [2970];

1 -methyl -N-(3 -( 1 -methyl -1 H-pyrazol -4 -yl)- 1 ,7-naphthyridin-6-yl-5 - )piperidine-4-carboxamide

[2971] ;

N-(3 -( 1 -methyl -1 H-pyrazol -4 -yl)- 1 ,7-naphthyridin-6-yl)- 1 -(2 -(methyl -<¾)propyl- 1 , 1 ,2,3,3, 3-de) piperidine-4-carboxamide [2972];

N-iS-il-methyl-lH-pyrazol^-y^-l -naphthyridin-e-y^^-ipyrrolidin-l-yl^^^^-i ^acetamide

[2973] ;

N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)-2-(4-(methyl-£/3)piperazin-l-yl)

acetamide [2974];

N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)-2-(moφholino-ί s)acetamide [2975]; ( S) -N-(3 -( 1 -(methyl -ds) - 1 H-pyrazol -4 -yl) - 1 ,7 -naphthyridin-6 -yl) -2 -(pyrrolidin- 1 -yl)propanamide

[2976];

l-isobutyl-N-(3-(l-(methyl-£/3)-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)piperidine-4-carboxamide

[2977];

N-(3-( 1 -(methyl -<¾)- lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl)-2-(4-methylpiperazin- 1 -yl)

acetamide [2978];

N-(3-( 1 -(methyl -<¾)- lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl)-2-(pyrrolidin-l -yl)acetamide

[2979];

N-(3-( 1 -(methyl -<¾)- lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl)-2-(piperidin-l -yl)acetamide [2980] ; N-(3-( 1 -(methyl -<¾)- lH-pyrazol-4-yl)-l ,7 -naphthyridin-6 -yl)- 1 -(3,3,3 -trifluoropropyl)piperidine- 4-carboxamide [2981];

N-(3 -( lH-pyrazol-4-yl)-l ,7-naphthyridin-6-yl)-2-(4-(methyl-£/3)piperazin- 1 -yl)isonicotinamide

[2982];

N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)-2-(4-(methyl-£/3)piperazin-l-yl)

isonicotinamide [2983];

N-(3-( 1 -(methyl -<¾)- lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl)-2-(4-methylpiperazin- 1 -yl)

isonicotinamide [2984];

N-(3-( 1 -(methyl -<¾)- lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl)-2-(4-(methyl-<i3)piperazin-l -yl) isonicotinamide [2985];

N-(3-( 1 -(methyl -<¾)- lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl)- 1 -(piperidin-4-yl)-lH-pyrazole-4- carboxamide [2986];

N-(3-( 1 -(methyl -d₃)- lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl)-l -( 1 -methylpiperidin-4-yl)-lH- pyrazole-4-carboxamide [2987];

N-(3-( 1 -(methyl-^)- lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl)-2-(piperidin-4-yl)oxazole-4- carboxamide [2988];

N-(3-( 1 -(methyl -<¾)- lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl)-2-( 1 -methylpiperidin-4-yl)oxazole- 4-carboxamide [2989];

N-(3 -( 1 -ethyl- lH-pyrazol-4-yl)-l ,7-naphthyridin-6-yl)-2-(pyrrolidin-l -yl)acetamide [2990] ; N-(3-(l-cyclopropyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)-2-(pyrrolidin-l-yl)acetamide

[2991];

N-(3-(l-cyclopropyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)-l-(3,3,3-trifluoropropyl)piperidine-

4-carboxamide [2992];

N-(3 -( 1 -( 1 -methylpiperidin-4-yl)-lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl)

cyclohexanecarboxamide [2993]; 2-(pyrrolidin- 1 -yl)-N-(3 -(5 -(trifluoromethyl)- lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl)acetamide

[2994];

N-(3-(5-(hydroxymethyl)-l-methyl-lH-pyrazol-4-yl)-l ,7-naphthyridin-6-yl)-l-methylpiperidine- 4-carboxamide [2995];

N-(3-(5-(hydroxymethyl)-l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)tetrahydro-2H-pyran-

4-carboxamide [2996];

N-(3-(5-(azetidin-l-ylmethyl)-l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)-4,4- difluorocyclohexane- 1 -carboxamide [2997] ;

4,4-difluoro-N-(3 -( 1 -methyl -5 -(pyrrolidin-1 -ylmethyl)- lH-pyrazol-4-yl)-l ,7-naphthyridin-6-yl) cyclohexane-1 -carboxamide [2998];

4,4-difluoro-N-(3 -( 1 -methyl -5 -(piperidin-1 -ylmethyl)- lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl) cyclohexane-1 -carboxamide [2999];

2-(2 -fluoroethyl) -N-(3 -( 1 -methyl -5 -(piperidin- 1 -ylmethyl) - 1 H-pyrazol -4 -yl) - 1 , 7-naphthyridin-6- yl)-2-azaspiro[3.3]heptane-6-carboxamide [3000] ;

fert-butyl 6 -((3 -( 1 -methyl -5 -(piperidin- 1 -ylmethyl) - 1 H-pyrazol -4 -yl) - 1 , 7-naphthyridin-6-yl) carbamoyl)-2-azaspiro[3.3]heptane-2-carboxylate [3001];

2-fluoro-2 -methyl -N-(3-( 1 -methyl-5 -(piperidin- 1 -ylmethyl)- lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6- yl)propanamide [3002];

2-(diethylamino)-N-(3-(l-methyl-5-(piperidin-l-ylmethyl)-lH-pyrazol-4-yl)-l,7-naphthyridin-6- yl)acetamide [3003];

fr «5-4-methoxy-N-(3-(l -methyl -5-(piperidin-l-ylmethyl)-lH-pyrazol-4-yl)-l,7-naphthyridin-6- yl)cyclohexane - 1 -carboxamide [3004] ;

fr «5-4-(hydroxymethyl)-N-(3-( 1 -methyl-5 -(piperidin- 1 -ylmethyl)- lH-pyrazol-4-yl)-l ,7- naphthyridin-6 -yl)cyclohexane - 1 -carboxamide [3005] ;

(R)-N-(3-(l-methyl-5-(piperidin-l-ylmethyl)-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)pyrrolidine-

2-carboxamide [3006];

l-isobutyl-N-(3-(l-methyl-5-(piperidin-l-ylmethyl)-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl) piperidine-4-carboxamide [3007];

N-(3 -( 1 -methyl-5 -(piperidin- 1 -ylmethyl)- lH-pyrazol-4-yl)-l ,7-naphthyridin-6-yl)- 1 -(oxetan-3 -yl) piperidine-4-carboxamide [3008];

1 -benzoyl -N-(3 -( 1 -methyl -5 -(piperidin- 1 -ylmethyl) - 1 H-pyrazol -4 -yl) - 1 ,7 -naphthyridin-6 -yl) piperidine-4-carboxamide [3009];

N-(3 -( 1 -methyl-5 -(piperidin- 1 -ylmethyl)- lH-pyrazol-4-yl)-l ,7-naphthyridin-6-yl)tetrahydro-2H- pyran-4-carboxamide [3010] ; N-(3 -( 1 -methyl -5 -(piperidin- 1 -ylmethyl)- lH-pyrazol-4-yl)-l ,7-naphthyridin-6-yl)-2-(4- methylpiperidin- 1 -yl)acetamide [3011] ;

N-(3 -( 1 -(difluoromethyl)-lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl)-2-(4-methylpiperazin- 1 -yl) isonicotinamide [3012];

N-(3-(l-ethyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [3013];

N-(3-(l-isopropyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)-3-(piperidin-4-yloxy)benzamide

[3014];

N-(3-(l-isopropyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)-3-((l-methylpiperidin-4-yl)oxy) benzamide [3015];

N-(3-(l-isopropyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)-4-(piperidin-4-yloxy)benzamide

[3016];

N-(3 -( 1 -cyclopropyl-lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl)-2-(4-methylpiperazin- 1 -yl)

isonicotinamide [3017];

4-fluoro-N-(3 -( 1 -( 1 -methylpiperidin-4-yl)- lH-pyrazol-4-yl)-l ,7-naphthyridin-6-yl)benzamide

[3018];

4- (difluoromethoxy)-N-(3 -( 1 -( 1 -methylpiperidin-4-yl)- lH-pyrazol-4-yl)-l ,7-naphthyridin-6-yl) benzamide [3019];

5- fluoro-N-(3 -( 1 -( 1 -methylpiperidin-4-yl)- lH-pyrazol-4-yl)-l ,7-naphthyridin-6-yl)nicotinamide

[3020];

N² -methyl -N⁵-(3 -( 1 -( 1 -methylpiperidin-4-yl)- lH-pyrazol-4-yl)-l ,7-naphthyridin-6-yl)pyridine- 2,5-dicarboxamide [3021];

1- isopropyl-N-(3-(l-(l-methylpiperidin-4-yl)-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)-lH- pyrazole-4-carboxamide [3022];

2- methyl-N-(3 -( 1 -( 1 -methylpiperidin-4-yl)- lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl)thiazole-5- carboxamide [3023];

N-(3-(5-amino-l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)-2-(4-methylpiperazin-l-yl) isonicotinamide [3024];

4-(difluoromethoxy)-N-(3-(5-(hydroxymethyl)-l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl) benzamide [3025];

N-(3-(5-(hydroxymethyl)-l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)-2-(4- methylpiperazin-l-yl)isonicotinamide [3026];

N-(3-(5-(hydroxymethyl)-l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)-2-(7-methyl-2,7- diazaspiro[3.5]nonan-2-yl)isonicotinamide [3027] ; 4-fluoro-N-(3 -( 1 -methyl-5-(pyrrolidin- 1 -ylmethyl)-lH-pyrazol-4-yl)-l ,7-naphthyridin-6-yl) benzamide [3028];

4-fluoro-N-(3-(l-methyl-5-(piperidin-l-ylmethyl)-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl) benzamide [3029];

4-(difluoromethoxy)-N-(3-(l-methyl-5-(piperidin-l-ylmethyl)-lH-pyrazol-4-yl)-l,7- naphthyridin-6-yl)benzamide [3030] ;

N-(3 -( 1 -methyl -5 -(piperidin- 1 -ylmethyl)- lH-pyrazol-4-yl)-l ,7-naphthyridin-6-yl)-3-(pyrrolidin-

1 -ylmethyl)benzamide [3031 ] ;

N-(3 -( 1 -methyl -5 -(piperidin- 1 -ylmethyl)- lH-pyrazol-4-yl)-l , 7-naphthyridin-6-yl)-2-(7-methyl-

2,7-diazaspiro[3.5]nonan-2-yl)isonicotinamide [3032];

N-(3 -( 1 -methyl -5 -(piperidin- 1 -ylmethyl)- lH-pyrazol-4-yl)-l ,7-naphthyridin-6-yl)-2- moφholinoisonicotinamide [3033] ;

N-(3 -( 1 -methyl -5 -^ο ηο1ίηοΓηεΐ1τγ1)-1Η^^ο1-4^1)- 1 ,7-naphthyridin-6-yl)-2- moφholinoisonicotinamide [3034] ;

N-(3 -(4,5 ,6,7-tetrahydropyrazolo[ 1 ,5 -a]pyrazin-3 -yl)-l ,7-naphthyridin-6-yl)- 1 -(( 1 -

(trifluoromethyl)cyclopropyl)methyl)piperidine-4-carboxamide [3035];

3,3-difluoro-N-(3-(5-methyl-4,5,6,7-tetrahydropyrazolo[l,5-a]pyrazin-3-yl)-l,7-naphthyridin-6- yl)cyclobutane - 1 -carboxamide [3036] ;

N-((4,4-difluorocyclohexyl)methyl)-3-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[l,5-a] pyrazin-3-yl)-l ,7-naphthyridin-6-amine [3037] ;

N-(3-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[l,5-a]pyrazin-3-yl)-l,7-naphthyridin-6-yl)-l-

(( 1 -(trifluoromethyl)cyclopropyl)methyl)piperidine-4-carboxamide [3038] ;

N-(3-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[l,5-a]pyrazin-3-yl)-l,7-naphthyridin-6-yl)-2-

(pyrrolidin- 1 -yl)acetamide [3039] ;

2-(7-azabicyclo[2.2.1]heptan-7-yl)-N-(3-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[l,5-a] pyrazin-3-yl)-l,7-naphthyridin-6-yl)acetamide [3040];

(R)-N-(3 -(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[ 1 ,5 -a]pyrazin-3 -yl)-l ,7-naphthyridin-6- yl)-l -isobutylpiperidine -3 -carboxamide [3041 ] ;

N-(3 -(5 -(2-fluoroethyl)-4,5 ,6,7-tetrahydropyrazolo [ 1 ,5 -a]pyrazin-3 -yl)- 1 ,7-naphthyridin-6-yl) piperidine-4-carboxamide [3042];

4-fluoro-N-(3-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[l,5-a]pyrazin-3-yl)-l,7- naphthyridin-6-yl)- 1 -isobutylpiperidine-4-carboxamide [3043] ;

N-(3-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[l,5-a]pyrazin-3-yl)-l,7-naphthyridin-6-yl)-2-

(4-methylpiperazin- 1 -yl)acetamide [3044] ; 4-fluoro-N-(3-(4,5,6,7 etrahydropyrazolo[l,5-a]pyrazin-3-yl)-l,7-naphthyridin-6-yl)benzamide

[3045];

N-(3-(5-(2-fluoroethyl)-4,5,6j etrahydropyrazolo[l,5-a]pyrazin-3-yl)-l,7-naphthyridin-6-yl)-3-

(4-methylpiperazin- 1 -yl)benzamide [3046] ;

N⁵-(3 -(5 -(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[ 1 ,5 -a]pyrazin-3-yl)-l ,7-naphthyridin-6-yl)-

N²-methylpyridine-2,5 -dicarboxamide [3047] ;

N-(3-(5-(2-fluoroethyl)-4,5,6j etrahydropyrazolo[l,5-a]pyrazin-3-yl)-l,7-naphthyridin-6-yl)-6-

(4-methylpiperazin- 1 -yl)nicotinamide [3048] ;

2-(azetidin-3 -yloxy)-N-(3 -(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[ 1 ,5 -a]pyrazin-3 -yl)-l ,7- naphthyridin-6-yl)isonicotinamide [3049] ;

N-(3-(l-methyl-lH-pyrazol-5-yl)-l ,7-naphthyridin-6-yl)-l-(3,3,3-trifluoropropyl)piperidine-4- carboxamide [3050];

1 -methyl -N-(3 -( 1 -methyl - 1 H-pyrazol -3 -yl) - 1 ,7 -naphthyridin-6-yl)piperidine -4 -carboxamide

[3051];

N-(3 -( 1 -methyl - 1 H-pyrazol -3 -yl) - 1 ,7 -naphthyridin-6 -yl)-2-(4 -methylpiperazin- 1 -yl)

isonicotinamide [3052];

2-fluoro-2 -methyl -N-(3 -( 1 -methyl- 1H- 1 ,2,3-triazol-4-yl)-l ,7-naphthyridin-6-yl)propanamide

[3053];

2,2,3, 3-tetramethyl-N-(3-(l-methyl-lH-l,2,3-triazol-4-yl)-l,7-naphthyridin-6-yl)cyclopropane-l- carboxamide [3054];

fr «5-N-(3-(l-methyl-lH-l,2,3-triazol-4-yl)-l,7-naphthyridin-6-yl)-4-(pyrrolidin-l-yl)

cyclohexane-1 -carboxamide [3055];

fr rø-N-(3-(l-methyl-lH-l,2,3-triazol-4-yl)-l,7-naphthyridin-6-yl)-4-mo holinocyclohexane-l- carboxamide [3056];

N-(3-(l-methyl-lH-l,2,3-triazol-4-yl)-l,7-naphthyridin-6-yl)-2-(piperidin-l-yl)acetamide [3057]; 1 -ethyl -4-fluoro-N-(3 -( 1 -methyl- 1H- 1 ,2,3 -triazol-4-yl)-l ,7-naphthyridin-6-yl)piperidine-4- carboxamide [3058];

4-fluoro- 1 -isobutyl-N-(3-( 1 -methyl- 1H- 1 ,2,3 -triazol-4-yl)-l ,7-naphthyridin-6-yl)piperidine-4- carboxamide [3059];

N-(3-(l-methyl-lH-l,2,3-triazol-4-yl)-l,7-naphthyridin-6-yl)-l-(3,3,3-trifluoropropyl)piperidine- 4-carboxamide [3060];

N-(3 -( 1 -methyl- lH-1 ,2,3-triazol-4-yl)- 1 ,7-naphthyridin-6-yl)cyclopropanecarboxamide [3061] ; 4,4-difluoro-N-(3 -( 1 -methyl- 1H- 1 ,2,3 -triazol-4-yl)- 1 ,7-naphthyridin-6-yl)cyclohexane- 1 - carboxamide [3062]; fra«s-4-(dimethylamino)-N-(3 -( 1 -methyl-lH- 1 ,2,3-triazol-4-yl)- 1 ,7-naphthyridin-6-yl) cyclohexane-1 -carboxamide [3063];

fra«s-N-(3-(l-methyl-lH-l,2,3-triazol-4-yl)-l ,7-naphthyridin-6-yl)-4-((4-methylpiperazin-l-yl) methyl)cyclohexane - 1 -carboxamide [3064] ;

N-(3-(l-methyl-lH-l,2,3-triazol-4-yl)-l,7-naphthyridin-6-yl)piperidine-4-carboxamide [3065]; 1 -isobutyl-N-(3-( 1 -methyl- lH-1 ,2,3-triazol-4-yl)-l ,7-naphthyridin-6-yl)piperidine-4- carboxamide [3066];

N-(3 -( 1 -methyl-lH-1 ,2,3-triazol-4-yl)- 1 ,7-naphthyridin-6-yl)-l -(( 1 -(trifluoromethyl)cyclopropyl) methyl)piperidine -4 -carboxamide [3067] ;

N-(3-(l-methyl-lH-l,2,3-triazol-4-yl)-l,7-naphthyridin-6-yl)-l-((3-methyloxetan-3-yl)

methyl)piperidine -4 -carboxamide [3068] ;

N-(3 -( 1 -methyl-lH-1 ,2,3-triazol-4-yl)- 1 ,7-naphthyridin-6-yl)-l -(2-(pyrrolidin- 1 -yl)

acetyl)piperidine-4-carboxamide [3069] ;

r-methyl-N-(3-(l-methyl-lH-l,2,3-triazol-4-yl)-l,7-naphthyridin-6-yl)-[l,4'-bipiperidine]-4- carboxamide [3070];

(R)-N-(3 -( 1 -methyl-lH- 1 ,2,3-triazol-4-yl)- 1 ,7-naphthyridin-6-yl)piperidine-3 -carboxamide

[3071];

(R)-l -isobutyl-N-(3 -( 1 -methyl-lH-1 ,2,3 -triazol-4-yl)- 1 ,7-naphthyridin-6-yl)piperidine-3- carboxamide [3072];

N-(3-(l-methyl-lH-l,2,3-triazol-4-yl)-l,7-naphthyridin-6-yl)-2-(pyrrolidin-l-yl)acetamide

[3073];

N-(3 -( 1 -methyl-lH-1 ,2,3-triazol-4-yl)- 1 ,7-naphthyridin-6-yl)-2-(4-methylpiperazin- 1 -yl)

acetamide [3074];

2-(7-azabicyclo[2.2.1]heptan-7-yl)-N-(3-(l-methyl-lH-l,2,3-triazol-4-yl)-l,7-naphthyridin-6-yl) acetamide [3075];

1 -(2-hydroxy-2-methylpropyl)-N-(3-( 1 -methyl- lH-1 ,2,3-triazol-4-yl)- 1 ,7-naphthyridin-6-yl) piperidine-4-carboxamide [3076];

N-(3 -( 1 -methyl-lH-1 ,2,3-triazol-4-yl)- 1 ,7-naphthyridin-6-yl)-2-moφholinoacetamide [3077] ; 2-(4-methoxypiperidin-l-yl)-N-(3-(l-methyl-lH-l,2,3-triazol-4-yl)-l,7-naphthyridin-6-yl)

acetamide [3078];

N-(3 -( 1 -methyl-lH-1 ,2,3-triazol-4-yl)- 1 ,7-naphthyridin-6-yl)morpholine-4 -carboxamide [3079] ; N-(3-(l-methyl-lH-l,2,3-triazol-4-yl)-l,7-naphthyridin-6-yl)-l-(piperidin-4-yl)-lH-pyrazole-4- carboxamide [3080]; N-(3 -( 1 -methyl-lH-1 ,2,3-triazol-4-yl)- 1 ,7-naphthyridin-6-yl)- 1 -( 1 -methylpiperidin-4-yl)-lH- pyrazole-4-carboxamide [3081];

1 -( 1 -ethylpiperidin-4-yl)-N-(3-( 1 -methyl- 1H- 1 ,2,3 -triazol-4-yl)- 1 ,7-naphthyridin-6-yl)-lH- pyrazole-4-carboxamide [3082];

l-(l-isopropylpiperidin-4-yl)-N-(3-(l-methyl-lH-l,2,3-triazol-4-yl)-l,7-naphthyridin-6-yl)-lH- pyrazole-4-carboxamide [3083];

N-(3-(l-methyl-lH-l,2,3-triazol-4-yl)-l,7-naphthyridin-6-yl)-l-(piperidin-4-yl)-lH-l,2,3- triazole-4-carboxamide [3084];

1 -( 1 -(2-fluoroethyl)piperidin-4-yl)-N-(3-( 1 -methyl-lH- 1 ,2,3-triazol-4-yl)-l ,7-naphthyridin-6-yl)- lH-l,2,3-triazole-4-carboxamide [3085];

1- (l-isopropylpiperidin-4-yl)-N-(3-(l-methyl-lH-l,2,3-triazol-4-yl)-l,7-naphthyridin-6-yl)-lH- l,2,3-triazole-4-carboxamide [3086];

N-(3-(l-methyl-lH-l,2,3-triazol-4-yl)-l,7-naphthyridin-6-yl)-2-(piperidin-4-yl)oxazole-4- carboxamide [3087];

N-(3 -( 1 -methyl-lH-1 ,2,3-triazol-4-yl)- 1 ,7-naphthyridin-6-yl)-2-( 1 -methylpiperidin-4-yl)oxazole- 4-carboxamide [3088];

2- (l-isopropylpiperidin-4-yl)-N-(3-(l-methyl-lH-l,2,3-triazol-4-yl)-l,7-naphthyridin-6-yl) oxazole-4-carboxamide [3089];

2-fluoro-N-(3 -( 1 -methyl- 1H- 1 ,2,3 -triazol-4-yl)-l ,7-naphthyridin-6-yl)benzamide [3090] ;

N-(3 -( 1 -methyl-lH-1 ,2,3-triazol-4-yl)- 1 ,7-naphthyridin-6-yl)-3-(( 1 -methylpiperidin-4-yl)oxy) benzamide [3091];

N²-methyl-N⁵-(3 -( 1 -methyl-lH- 1 ,2,3-triazol-4-yl)- 1 ,7-naphthyridin-6-yl)pyridine-2,5- dicarboxamide [3092];

N-(3 -( 1 -methyl-lH-1 ,2,3-triazol-4-yl)- 1 ,7-naphthyridin-6-yl)-6-(4-methylpiperazin- 1 -yl)

nicotinamide [3093];

2-(3 -(dimethylamino)azetidin- 1 -yl)-N-(3-( 1 -methyl- 1H- 1 ,2,3-triazol-4-yl)- 1 ,7-naphthyridin-6-yl) isonicotinamide [3094];

N-(3 -( 1 -methyl-lH-1 ,2,3-triazol-4-yl)- 1 ,7-naphthyridin-6-yl)-2-( 1 -methylpiperidin-4-yl)

isonicotinamide [3095];

2-(4-(dimethylamino)piperidin-l-yl)-N-(3-(l-methyl-lH-l,2,3-triazol-4-yl)-l,7-naphthyridin-6- yl)isonicotinamide [3096];

N-(3 -( 1 -methyl-lH-1 ,2,3-triazol-4-yl)- 1 ,7-naphthyridin-6-yl)-2-moφholinoisonicotinamide

[3097]; N-(3 -( 1 -methyl-lH-1 ,2,3-triazol-4-yl)- 1 ,7-naphthyridin-6-yl)-2-(4-methylpiperazin- 1 -yl) isonicotinamide [3098];

2-(4-methyl-l,4-diazepan-l-yl)-N-(3-(l-methyl-lH-l,2,3-triazol-4-yl)-l,7-naphthyridin-6-yl) isonicotinamide [3099];

2-(4-isopropylpiperazin-l -yl)-N-(3-( 1 -methyl- IH- 1 ,2,3-triazol-4-yl)-l ,7-naphthyridin-6-yl) isonicotinamide [3100];

N-(3 -( 1 -methyl-lH-1 ,2,3-triazol-4-yl)- 1 ,7-naphthyridin-6-yl)-2-(piperidin-4-ylamino)

isonicotinamide [3101];

2-(methyl( 1 -methylpiperidin-4-yl)amino)-N-(3 -( 1 -methyl- IH- 1 ,2,3 -triazol-4-yl)-l ,7- naphthyridin-6-yl)isonicotinamide [3102] ;

N-(3 -( 1 -methyl-lH-1 ,2,3-triazol-4-yl)- 1 ,7-naphthyridin-6-yl)-2-(( 1 -methylpiperidin-4-yl)thio) isonicotinamide [3103];

2-methyl-N-(3-(l-methyl-lH-l,2,3-triazol-4-yl)-l,7-naphthyridin-6-yl)-l,2,3,4- tetrahydroisoquinoline-6-carboxamide [3104] ;

N-(3-(l-methyl-lH-l,2,3-triazol-4-yl)-l,7-naphthyridin-6-yl)-2-(piperazin-l-yl)isonicotinamide

[3105];

N-(3-(l-methyl-lH-l,2,3-triazol-4-yl)-l,7-naphthyridin-6-yl)-2-(2-(4-methylpiperazin-l-yl) pyridin-4-yl)acetamide [3106];

1 , 1 -bis(methyl-£/3)-4-(4-((3-( 1 -methyl- IH- 1 ,2,3 -triazol-4-yl)- 1 ,7-naphthyridin-6-yl)carbamoyl) pyridin-2-yl)piperazin-l-ium iodide [3107];

N-(3-(l-methyl-lH-l,2,3-triazol-4-yl)-l,7-naphthyridin-6-yl)-2-(4-(methyl-£/₃)piperazin-l-yl) isonicotinamide [3108];

N-(3-(l-methyl-lH-l,2,3-triazol-5-yl)-l,7-naphthyridin-6-yl)-l-(3,3,3-trifluoropropyl)piperidine- 4-carboxamide [3109];

N-(3 -(4-methyl-4H-l ,2,4-triazol-3 -yl)- 1 ,7-naphthyridin-6-yl)-2-moφholinoacetamide [3110]; N-(3 -(4-methyl-4H-l ,2,4-triazol-3 -yl)- 1 ,7-naphthyridin-6-yl)- 1 -(3,3,3 -trifluoropropyl)piperidine- 4-carboxamide [3111];

4-fluoro- 1 -isobutyl-N-(3-(4-methyl-4H- 1 ,2,4-triazol-3 -yl)-l ,7-naphthyridin-6-yl)piperidine-4- carboxamide [3112];

N-(3-(4,5-dimethyl-4H-l,2,4-triazol-3-yl)-l,7-naphthyridin-6-yl)-2-moφholinoacetamide [3113]; N-(3-(4,5-dimethyl-4H-l,2,4-triazol-3-yl)-l,7-naphthyridin-6-yl)-l-(3,3,3- trifluoropropyl)piperidine-4-carboxamide [3114];

N-(3 -( IH- 1 ,2,3 -triazol-1 -yl)- 1 ,7-naphthyridin-6-yl)-4-fluoro- 1 -isobutylpiperidine-4-carboxamide

[3115]; N-(3 -(2H- 1 ,2,3 -triazol-2-yl)- 1 ,7-naphthyridin-6-yl)-4-fluoro- 1 -isobutylpiperidine-4-carboxamide

[3116];

N-(3 -( 1H- 1 ,2,4-triazol-l -yl)- 1 ,7-naphthyridin-6-yl)-2-(4-methylpiperazin-l -yl)isonicotinamide

[3117];

1- isobutyl-N-(3-(l-methyl-lH etrazol-5-yl)-l,7-naphthyridin-6-yl)piperidine-4-carboxamide

[3118];

2,2,3, 3-tetramethyl-N-(3-( 1 -methyl -IH-imidazol -5 -yl)- 1 ,7-naphthyridin-6-yl)cyclopropane- 1 - carboxamide [3119];

4,4-difluoro-N-(3 -( 1 -methyl -IH-imidazol -5 -yl)-l ,7-naphthyridin-6-yl)cyclohexane- 1 - carboxamide [3120];

N-(3-(l-methyl-lH-imidazol-5-yl)-l,7-naphthyridin-6-yl)-2-(piperidin-l-yl)acetamide [3121];

2 - fluoro-2 -methyl -N-(3 -( 1 -methyl -IH-imidazol -5 -yl)- 1 ,7-naphthyridin-6-yl)propanamide [3122] ; 1 -fluoro-N-(3 -( 1 -methyl- lH-imidazol-5 -yl)- 1 ,7-naphthyridin-6-yl)cyclopropane- 1 -carboxamide

[3123];

2-methyl-N-(3 -( 1 -methyl-lH-imidazol-5 -yl)- 1 ,7-naphthyridin-6-yl)-2-azaspiro[3.3]heptane-6- carboxamide [3124];

1 -fluoro-N-(3 -( 1 -methyl- lH-imidazol-5 -yl)- 1 ,7-naphthyridin-6-yl)cyclohexane-l -carboxamide

[3125];

fr «5-4-methoxy-N-(3-( 1 -methyl- lH-imidazol-5-yl)- 1 ,7-naphthyridin-6-yl)cyclohexane-l - carboxamide [3126];

fr «5-4-(hydroxymethyl)-N-(3-(l-methyl-lH-imidazol-5-yl)-l,7-naphthyridin-6-yl)cyclohexane- 1 -carboxamide [3127];

N-(3 -( 1 -methyl-lH-imidazol-5-yl)-l ,7-naphthyridin-6-yl)azetidine-3 -carboxamide [3128] ;

(R) -N-(3 -( 1 -methyl - 1 H-imidazol-5 -yl) - 1 , 7-naphthyridin-6 -yl)tetrahydrofuran-2 -carboxamide

[3129];

1 -(2-methoxyethyl) -N-(3 -( 1 -methyl - 1 H-imidazol-5 -yl) - 1 , 7-naphthyridin-6-yl)piperidine -4 - carboxamide [3130];

N-(3 -( 1 -methyl - 1 H-imidazol-5 -yl) - 1 , 7-naphthyridin-6 -yl) - 1 -(3 , 3 ,3 -trifluoropropyl)piperidine -4 - carboxamide [3131];

l-isobutyl-N-(3-(l-methyl-lH-imidazol-5-yl)-l,7-naphthyridin-6-yl)piperidine-4-carboxamide

[3132];

N-(3 -( 1 -methyl-lH-imidazol-5-yl)- 1 ,7-naphthyridin-6-yl)- 1 -(methylsulfonyl)piperidine-4- carboxamide [3133];

N-(3 -( 1 -methyl-lH-imidazol-5-yl)- 1 ,7-naphthyridin-6-yl)-2-(pyrrolidin- 1 -yl)propanamide [3134] ; 2- isopropoxy-N-(3 -( 1 -methyl -lH-imidazol -5 -yl)- 1,7-naphthyridin-6-yl)acetamide [3135];

3- isopropoxy-N-(3 -( 1 -methyl -lH-imidazol -5 -yl)- 1,7-naphthyridin-6-yl)propanamide [3136]; N-(3-(l,2-dimethyl-lH-imidazol-5-yl)-l,7-naphthyridin-6-yl)cyclopropanecarboxamide [3137]; N-(3-(l,2-dimethyl-lH-imidazol-5-yl)-l,7-naphthyridin-6-yl)cyclohexanecarboxamide [3138]; N-(3 -( 1 ,2-dimethyl- lH-imidazol-5-yl)-l,7-naphthyridin-6-yl)-4,4-difluorocyclohexane- 1 - carboxamide [3139];

(S)-N-(3 -( 1 ,2-dimethyl- lH-imidazol-5 -yl)- 1,7-naphthyridin-6-yl)tetrahydrofuran-2 -carboxamide

[3140];

N-(3-(l,2-dimethyl-lH-imidazol-5-yl)-l,7-naphthyridin-6-yl)-3,3-difluorocyclobutane-l- carboxamide [3141];

N-(3 -( 1 ,2-dimethyl- lH-imidazol-5-yl)-l,7-naphthyridin-6-yl)- 1 -fluorocyclopropane-1 - carboxamide [3142];

N-(3-(l,2-dimethyl-lH-imidazol-5-yl)-l,7-naphthyridin-6-yl)moφholine-4-carboxamide [3143]; N-(3-(l,2-dimethyl-lH-imidazol-5-yl)-l,7-naphthyridin-6-yl)moφholine-ίs-4-carboxamide

[3144];

1 -methyl -N-(3 -( 1 -methyl-lH-imidazol-5 -yl)- 1,7-naphthyridin-6-yl)-lH-pyrazole-4-carboxamide

[3145];

l-ethyl-N-(3-(l-methyl-lH-imidazol-5-yl)-l,7-naphthyridin-6-yl)-lH-pyrazole-4-carboxamide

[3146];

1 -isopropyl-N-(3 -( 1 -methyl- lH-imidazol-5-yl)- 1,7-naphthyridin-6-yl)- lH-pyrazole-4- carboxamide [3147];

1 -cyclopropyl-N-(3 -( 1 -methyl -lH-imidazol -5 -yl)- 1,7-naphthyridin-6-yl)- lH-pyrazole-4- carboxamide [3148];

l-isobutyl-N-(3-(l-methyl-lH-imidazol-5-yl)-l,7-naphthyridin-6-yl)-lH-pyrazole-4-carboxamide

[3149];

1 -methyl -N-(3 -( 1 -methyl - 1 H-imidazol-5 -yl) - 1,7 -naphthyridin-6 -yl) - 1 H-pyrazole -3 -carboxamide

[3150];

N-(3 -( 1 -methyl-lH-imidazol-5-yl)-l,7-naphthyridin-6-yl)-2-( 1 -methyl- lH-pyrazol-4-yl)

acetamide [3151];

1 -methyl -N-(3 -( 1 -methyl-lH-imidazol-5 -yl)- 1,7-naphthyridin-6-yl)-lH-imidazole-4 -carboxamide

[3152];

1 -isopropyl-N -(3 -( 1 -methyl- lH-imidazol-5-yl)- 1,7-naphthyridin-6-yl)- lH-imidazole-4- carboxamide [3153]; N-(3 -( 1 -methyl-lH-imidazol-5-yl)-l ,7-naphthyridin-6-yl)- 1 -(tetrahydro-2H-pyran-4-yl)- 1H- imidazole-4-carboxamide [3154];

1 ,2-dimethyl-N-(3 -( 1 -methyl -lH-imidazol -5 -yl)- 1 ,7-naphthyridin-6-yl)- lH-imidazole-5- carboxamide [3155];

1 -methyl -N-(3 -( 1 -methyl-lH-imidazol-5 -yl)- 1 ,7-naphthyridin-6-yl)-lH-l ,2,4-triazole-3 - carboxamide [3156];

2-methyl-N-(3 -( 1 -methyl-lH-imidazol-5 -yl)- 1 ,7-naphthyridin-6-yl)oxazole-4-carboxamide

[3157] ;

2-isopropyl-N-(3 -( 1 -methyl- lH-imidazol-5-yl)- 1 ,7-naphthyridin-6-yl)oxazole-4 -carboxamide

[3158] ;

4-methyl-N-(3 -( 1 -methyl-lH-imidazol-5 -yl)- 1 ,7-naphthyridin-6-yl)oxazole-2 -carboxamide

[3159] ;

4-methyl-N-(3 -( 1 -methyl-lH-imidazol-5 -yl)- 1 ,7-naphthyridin-6-yl)thiazole-2 -carboxamide

[3160] ;

2-methyl-N-(3 -( 1 -methyl-lH-imidazol-5 -yl)- 1 ,7-naphthyridin-6-yl)thiazole-4 -carboxamide

[3161] ;

5 -methyl -N-(3 -( 1 -methyl - 1 H-imidazol-5 -yl) - 1 ,7 -naphthyridin-6 -yl) - 1 , 3 ,4 -oxadiazole -2 - carboxamide [3162];

5 -methyl -N-(3 -( 1 -methyl - 1 H-imidazol-5 -yl) - 1 ,7 -naphthyridin-6 -yl) - 1 , 3 ,4 -thiadiazole -2 - carboxamide [3163];

1 -isopropyl-N-(3 -( 1 -isopropyl- lH-imidazol-5-yl)- 1 ,7-naphthyridin-6-yl)- lH-pyrazole-4- carboxamide [3164];

N-(3 -( 1 ,2-dimethyl- lH-imidazol-5-yl)-l ,7-naphthyridin-6-yl)- 1 -methyl- lH-pyrazole-4- carboxamide [3165];

N-(3-( l,2-dimethyl-lH-imidazol-5-yl)-l,7-naphthyridin-6-yl)-l-isopropyl-lH-pyrazole-4- carboxamide [3166];

N-(3-( l,2-dimethyl-lH-imidazol-5-yl)-l,7-naphthyridin-6-yl)-2-methylthiazole-5-carboxamide

[3167] ;

4-fluoro-N-(3 -( 1 -methyl- lH-imidazol-5 -yl)- 1 ,7-naphthyridin-6-yl)benzamide [3168] ;

4-fluoro-N-(3-( l-methyl-lH-imidazol-5-yl)-l,7-naphthyridin-6-yl)benzamide-2,3,5,6-£/4 [3169] ; 2-chloro-N-(3-(l-methyl-lH-imidazol-5-yl)-l,7-naphthyridin-6-yl)benzamide-3,4,5,6-£/4 [3170]; 4-chloro-N-(3-(l-methyl-lH-imidazol-5-yl)-l,7-naphthyridin-6-yl)benzamide-2,3,5,6-£/4 [3171]; 4-(methyl-c? 3) -N-(3 -( 1 -methyl - 1 H-imidazol -5 -yl) - 1 , 7-naphthyridin-6 -yl)benzamide [3172] ; 4-methyl-N-(3 -( 1 -methyl-lH-imidazol-5 -yl)- 1 ,7-naphthyridin-6-yl)benzamide-2,3 ,5,6-d4 [3173] ; 4-(methyl-d3)-N-(3-( 1 -methyl- lH-imi

[3174];

4-(methoxy-£/3)-N-(3-(l-methyl-lH-imidazol-5-yl)-l,7-naphthyridin-6-yl)benzamide [3175]; 4-(methoxy- 3)-N-(3-(l-methyl-lH-imidazol-5-yl)-l,7-naphthyridin-6-yl)benzamide-2,3,5,6-ii4

[3176];

4-methoxy-N-(3 -( 1 -methyl- lH-imidazol -5 -yl)- 1 ,7-naphthyridin-6-yl)benzamide-2,3,5,6-<¾

[3177];

(E)-N-(3-(l,2-dimethyl-lH-imidazol-5-yl)-l,7-naphthyridin-6-yl)-3-(phenyl-2,3,4,5,6- j)

acrylamide [3178];

(E)-N-(3-(l,2-dimethyl-lH-imidazol-5-yl)-l,7-naphthyridin-6-yl)-3-(phenyl-2,3,4,5,6- j)

acrylamide-2,3-£/₂ [3179];

N-(3-(l,2-dimethyl-lH-imidazol-5-yl)-l,7-naphthyridin-6-yl)-2-(4-fluorophenyl)acetamide-2,2- d₂ [3180];

(E)-N-(3-(l-methyl-lH-imidazol-5-yl)-l,7-naphthyridin-6-yl)-3-(phenyl-2,3,4,5,6-£/j)acrylamide

[3181];

(E)-N-(3-(l-methyl-lH-imidazol-5-yl)-l,7-naphthyridin-6-yl)-3-(phenyl-2,3,4,5,6-£/j)acrylamide- 2,2-d₂ [3182];

2-(4-fluorophenyl)-N-(3-(l-methyl-lH-imidazol-5-yl)-l,7-naphthyridin-6-yl)acetamide-2,2-£/2

[3183];

N-(3 -( 1 -methyl-lH-imidazol-5-yl)-l ,7-naphthyridin-6-yl)-2-(4-methylpiperazin- 1 -yl)

isonicotinamide [3184];

2-(dimethylamino)-N-(3 -( 1 -methyl- lH-imidazol-5-yl)- 1 ,7-naphthyridin-6-yl)isonicotinamide

[3185];

2-(3 -aminoazetidin- 1 -yl)-N-(3 -( 1 -methyl -lH-imidazol -5 -yl)- 1 ,7-naphthyridin-6-yl)

isonicotinamide [3186];

N-(3 -( 1 -methyl-lH-imidazol-5-yl)- 1 ,7-naphthyridin-6-yl)-2-(pyrrolidin- 1 -yl)isonicotinamide

[3187];

N-(3-(l-methyl-lH-imidazol-5-yl)-l,7-naphthyridin-6-yl)-2-(piperidin-l-yl)isonicotinamide

[3188];

N-(3-(l-methyl-lH-imidazol-5-yl)-l,7-naphthyridin-6-yl)-2-moφholinoisonicotinamide [3189]; 2-(4-isopropylpiperazin- 1 -yl)-N-(3-( 1 -methyl- lH-imidazol-5 -yl)- 1 ,7-naphthyridin-6-yl)

isonicotinamide [3190];

2-(4-cyclopropylpiperazin- 1 -yl)-N-(3-( 1 -methyl- lH-imidazol-5 -yl)- 1 ,7-naphthyridin-6-yl)

isonicotinamide [3191]; N-(3-(l-methyl-lH-imidazol-5-yl)-l,7-naphthyridin-6-yl)-2-(2,7-diazaspiro[3.5]nonan-2-yl) isonicotinamide [3192];

N-(3-(l-methyl-lH midazol-5-yl)-l,7-naphthyridin-6-yl)-2-(7-methyl-2,7-diazaspiro[3.5]nonan-

2-yl)isonicotinamide [3193];

N-(3-(l-methyl-lH midazol-5-yl)-l,7-naphthyridin-6-yl)isoindoline-5-carboxamide [3194] ; 2-methyl-N-(3 -( 1 -methyl-lH-imidazol-5 -yl)- 1 ,7-naphthyridin-6-yl)isoindoline-5 -carboxamide

[3195] ;

2-(azetidin- 1 -yl)-N-(3 -( 1 -methyl-lH-imidazol-5-yl)-l ,7-naphthyridin-6-yl)isonicotinamide

[3196] ;

2-methoxy-N-(3 -( 1 -methyl- IH-imidazol -5 -yl)- 1 ,7-naphthyridin-6-yl)isonicotinamide [3197] ; 2-methyl-N-(3 -( 1 -methyl-lH-imidazol-5 -yl)- 1 ,7-naphthyridin-6-yl)isonicotinamide [3198] ; 2-cyano-N-(3 -( 1 -methyl-lH-imidazol-5 -yl)- 1 ,7-naphthyridin-6-yl)isonicotinamide [3199] ; 2-(3,3-difluoroazetidin-l-yl)-N-(3-(l-methyl-lH-imidazol-5-yl)-l,7-naphthyridin-6-yl)

isonicotinamide [3200];

2-(4,4-difluoropiperidin-l -yl)-N-(3 -( 1 -methyl- lH-imidazol-5 -yl)- 1 ,7-naphthyridin-6-yl)

isonicotinamide [3201];

2-isopropoxy-N-(3 -( 1 -methyl -IH-imidazol -5 -yl)- 1 ,7-naphthyridin-6-yl)isonicotinamide [3202] ; N-(3 -( 1 -methyl-lH-imidazol-5-yl)- 1 ,7-naphthyridin-6-yl)-2-(pyrrolidin- 1 -yl -2,2,5, 5-<¾)

isonicotinamide [3203];

N-(3 -( 1 -methyl-lH-imidazol-5-yl)- 1 ,7-naphthyridin-6-yl)-2-(pyrrolidin- 1 -yl-<¾)isonicotinamide

[3204] ;

N-(3-(l-methyl-lH-imidazol-5-yl)-l,7-naphthyridin-6-yl)-2-(piperidin-l-yl-£/;o)isonicotinamide

[3205] ;

N-(3-(l-methyl-lH-imidazol-5-yl)-l,7-naphthyridin-6-yl)-2-(moφholino-ί s)isonicotinamide

[3206] ;

N-(3 -( 1 ,2-dimethyl- lH-imidazol-5-yl)-l ,7-naphthyridin-6-yl)-4-isopropoxybenzamide [3207] ; N-(3-(l,2-dimethyl-lH-imidazol-5-yl)-l,7-naphthyridin-6-yl)-4-(piperidin-4-yloxy)benzamide

[3208] ;

4-(benzyloxy)-N-(3-( 1 ,2-dimethyl- lH-imidazol-5-yl)- 1 ,7-naphthyridin-6-yl)benzamide [3209] ; N-(3-(l,2-dimethyl-lH-imidazol-5-yl)-l,7-naphthyridin-6-yl)-2-fluorobenzamide-3,4,5,6-£/4

[3210] ;

N-(3-(l,2-dimethyl-lH-imidazol-5-yl)-l,7-naphthyridin-6-yl)-4-fluorobenzamide-2,3,5,6-£/4

[3211] ; 2-chloro-N-(3-(l,2-dimethyl-lH midazol-5-yl)-l -naphthyridin-6-yl)benzamide-3 ,4,5,6-<¾

[3212] ;

4-chloro-N-(3-(l,2-dimethyl-lH-imidazol-5-yl)-l -naphthyridin-6-yl)benzamide-2,3,5,6-<¾

[3213] ;

N-(3-(l,2-dimethyl-lH-imidazol-5-yl)-l,7-naphthyridin-6-yl)-4-(methyl-ii3)benzamide [3214]; N-(3-(l,2-dimethyl-lH-imidazol-5-yl)-l,7-naphthy^

[3215] ;

N-(3-(l,2-dimethyl-lH-imidazol-5-yl)-l,7-naphthy^

[3216] ;

N-(3-(l,2-dimethyl-lH-imidazol-5-yl)-l,7-naphthyridin-6-yl)-4-(methoxy-d3)benzamide [3217] ; N-(3-(l,2-dimethyl-lH-imidazol-5-yl)-l,7-naphthy^

d₄ [3218] ;

N-(3-(l,2-dimethyl-lH-imidazol-5-yl)-l,7-naphthy^

[3219] ;

N-(3 -( 1 ,2-dimethyl- lH-imidazol-5-yl)-l ,7-naphthyridin-6-yl)-2-(4-methylpiperazin- 1 -yl)

isonicotinamide [3220];

[3221] ;

N-(3-(l,2-dimethyl-lH-imidazol-5-yl)-l,7-naphthy^

[3222] ;

N-(3-(l,2-dimethyl-lH-imidazol-5-yl)-l,7-naphthyridin-6-yl)-2-(dimethylamino)isoni

[3223] ;

N-(3-(l,2-dimethyl-lH-imidazol-5-yl)-l,7-naphthyridin-6-yl)-2-(pyrrolidin-l-yl-2,2,5,5-ii4) isonicotinamide [3324];

N-(3-(l,2-dimethyl-lH-imidazol-5-yl)-l,7-naphthyridin-6-yl)-2-(pyrrolidin-l-yl-£/s)

isonicotinamide [3225];

N-(3-(l,2-dimethyl-lH-imidazol-5-yl)-l,7-naphthyridin-6-yl)-2-(piperidin-l-yl-£/;o)

isonicotinamide [3226];

N-(3-(l,2-dimethyl-lH-imidazol-5-yl)-l,7-naphthyridin-6-yl)-2-(moφholino- s)isonicotinamide

[3227] ;

N-(3-(5,6,7,8-tetrahydroimidazo[l,2-a]pyrazin-3-yl)-l,7-naphthyridin-6-yl)

cyclopropanecarboxamide [3228];

N-(3-(7-methyl-5,6,7,8-tetrahydroimidazo[l,2-a]pyrazin-3-yl)-l,7-naphthyridin-6-yl)

cyclopropanecarboxamide [3229]; 3,3-difluoro-N-(3-(5,6,7,8 etrahydroimidazo[l,2-a]pyrazin-3-yl)-l,7-naphthyridin-6-yl) cyclobutane-l-carboxamide [3230];

(R)-N-(3-(5,6,7,8-tetrahydroimidazo[l,2-a]pyrazin-3-yl)-l ,7-naphthyridin-6-yl)pyrrolidine-2- carboxamide [3231];

(R)-N-(3 -(5,6,7,8-tetrahydroimidazo[ 1 ,2-a]pyrazin-3-yl)- 1 ,7-naphthyridin-6-yl)piperidine-3 - carboxamide [3232];

l-methyl-N-(3-(5,6,7,8-tetrahydroimidazo[l,2-a]py

4-carboxamide [3233];

N-(3-(5,6J,8-tetrahydroimidazo[l,2-a]pyrazin-3-yl)-l,7-naphthyridin-6-yl)-l-((l-

(trifluoromethyl)cyclopropyl)methyl)piperidine-4-carboxamide [3234];

1- benzoyl-N-(3-(5,6J,8 etrahydroimidazo[l,2-a]pyrazin-3-yl)-l,7-naphthyridin-6-yl)piperidine-

4-carboxamide [3235];

4-fluoro-l-isobutyl-N-(3-(5,6J,8 etrahydroimidazo[l,2-a]pyrazin-3-yl)-l,7-naphthyridin-6-yl) piperidine-4-carboxamide [3236];

(R)-2-(2-methylpyrrolidin-l-yl)-N-(3-(5,6,7,8 etrahydroimidazo[l,2-a]pyrazin-3-yl)-l,7- naphthyridin-6-yl)acetamide [3237] ;

2- (cyclobutyl(methyl)amino)-N-(3-(5,6,7,8-tetrahydroimidazo[l,2-a]pyrazin-3-yl)-l,7- naphthyridin-6-yl)acetamide [3238] ;

4-fluoro-N-(3-(5,6,7,8 etrahydroimidazo[l,2-a]pyrazin-3-yl)-l,7-naphthyridin-6-yl)benzamide

[3239];

4-isopropoxy-N-(3-(5,6,7,8 etrahydroimidazo[l,2-a]pyrazin-3-yl)-l,7-naphthyridin-6-yl)

benzamide [3240];

4-(difluoromethoxy)-N-(3-(5,6,7,8 etrahydroimidazo[l,2-a]pyrazin-3-yl)-l,7-naphthyridin-6- yl)benzamide [3241];

2-((2-(dimethylamino)ethyl)amino)-N-(3-(5,6J,8 etrahydroimidazo[l,2-a]pyrazin-3-yl)-l,7- naphthyridin-6-yl)isonicotinamide [3242] ;

2-(( 1 -isopropylpiperidin-4-yl)oxy)-N-(3 -(5,6,7,8-tetrahydroimidazo[ 1 ,2-a]pyrazin-3 -yl)- 1 ,7- naphthyridin-6-yl)isonicotinamide [3243] ;

N-(3 -(oxazol-5 -yl)- 1 ,7-naphthyridin-6-yl)- 1 -(3,3,3 -trifluoropropyl)piperidine -4 -carboxamide

[3244];

N-(3-(oxazol-5-yl)-l,7-naphthyridin-6-yl)cyclopropanecarboxamide [3245];

(R)-N-(3 -(oxazol-5 -yl)-l ,7-naphthyridin-6-yl)tetrahydrofuran-2 -carboxamide [3246] ;

(R)-N-(3-(oxazol-5-yl)-l,7-naphthyridin-6-yl)piperidine-3-carboxamide [3247];

N-(3 -(oxazol-5 -yl)- 1 ,7-naphthyridin-6-yl)tetrahydro-2H-pyran -4 -carboxamide [3248] ; N-(3 -(oxazol-5 -yl)- 1 ,7-naphthyridin-6-yl)- 1 -(2-(pyrrolidin- 1 -yl)acetyl)piperidine-4-carboxamide

[3249];

1 '-methyl -N-(3 -(oxazol-5 -yl)- 1 ,7-naphthyridin-6-yl)-[ 1 ,4'-bipiperidine] -4-carboxamide [3250] ; c/. ·-4-moφholino-N-(3-(oxazol-5-yl)-l,7-naphthyridin-6-yl)cyclohexane-l-carboxamide [3251]; 2-(cyclobutyl(methyl)amino)-N-(3-(oxazol-5-yl)-l,7-naphthyridin-6-yl)acetamide [3252];

N-(3 -(oxazol-5 -yl)- 1 ,7-naphthyridin-6-yl)-2-(pyrrolidin- 1 -yl)acetamide [3253] ;

(R)-2-(2-methylpyrrolidin- 1 -yl)-N-(3 -(oxazol-5 -yl)- 1 ,7-naphthyridin-6-yl)acetamide [3254] ; 2-(4-methylpiperazin- 1 -yl)-N-(3-(oxazol-5 -yl)- 1 ,7-naphthyridin-6-yl)acetamide [3255] ;

fr «5-4-((4-methylpiperazin-l-yl)methyl)-N-(3-(oxazol-5-yl)-l,7-naphthyridin-6-yl)cyclohexane- 1-carboxamide [3256];

1- (2,2-difluoropropyl)-N-(3-(oxazol-5-yl)-l,7-naphthyridin-6-yl)piperidine-4-carboxamide

[3257];

4-(difluoromethoxy)-N-(3 -( 1 -methyl- lH-imidazol-5-yl)-l ,7-naphthyridin-6-yl)benzamide [3258] ; N-(3 -( 1 -methyl-lH-imidazol-5-yl)- 1 ,7-naphthyridin-6-yl)-3-(pyrrolidin- 1 -ylmethyl)benzamide

[3259];

2- fluoro-N-(3-(l-methyl-lH-imidazol-5-yl)-l,7-naphthyridin-6-yl)benzamide-3,4,5,6-£/4 [3260]; fr «5-4-(hydroxymethyl)-N-(3-(2-methyloxazol-5 -yl)- 1 ,7-naphthyridin-6-yl)cyclohexane- 1 - carboxamide [3261];

trans -4 -(methylamino) -N-(3 -(2 -methyloxazol -5 -yl) - 1 , 7-naphthyridin-6-yl)cyclohexane - 1 - carboxamide [3262];

fr «5-4-((l,3-difluoropropan-2-yl)amino)-N-(3-(2-methyloxazol-5-yl)-l,7-naphthyridin-6-yl) cyclohexane-1 -carboxamide [3263];

fr «5-N-(3-(2-methyloxazol-5-yl)-l,7-naphthyridin-6-yl)-4-((propan-2-yl-l, l,l,3,3,3-£/6)

amino)cyclohexane-l -carboxamide [3264];

fr «5-4-((2,2-difluoroethyl)amino)-N-(3-(2-methyloxazol-5-yl)-l,7-naphthyridin-6-yl)

cyclohexane-1 -carboxamide [3265];

fr «5-N-(3-(2-methyloxazol-5-yl)-l,7-naphthyridin-6-yl)-4-((3,3,3- trifluoropropyl)amino)cyclohexane - 1 -carboxamide [3266] ;

fr «5-4-((2-methoxyethyl)amino)-N-(3-(2-methyloxazol-5-yl)-l,7-naphthyridin-6-yl)

cyclohexane-1 -carboxamide [3267];

fr «5-4-(dimethylamino)-N-(3-(2-methyloxazol-5-yl)-l,7-naphthyridin-6-yl)cyclohexane-l- carboxamide [3268];

fr «5-4-(bis(methyl-£/3)amino)-N-(3-(2-methyloxazol-5-yl)-l,7-naphthyridin-6-yl)cyclohexane-l- carboxamide [3269]; c/5-4-(dimethylamino)-N-(3-(2-methyloxazol-5-yl)-l,7-naphthyridin-6-yl)cyclohexane-l- carboxamide [3270];

fr «5-4-((2,2-difluoroe1hyl)(methyl)amino)-N-(3-(2-methyloxazol-5-yl)-l,7-naphthyridin-6-yl) cyclohexane-1 -carboxamide [3271];

fr «5-4-(methyl(oxetan-3-yl)amino)-N-(3-(2-methyloxazol-5-yl)-l,7-naphthyridin-6-yl)

cyclohexane-1 -carboxamide [3272];

trans -4 -((2-fluoroethyl)amino) -N-(3 -(2 -methyloxazol -5 -yl) - 1 , 7-naphthyridin-6 -yl)cyclohexane-l- carboxamide [3273];

fr «5-4-(2-(fluoromethyl)aziridin-l-yl)-N-(3-(2-methyloxazol-5-yl)-l,7-naphthyridin-6-yl)

cyclohexane-1 -carboxamide [3274];

trans-4-((3 -fluoroazetidin- 1 -yl)methyl)-N-(3-(2-methyloxazol-5 -yl)- 1 ,7-naphthyridin-6-yl)

cyclohexane-1 -carboxamide [3275];

fr «5-N-(3-(2-methyloxazol-5 -yl)- 1 ,7-naphthyridin-6-yl)-3-morpholinocyclobutane- 1 - carboxamide [3276];

fr rø-N-(3-(2-methyloxazol-5-yl)-l,7-naphthyridin-6-yl)-4-moφholinocyclohexane-l- carboxamide [3277];

N-(3 -(2-methyloxazol-5-yl)- 1 ,7-naphthyridin-6-yl)-2-(piperidin- 1 -yl)acetamide [3278] ;

2-(4-methoxypiperidin-l-yl)-N-(3-(2-methyloxazol-5-yl)-l,7-naphthyridin-6-yl)acetamide

[3279];

N-(3-(2-methyloxazol-5-yl)-l,7-naphthyridin-6-yl)-2-(4-methylpiperazin-l-yl)acetamide [3280]; N-(3 -(2-methyloxazol-5-yl)- 1 ,7-naphthyridin-6-yl)mo holine-4-carboxamide [3281] ;

N-(3-(2-methyloxazol-5-yl)-l,7-naphthyridin-6-yl)-2-mo holinoacetamide [3282];

N-(3 -(2-methyloxazol-5-yl)- 1 ,7-naphthyridin-6-yl)-3 -mo holinopropanamide [3283] ;

1 -methyl -N-(3 -(2 -methyloxazol -5 -yl)- 1 ,7-naphthyridin-6-yl)piperidine-4 -carboxamide [3284] ; 1 -(2,2-difluoropropyl)-N-(3-(2-methyloxazol-5 -yl)- 1 ,7-naphthyridin-6-yl)piperidine-4- carboxamide [3285];

N-(3 -(2-methyloxazol-5-yl)- 1 ,7-naphthyridin-6-yl)-4-moφholinopiperidine- 1 -carboxamide

[3286];

4-((l,3-difluoropropan-2-yl)amino)-N-(3-(2-methyloxazol-5-yl)-l,7-naphthyridin-6-yl)

piperidine-1 -carboxamide [3287];

( lR,3s,5 S)-3 -(( 1 ,3-difluoropropan-2-yl)amino)-N-(3 -(2-methyloxazol-5 -yl)- 1 ,7-naphthyridin-6- yl)-8-azabicyclo[3.2.1] octane -8 -carboxamide [3288];

( lR,3s,5 S)-3 -(( 1 ,3-difluoropropan-2-yl)amino)-N-(3 -(2-methyloxazol-5 -yl)- 1 ,7-naphthyridin-6- yl)-8-azabicyclo[3.2.1] octane -8 -carboxamide [3289]; 4-(dimethylamino) -N-(3 -(2 -methyloxazol -5 -yl) - 1 ,7 -naphthyridin-6 -yl)piperidine - 1 -carboxamide

[3290] ;

4-((2,2-difluoroethyl)(methyl)amino)-N-(3-(2-methyloxazol-5-yl)-l,7-naphthyridin-6-yl)

piperidine-1 -carboxamide [3291];

(3S,4S)-4-amino-3-fluoro-N-(3-(2-methyloxazol-5-yl)-l,7-naphthyridin-6-yl)piperidine-l- carboxamide [3292];

(3S,4S)-3-fluoro-4-(methylamino)-N-(3-(2-methyloxazol-5-yl)-l,7-naphthyridin-6-yl)piperidine- 1 -carboxamide [3293];

(3R,4R)-4-amino-3-fluoro-N-(3-(2-methyloxazol-5-yl)-l,7-naphthyridin-6-yl)piperidine-l- carboxamide [3294];

(3R,4R)-3-fluoro-4-(methylamino)-N-(3-(2-methyloxazol-5-yl)-l,7-naphthyridin-6-yl)piperidine-

1 -carboxamide [3295];

4-((2-fluoroethyl)amino)-N-(3-(2-methyloxazol-5 -yl)- 1 ,7-naphthyridin-6-yl)piperidine- 1 - carboxamide [3296];

4-((2,2-difluoroethyl)amino)-N-(3-(2-methyloxazol-5-yl)-l,7-naphthyridin-6-yl)piperidine-l- carboxamide [3297];

(lR,3s,5S)-3-amino-N-(3-(2-methyloxazol-5-yl)-l,7-naphthyridin-6-yl)-8-azabicyclo[3.2.1] octane-8-carboxamide [3298] ;

(lR,3r,5S)-3-amino-N-(3-(2-methyloxazol-5-yl)-l,7-naphthyridin-6-yl)-8-azabicyclo[3.2.1] octane-8-carboxamide [3299] ;

( lR,3r,5 S)-3-((2-fluoroethyl)amino)-N-(3 -(2-methyloxazol-5 -yl)- 1 ,7-naphthyridin-6-yl)-8- azabicyclo[3.2.1] octane -8 -carboxamide [3300];

(lR,3r,5S)-3-((2,2-difluoroethyl)amino)-N-(3-(2-methyloxazol-5-yl)-l,7-naphthyridin-6-yl)-8- azabicyclo[3.2.1] octane -8 -carboxamide [3301];

(lR,3s,5S)-N-(3-(2-methyloxazol-5-yl)-l,7-naphthyridin-6-yl)-3-((3,3,3-trifluoropropyl)amino)-

8 -azabicyclo [3.2.1] octane -8 -carboxamide [3302] ;

(3S,4S)-3-fluoro-4-(isopropylamino)-N-(3-(2-methyloxazol-5-yl)-l,7-naphthyridin-6- yl)piperidine - 1 -carboxamide [3303] ;

N-(3-(2-methyloxazol-5-yl)-l,7-naphthyridin-6-yl)-5,6-dihydroimidazo[l,2-a]pyrazine-7(8H)- carboxamide [3304];

2-methyl-N-(3 -(2 -methyloxazol -5 -yl)- 1 ,7-naphthyridin-6-yl)-5,6-dihydroimidazo[ 1 ,2-a]pyrazine-

7(8H)-carboxamide [3305] ;

N-(3 -(2-methyloxazol-5-yl)- 1 ,7-naphthyridin-6-yl)-2-(mo holino-ί s)acetamide [3306] ; fra«s-N-(3-(2-methyloxazol-4-yl)- 1 ,7-naphthyridin-6-yl)-4-(4-methylpiperazin- 1 -yl)cyclohexane- 1-carboxamide [3307];

N-(3-(2-methyloxazol-5-yl)-l ,7-naphthyridin-6-yl)-l-(l-methylpiperidin-4-yl)-lH-pyrazole-4- carboxamide [3308];

2- ( lH-imidazol- 1 -yl)-N-(3 -(2-methyloxazol-5 -yl)- 1 ,7-naphthyridin-6-yl)acetamide [3309] ;

4-(difluoromethoxy)-N-(3 -(oxazol-5 -yl)- 1 ,7-naphthyridin-6-yl)benzamide [3310] ;

3- ((l-methylpiperidin-4-yl)oxy)-N-(3-(oxazol-5-yl)-l ,7-naphthyridin-6-yl)benzamide [3311]; N-(3 -(oxazol-5 -yl)- 1 ,7-naphthyridin-6-yl)isonicotinamide [3312] ;

2-(3-aminoazetidin-l -yl)-N-(3 -(oxazol-5 -yl)- 1 ,7-naphthyridin-6-yl)isonicotinamide [3313] ; 2-(l-methylpiperidin-4-yl)-N-(3-(oxazol-5-yl)-l,7-naphthyridin-6-yl)isonicotinamide [3314]; l'-methyl-N-(3 -(oxazol-5 -yl)- 1 ,7-naphthyridin-6-yl)-l ',2',3',6'-tetrahydro-[2,4'-bipyridine] -4- carboxamide [3315];

2-(4-methylpiperazin-l-yl)-N-(3-(oxazol-5-yl)-l,7-naphthyridin-6-yl)isonicotinamide [3316]; 2-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl)-N-(3-(oxazol-5-yl)-l,7-naphthyridin-6-yl)

isonicotinamide [3317];

N-(3 -(oxazol-5 -yl)-l ,7-naphthyridin-6-yl)-2-(2,7-diazaspiro[3.5]nonan-7-yl)isonicotinamide

[3318];

N-(3 -(oxazol-5 -yl)-l J-naphthyridin-6-yl)-2-(piperidin-4-ylamino)isonicotinamide [3319];

2-methyl-N-(3 -(oxazol-5 -yl)-l ,7-naphthyridin-6-yl)isoindoline-5 -carboxamide [3320] ;

N-(3-(oxazol-5-yl)-l ,7-naphthyridin-6-yl)-l,2,3,4-tetrahydroisoquinoline-7-carboxamide [3321]; N-(3-(2-methyloxazol-5-yl)-l ,7-naphthyridin-6-yl)-2-(4-methylpiperazin-l-yl)isonicotinamide

[3322];

N-(3-(3-methylisoxazol-5-yl)-l,7-naphthyridin-6-yl)-l-(3,3,3-trifluoropropyl)piperidine-4- carboxamide [3323];

4- fluoro-l-isobutyl-N-(3-(5-methyl-l,3,4-oxadiazol-2-yl)-l,7-naphthyridin-6-yl)piperidine-4- carboxamide [3324];

l-isobutyl-N-(3-(5-methyl-l,3,4-oxadiazol-2-yl)-l,7-naphthyridin-6-yl)piperidine-4-carboxamide

[3325];

N-(3-(5-(dimethylamino)-l,3,4-oxadiazol-2-yl)-l,7-naphthyridin-6-yl)piperidine-4-carboxami

[3326];

N-(3-(5-(dimethylamino)-l,3,4-oxadiazol-2-yl)-l,7-nap

carboxamide [3327];

N-(3-(5-methyl-l,3,4-oxadiazol-2-yl)-l,7-naphthyridin-6-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [3328]; 3 , 3 -difluoro -N-(3 -(thiazol-5 -yl) - 1 , 7 -naphthyridin-6 -yl)cyclobutane- 1 -carboxamide [3329] ;

2-methyl-N-(3-(thiazol-5-yl)-l,7-naphthyridin-6-yl)-2-azaspiro[3 ]heptane-6-carboxamide

[3330];

1 -fluoro-N-(3 -(thiazol-5 -yl)- 1 ,7-naphthyridin-6-yl)cyclohexane-l -carboxamide [3331] ;

fr «5-4-(dimethylamino)-N-(3 -(thiazol-5-yl)- 1 ,7-naphthyridin-6-yl)cyclohexane- 1 -carboxamide

[3332];

fr «5-4-((3-fluoroazetidin- 1 -yl)methyl)-N-(3 -(thiazol-5 -yl)- 1 ,7-naphthyridin-6-yl)cyclohexane-l - carboxamide [3333];

N-(3 -(thiazol-5-yl)- 1 ,7-naphthyridin-6-yl)azetidine-3-carboxamide [3334] ;

l-methyl-N-(3-(thiazol-5-yl)-l,7-naphthyridin-6-yl)piperidine-4-carboxamide [3335];

1 -(2,2-difluoropropyl)-N-(3-(thiazol-5 -yl)- 1 ,7-naphthyridin-6-yl)piperidine-4-carboxamide

[3336];

1- (oxetan-3-yl)-N-(3-(thiazol-5-yl)-l,7-naphthyridin-6-yl)piperidine-4-carboxamide [3337];

1 -(2-(pyrrolidin- 1 -yl)acetyl)-N-(3 -(thiazol-5-yl)-l ,7-naphthyridin-6-yl)piperidine-4-carboxamide

[3338];

1 '-methyl -N-(3 -(thiazol-5 -yl)- 1 ,7-naphthyridin-6-yl)-[ 1 ,4'-bipiperidine] -4-carboxamide [3339] ;

2- (pyrrolidin- 1 -yl)-N-(3 -(thiazol-5 -yl)- 1 ,7-naphthyridin-6-yl)propanamide [3340] ;

2-(piperidin-l-yl)-N-(3-(thiazol-5-yl)-l,7-naphthyridin-6-yl)acetamide [3341];

2-(4-methylpiperazin-l-yl)-N-(3-(thiazol-5-yl)-l,7-naphthyridin-6-yl)acetamide [3342];

2-moφholino-N-(3-(thiazol-5-yl)-l,7-naphthyridin-6-yl)acetamide [3343];

4-(piperidin-4-yloxy)-N-(3-(thiazol-5-yl)-l,7-naphthyridin-6-yl)benzamide [3344];

N-(3 -(thiazol-5-yl)- 1 ,7-naphthyridin-6-yl)isonicotinamide [3345] ;

6-(4-methylpiperazin-l-yl)-N-(3-(thiazol-5-yl)-l,7-naphthyridin-6-yl)nicotinamide [3346]; r-methyl-N-(3 -(thiazol-5 -yl)- 1 ,7-naphthyridin-6-yl)- 1 ',2',3 ',6'-tetrahydro-[2,4'-bipyridine] -4- carboxamide [3347];

2-(3 -(dimethylamino)azetidin- 1 -yl)-N-(3-(thiazol-5 -yl)-l ,7-naphthyridin-6-yl)isonicotinamide

[3348];

2-(4-(dimethylamino)piperidin-l-yl)-N-(3-(thiazol-5-yl)-l,7-naphthyridin-6-yl)isonicotinamide

[3349];

2-(4-methylpiperazin-l-yl)-N-(3-(thiazol-5-yl)-l,7-naphthyridin-6-yl)isonicotinamide [3350]; 2-(( 1 -methylpiperidin-4-yl)thio)-N-(3-(thiazol-5 -yl)- 1 ,7-naphthyridin-6-yl)isonicotinamide

[3351];

N-(3 -(thiazol-5-yl)- 1 ,7-naphthyridin-6-yl)- 1 ,2,3,4-tetrahydroisoquinoline-7 -carboxamide [3352] ; trans-4-(( 1 ,3 -difluoropropan-2-yl)amino)-N-(3 -(5 -methyl- 1 ,3,4-thiadiazol-2-yl)-l ,7- naphthyridin-6-yl)cyclohexane- 1 -carboxamide [3353] ;

N-(3-(2-methylthiazol-5-yl)-l,7-naphthyridin-6-yl)mo holine-4-carboxamide [3354];

N-(3-(2-methylthiazol-5-yl)-l,7-naphthyridin-6-yl)-2-(pyrrolidin-l-yl)acetamide [3355];

2-((lR,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(3-(2-methylthiazol-5-yl)-l,7-naphthyridin-

6-yl)acetamide [3356];

N-(3 -(2-methylthiazol-5-yl)- 1 ,7-naphthyridin-6-yl)-2-moφholinoacetamide [3357] ;

N-(3 -(2-methylthiazol-5 -yl)- 1 ,7-naphthyridin-6-yl)-2-(moφholino-ί s)acetamide [3358] ;

2-(4-methylpiperazin-l-yl)-N-(3-(2-methylthiazol-5-yl)-l,7-naphthyridin-6-yl)acetamide [3359];

1- methyl-N-(3-(2-methylthiazol-5-yl)-l,7-naphthyridin-6-yl)piperidine-4-carboxamide [3360]; N-(3 -(2-methylthiazol-5-yl)- 1 ,7-naphthyridin-6-yl)isonicotinamide [3361] ;

N-(3 -(2-methylthiazol-5 -yl)- 1 ,7-naphthyridin-6-yl)nicotinamide [3362] ;

2- (4-methylpiperazin-l-yl)-N-(3-(2-methylthiazol-5-yl)-l,7-naphthyridin-6-yl)isonicotinamide

[3363];

fr rø-N-(3-(5-methyl-l,3,4-thiadiazol-2-yl)-l,7-naphthyridin-6-yl)-4-moφholinocyclohexane-l- carboxamide [3364];

fr «5-N-(3-(5-methyl-l,3,4-thiadiazol-2-yl)-l,7-naphthyridin-6-yl)-4-(4-methylpiperazin-l-yl) cyclohexane-1 -carboxamide [3365];

4-isopropyl-N-(3-(5-methyl-l,3,4-thiadiazol-2-yl)-l,7-naphthyridin-6-yl)piperazine-l- carboxamide [3366];

4-((2-methoxyethyl)(methyl)amino)-N-(3-(5-methyl-l,3,4-thiadiazol-2-yl)-l,7-naphthyridin-6-yl) piperidine-1 -carboxamide [3367];

4-(( 1 ,3 -difluoropropan-2-yl)amino)-N-(3-(5 -methyl- 1 ,3,4-thiadiazol-2-yl)- 1 ,7-naphthyridin-6-yl) piperidine-1 -carboxamide [3368];

N-(3-(5-methyl-l,3,4-thiadiazol-2-yl)-l ,7-naphthyridin-6-yl)-4-((3,3,3-trifluoropropyl)amino) piperidine-1 -carboxamide [3369];

4-((2-fluoroethyl)amino)-N-(3-(5 -methyl- 1 ,3,4-thiadiazol-2-yl)- 1 ,7-naphthyridin-6-yl)piperidine-

1 -carboxamide [3370];

(3R,4S)-4-amino-3-fluoro-N-(3-(5-methyl-l,3,4-thiadiazol-2-yl)-l,7-naphthyridin-6-yl)

piperidine-1 -carboxamide [3371];

(3R,4R)-4-amino-3-fluoro-N-(3-(5-methyl-l,3,4-thiadiazol-2-yl)-l,7-naphthyridin-6-yl)

piperidine-1 -carboxamide [3372];

(3S,4S)-3-fluoro-N-(3-(5-methyl-l,3,4-thiadiazol-2-yl)-l,7-naphthyridin-6-yl)-4-(methylamino) piperidine-1 -carboxamide [3373]; (3R,4R)-3 -fluoro-N-(3-(5 -methyl- 1 ,3 ,4-thiadiazol-2-yl)- 1 ,7-naphthyridin-6-yl)-4-(methylamino) piperidine-l-carboxamide [3374];

4-amino-3,3-difluoro-N-(3-(5-methyl-l,3,4-thiadiazol-2-yl)-l,7-naphthyridin-6-yl)piperidine-l- carboxamide [3375];

(3R,4R)-3-fluoro-4-(isopropylamino)-N-(3-(5-methyl-l,3,4-thiadiazol-2-yl)-l,7-naphthyridin-6- yl)piperidine-l-carboxamide [3376];

(3R,4S)-3 -fluoro-4-(isopropylamino)-N-(3 -(5-methyl- 1 ,3 ,4-thiadiazol-2-yl)-l ,7-naphthyridin-6- yl)piperidine-l-carboxamide [3377];

3,3-difluoro-4-(isopropylamino)-N-(3-(5-methyl-l,3,4-thiadiazol-2-yl)-l,7-naphthyridin-6-yl) piperidine-l-carboxamide [3378];

(3S,4S)-3-fluoro-N-(3-(5-methyl-l,3,4-thiadiazol-2-yl)-l,7-naphthyridin-6-yl)-4-((propan-2-yl-

1, 1, 1 ,3 ,3 ,3 -d6)amino)piperidine- 1 -carboxamide [3379] ;

(lR,3s,5S)-3-((l,3-difluoropropan-2-yl)amino)-N-(3-(5-methyl-l,3,4-thiadiazol-2-yl)-l,7- naphthyridin-6-yl)-8-azabicyclo[3.2. l]octane-8-carboxamide [3380];

(lR,3s,5S)-3-((l,3-difluoropropan-2-yl)amino)-N-(3-(5-methyl-l,3,4-thiadiazol-2-yl)-l,7- naphthyridin-6-yl)-8-azabicyclo[3.2.1]octane-8-carboxamide [3381];

4-(dimethylamino)-N-(3-(2-methylthiazol-5-yl)-l,7-naphthyridin-6-yl)piperidine-l-carboxamide

[3382];

4-((2,2-difluoroethyl)amino)-N-(3-(5-methyl-l,3,4-thiadiazol-2-yl)-l,7-naphthyridin-6-yl)

piperidine-l-carboxamide [3383];

4-((2,2-difluoroethyl)(methyl-d3)amino)-N-(3-(5-methyl-l,3,4-thiadiazol-2-yl)-l,7-naphthyridin-

6-yl)piperidine-l -carboxamide [3384];

N-(3 -(5-methyl-l ,3,4-thiadiazol-2-yl)- 1 ,7-naphthyridin-6-yl)-4-mo holinopiperidine- 1 - carboxamide [3385];

N-(3 -(5-methyl-l ,3,4-thiadiazol -2 -yl)- 1 ,7-naphthyridin-6-yl)-4-(4-methylpiperazin- 1 -yl)

piperidine-l-carboxamide [3386];

(R)-3,4-dimethyl-N-(3-(5-methyl-l,3,4-thiadiazol-2-yl)-l,7-naphthyridin-6-yl)piperazine-l- carboxamide [3387];

(S)-3,4-dimethyl-N-(3-(5-methyl-l,3,4-thiadiazol-2-yl)-l,7-naphthyridin-6-yl)piperazine-l- carboxamide [3388];

(lR,3r,5S)-3-((2-fluoroethyl)amino)-N-(3-(5-methyl-l,3,4-thiadiazol-2-yl)-l,7-naphthyridin-6- yl)-8-azabicyclo[3.2. l]octane-8-carboxamide [3389];

(lR,3r,5S)-3-((2,2-difluoroethyl)amino)-N-(3-(5-methyl-l,3,4-thiadiazol-2-yl)-l,7-naphthyridin-

6-yl)-8-azabicyclo[3.2. l]octane-8-carboxamide [3390]; ( lR,3r,5 S)-3-amino-N-(3 -(5-methyl- 1 ,3,4-thiadiazol-2-yl)- 1 ,7-naphthyridin-6-yl)-8-azabicyclo

[3.2.1] octane -8 -carboxamide [3391];

( 1 S,4S)-5 -methyl -N-(3 -(5 -methyl-1 ,3,4-thiadiazol-2-yl)- 1 ,7-naphthyridin-6-yl)-2,5-diazabicyclo

[2.2. l]heptane-2 -carboxamide [3392];

(lR,4R)-5-methyl-N-(3-(5-methyl-l,3,4-thiadiazol-2-yl)-l,7-naphthyridin-6-yl)-2,5-diazabicyclo

[2.2. l]heptane-2 -carboxamide [3393];

8-methyl-N-(3-(5-methyl-l,3,4-thiadiazol-2-yl)-l,7-naphthyridin-6-yl)-3,8-diazabicyclo[3.2.1] octane-3 -carboxamide [3394];

3-methyl-N-(3-(5-methyl-l,3,4-thiadiazol-2-yl)-l,7-naphthyridin-6-yl)-3,8-diazabicyclo[3.2.1] octane-8-carboxamide [3395];

N-(3-(5-methyl-l,3,4-thiadiazol-2-yl)-l ,7-naphthyridin-6-yl)-5,6-dihydroimidazo[l,2-a]pyrazine-

7(8H)-carboxamide [3396];

2-(4-methylpiperazin-l-yl)-N-(3-(5-methylthiazol-2-yl)-l,7-naphthyridin-6-yl)isonicotinamide

[3397];

2-(4-methylpiperazin- 1 -yl)-N-(3-(4-methylthiazol-2-yl)- 1 ,7-naphthyridin-6-yl)isonicotinamide

[3398];

N-(3 -(2-(methylamino)thiazol-5 -yl)-l ,7-naphthyridin-6-yl)piperidine-4 -carboxamide [3399] ;

1- methyl-N-(3-(2-(methylamino)thiazol-5-yl)-l,7-naphthyridin-6-yl)piperidine-4-carboxamide

[3400];

N-(3 -(2-(diethylamino)thiazol-5-yl)- 1 ,7-naphthyridin-6-yl)-2-(4-fluoropiperidin- 1 -yl)acetamide

[3401];

N-(3 -(2-(diethylamino)thiazol-5-yl)- 1 ,7-naphthyridin-6-yl)-2-(4-methylpiperazin- 1 -yl)acetamide

[3402];

N-(3-(2-aminothiazol-5-yl)-l,7-naphthyridin-6-yl)-2-(4-methylpiperazin-l-yl)isonicotinamide

[3403];

N-(3-(2-(methylamino)thiazol-5-yl)-l,7-naphthyridin-6-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [3404];

N-(3 -(2-(dimethylamino)thiazol-5 -yl)- 1 ,7-naphthyridin-6-yl)-2-(4-methylpiperazin-l -yl)

isonicotinamide [3405];

2- (4-isopropylpiperazin-l-yl)-N-(3-(2-(methylamino)thiazol-5-yl)-l,7-naphthyridin-6-yl)

isonicotinamide [3406];

2-(3-(dimethylamino)azetidin-l-yl)-N-(3-(2-(methylamino)thiazol-5-yl)-l,7-naphthyridin-6-yl) isonicotinamide [3407]; 2-(3 -(dimethylamino)azetidin-l -yl)-N-(3-(2-(dimethylamino)thiazol-5 -yl)- 1 ,7-naphthyridin-6-yl) isonicotinamide [3408];

2-(3 -aminoazetidin- 1 -yl) -N-(3 -(2-(dimethylamino)thiazol-5 -yl)- 1 ,7-naphthyridin-6-yl)

isonicotinamide [3409];

N-(3 -(5 -chlorothiazol-2-yl)- 1 ,7-naphthyridin-6-yl)-2-(4-methylpiperazin- 1 -yl)isonicotinamide

[3410];

2-(6-(2-(4-methylpiperazin-l-yl)isonicotinamido)-l,7-naphthyridin-3-yl)thiazole-5-carboxamide

[3411];

N-(3 -(isothiazol-4-yl)- 1 ,7-naphthyridin-6-yl)-l -methylpiperidine-4-carboxamide [3412] ;

N-(3-(l,3,4-thiadiazol-2-yl)-l,7-naphthyridin-6-yl)-4-(difluoromethoxy)benzamide [3413]; N-(3-(l,3,4-thiadiazol-2-yl)-l,7-naphthyridin-6-yl)-4-(piperidin-4-yloxy)benzamide [3414]; N-(3-(l,3,4-thiadiazol-2-yl)-l,7-naphthyridin-6-yl)-4-((l-methylpiperidin-4-yl)oxy)benzamide

[3415];

N-(3-(l,3,4-thiadiazol-2-yl)-l,7-naphthyridin-6-yl)-3-((l-methylpiperidin-4-yl)oxy)benzamide

[3416];

N⁵-(3 -( 1 ,3,4-thiadiazol-2-yl)- 1 ,7-naphthyridin-6-yl)-N²-methylpyridine-2,5-dicarboxamide

[3417];

N-(3 -( 1 , 3 ,4-thiadiazol -2 -yl) - 1 , 7-naphthyridin-6 -yl) -6 -(4-methylpiperazin- 1 -yl)nicotinamide

[3418];

N-(3-(l,3,4-thiadiazol-2-yl)-l -naphthyridin-6-yl)-l'-methyl-l',2',3',6'-tetrahydro-[2,4'- bipyridine] -4 -carboxamide [3419];

N-(3 -( 1 ,3,4-thiadiazol-2-yl)-l ,7-naphthyridin-6-yl)-2-(3-(dimethylamino)azetidin- 1 -yl)

isonicotinamide [3420];

N-(3-(l,3,4-thiadiazol-2-yl)-l,7-naphthyridin-6-yl)-2-(4-methylpiperazin-l-yl)isonicotinamide

[3421];

N-(3-(l,3,4-thiadiazol-2-yl)-l,7-naphthyridin-6-yl)-2-(4-isopropylpiperazin-l-yl)isonicotinamide

[3422];

N-(3-(l,3,4-thiadiazol-2-yl)-l,7-naphthyridin-6-yl)-2-mo holinoisonicotinamide [3423];

1 -fluoro-N-(3 -(5-methyl- 1 ,3,4-thiadiazol-2-yl)- 1 ,7-naphthyridin-6-yl)cyclohexane-l - carboxamide [3424];

fr «5-4-methoxy-N-(3-(5 -methyl- 1 ,3,4-thiadiazol-2-yl)-l ,7-naphthyridin-6-yl)cyclohexane- 1 - carboxamide [3425];

c/5-4-methoxy-N-(3 -(5-methyl- 1 ,3,4-thiadiazol-2-yl)- 1 ,7-naphthyridin-6-yl)cyclohexane- 1 - carboxamide [3426]; fr «5-4-amino-N-(3-(5-methyl-l,3,4-thiadiazol-2-yl)-l ,7-naphthyridin-6-yl)cyclohexane-l- carboxamide [3427];

fr «5-4-(dimethylamino)-N-(3-(5-methyl-l,3,4-thiadiazol-2-yl)-l ,7-naphthyridin-6-yl)

cyclohexane-l-carboxamide [3428];

fr rø-N-(3-(5-methyl-l,3,4 hiadiazol-2-yl)-l,7-naphthyridin-6-yl)-4-moφholinocyclohexane-l- carboxamide [3429];

fr «5-4-(hydroxymethyl)-N-(3-(5-methyl-l,3,4-thiadiazol-2-yl)-l,7-naphthyridin-6-yl)

cyclohexane-l-carboxamide [3430];

N-(3-(5-methyl-l,3,4-thiadiazol-2-yl)-l,7-naphthyridin-6-yl)piperidine-4-carboxamide [3431]; 4-fluoro-N-(3 -(5-methyl- 1 ,3,4-thiadiazol-2-yl)- 1 ,7-naphthyridin-6-yl)piperidine-4-carboxamide

[3432];

1 -methyl -N-(3 -(5 -methyl-1 ,3,4-thiadiazol-2-yl)- 1 ,7-naphthyridin-6-yl)piperidine-4-carboxamide

[3433];

4-fluoro-l-methyl-N-(3-(5-methyl-l,3,4-thiadiazol-2-yl)-l,7-naphthyridin-6-yl)piperidine-4- carboxamide [3434];

1 -(2-fluoroethyl)-N-(3-(5 -methyl- 1 ,3,4-thiadiazol-2-yl)- 1 ,7-naphthyridin-6-yl)piperidine-4- carboxamide [3435];

l-(2,2-difluoroethyl)-N-(3-(5-methyl-l,3,4-thiadiazol-2-yl)-l,7-naphthyridin-6-yl)piperidine-4- carboxamide [3436];

N-(3-(5-methyl-l,3,4-thiadiazol-2-yl)-l ,7-naphthyridin-6-yl)-l-(3,3,3-trifluoropropyl)piperidine- 4-carboxamide [3437];

l-(2,2-difluoropropyl)-N-(3-(5-methyl-l,3,4-thiadiazol-2-yl)-l,7-naphthyridin-6-yl)piperidine-4- carboxamide [3438];

1- benzoyl-N-(3-(5-methyl-l,3,4-thiadiazol-2-yl)-l,7-naphthyridin-6-yl)piperidine-4-carboxamide

[3439];

N-(3 -(5-methyl-l ,3,4-thiadiazol-2-yl)- 1 ,7-naphthyridin-6-yl)-2-(pyrrolidin- 1 -yl)acetamide

[3440];

N-(3 -(5-methyl-l ,3,4-thiadiazol-2-yl)- 1 ,7-naphthyridin-6-yl)-2-(piperidin- 1 -yl)acetamide [3441] ;

2- (4-methoxypiperidin-l-yl)-N-(3-(5-methyl-l,3,4-thiadiazol-2-yl)-l,7-naphthyridin-6-yl)

acetamide [3442];

N-(3 -(5-methyl-l ,3,4-thiadiazol -2 -yl)- 1 ,7-naphthyridin-6-yl)-2-(4-methylpiperazin- 1 -yl)

acetamide [3443];

N-(3-(5-methyl-l,3,4-thiadiazol-2-yl)-l,7-naphthyridin-6-yl)-2-mo holinoacetamide [3444]; (R)-N-(3-(5-methyl-l,3,4 hiadiazol-2-yl)-l,7-naphthyridin-6-yl)-2-(3-methylmoφholino) acetamide [3445];

2-(7-azabicyclo[2.2 ]heptan-7-yl)-N-(3-(5-methyl-l,3,4-thiadiazol-2-yl)-l,7-naphthyridin-6-yl) acetamide [3446];

2-((lR,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(3-(5-methyl-l,3,4-thiadiazol-2-yl)-l,7- naphthyridin-6-yl)acetamide [3447] ;

2-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-N-(3-(5-methyl-l,3,4-thiadiazol-2-yl)-l ,7-naphthyridin-

6-yl)acetamide [3448];

2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-N-(3-(5-methyl-l,3,4-thiadiazol-2-yl)-l ,7-naphthyridin- 6-yl)acetamide [3449];

N-(3-(5-methyl-l,3,4-thiadiazol-2-yl)-l ,7-naphthyridin-6-yl)-2-(l,4-oxazepan-4-yl)acetamide

[3450];

N-(3-(5-methyl-l,3,4-thiadiazol-2-yl)-l ,7-naphthyridin-6-yl)-2-mo holinoacetamide-2,2-ί 2

[3451];

N-(3-(5-methyl-l,3,4-thiadiazol-2-yl)-l ,7-naphthyridin-6-yl)-2-(mo holino-ί s)acetamide [3452]; 1 -methyl-3-(3 -(5 -methyl-1 ,3,4-thiadiazol-2-yl)- 1 ,7-naphthyridin-6-yl)- 1 -( 1 -methylpiperidin-4-yl) urea [3453];

(3S,4S)-4-amino-3-fluoro-N-(3-(5-methyl-l,3,4-thiadiazol-2-yl)-l,7-naphthyridin-6-yl)

piperidine-1 -carboxamide [3454];

(3S,4S)-4-(dimethylamino)-3-fluoro-N-(3-(5^

piperidine-1 -carboxamide [3455];

N-(3-(5-methyl-l,3,4-thiadiazol-2-yl)-l ,7-naphthyridin-6-yl)mo holine-4-carboxamide [3456]; N-(3-(5-methyl-l,3,4-thiadiazol-2-yl)-l ,7-naphthyridin-6-yl)-4-(methylamino)piperidine-l- carboxamide [3457];

4-(dimethylamino)-N-(3-(5-methyl-l,3,4-thiadiazol-2-yl)-l ,7-naphthyridin-6-yl)piperidine-l- carboxamide [3458];

4-((2,2-difluoroethyl)(methyl)amino)-N-(3-(5 -methyl- 1 ,3,4-thiadiazol-2-yl)- 1 ,7-naphthyridin-6- yl)piperidine - 1 -carboxamide [3459] ;

(3S,4S)-3-fluoro-4-(isopropylamino)-N-(3-(5-methyl-l,3,4-thiadiazol-2-yl)-l,7-naphthyridin-6- yl)piperidine - 1 -carboxamide [3460] ;

2-methyl-N-(3-(5-methyl-l,3,4-thiadiazol-2-yl)-l,7-naphthyridin-6-yl)-5,6-dihydroimidazo[l,2-a] pyrazine-7(8H)-carboxamide [3461];

4-methyl-N-(3 -(5 -methyl-1 ,3,4-thiadiazol-2-yl)- 1 ,7-naphthyridin-6-yl)piperazine- 1 -carboxamide

[3462]; N-(3 -(5-methyl-l ,3,4-thiadiazol-2-yl)- 1 ,7-naphthyridin-6-yl)- 1 -( 1 -methylpiperidin-4-yl)- 1H- pyrazole-4-carboxamide [3463];

1 -( 1 -isopropylpiperidin-4-yl)-N-(3-(5 -methyl- 1 ,3,4-thiadiazol-2-yl)- 1 ,7-naphthyridin-6-yl)- 1H- pyrazole-4-carboxamide [3464];

N-(3 -(5-methyl-l ,3,4-thiadiazol-2-yl)- 1 ,7-naphthyridin-6-yl)- 1 -( 1 -methylpiperidin-4-yl)- 1H- l,2,3-triazole-4-carboxamide [3465];

N-(3-(5-methyl-l,3,4-thiadiazol-2-yl)-l,7-naphthyridin-6-yl)-2-(piperidin-4-yl)oxazole-4- carboxamide [3466];

N-(3-(5-methyl-l,3,4-thiadiazol-2-yl)-l,7-naphthyridin-6-yl)-2-(l-methylpiperidin-4-yl)oxazole- 4-carboxamide [3467];

2-(3 -(dimethylamino)azetidin- 1 -yl)-N-(3-(5-methyl- 1 ,3 ,4-thiadiazol-2-yl)-l ,7-naphthyridin-6-yl) isonicotinamide [3468];

r-methyl-N-(3-(5-methyl-l,3,4-thiadiazol-2-yl)-l,7-naphthyridin-6-yl)-l',2',3',6'-tetrahydro-[2,4'- bipyridine] -4 -carboxamide [3469] ;

N-(3 -(5-methyl-l ,3,4-thiadiazol-2-yl)- 1 ,7-naphthyridin-6-yl)-2-(4-methylpiperazin- 1 -yl)

isonicotinamide [3470];

2-(methyl( 1 -methylpiperidin-4-yl)amino)-N-(3 -(5-methyl- 1 ,3 ,4-thiadiazol-2-yl)-l ,7- naphthyridin-6-yl)isonicotinamide [3471] ;

2-(azetidin-3-yloxy)-N-(3-(5-methyl-l,3,4-thiadiazol-2-yl)-l,7-naphthyridin-6-yl)isonicotinamide

[3472];

N-(3-(5-methyl-l,3,4-thiadiazol-2-yl)-l,7-naphthyridin-6-yl)-3-((l-methylpiperidin-4-yl)oxy) benzamide [3473];

N-(3-(5-methyl-l,3,4-thiadiazol-2-yl)-l,7-naphthyridin-6-yl)-2-((l-methylpiperidin-4-yl)thio) isonicotinamide [3474];

6-(4-methylpiperazin-l-yl)-N-(3-(5-(trifluoromethyl)-l,3,4-thiadiazol-2-yl)-l,7-naphthyridin-6- yl)nicotinamide [3475];

2-(4-methylpiperazin-l-yl)-N-(3-(5-(trifluoromethyl)-l,3,4-thiadiazol-2-yl)-l,7-naphthyridin-6- yl)isonicotinamide [3476];

N-(3-(5-amino-l,3,4-thiadiazol-2-yl)-l,7-naphthyridin-6-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [3477];

N-(3-(5-(dimethylamino)-l,3,4-thiadiazol-2-yl)-l,7-naphthyridin-6-yl)-2-(4-methylpiperazin-l- yl)isonicotinamide [3478];

N-(3 -(3-amino-5 -fluorophenyl)- 1 ,7-naphthyridin-6-yl)-2-(4-methylpiperazin- 1 -yl)

isonicotinamide [3479]; N-(3-(3-fluoro-5-(isopropylamino)phenyl)-l,7-naphthyridin-6-yl)-2-(4-methylpiperazin-l-yl) isonicotinamide [3480];

1 -methyl -N-(3 -(pyridin-2-yl)-l ,7-naphthyridin-6-yl)piperidine-4-carboxamide [3481] ;

2-(4-methylpiperazin-l -yl)-N-(3 -(pyridin-2-yl)- 1 ,7-naphthyridin-6-yl)isonicotinamide [3482] ; 2-(4-methylpiperazin-l -yl)-N-(3 -(pyridin-4-yl)- 1 ,7-naphthyridin-6-yl)isonicotinamide [3483] ; N-(3 -(pyridin-3 -yl)- 1 ,7-naphthyridin-6-yl)cyclopropanecarboxamide [3484] ;

N-(3 -(pyridin-3 -yl) - 1 , 7 -naphthyridin-6 -yl) -2 -(pyrrolidin- 1 -yl)acetamide [3485] ;

1 -methyl -N-(3 -(pyridin-3 -yl)-l ,7-naphthyridin-6-yl)piperidine-4-carboxamide [3486] ;

N-(3 -(pyridin-3 -yl)- 1 ,7-naphthyridin-6-yl)quinuclidine-4-carboxamide [3487] ;

2-morpholino-N -(3 -(pyridin-3 -yl)- 1 ,7-naphthyridin-6-yl)acetamide [3488] ;

2-(moφholino-ί s)- -(3-(pyridin-3-yl)-l,7-naphthyridin-6-yl)acetamide [3489];

2-(4-methylpiperazin-l -yl)-N-(3 -(pyridin-3 -yl)- 1 ,7-naphthyridin-6-yl)acetamide [3490] ;

2-(4-methyl- 1 ,4-diazepan- 1 -yl)-N-(3-(pyridin-3-yl)- 1 ,7-naphthyridin-6-yl)acetamide [3491] ; 2-(4-methylpiperazin-l -yl)-N-(3 -(pyridin-3 -yl)- 1 ,7-naphthyridin-6-yl)isonicotinamide [3492] ; 2-(2 -methyl- IH-imidazol- 1 -yl)-N-(3-(pyridin-3-yl)- 1 ,7-naphthyridin-6-yl)acetamide [3493] ; 2-(lH-imidazol-l-yl)-N-(3-(pyridin-3-yl)-l,7-naphthyridin-6-yl)acetamide [3494];

2-(piperidin-4-yl)-N-(3-(pyridin-3-yl)-l,7-naphthyridin-6-yl)oxazole-4-carboxamide [3495]; 2-( 1 -methylpiperidin-4-yl)-N-(3 -(pyridin-3 -yl)-l ,7-naphthyridin-6-yl)oxazole-4-carboxamide

[3496];

2-(l-isopropylpiperidin-4-yl)-N-(3-(pyridin-3-yl)-l,7-naphthyridin-6-yl)oxazole-4-carboxamide

[3497];

fr rø-N-(3-(5-fluoropyridin-3-yl)-l,7-naphthyridin-6-yl)-3-moφholinocyclobutane-l- carboxamide [3498];

fr «5-N-(3-(5-fluoropyridin-3-yl)-l,7-naphthyridin-6-yl)-4-((4-methylpiperazin-l-yl)methyl) cyclohexane-l-carboxamide [3499];

N-(3 -(5-fluoropyridin-3 -yl)-l ,7-naphthyridin-6-yl)-2-(pyrrolidin- 1 -yl)acetamide [3500] ;

N-(3 -(5-fluoropyridin-3 -yl)-l ,7-naphthyridin-6-yl)- 1 -methylpiperidine-4-carboxamide [3501] ; N-(3-(5-fluoropyridin-3-yl)-l,7-naphthyridin-6-yl)-2-(4-methylpiperazin-l-yl)acetamide [3502]; N-(3-(6-fluoropyridin-3-yl)-l,7-naphthyridin-6-yl)-2-(4-methylpiperazin-l-yl)acetamide [3503]; N-(3-(5-fluoropyridin-3-yl)-l,7-naphthyridin-6-yl)-2-moφholinoacetamide [3504];

N-(3-(5-fluoropyridin-3-yl)-l,7-naphthyridin-6-yl)-3-moφholinopropanamide [3505];

N-(3-(5-fluoropyridin-3-yl)-l,7-naphthyridin-6-yl)-2-(4-methylpiperazin-l-yl)isonicotinamide

[3506]; N-(3-(5-fluoropyridin-3-yl)-l ,7-naphthyridin-6-yl)-2-(piperidin-4-yl)oxazole-4-carboxamide [3507];

N-(3-(5-fluoropyridin-3-yl)-l,7-naphthyridin-6-yl)-2-(l-methylpiperidin-4-yl)oxazole-4- carboxamide [3508];

N-(3-(5-fluoropyridin-3-yl)-l,7-naphthyridin-6-yl)-2-(l-isopropylpiperidin-4-yl)oxazole-4- carboxamide [3509];

N-(3-(5-chloropyridin-3-yl)-l ,7-naphthyridin-6-yl)-2-(4-methylpiperazin-l-yl)isonicotinamide

[3510];

N-(3-(5-methylpyridin-3-yl)-l,7-naphthyridin-6-yl)-2-moφholinoacetamide [3511];

N-(3-(5-(difluoromethyl)pyridin-3-yl)-l ,7-naphthyridin-6-yl)-3-(piperidin-4-yl)benzamide

[3512];

N-(3 -(5-(difluoromethyl)pyridin-3-yl)- 1 ,7-naphthyridin-6-yl)-3 -( 1 -methylpiperidin-4-yl)

benzamide [3513];

N-(3 -(5-(difluoromethyl)pyridin-3-yl)- 1 ,7-naphthyridin-6-yl)-2-(4-methylpiperazin- 1 -yl)

isonicotinamide [3514];

2-(4-methylpiperazin-l-yl)-N-(3-(5-(trifluoromethyl)pyridin-3-yl)-l,7-naphthyridin-6-yl)

acetamide [3515];

2-(4-methylpiperazin-l-yl)-N-(3-(6-(trifluoromethyl)pyridin-3-yl)-l,7-naphthyridin-6-yl)

acetamide [3516];

N-(3-(5-(hydroxymethyl)pyridin-3-yl)-l ,7-naphthyridin-6-yl)-l-methylpiperidine-4-carboxamide

[3517];

N-(3 -(5-cyanopyridin-3 -yl)-l ,7-naphthyridin-6-yl)- 1 -methylpiperidine-4-carboxamide [3518] ; N-(3 -(5-methoxypyridin-3 -yl)-l ,7-naphthyridin-6-yl)- 1 -methylpiperidine-4-carboxamide [3519] ; N-(3 -(5 -methoxypyridin-3 -yl)- 1 ,7-naphthyridin-6-yl)-2-moφholinoacetamide [3520] ;

N-(3 -(5 -methoxypyridin-3 -yl)-l ,7-naphthyridin-6-yl)-2-(4-methylpiperazin- 1 -yl)isonicotinamide

[3521];

4-fluoro-N-(3-(5-(piperidin-4-yloxy)pyridin-3-yl)-l,7-naphthyridin-6-yl)benzamide [3522]; N-(3 -(5-aminopyridin-3 -yl)- 1 ,7-naphthyridin-6-yl)-4-fluorobenzamide [3523] ;

N-(3-(5-aminopyridin-3-yl)-l,7-naphthyridin-6-yl)-4-(piperidin-4-yloxy)benzamide [3524]; N-(3 -(5-aminopyridin-3 -yl)- 1 ,7-naphthyridin-6-yl)-2-(4-methylpiperazin- 1 -yl)isonicotinamide

[3525];

N-(3-(5-aminopyridin-3-yl)-l,7-naphthyridin-6-yl)-2-(piperidin-4-yl)oxazole-4-carboxamide

[3526]; N-(3 -(6-aminopyridin-3 -yl)- 1 ,7-naphthyridin-6-yl)-2-(4-methylpiperazin- 1 -yl)isonicotinamide [3527];

N-(3-(6-(methylamino)pyridin-3-yl)-l,7-naphthyridin-6-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [3528];

N-(3 -(5-(isopropylamino)pyridin-3 -yl)- 1 ,7-naphthyridin-6-yl)-3 -(piperidin-4-yl)benzamide

[3529];

N-(3 -(5-(isopropylamino)pyridin-3 -yl)- 1 ,7-naphthyridin-6-yl)-3 -( 1 -methylpiperidin-4-yl)

benzamide [3530];

N-(3 -(5-(isopropylamino)pyridin-3 -yl)- 1 ,7-naphthyridin-6-yl)-2-(4-methylpiperazin- 1 -yl)

isonicotinamide [3531];

N-(3-(5-(piperidin-4-ylamino)pyridin-3-yl)-l,7-naphthyridin-6-yl)cyclohexanecarboxamide

[3532];

4-fluoro-N-(3-(5-(piperidin-4-ylamino)pyridin-3-yl)-l,7-naphthyridin-6-yl)benzamide [3533]; 4-fluoro-N-(3 -(5-(( 1 -methylpiperidin-4-yl)amino)pyridin-3 -yl)- 1 ,7-naphthyridin-6-yl)benzamide

[3534];

N-(3 -(5 -acetamidopyridin-3 -yl) - 1 ,7 -naphthyridin-6 -yl) - 1 -methylpiperidine -4 -carboxamide

[3535];

N-(3-(5-(dimethylamino)pyridin-3-yl)-l,7-naphthyridin-6-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [3536];

N-(3-(6-(dimethylamino)pyridin-3-yl)-l,7-naphthyridin-6-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [3537];

l-methyl-N-(3-(5-(pyrrolidin-l-yl)pyridin-3-yl)-l,7-naphthyridin-6-yl)piperidine-4-carboxamide

[3538];

N-(3 -(5 -(pyrrolidin- 1 -ylmethyl)pyridin-3 -yl)- 1 ,7-naphthyridin-6-yl)cyclopropanecarboxamide

[3539];

4-fluoro-N-(3 -(5 -(pyrrolidin- 1 -ylmethyl)pyridin-3 -yl)- 1 ,7-naphthyridin-6-yl)benzamide [3540] ; N-(3-(5-((4-hydroxypiperidin-l-yl)methyl)pyridin-3-yl)-l,7-naphthyridin-6-yl)

cyclopropanecarboxamide [3541];

4-fluoro-N-(3-(5-((4-hydroxypiperidin-l-yl)methyl)pyridin-3-yl)-l,7-naphthyridin-6-yl)

benzamide [3542];

N-(3 -(5 -(piperazin- 1 -ylmethyl)pyridin-3 -yl)- 1 ,7-naphthyridin-6-yl)cyclopropanecarboxamide

[3543];

N-(3 -(5 -((4-methylpiperazin- 1 -yl)methyl)pyridin-3 -yl)- 1 ,7-naphthyridin-6-yl)

cyclopropanecarboxamide [3544]; N-(3-(5-(mo holinomethyl)pyridin-3-yl)-l,7-naphthyridin-6-yl)cyclopropanecarboxamide

[3545];

N-methyl-5-(6-(l-methylpiperidine-4-carboxamido)-l,7-naphthyridin-3-yl)nicotinamide [3546]; N-methyl-5-(6-(2-(4-methylpiperazin-l-yl)isonicotinamido)-l ,7-naphthyridin-3-yl)nicotinamide

[3547];

N-(3 -(pyridin-3 -yl-<¾)- 1 ,7-naphthyridin-6-yl)-2-(pyrrolidin-l -yl)acetamide [3548] ;

2-(4-methylpiperazin- 1 -yl)-N -(3 -(pyridin-3 -yl-<¾)- 1 ,7-naphthyridin-6-yl)acetamide [3549] ;

2-moφholino-N-(3-(pyridin-3-yl-ί 4)-l,7-naphthyridin-6-yl)acetamide [3550];

1 -methyl -N-(3 -(2-methylpyrimidin-5 -yl)- 1 ,7-naphthyridin-6-yl)piperidine-4-carboxamide [3551] ; 2-(4-methylpiperazin-l-yl)-N-(3-(2-methylpyrimidin-5-yl)-l,7-naphthyridin-6-yl)isonicotinamide

[3552];

N-(3-(2-aminopyrimidin-5-yl)-l,7-naphthyridin-6-yl)-l-methylpiperidine-4-carboxamide [3553]; 2-moφholino-N-(3-(pyridazin-3-yl)-l,7-naphthyridin-6-yl)acetamide [3554];

2-moφholino-N-(3-(pyridazin-4-yl)-l,7-naphthyridin-6-yl)acetamide [3555];

N-(3 -(pyridazin-4-yl) -1,7 -naphthyridin-6 -yl) -2 -(pyrrolidin- 1 -yl)acetamide [3556] ;

fr rø-3-moφholino-N-(3-(pyrazin-2-yl)-l,7-naphthyridin-6-yl)cyclobutane-l-carboxamide

[3557];

fr «5-4-(dimethylamino)-N-(3 -(pyrazin-2-yl)-l ,7-naphthyridin-6-yl)cyclohexane- 1 -carboxamide

[3558];

fr rø-4-moφholino-N-(3-(pyrazin-2-yl)-l,7-naphthyridin-6-yl)cyclohexane-l-carboxamide

[3559];

trans-4-((3 -fluoroazetidin- 1 -yl)methyl)-N-(3-(pyrazin-2-yl)- 1 ,7-naphthyridin-6-yl)cyclohexane-

1 -carboxamide [3560];

fr «5-4-((4-methylpiperazin-l-yl)methyl)-N-(3-(pyrazin-2-yl)-l,7-naphthyridin-6-yl)

cyclohexane-1 -carboxamide [3561];

N-(3-(pyrazin-2-yl)-l,7-naphthyridin-6-yl)-2-(pyrrolidin-l-yl)acetamide [3562];

l-methyl-N-(3-(pyrazin-2-yl)-l,7-naphthyridin-6-yl)piperidine-4-carboxamide [3563];

4-fluoro-l -methyl -N-(3-(pyrazin-2-yl)-l,7-naphthyridin-6-yl)piperidine-4-carboxamide [3564];

1- (2-fluoroethyl)-N-(3-(pyrazin-2-yl)-l,7-naphthyridin-6-yl)piperidine-4-carboxamide [3565]; 1 -(oxetan-3-yl)-N-(3 -(pyrazin-2-yl)- 1 ,7-naphthyridin-6-yl)piperidine-4-carboxamide [3566] ;

2- moφholino-N-(3-(pyrazin-2-yl)-l,7-naphthyridin-6-yl)acetamide [3567];

1 -methyl -N-(3 -(pyrazin-2 -yl) - 1 , 7-naphthyridin-6 -yl)azepane -4 -carboxamide [3568] ;

l-isobutyl-N-(3-(pyrazin-2-yl)-l,7-naphthyridin-6-yl)azepane-4-carboxamide [3569]; 1 -(2-hydroxy-2-methylpropyl)-N-(3 -(pyrazin-2-yl)- 1 ,7-naphthyridin-6-yl)azepane-4-carboxamide

[3570];

4-(moφholinomethyl)-N-(3-(pyrazin-2-yl)-l,7-naphthyridin-6-yl)benzamide [3571];

2-(4-methylpiperazin-l-yl)-N-(3-(pyrazin-2-yl)-l,7-naphthyridin-6-yl)isonicotinami

N-(3 -(6-(methylamino)pyrazin-2-yl)-l ,7-naphthyridin-6-yl)-2-(4-methylpiperazin- 1 -yl)

isonicotinamide [3573];

N-(3 -(6-(isopropylamino)pyrazin-2-yl)- 1 ,7-naphthyridin-6-yl)azetidine-3-carboxamide [3574] ; N-(3 -(6-(isopropylamino)pyrazin-2-yl)- 1 ,7-naphthyridin-6-yl)piperidine-4-carboxamide [3575] ; N-(3 -(6-(isopropylamino)pyrazin-2-yl)- 1 ,7-naphthyridin-6-yl)- 1 -methylpiperidine-4-carboxamide

[3576];

l-(2-fluoroethyl)-N-(3-(6-(isopropylamino)pyrazin-2-yl)-l ,7-naphthyridin-6-yl)piperidine-4- carboxamide [3577];

l-isopropyl-N-(3-(6-(isopropylamino)pyrazin-2-yl)-l,7-naphthyridin-6-yl)piperidine-4- carboxamide [3578];

l-isopentyl-N-(3-(6-(isopropylamino)pyrazin-2-yl)-l,7-naphthyridin-6-yl)piperidine-4- carboxamide [3579];

N-(3-(6-(isopropylamino)pyrazin-2-yl)-l ,7-naphthyridin-6-yl)-3-(piperidin-4-yl)benzamide

[3580];

N-(3 -(6-(isopropylamino)pyrazin-2-yl)- 1 ,7-naphthyridin-6-yl)-3-( 1 -methylpiperidin-4-yl)

benzamide [3581];

N-(3-(6-(isopropylamino)pyrazin-2-yl)-l,7-naphthyridin-6-yl)-l-(piperidin-4-yl)-lH-l,2,3- triazole-4-carboxamide [3582];

l-(l-(2-fluoroethyl)piperidin-4-yl)-N-(3-(6-(isopropylamino)pyrazin-2-yl)-l,7-naphthyridin-6- yl)- 1H- 1 ,2,3 -triazole-4-carboxamide [3583] ;

N-(3 -(6-(isopropylamino)pyrazin-2-yl)- 1 ,7-naphthyridin-6-yl)- 1 -( 1 -isopropylpiperidin-4-yl)-lH- l,2,3-triazole-4-carboxamide [3584];

N-(3 -(6-(isopropylamino)pyrazin-2-yl)- 1 ,7-naphthyridin-6-yl)-2-(4-methylpiperazin- 1 -yl)

isonicotinamide [3585];

N-(3-(6-(feri-butylamino)pyrazin-2-yl)-l,7-naphthyridin-6-yl)-2-(3-(dimethylamino)azetidin-l- yl)isonicotinamide [3586];

N-(3-(6-(fert-butylamino)pyrazin-2-yl)- 1 ,7-naphthyridin-6-yl)- 1 '-methyl- 1 ',2',3 ',6'-tetrahydro-

[2,4'-bipyridine]-4-carboxamide [3587];

N-(3-(6-(feri-butylamino)pyrazin-2-yl)-l,7-naphthyridin-6-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [3588]; N-(3-(6-(fer^butylamino)pyrazin-2-yl)-l,7-naphthyridin-6-yl)-2-(4-isopropylpiperazin-l-yl) isonicotinamide [3589];

N-(3-(6-(fer^butylamino)pyrazin-2-yl)-l,7-naphthyridin-6-yl)-2-moφholinoisonicotinamide

[3590];

N-(3-(6-(((3-fluoroazetidin-3-yl)methyl)amino)pyrazin-2-yl)-l,7-naphthyridin-6-yl)

cyclopropanecarboxamide [3591];

4-fluoro-N-(3-(6-(((3-fluoroazetidin-3-yl)methyl)amino)pyrazin-2-yl)-l ,7-naphthyridin-6-yl) benzamide [3592];

N-(3-(6-(piperidin-4-ylamino)pyrazin-2-yl)-l,7-naphthyridin-6-yl)cyclobutanecarboxamide

[3593];

3.3- difluoro-N-(3-(6-(piperidin-4-ylamino)pyrazin-2-yl)-l,7-naphthyridin-6-yl)cyclobutane-l- carboxamide [3594];

N-(3-(6-(piperidin-4-ylamino)pyrazin-2-yl)-l,7-naphthyridin-6-yl)cyclopentanecarboxamide

[3595];

4.4- difluoro-N-(3 -(6-(piperidin-4-ylamino)pyrazin-2-yl)-l ,7-naphthyridin-6-yl)cyclohexane- 1 - carboxamide [3596];

N-(3-(6-(piperidin-4-ylamino)pyrazin-2-yl)-l,7-naphthyridin-6-yl)tetrahydro-2H-pyran-4- carboxamide [3597];

4-fluoro-N-(3 -(6-(piperidin-4-ylamino)pyrazin-2-yl)- 1 ,7-naphthyridin-6-yl)benzamide [3598] ; N-(3-(6-(((3S,4S)-3-fluoropiperidin-4-yl)amino)pyrazin-2-yl)-l,7-naphthyridin-6-yl)

cyclopropanecarboxamide [3599];

4-fluoro-N-(3-(6-(((3S,4S)-3-fluoropiperidin-4-yl)amino)pyrazin-2-yl)-l,7-naphthyridin-6-yl) benzamide [3600];

N-(3-(6-((l-methylpiperidin-4-yl)amino)pyrazin-2-yl)-l,7-naphthyridin-6-yl)

cyclobutanecarboxamide [3601];

N-(3-(6-((l-methylpiperidin-4-yl)amino)pyrazin-2-yl)-l,7-naphthyridin-6-yl)

cyclopentanecarboxamide [3602];

4-fluoro-N-(3-(6-((l-methylpiperidin-4-yl)amino)pyrazin-2-yl)-l,7-naphthyridin-6-yl)benzamide

[3603];

N-(3-(6-((l-isopropylpiperidin-4-yl)amino)pyrazin-2-yl)-l,7-naphthyridin-6-yl)

cyclopropanecarboxamide [3604];

3,3-difluoro-N-(3-(6-((l-isopropylpiperidin-4-yl)amino)pyrazin-2-yl)-l,7-naphthyridin-6-yl) cyclobutane- 1 -carboxamide [3605] ; N-(3-(6-((1 sopropylpiperidin-4-yl)amino)pyrazin-2-yl)-l,7-naphthyridin-6-yl) cyclopentanecarboxamide [3606];

4-fluoro-N-(3 -(6-(( 1 -isopropylpiperidin-4-yl)amino)pyrazin-2-yl)- 1 ,7-naphthyridin-6-yl)

benzamide [3607];

N-(3-(6-(dimethylamino)pyrazin-2-yl)-l,7-naphthyridin-6-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [3608];

N-(3 -(6-(diethylamino)pyrazin-2-yl)-l ,7-naphthyridin-6-yl)-2-(4-methylpiperazin- 1 -yl)

isonicotinamide [3609];

N-(3-(6-(3-aminoazetidin-l-yl)pyrazin-2-yl)-l,7-naphthyridin-6-yl)-4-fluorobenzamide [3610]; 2-(4-methylpiperazin- 1 -yl)-N-(3-(6-(pyrrolidin- 1 -yl)pyrazin-2-yl)- 1 ,7-naphthyridin-6-yl)

isonicotinamide [3611];

N-(3 -(6-(azetidin-3 -ylmethoxy)pyrazin-2-yl)-l ,7-naphthyridin-6-yl)-4-fluorobenzamide [3612] ; N-(3 -(6-(azetidin-3 -yloxy)pyrazin-2-yl)- 1 ,7-naphthyridin-6-yl)-4-fluorobenzamide [3613] ; N-(3 -( lH-pyrrolo[2,3-b]pyridin-5-yl)- 1 ,7-naphthyridin-6-yl)- 1 -( 1 -methylpiperidin-4-yl)-lH- pyrazole-4-carboxamide [3614];

N-(3 -( lH-pyrrolo[3,2-b]pyridin-6-yl)- 1 ,7-naphthyridin-6-yl)- 1 -( 1 -methylpiperidin-4-yl)-lH- pyrazole-4-carboxamide [3615];

N-(3 -( lH-pyrrolo[2,3-c]pyridin-4-yl)-l ,7-naphthyridin-6-yl)- 1 -( 1 -methylpiperidin-4-yl)- 1H- pyrazole-4-carboxamide [3616];

N-(3-(lH-pyrrolo[2,3-b]pyridin-5-yl)-l,7-naphthyridin-6-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [3617];

N-(3-(lH-pyrrolo[3,2-b]pyridin-6-yl)-l,7-naphthyridin-6-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [3618];

N-(3-(lH-pyrrolo[2,3-c]pyridin-4-yl)-l,7-naphthyridin-6-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [3619];

2-(4-methylpiperazin-l-yl)-N-(3-(oxazolo[5,4-b]pyridin-6-yl)-l,7-naphthyridin-6-yl)

isonicotinamide [3620];

N-(3-(2-methyl-lH-pyrrolo[2,3-b]pyridin-5-yl)-l,7-naphthyridin-6-yl)-2-(4-methylpiperazin-l- yl)isonicotinamide [3621];

N-(3-(3-methyl-lH-pyrrolo[2,3-b]pyridin-5-yl)-l,7-naphthyridin-6-yl)-2-(4-methylpiperazin-l- yl)isonicotinamide [3622];

N-(3-(2-methyl-lH-pyrrolo[3,2-b]pyridin-6-yl)-l,7-naphthyridin-6-yl)-2-(4-methylpiperazin-l- yl)isonicotinamide [3623]; N-(3-(5H-pyrrolo[2,3-b]pyrazin-2-yl)-l,7-naphthyridin-6-yl)-2-(4-methylpiperazin-l-yl) isonicotinamide [3624];

N-(3-(5H-pyrrolo[2,3-b]pyrazin-3-yl)-l,7-naphthyridin-6-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [3625];

l-isopropyl-N-(3-(6-(piperidin-4-ylamino)pyrazin-2-yl)-l,7-naphthyridin-6-yl)-lH-pyrazole-4- carboxamide [3626];

l-isopropyl-N-(3-(6-((l-methylpiperidin-4-yl)amino)pyrazin-2-yl)-l,7-naphthyridin-6-yl)-lH- pyrazole-4-carboxamide [3627];

fr «5-4-((2-fluoroethyl)amino)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)

cyclohexane-l-carboxamide [4597];

fr «5-4-((2-methoxyethyl)amino)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)

cyclohexane-l-carboxamide [4598];

fert-butyl (fr «5-4-((6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)carbamoyl)cyclohexyl) carbamate [4599];

N-(6-( 1 -methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl)-2-(( 1 -methylpiperidin-4-yl)amino) isonicotinamide [4600];

N-(6-(l-methyl-lH-pyrazol-4-yl)-2 -naphthyridin-3-yl)-2-(4-methylpiperazin-l-yl)thiazole-5- carboxamide [4601];

N-(6-(l-methyl-lH-pyrazol-4-yl)-2 -naphthyridin-3-yl)-2-(4-methylpiperazin-l-yl)thiazole-5- carboxamide [4602];

N-(6-( 1 -methyl -5 -(piperidin- 1 -ylmethyl)- lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl)-2-(2,7- diazaspiro[3.5]nonan-2-yl)isonicotinamide [4603] ;

N-(6-(l-methyl-lH-l,2,3-triazol-4-yl)-2,7-naphthyridin-3-yl)-4-(piperidin-4-yloxy)benzamide

[4604];

N-(6-(l-methyl-lH etrazol-5-yl)-2J-naphthyridin-3-yl)-l-(3,3,3-trifluoropropyl)piperidine-4- carboxamide [4605];

N-(6-(l,2-dimethyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)-2-(pyrrolidin-l-yl)propanamide

[4606];

N-(6-( 1 ,2-dimethyl- lH-imidazol-5-yl)-2,7-naphthyridin-3 -yl)-2-(piperidin- 1 -yl)propanamide

[4607];

4-isopropoxy-N-(6-(7-methyl-5,6,7,8-tetrahydroimidazo[l,2-a]pyrazin-3-yl)-2,7-naphthyridin-3- yl)benzamide [4608];

trans-3 -mo holino-N-(6-(oxazol-5 -yl)-2,7-naphthyridin-3-yl)cyclobutane- 1 -carboxamide

[4609]; fr «5-4-(hydroxymethyl)-N-(6-(oxazol-5-yl)-2,7-naphthyridin-3-yl)cyclohexane-l-carboxamide

[4610] ;

N-(6-(oxazol-5-yl)-2,7-naphthyridin-3-yl)piperidine-4-carboxamide [4611];

4-moφholino-N-(6-(oxazol-5-yl)-2,7-naphthyridin-3-yl)piperidine-l -carboxamide [4612] ;

N-(6-(oxazol-5-yl)-2,7-naphthyridin-3-yl)-4-(piperidin-4-yloxy)benzamide [4613];

N-(6-(oxazol-5-yl)-2,7-naphthyridin-3-yl)-3-(piperidin-4-yloxy)benzamide [4614];

2-methyl-N-(6-(oxazol-5-yl)-2,7-naphthyridin-3-yl)-5,6-dm^

carboxamide [4615];

2-(lH-imidazol-l -yl)-N-(6-(oxazol-5-yl)-2,7-naphthyridin-3-yl)acetamide [4616];

trans -4 -(hydroxymethyl) -N-(6-(thiazol -5 -yl) -2 ,7 -naphthyridin-3 -yl)cyclohexane - 1 -carboxamide

[4617] ;

fr «5-4-(dimethylamino)-N-(6-(thiazol-5-yl)-2,7-naphthyridin-3-yl)cyclohexane-l-carboxamide

[4618] ;

N-(6-(thiazol-5-yl)-2,7-naphthyridin-3-yl)-l -((l -(trifluoromethyl)cyclopropyl)methyl)piperidine- 4-carboxamide [4619];

fr «5-4-(hydroxymethyl)-N-(6-(2-methylthiazol-5-yl)-2,7-naphthyridin-3-yl)cyclohexane-l- carboxamide [4620];

fr «5-4-(dimethylamino)-N-(6-(2-methylthiazol-5-yl)-2,7-naphthyridin-3-yl)cyclohexane-l- carboxamide [4621];

N-(6-(2-methylthiazol-5-yl)-2,7-naphthyridin-3-yl)-l -(oxetan-3-yl)piperidine-4 -carboxamide

[4622] ;

N-(6-(2-methylthiazol-5-yl)-2,7-naphthyridin-3-yl)-l -(2-(pyrrolidin-l-yl)acetyl)piperidine-4- carboxamide [4623];

2-((l S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)-2,7- naphthyridin-3 -yl)acetamide [4624] ;

N-(6-(5-(cyano(4-hydroxypiperidin-l-yl)methyl)pyridin-3-yl)-2,7-naphthyridin-3-yl)

cyclopropanecarboxamide [4625];

4-fluoro-N-(6-(6-(( l-methylazetidin-3-yl)methoxy)pyrazin-2-yl)-2,7-naphthyridin-3-yl)

benzamide [4626] ;

l-isopropyl-N-(6-(6-(( l-methylpiperidin-4-yl)amino)pyrazin-2-yl)-2,7-naphthyridin-3-yl)-lH- pyrazole-4-carboxamide [4627]; or a pharmaceutically acceptable salt thereof.

24. The compound according to any one of claims 1-19, wherein the compound of Formula I is selected from the group consisting of:

N-(6-( lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl)- 1 -isobutylpiperidine-4-carboxamide [3628] ; N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)cyclopropanecarboxamide [3629]; 4,4-difluoro-N-(6-(l-methyl-lH-pyrazol-4-yl)-2 ,7-naphthyridin-3-yl)cyclohexane-l-carboxamide

[3630];

fr «5-4-methoxy-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)cyclohexane-l- carboxamide [3631];

trans-N-(6-( 1 -methyl- lH-pyrazol-4-yl)-2,7-naphthyridin -3 -yl)-4-morpholinocyclohexane- 1 - carboxamide [3632];

trans-4-((3 -fluoroazetidin- 1 -yl)methyl)-N-(6-( 1 -methyl- lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl) cyclohexane-1 -carboxamide [3633];

fr «5-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-4-((4-methylpiperazin-l-yl) methyl)cyclohexane - 1 -carboxamide [3634] ;

N-(6-( 1 -methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl)-2-(pyrrolidin- 1 -yl)acetamide [3635] ; (S)-2-(3 -fluoropyrrolidin- 1 -yl)-N-(6-( 1 -methyl- lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)

acetamide [3636];

(S)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)tetrahydrofuran-2 -carboxamide

[3637];

N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)piperidine-4-carboxamide [3638];

1 -methyl -N-(6 -( 1 -methyl - 1 H-pyrazol -4 -yl) -2,7 -naphthyridin-3 -yl)piperidine -4 -carboxamide

[3639];

l-isopropyl-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)piperidine-4 -carboxamide

[3640];

1 -(fert-butyl)-N-(6-( 1 -methyl- lH-pyrazol-4-yl)-2,7-naphthyridin -3 -yl)piperidine-4-carboxamide

[3641];

l-cyclopropyl-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)piperidine-4-carboxamide

[3642];

1 -isobutyl-N-(6-( 1 -methyl- lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl)piperidine-4-carboxamide

[3643];

N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-l-neopentylpiperidine-4-carboxamide

[3644];

1 -(2-fluoroethyl)-N-(6-( 1 -methyl- lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl)piperidine-4- carboxamide [3645];

N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-l-(3,3,3-trifluoropropyl)piperidine-4- carboxamide [3646]; 1 -butyl -N-(6 -( 1 -methyl - 1 H-pyrazol -4 -yl) -2,7 -naphthyridin-3 -yl)piperidine -4 -carboxamide

[3647];

l-benzoyl-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)piperidine-4 -carboxamide

[3648];

l-(2,2-difluoropropyl)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)piperidine-4- carboxamide [3649];

N-(6 -( 1 -methyl - 1 H-pyrazol -4-yl) -2 ,7 -naphthyridin-3 -yl)azetidine -3 -carboxamide [3650] ;

l-(2,2-difluoroethyl)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)piperidine-4- carboxamide [3651];

l-(2-fluoro-2-methylpropyl)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)piperidine-

4-carboxamide [3652];

N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-l-(oxetan-3-yl)piperidine-4- carboxamide [3653];

N-(6-( 1 -methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl)- 1 -((3-methyloxetan-3 -yl)methyl)

piperidine-4-carboxamide [3654];

l-(2-methoxyethyl)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)piperidine-4- carboxamide [3655];

l-(2-isopropoxyethyl)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)piperidine-4- carboxamide [3656];

1 , 1 -diisobutyl-4-((6-( 1 -methyl- lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)carbamoyl)piperidin- 1 - ium [3657];

4-fluoro-N-(6-( 1 -methyl- lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl)piperidine-4-carboxamide

[3658];

4-fluoro-l-methyl-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)piperidine-4- carboxamide [3659];

4-fluoro- 1 -isobutyl-N-(6-( 1 -methyl- lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)piperidine-4- carboxamide [3660];

(S)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)piperidine-3-carboxamide [3661]; (R)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)piperidine-3-carboxamide [3662]; (S)- 1 -isobutyl-N-(6-( 1 -methyl- lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)piperidine-3 -carboxamide

[3663];

(R)-l-isobutyl-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)piperidine-3-carboxamide

[3664]; N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)tetrahydro-2H-pyran-4-carboxamide

[3665];

N-(6-( 1 -methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl)-2-(piperidin- 1 -yl)acetamide [3666] ; 2-(4-fluoropiperidin-l -yl)-N-(6-( 1 -methyl- lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl)acetamide

[3667];

fr «5-4-amino-N-(6-( 1 -methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl)cyclohexane- 1 - carboxamide [3668];

N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-2-(4-methylpiperazin-l-yl)acetamide

[3669];

(S)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)piperidine-2 -carboxamide [3670]; 2-(4-isobutylpiperazin-l-yl)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)acetamide

[3671];

2-(3,3-dimethylazetidin-l-yl)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2J-naphthyridin-3-yl)acetamide

[3672];

(R)-2-(3-fluoropyrrolidin-l-yl)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)

acetamide [3673];

(S)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-2-(2-methylpyrrolidin-l-yl)

acetamide [3674];

2-(3-azabicyclo[3.1.0]hexan-3-yl)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl) acetamide [3675];

2-(7-azabicyclo[2.2.1]heptan-7-yl)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl) acetamide [3676];

N-(6 -( 1 -methyl - 1 H-pyrazol -4 -yl) -2 ,7 -naphthyridin-3 -yl)-2-(4 -methylpiperidin- 1 -yl)acetamide

[3677];

N-(6-( 1 -methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl)-2-(4-(trifluoromethyl)piperidin- 1 -yl) acetamide [3678];

2-(4-(difluoromethyl)piperidin-l-yl)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl) acetamide [3679];

N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-2-(6-azaspiro[2.5]octan-6-yl)acetamide

[3680];

N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-2-(pyrrolidin-l-yl)propanamide [3681]; (R)-N-(6-( 1 -methyl- lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl)-2-(2-methylpyrrolidin- 1 -yl)

acetamide [3682]; 2-(cyclobutyl(methyl)amino)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)acetamide [3683];

2-(diethylamino)-N-(6-( 1 -methyl- lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl)acetamide [3684] ; 7-(2-fluoroethyl)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-7-azaspiro[3.5]

nonane-2-carboxamide [3685] ;

4-methyl-N-(6 -( 1 -methyl - 1 H-pyrazol -4 -yl) -2 ,7 -naphthyridin-3 -yl)piperazine - 1 -carboxamide

[3686];

(S)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-2-(pyrrolidin-l-yl)propanamide

[3687];

(R)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-2-(pyrrolidin-l-yl)propanamide

[3688];

(R)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)pyrrolidine-2 -carboxamide [3689]; 2-methyl-N-(6 -( 1 -methyl - 1 H-pyrazol -4 -yl) -2 ,7 -naphthyridin-3 -yl) -2 -azaspiro [3.3 ]heptane -6 - carboxamide [3690];

N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-2-(2,2,2-trifluoroacetyl)-2-azaspiro[3.3] heptane-6-carboxamide [3691];

2-(2-fluoroethyl)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-2-azaspiro[3.3]

heptane-6-carboxamide [3692] ;

trans -4 -(dimethylamino) -N-(6 -( 1 -methyl - 1 H-pyrazol -4 -yl) -2,7 -naphthyridin-3 -yl)cyclohexane - 1 - carboxamide [3693];

1 -acetyl -N-(6 -( 1 -methyl - 1 H-pyrazol -4 -yl) -2,7 -naphthyridin-3 -yl)piperidine -4 -carboxamide

[3694];

N-(6-( 1 -methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl)- 1 -(( 1 -(trifluoromethyl)cyclopropyl) methyl)piperidine -4 -carboxamide [3695] ;

(S)- 1 -(2-fluoropropyl)-N-(6-( 1 -methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl)piperidine-4- carboxamide [3696];

(R)-l-(2-fluoropropyl)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)piperidine-4- carboxamide [3697];

N-(6 -( 1 -methyl - 1 H-pyrazol-4-yl) -2 ,7 -naphthyridin-3 -y 1) -2 -(piperidin- 1 -yl)propanamide [3698] ; N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-l-(methylsulfonyl)piperidine-4- carboxamide [3699];

1 '-methyl -N-(6-( 1 -methyl- lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl)-[ 1 ,4'-bipiperidine] -4- carboxamide [3700]; fra«s-4-(hydroxymethyl)-N-(6-( 1 -methyl- lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl)cyclohexane- 1 - carboxamide [3701];

methyl 2-(4-((6-( 1 -methyl- lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl)carbamoyl)piperidin- 1 -yl) acetate [3702];

1 -benzyl -N-(6 -( 1 -methyl - 1 H-pyrazol -4 -yl) -2,7 -naphthyridin-3 -yl)piperidine -4 -carboxamide

[3703];

N-(6 -( 1 -methyl - 1 H-pyrazol -4 -yl) -2 ,7 -naphthyridin-3 -yl)- 1 -(2 -(pyrrolidin- 1 -yl)acetyl)piperidine -

4-carboxamide [3704];

N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-2-moφholinoacetamide [3705];

(S)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-2-(3-methylmo holino)acetamide

[3706];

(R)-N-(6-( 1 -methyl- lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl)-2-(3 -methylmorpholino)acetamide

[3707];

(S)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-2-(2-methylmo holino)acetamide

[3708];

2-((2R,6S)-2,6-dimethylmoφholino)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl) acetamide [3709];

2-((lS,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7- naphthyridin-3 -yl)acetamide [3710] ;

2-((lR,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7- naphthyridin-3 -yl)acetamide [3711];

2-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl) acetamide [3712];

(S)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-2-moφholinopropanamide [3713]; N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-2-(moφholin-2-yl)acetamide [3714]; N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-2-(4-methylmoφholin-2-yl)acetamide

[3715];

2-(4-ethylpiperazin-l-yl)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)acetamide

[3716];

2-(4-isopropylpiperazin- 1 -yl)-N-(6-( 1 -methyl- lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)acetamide

[3717];

2-(4-cyclopropylpiperazin-l-yl)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)

acetamide [3718]; 2-(4-(2-fluoroethyl)piperazin-l-yl)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl) acetamide [3719];

(S)-2-(2,4-dimethylpiperazin-l-yl)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl) acetamide [3720];

1 -(2-hydroxyethyl)-N-(6-( 1 -methyl- lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl)piperidine-4- carboxamide [3721];

N-(6-( 1 -methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl)- 1 -(pyridin-2-ylmethyl)piperidine-4- carboxamide [3722];

N-(6 -( 1 -methyl - 1 H-pyrazol -4-yl) -2 ,7 -naphthyridin-3 -y 1) - 1 -(oxazol-2 -ylmethyl)piperidine -4 - carboxamide [3723];

(R)-N-(6-( 1 -methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl)- 1 -oxotetrahydro- lH-pyrrolo[ 1 ,2-c] imidazole-2(3H)-carboxamide [3724] ;

(R)-l -methyl -N-(6-( 1 -methyl- lH-pyrazol-4-yl)-2,7-naphthyridin -3 -yl)pyrrolidine-2 -carboxamide

[3725];

N-(6-( 1 -methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl)- 1 -(tetrahydro-2H-pyran-4-yl)piperidine- 4-carboxamide [3726];

N-(6-( 1 -methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl)- 1 -(pyrimidin-2-ylmethyl)piperidine-4- carboxamide [3727];

N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-l-(pyrazin-2-ylmethyl)piperidine-4- carboxamide [3728];

1 -((5 -methyl- 1 ,2,4-oxadiazol-3-yl)methyl)-N-(6-( 1 -methyl- lH-pyrazol-4-yl)-2,7-naphthyridin-3 - yl)piperidine -4 -carboxamide [3729] ;

1 -(2-hydroxy-2-methylpropyl)-N-(6-( 1 -methyl- lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl)

piperidine-4-carboxamide [3730];

fert-butyl 2-(4-((6-( 1 -methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl)carbamoyl)piperidin- 1 -yl) acetate [3731];

2-(4-((6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)carbamoyl)piperidin-l-yl)acetic acid

[3732];

2-(4-methyl- 1 ,4-diazepan- 1 -yl)-N-(6-( 1 -methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl)

acetamide [3733];

fert-butyl (6-( 1 -methyl- 1 H-pyrazol-4-yl) -2,7-naphthyridin-3 -yl)carbamate [3734] ;

N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)but-2-ynamide [3735];

trans-4-((6-( 1 -methyl- lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)carbamoyl)cyclohexane- 1 - carboxylic acid [3736]; N-(6-( l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-3-moφholinopropanamide [3737]; trans-N-(6-( 1 -methyl- lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-3 -moφholinocyclobutane- 1 - carboxamide [3738];

N-(6-( l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)quinuclidine-4-carboxamide [3739]; 1 -isobutyl-N-(6-( 1 -methyl- lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl)azepane-4-carboxamide

[3740] ;

2-(4-methoxypiperidin- 1 -yl)-N-(6-( 1 -methyl- lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl)acetamide

[3741] ;

2- (4-hydroxypiperidin-l -yl)-N-(6-( l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)acetamide

[3742] ;

3- (hydroxymethyl)-N-(6-(l -methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)bicyclo[l . l . l]

pentane-1 -carboxamide [3743] ;

1- methyl-N-(6-(l -methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)azepane-4-carboxamide [3744]; fr «5-4-(dimethylamino)-N-(6-(l -methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)cyclohexane-l - carboxamide [3745];

fra«s-4-(bis(methyl-d3)amino)-N-(6-( 1 -methyl- lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl)

cyclohexane-1 -carboxamide [3746];

N-(6-( l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-3-((4-methylpiperazin-l-yl)methyl) bicyclo[l .1. l]pentane-l -carboxamide [3747];

methyl trans-4-((6-( 1 -methyl- lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)carbamoyl)cyclohexane- 1 - carboxylate [3748];

2- ( 1 -isobutylpyrrolidin-3 -yl)-N-(6-( 1 -methyl- lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)acetamide

[3749] ;

fr «5-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-4-(4-methylpiperazine-l - carbonyl)cyclohexane- 1 -carboxamide [3750] ;

1 -isobutyl-N-(6-( 1 -methyl- lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl)piperidine-4-carboxamide

[3751] ;

N-(6-( l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-l -(phenylsulfonyl)piperidine-4- carboxamide [3752];

8 -methyl -N-(6 -( 1 -methyl - 1 H-pyrazol -4 -yl) -2,7 -naphthyridin-3 -yl) -3 , 8 -diazabicyclo [3.2.1] octane - 3 -carboxamide [3753];

3 -methyl -N-(6 -( 1 -methyl - 1 H-pyrazol -4 -yl) -2,7 -naphthyridin-3 -yl) -3 , 8 -diazabicyclo [3.2.1] octane - 8-carboxamide [3754]; (lR,3s,5S)-3-amino-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-8-azabicyclo[3.2.1] octane-8-carboxamide [3755];

(lR,3s,5S)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2 -naphthyridin-3-yl)-3-((3,3,3-trifluoropropyl) amino)-8 -azabicyclo [3.2.1 ]octane-8 -carboxamide [3756] ;

(lR,3s,5S)-3-((l,3-difluoropropan-2-yl)amino)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7- naphthyridin-3-yl)-8-azabicyclo[3.2.1]octane-8-carboxamide [3757];

N-(6 -( 1 -methyl - 1 H-pyrazol -4 -yl) -2,7 -naphthyridin-3 -yl)morpholine -4 -carboxamide [3758] ; 4-(dimethylamino)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)piperidine-l- carboxamide [3759];

(S)-2,4-dimethyl-N-(6-( 1 -methyl- lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)piperazine- 1 - carboxamide [3760];

1 -methyl-3 -(6 -( 1 -methyl - 1 H-pyrazol -4 -yl) -2,7 -naphthyridin-3 -yl) - 1 -( 1 -methylpiperidin-4 -yl)urea

[3761];

1 -(6-( 1 -methyl- lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-3 -( 1 -methylpiperidin-4-yl)urea [3762] ; 4-isopropyl-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)piperazine-l -carboxamide

[3763];

(R)-3,4-dimethyl-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)piperazine-l- carboxamide [3764];

N-(6-(lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-2-(4-methylpiperazin-l-yl)isonicotinamide

[3765];

N-(6-( 1 -methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-3 -(piperazin- 1 -yl)benzamide [3766] ; N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-3-(4-methylpiperazin-l-yl)benzamide

[3767];

N-(6 -( 1 -methyl - 1 H-pyrazol -4 -yl) -2,7 -naphthyridin-3 -yl)-3 -(pyrrolidin- 1 -ylmethyl)benzamide

[3768];

N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-3-(piperidin-4-yloxy)benzamide [3769]; N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-3-((l-methylpiperidin-4-yl)oxy)

benzamide [3770];

N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-4-(piperidin-4-yloxy)benzamide [3771]; N-(6-( 1 -methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl)-4-(( 1 -methylpiperidin-4-yl)oxy)

benzamide [3772];

N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-2-(piperazin-l-yl)isonicotinamide

[3773]; N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-2-(4-methylpiperazin-l-yl) isonicotinamide [3774];

2-(4-isopropylpiperazin- 1 -yl)-N-(6-( 1 -methyl- lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)

isonicotinamide [3775];

2-(4-cyclopropylpiperazin-l-yl)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)

isonicotinamide [3776];

2-(4-(2-fluoroethyl)piperazin- 1 -yl)-N-(6-( 1 -methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl) isonicotinamide [3777];

N-(6-( 1 -methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl)-6-(4-methylpiperazin- 1 -yl)nicotinamide

[3778];

N-(6 -( 1 -methyl - 1 H-pyrazol -4-yl) -2 ,7 -naphthyridin-3 -y 1) -5 -(piperidin-4-yloxy)nicotinamide

[3779];

N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-2-(piperidin-4-yloxy)isonicotinamide

[3780];

N-(6-( 1 -methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl)-2-(( 1 -methylpiperidin-4-yl)oxy)

isonicotinamide [3781];

N-(6 -( 1 -methyl - 1 H-pyrazol -4-yl) -2 ,7 -naphthyridin-3 -y 1) -5 -(piperidin-4-ylamino)nicotinamide

[3782];

N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-5-((l-methylpiperidin-4-yl)amino) nicotinamide [3783];

2-(4-aminopiperidin-l-yl)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)

isonicotinamide [3784];

N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-2-(4-(methylamino)piperidin-l-yl) isonicotinamide [3785];

2-(4-(dimethylamino)piperidin-l-yl)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl) isonicotinamide [3786];

2-(( 1 -isopropylpiperidin-4-yl)oxy)-N-(6-( 1 -methyl- lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl) isonicotinamide [3787];

2-(3 -aminoazetidin- 1 -yl)-N-(6-( 1 -methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)

isonicotinamide [3788];

2-(3 -(dimethylamino)azetidin- 1 -yl)-N-(6-( 1 -methyl- lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl) isonicotinamide [3789];

N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-2-moφholinoisonicotinamide [3790]; 2-((2-(dimethylamino)ethyl)amino)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl) isonicotinamide [3791];

2-(2-(dimethylamino)ethoxy)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)

isonicotinamide [3792];

2-(4-isobutylpiperazin-l-yl)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)

isonicotinamide [3793];

2-(azetidin-3-yloxy)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2 -naphthyridin-3-yl)isonicotinamide

[3794];

N-(6-( 1 -methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl)-2-(( 1 -methylazetidin-3 -yl)oxy)

isonicotinamide [3795];

2-(4-ethylpiperazin-l-yl)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)

isonicotinamide [3796];

4-((dimethylamino)methyl)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)benzamide

[3797];

N-(6 -( 1 -methyl - 1 H-pyrazol -4 -yl) -2,7 -naphthyridin-3 -yl)-3 -( 1 -methylpiperidin-4 -yl)benzamide

[3798];

N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-3-((4-methylpiperazin-l-yl)methyl) benzamide [3799];

N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)isonicotinamide [3800];

2-hydroxy-N-(6-( 1 -methyl- lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl)isonicotinamide [3801] ; 2-isopropoxy-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)isonicotinamide [3802]; N-(6-( 1 -methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl)-2-( 1 -methylpiperidin-4 -yl)

isonicotinamide [3803];

r-methyl-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-r,2',3',6'-tetrahydro-[2,4'- bipyridine] -4 -carboxamide [3804] ;

N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-2-(4-(6-(4-methylpiperazin-l-yl) nicotinoyl)piperazin- 1 -yl)isonicotinamide [3805] ;

2-(4-hydroxy-4-methyl-4 4-piperazin-l-yl)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-

3-yl)isonicotinamide [3806];

2-methyl-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-6-(4-methylpiperazin-l-yl) isonicotinamide [3807];

3 -methyl -N-(6 -( 1 -methyl - 1 H-pyrazol -4 -yl) -2 ,7 -naphthyridin-3 -yl) -2 -(4-methylpiperazin- 1 -yl) isonicotinamide [3808]; 2-(4-methyl- 1 ,4-diazepan- 1 -yl)-N-(6-( 1 -methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl) isonicotinamide [3809];

2-((2S,6R)-2,6-dimethylmoφholino)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl) isonicotinamide [3810];

N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-2-(2,7-diazaspiro[3.5]nonan-2-yl)

isonicotinamide [3811];

N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-2-(7-methyl-2,7-diazaspiro[3.5]nonan-

2-yl)isonicotinamide [3812];

N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-2-(2,7-diazaspiro[3.5]nonan-7-yl)

isonicotinamide [3813];

N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-2-(2-methyl-2,7-diazaspiro[3.5]nonan-

7-yl)isonicotinamide [3814];

2-(methyl( 1 -methylpiperidin-4-yl)amino)-N-(6-( 1 -methyl- lH-pyrazol-4-yl)-2,7-naphthyridin-3- yl)isonicotinamide [3815];

N-(6-( 1 -methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl)-2-(( 1 -methylpiperidin-4-yl)thio)

isonicotinamide [3816];

N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-2-(4-methylpiperazin-l-yl)pyrimidine- 4-carboxamide [3817];

N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-6-(4-methylpiperazin-l-yl)pyridazine-4- carboxamide [3818];

N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-6-(4-methylpiperazin-l-yl)pyrimidine-

4-carboxamide [3819];

N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-2-phenylacetamide [3820];

N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-3-phenylpropanamide [3821];

N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-2-(pyridin-3-yl)acetamide [3822]; N-(6 -( 1 -methyl - 1 H-pyrazol -4 -yl) -2,7 -naphthyridin-3 -yl)-3 -(pyridin-3 -yl)propanamide [3823] ; N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-2-(pyridin-4-yl)acetamide [3824]; N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-3-(pyridin-4-yl)propanamide [3825]; N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)isoindoline-5-carboxamide [3826]; 2-methyl-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)isoindoline-5-carboxamide

[3827];

N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-l,2,3,4-tetrahydroisoquinoline-7- carboxamide [3828]; 2-methyl-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-l,2,3,4- tetrahydroisoquinoline-7 -carboxamide [3829] ;

2- methyl-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-l,2,3,4- tetrahydroisoquinoline-6-carboxamide [3830] ;

N-(6-(l-methyl-lH-pyrazol-4-yl)-2J-naphthyridin-3-yl)-l,2,3,4-tetrahydroisoquinoline-6- carboxamide [3831];

N-(6 -( 1 -methyl - 1 H-pyrazol -4 -yl) -2 ,7 -naphthyridin-3 -yl) - 1 H-indole-5 -carboxamide [3832] ; N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)benzofuran-5-carboxamide [3833]; N-(6-(l-methyl-lH-pyrazol-4-yl)-2J-naphthyridin-3-yl)furo[2,3-c]pyridine-5-carboxamide

[3834];

N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)benzo[b]thiophene-5-carboxamide

[3835];

N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)benzofuran-6-carboxamide [3836]; N-(6 -( 1 -methyl - 1 H-pyrazol -4 -yl) -2,7 -naphthyridin-3 -yl)benzo [d] oxazole -6 -carboxamide [3837] ; N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)benzo[d]thiazole-6-carboxamide [3838]; N-(6 -( 1 -methyl - 1 H-pyrazol -4 -yl) -2,7 -naphthyridin-3 -yl)benzo [d] oxazole -5 -carboxamide [3839] ; N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)benzo[d]thiazole-5-carboxamide [3840]; N-(6 -( 1 -methyl - 1 H-pyrazol -4 -yl) -2,7 -naphthyridin-3 -yl)quinoline -3 -carboxamide [3841];

N-(6 -( 1 -methyl - 1 H-pyrazol -4 -yl) -2,7 -naphthyridin-3 -yl)quinoline -6-carboxamide [3842] ;

N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)quinoxaline-6-carboxamide [3843]; 5-chloro-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-2-(4-methylpiperazin-l-yl) isonicotinamide [3844];

3- chloro-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-2-(4-methylpiperazin-l-yl) isonicotinamide [3845];

2- (2,5-diazabicyclo[2.2.1]heptan-2-yl)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl) isonicotinamide [3846];

N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-2-(5-methyl-2,5-diazabicyclo[2.2.1] heptan-2-yl)isonicotinamide [3847] ;

3- fluoro-N-(6-( 1 -methyl- lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl)-2-(4-methylpiperazin- 1 -yl) isonicotinamide [3848];

N-(6-( 1 -methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl)-2-((4-methylpiperazin- 1 -yl)methyl) isonicotinamide [3849];

N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-2-(mo holinomethyl)isonicotinamide

[3850]; N-(6-( 1 -methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl)-2-(pyrrolidin- 1 -ylmethyl)

isonicotinamide [3851];

N-(6-( 1 -methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl)-2-(2-(4-methylpiperazin- 1 -yl)pyridin-4- yl)acetamide [3852];

1 -methyl -N-(6 -( 1 -methyl - 1 H-pyrazol -4 -yl) -2 ,7 -naphthyridin-3 -yl) - 1 H-indazole -5 -carboxamide

[3853];

1 -methyl -N-(6 -( 1 -methyl - 1 H-pyrazol -4 -yl) -2 ,7 -naphthyridin-3 -yl) - 1 H-benzo [d] imidazole-5 - carboxamide [3854];

N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-l-(piperidin-4-yl)-lH-pyrazole-4- carboxamide [3855];

N-(6-( 1 -methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl)- 1 -( 1 -methylpiperidin-4-yl)- 1H- pyrazole -4 -carboxamide [3856];

1 -( 1 -ethylpiperidin-4-yl)-N-(6-( 1 -methyl- lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)- lH-pyrazole- 4-carboxamide [3857];

l-(l-(2-fluoroethyl)piperidin-4-yl)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-lH- pyrazole -4 -carboxamide [3858];

l-(l-isopropylpiperidin-4-yl)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-lH- pyrazole -4 -carboxamide [3859];

1 -( 1 -cyclopropylpiperidin-4-yl)-N-(6-( 1 -methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl)- 1H- pyrazole -4 -carboxamide [3860];

isopropyl 4-(4-((6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)carbamoyl)-lH-pyrazol-l- yl)piperidine-l-carboxylate [3861];

N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-l-(piperidin-4-yl)-lH-l,2,3-triazole-4- carboxamide [3862];

N-(6-( 1 -methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl)- 1 -( 1 -methylpiperidin-4-yl)- 1H- 1,2,3- triazole -4 -carboxamide [3863];

l-(l-(2-fluoroethyl)piperidin-4-yl)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-lH- l,2,3-triazole-4-carboxamide [3864];

1- (l-isopropylpiperidin-4-yl)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-lH-l,2,3- triazole -4 -carboxamide [3865];

N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-2-(4-methylpiperazin-l-yl)oxazole-5- carboxamide [3866];

2- (3 -(dimethylamino)azetidin- 1 -yl)-N-(6-( 1 -methyl- lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl) oxazole -4 -carboxamide [3867]; N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-2-(piperidin-4-yl)oxazole-4- carboxamide [3868];

N-(6-( 1 -methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl)-2-( 1 -methylpiperidin-4-yl)oxazole-4- carboxamide [3869];

2-(l-(2-fluoroethyl)piperidin-4-yl)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl) oxazole-4-carboxamide [3870];

2-(1 sopropylpiperidin-4-yl)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)oxazole-4- carboxamide [3871];

N-(6 -( 1 -methyl - 1 H-pyrazol -4 -yl) -2 ,7 -naphthyridin-3 -yl)-2-(4 -methylpiperazin- 1 -yl)oxazole -4 - carboxamide [3872];

2-(3 -(dimethylamino)azetidin- 1 -yl)-N-(6-( 1 -methyl- lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl) thiazole-5 -carboxamide [3873];

N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-2-(piperidin-4-yl)thiazole-4- carboxamide [3874];

N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-2-(4-methylpiperazin-l-yl)thiazole-4- carboxamide [3875];

2-(l-(2-fluoroethyl)piperidin-4-yl)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl) thiazole-4-carboxamide [3876] ;

2-(l-isopropylpiperidin-4-yl)-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)thiazole-4- carboxamide [3877];

l-methyl-N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl-4-£/)piperidine-4-carboxamide

[3878];

N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-l-(2-(methyl-d3)propyl-l, l,2,3,3,3- ₆) piperidine-4-carboxamide [3879];

N-ie-il-methyl-lH-pyrazol^-y^^J-naphthyridin-S-y^^-ipyrrolidin-l-yl^^^^-i ^acetamide

[3880];

N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-2-(4-(methyl-£/3)piperazin-l-yl)

acetamide [3881];

N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-2-(moφholino-d8)acetamide [3882]; ( S) -N-(6 -( 1 -(methyl -ds) - 1 H-pyrazol -4 -yl) -2,7 -naphthyridin-3 -yl) -2 -(pyrrolidin- 1 -yl)propanamide

[3883];

l-isobutyl-N-(6-(l-(methyl-£/3)-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)piperidine-4-carboxamide

[3884]; N-(6-( 1 -(methyl -<¾)- lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-2-(4-methylpiperazin- 1 -yl) acetamide [3885];

N-(6-(l-(methyl-£/3)-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-2-(pyrrolidin-l-yl)acetamide

[3886];

N-(6-(l-(methyl-£/3)-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-2-(piperidin-l-yl)acetamide [3887]; N-(6-( 1 -(methyl -<¾)- lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl)- 1 -(3,3,3 -trifluoropropyl)piperidine- 4-carboxamide [3888];

N-(6-( lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl)-2-(4-(methyl- 3)piperazin- 1 -yl)isonicotinamide

[3889];

N-(6-(l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-2-(4-(methyl-£/3)piperazin-l-yl)

isonicotinamide [3890];

N-(6-( 1 -(methyl-^)- lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-2-(4-methylpiperazin- 1 -yl)

isonicotinamide [3891];

N-(6-(l-(methyl-£/3)-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-2-(4-(methyl-£/3)piperazin-l-yl) isonicotinamide [3892];

N-(6-( 1 -(methyl-^)- lH-pyrazol-4-yl)-2,7-naphthyridin -3 -yl)- 1 -(piperidin-4-yl)-lH-pyrazole-4- carboxamide [3893];

N-(6-(l-(methyl- 3)-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-l-(l-methylpiperidin-4-yl)-lH- pyrazole-4-carboxamide [3894];

N-(6-(l-(methyl-£/3)-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-2-(piperidin-4-yl)oxazole-4- carboxamide [3895];

N-(6-( 1 -(methyl-^)- lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-2-( 1 -methylpiperidin-4-yl)oxazole- 4-carboxamide [3896];

N-(6-( 1 -ethyl- lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl)-2-(pyrrolidin-l -yl)acetamide [3897] ; N-(6-(l-cyclopropyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-2-(pyrrolidin-l-yl)acetamide

[3898];

N-(6-(l-cyclopropyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-l-(3,3,3-trifluoropropyl)piperidine-

4-carboxamide [3899];

N-(6-(l-(l -methylpiperidin-4-yl) - 1 H-pyrazol -4 -yl) -2, 7-naphthyridin-3 -yl)

cyclohexanecarboxamide [3900];

2-(pyrrolidin-l-yl)-N-(6-(5-(trifluoromethyl)-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)acetamide

[3901];

N-(6-(5-(hydroxymethyl)-l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-l-methylpiperidine- 4-carboxamide [3902]; N-(6-(5-(hydroxymethyl)-l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)tetrahydro-2H-pyran-

4-carboxamide [3903];

N-(6-(5-(azetidin-l-ylmethyl)-l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-4,4- difluorocyclohexane - 1 -carboxamide [3904] ;

4,4-difluoro-N-(6-(l-methyl-5-(pyrrolidin-l-ylmethyl)-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl^ cyclohexane-1 -carboxamide [3905];

4,4-difluoro-N-(6-(l-methyl-5-(piperidin-l-ylmethyl)-lH-pyrazol-4-yl)-2 -naphthyridin-3-yl) cyclohexane-1 -carboxamide [3906];

2-(2 -fluoroethyl) -N-(6 -( 1 -methyl -5 -(piperidin- 1 -ylmethyl) - 1 H-pyrazol -4 -yl) -2, 7-naphthyridin-3 - yl)-2-azaspiro[3.3]heptane-6-carboxamide [3907] ;

fert-butyl 6-((6-(l-methyl-5-(piperidin-l-ylmethyl)-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl) carbamoyl)-2-azaspiro[3.3]heptane-2-carboxylate [3908];

2-fluoro-2 -methyl -N-(6-( 1 -methyl-5 -(piperidin- 1 -ylmethyl)- lH-pyrazol-4-yl)-2,7-naphthyridin-3 - yl)propanamide [3909];

2-(diethylamino)-N-(6-(l-methyl-5-(piperidin-l-ylmethyl)-lH-pyrazol-4-yl)-2,7-naphthyridin-3- yl)acetamide [3910];

fr «5-4-methoxy-N-(6-( 1 -methyl-5 -(piperidin-1 -ylmethyl)- lH-pyrazol-4-yl)-2,7-naphthyridin-3 - yl)cyclohexane - 1 -carboxamide [3911];

fr «5-4-(hydroxymethyl)-N-(6-( 1 -methyl-5 -(piperidin- 1 -ylmethyl)- lH-pyrazol-4-yl)-2,7- naphthyridin-3 -yl)cyclohexane - 1 -carboxamide [3912];

(R)-N-(6-(l-methyl-5-(piperidin-l-ylmethyl)-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)pyrrolidine-

2-carboxamide [3913];

l-isobutyl-N-(6-(l-methyl-5-(piperidin-l-ylmethyl)-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl) piperidine-4-carboxamide [3914];

N-(6-( 1 -methyl-5 -(piperidin- 1 -ylmethyl)- lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl)- 1 -(oxetan-3 -yl) piperidine-4-carboxamide [3915];

l-benzoyl-N-(6-(l-methyl-5-(piperidin-l-ylmethyl)-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl) piperidine-4-carboxamide [3916];

N-(6-( 1 -methyl-5 -(piperidin- 1 -ylmethyl)- lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl)tetrahydro-2H- pyran-4-carboxamide [3917];

N-(6-( 1 -methyl-5 -(piperidin- 1 -ylmethyl)- lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl)-2-(4- methylpiperidin- 1 -yl)acetamide [3918] ;

N-(6-(l-(difluoromethyl)-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-2-(4-methylpiperazin-l-yl) isonicotinamide [3919]; N-(6-(l-ethyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [3920];

N-(6-(l-isopropyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-3-(piperidin-4-yloxy)benzamide

[3921];

N-(6-(l-isopropyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-3-((l-methylpiperidin-4-yl)oxy) benzamide [3922];

N-(6-(l-isopropyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-4-(piperidin-4-yloxy)benzamide

[3923];

N-(6-(l-cyclopropyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [3924];

4-fluoro-N-(6-( 1 -( 1 -methylpiperidin-4-yl)- lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)benzamide

[3925];

4- (difluoromethoxy)-N-(6-( 1 -( 1 -methylpiperidin-4-yl)- lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl) benzamide [3926];

5- fluoro-N-(6-(l-(l-methylpiperidin-4-yl)-lH-pyrazol-4-yl)-2 ,7-naphthyridin-3-yl)nicotinamide

[3927];

N² -methyl -N⁵-(6-( 1 -( 1 -methylpiperidin-4-yl)- lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)pyridine- 2,5-dicarboxamide [3928];

1- isopropyl-N-(6-(l-(l-methylpiperidin-4-yl)-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-lH- pyrazole-4-carboxamide [3929];

2- methyl-N-(6-( 1 -( 1 -methylpiperidin-4-yl)- lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl)thiazole-5- carboxamide [3930];

N-(6-(5-amino-l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-2-(4-methylpiperazin-l-yl) isonicotinamide [3931];

4-(difluoromethoxy)-N-(6-(5-(hydroxymethyl)-l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl) benzamide [3932];

N-(6-(5-(hydroxymethyl)-l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-2-(4- methylpiperazin-l-yl)isonicotinamide [3933];

N-(6-(5-(hydroxymethyl)-l-methyl-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)-2-(7-methyl-2,7- diazaspiro[3.5]nonan-2-yl)isonicotinamide [3934] ;

4-fluoro-N-(6-(l-methyl-5-(pyrrolidin-l-ylmethyl)-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl) benzamide [3935];

4-fluoro-N-(6-(l-methyl-5-(piperidin-l-ylmethyl)-lH-pyrazol-4-yl)-2,7-naphthyridin-3-yl)

benzamide [3936]; 4-(difluoromethoxy)-N-(6-(l-methyl-5-(piperidin-l-ylmethyl)-lH-pyrazol-4-yl)-2,7- naphthyridin-3 -yl)benzamide [3937] ;

N-(6-( 1 -methyl -5 -(piperidin- 1 -ylmethyl)- lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl)-3-(pyrrolidin- l-ylmethyl)benzamide [3938];

N-(6-( 1 -methyl -5 -(piperidin- 1 -ylmethyl)- lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl)-2-(7-methyl-

2,7-diazaspiro[3.5]nonan-2-yl)isonicotinamide [3939];

N-(6-( 1 -methyl -5 -(piperidin- 1 -ylmethyl)- lH-pyrazol-4-yl)-2,7-naphthyridin-3 -yl)-2- moφholinoisonicotinamide [3940] ;

N-(6 -( 1 -methyl -5 -(mo holinomethyl) - 1 H-pyrazol -4 -yl)-2,7 -naphthyridin-3 -yl) -2 - moφholinoisonicotinamide [3941];

N-(6-(4,5 ,6,7-tetrahydropyrazolo[ 1 ,5 -a]pyrazin-3 -yl)-2,7-naphthyridin-3-yl)- 1 -(( 1 -

(trifluoromethyl)cyclopropyl)methyl)piperidine-4-carboxamide [3942];

3.3- difluoro-N-(6-(5-methyl-4,5,6,7-tetrahydropyrazolo[l,5-a]pyrazin-3-yl)-2,7-naphthyridin-3- yl)cyclobutane- 1 -carboxamide [3943] ;

4.4- difluoro-N-(6-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[l,5-a]pyrazin-3-yl)-2,7- naphthyridin-3 -yl)cyclohexane - 1 -carboxamide [3944] ;

N-(6-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[l,5-a]pyrazin-3-yl)-2,7-naphthyridin-3-yl)-l-

(( 1 -(trifluoromethyl)cyclopropyl)methyl)piperidine-4-carboxamide [3945] ;

N-(6-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[l,5-a]pyrazin-3-yl)-2,7-naphthyridin-3-yl)-2-

(pyrrolidin- 1 -yl)acetamide [3946] ;

2-(7-azabicyclo[2.2.1]heptan-7-yl)-N-(6-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[l,5-a] pyrazin-3-yl)-2,7-naphthyridin-3-yl)acetamide [3947];

(R)-N-(6-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[l,5-a]pyrazin-3-yl)-2,7-naphthyridin-3- yl)-l-isobutylpiperidine-3-carboxamide [3948];

N-(6-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[l,5-a]pyrazin-3-yl)-2,7-naphthyridin-3-yl) piperidine-4-carboxamide [3949];

4-fluoro-N-(6-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[l,5-a]pyrazin-3-yl)-2,7- naphthyridin-3 -yl)- 1 -isobutylpiperidine-4-carboxamide [3950] ;

N-(6-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[l,5-a]pyrazin-3-yl)-2,7-naphthyridin-3-yl)-2-

(4-methylpiperazin- 1 -yl)acetamide [3951] ;

4-fluoro-N-(6-(4,5,6,7-tetrahydropyrazolo[l,5-a]pyrazin-3-yl)-2,7-naphthyridin-3-yl)benzamide

[3952];

N-(6-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[l,5-a]pyrazin-3-yl)-2,7-naphthyridin-3-yl)-3- (4-methylpiperazin- 1 -yl)benzamide [3953] ; N⁵-(6-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[l,5-a]pyrazin-3-yl)-2,7-naphthyridin-3-yl)-

N²-methylpyridine-2,5 -dicarboxamide [3954] ;

N-(6-(5-(2-fluoroethyl)-4,5,6j etrahydropyrazolo[l,5-a]pyrazin-3-yl)-2,7-naphthyridin-3-yl)-6-

(4-methylpiperazin- 1 -yl)nicotinamide [3955] ;

2-(azetidin-3-yloxy)-N-(6-(5-(2-fluoroethyl)-4,5,6,7-tetrahydropyrazolo[l,5-a]pyrazin-3-yl)-2,7- naphthyridin-3 -yl)isonicotinamide [3956] ;

N-(6 -( 1 -methyl - 1 H-pyrazol-5 -yl) -2 ,7 -naphthyridin-3 -yl) - 1 -(3 ,3 , 3 -trifluoropropyl)piperidine -4 - carboxamide [3957];

1 -methyl -N-(6 -( 1 -methyl - 1 H-pyrazol -3 -yl) -2 ,7 -naphthyridin-3 -yl)piperidine -4 -carboxamide

[3958] ;

N-(6-( l-methyl-lH-pyrazol-3-yl)-2,7-naphthyridin-3-yl)-2-(4-methylpiperazin-l -yl)

isonicotinamide [3959];

2-fluoro-2 -methyl -N-(6-( l-methyl-lH-l,2,3-triazol-4-yl)-2,7-naphthyridin-3-yl)propanamide

[3960] ;

2,2,3,3-tetramethyl-N-(6-(l -methyl-lH-l,2,3-triazol-4-yl)-2,7-naphthyridin-3-yl)cyclopropane-l - carboxamide [3961];

trans-N-(6-( 1 -methyl-lH-1 ,2,3-triazol-4-yl)-2,7-naphthyridin-3 -yl)-4-(pyrrolidin- 1 -yl)

cyclohexane-1 -carboxamide [3962];

fr rø-N-(6-(l-methyl-lH-l ,2,3-triazol-4-yl)-2,7-naphthyridin-3-yl)-4-mo holinocyclohexane-l- carboxamide [3963];

N-(6-( l-methyl-lH-l,2,3-triazol-4-yl)-2,7-naphthyridin-3-yl)-2-(piperidin-l -yl)acetamide [3964]; 1 -ethyl -4-fluoro-N-(6-( 1 -methyl- 1H- 1 ,2,3 -triazol-4-yl)-2,7-naphthyridin-3 -yl)piperidine-4- carboxamide [3965];

4-fluoro- 1 -isobutyl-N-(6-( 1 -methyl- 1H- 1 ,2,3 -triazol-4-yl)-2,7-naphthyridin-3 -yl)piperidine-4- carboxamide [3966];

N-(6-( l-methyl-lH-l,2,3-triazol-4-yl)-2,7-naphthyridin-3-yl)-l -(3,3,3-trifluoropropyl)piperidine- 4-carboxamide [3967];

N-(6-( l-methyl-lH-l,2,3-triazol-4-yl)-2,7-naphthyridin-3-yl)cyclopropanecarboxamide [3968] ; 4,4-difluoro-N-(6-( 1 -methyl- 1H- 1 ,2,3 -triazol-4-yl)-2,7-naphthyridin-3-yl)cyclohexane- 1 - carboxamide [3969];

fr «5-4-(dimethylamino)-N-(6-( l-methyl-lH-l,2,3-triazol-4-yl)-2,7-naphthyridin-3-yl)

cyclohexane-1 -carboxamide [3970];

fr «5-N-(6-(l-methyl-lH-l ,2,3-triazol-4-yl)-2,7-naphthyridin-3-yl)-4-((4-methylpiperazin-l -yl) methyl)cyclohexane- 1 -carboxamide [3971] ; N-(6-(l-methyl-lH-l,2,3 riazol-4-yl)-2,7-naphthyridin-3-yl)piperidine-4-carboxamide [3972]; 1 -isobutyl-N-(6-( 1 -methyl- lH-1 ,2,3-triazol-4-yl)-2,7-naphthyridin -3 -yl)piperidine-4- carboxamide [3973];

N-(6-(l-methyl-lH-l,2,3-triazol-4-yl)-2,7-naphthyridin-3-yl)-l-((l-(trifluoromethyl)cyclopropyl) methyl)piperidine -4 -carboxamide [3974] ;

N-(6-(l-methyl-lH-l,2,3-triazol-4-yl)-2,7-naphthyridin-3-yl)-l-((3-methyloxetan-3-yl)methyl) piperidine-4-carboxamide [3975];

N-(6-(l-methyl-lH-l,2,3-triazol-4-yl)-2,7-naphthyridin-3-yl)-l-(2-(pyrrolidin-l-yl)acetyl)

piperidine-4-carboxamide [3976];

1 '-methyl-N-(6-( 1 -methyl- lH-1 ,2,3 -triazol-4-yl)-2,7-naphthyridin-3 -yl)-[ 1 ,4'-bipiperidine] -4- carboxamide [3977];

(R)-N-(6-( 1 -methyl-lH- 1 ,2,3-triazol-4-yl)-2,7-naphthyridin-3 -yl)piperidine-3 -carboxamide

[3978];

(R)-l-isobutyl-N-(6-(l-methyl-lH-l,2,3-triazol-4-yl)-2,7-naphthyridin-3-yl)piperidine-3- carboxamide [3979];

N-(6-(l-methyl-lH-l,2,3-triazol-4-yl)-2,7-naphthyridin-3-yl)-2-(pyrrolidin-l-yl)acetamide

[3980];

N-(6-( 1 -methyl-lH-1 ,2,3-triazol-4-yl)-2,7-naphthyridin-3 -yl)-2-(4-methylpiperazin- 1 -yl)

acetamide [3981];

2-(7-azabicyclo[2.2.1]heptan-7-yl)-N-(6-(l-methyl-lH-l,2,3-triazol-4-yl)-2,7-naphthyridin-3-yl) acetamide [3982];

1 -(2-hydroxy-2-methylpropyl)-N-(6-( 1 -methyl- 1H- 1 ,2,3-triazol-4-yl)-2,7-naphthyridin-3 -yl) piperidine-4-carboxamide [3983];

N-(6-(l-methyl-lH-l,2,3-triazol-4-yl)-2,7-naphthyridin-3-yl)-2-moφholinoacetamide [3984]; 2-(4-methoxypiperidin-l-yl)-N-(6-(l-methyl-lH-l,2,3-triazol-4-yl)-2,7-naphthyridin-3-yl)

acetamide [3985];

N-(6-(l-methyl-lH-l,2,3-triazol-4-yl)-2,7-naphthyridin-3-yl)mo holine-4-carboxamide [3986]; N-(6-(l-methyl-lH-l,2,3-triazol-4-yl)-2,7-naphthyridin-3-yl)-l-(piperidin-4-yl)-lH-pyrazole-4- carboxamide [3987];

N-(6-(l-methyl-lH-l,2,3-triazol-4-yl)-2,7-naphthyridin-3-yl)-l-(l-methylpiperidin-4-yl)-lH- pyrazole -4 -carboxamide [3988];

1 -( 1 -ethylpiperidin-4-yl)-N-(6-( 1 -methyl- 1H- 1 ,2,3 -triazol-4-yl)-2,7-naphthyridin-3-yl)-lH- pyrazole -4 -carboxamide [3989]; l-(l-isopropylpiperidin-4-yl)-N-(6-(l-methyl-lH-l,2,3 riazol-4-yl)-2,7-naphthyridin-3-yl)-lH- pyrazole-4-carboxamide [3990];

N-(6-(l-methyl-lH-l,2,3-triazol-4-yl)-2,7-naphthyridin-3-yl)-l-(piperidin-4-yl)-lH-l,2,3- triazole -4 -carboxamide [3991 ] ;

1 -( 1 -(2-fluoroethyl)piperidin-4-yl)-N-(6-( 1 -methyl-lH- 1 ,2,3-triazol-4-yl)-2 ,7-naphthyridin-3-yl)- lH-l,2,3-triazole-4-carboxamide [3992];

1- (l-isopropylpiperidin-4-yl)-N-(6-(l-methyl-lH-l,2,3 riazol-4-yl)-2,7-naphthyridin-3-yl)-lH- l,2,3-triazole-4-carboxamide [3993];

N-(6-(l-methyl-lH-l,2,3-triazol-4-yl)-2,7-naphthyridin-3-yl)-2-(piperidin-4-yl)oxazole-4- carboxamide [3994];

N-(6-(l-methyl-lH-l,2,3 riazol-4-yl)-2,7-naphthyridin-3-yl)-2-(l-methylpiperidin-4-yl)oxazole- 4-carboxamide [3995];

2- ( 1 -isopropylpiperidin-4-yl)-N-(6-( 1 -methyl- 1H- 1 ,2,3-triazol-4-yl)-2,7-naphthyridin-3-yl) oxazole -4 -carboxamide [3996];

2-fluoro-N-(6-( 1 -methyl- 1H- 1 ,2,3 -triazol-4-yl)-2,7-naphthyridin-3 -yl)benzamide [3997] ;

N-(6-(l-methyl-lH-l,2,3-triazol-4-yl)-2,7-naphthyridin-3-yl)-3-((l-methylpiperidin-4-yl)oxy) benzamide [3998];

N²-methyl-N⁵-(6-(l-methyl-lH-l,2,3-triazol-4-yl)-2,7-naphthyridin-3-yl)pyridine-2,5- dicarboxamide [3999];

N-(6-( 1 -methyl-lH-1 ,2,3-triazol-4-yl)-2,7-naphthyridin-3 -yl)-6-(4-methylpiperazin- 1 -yl)

nicotinamide [4000];

2-(3 -(dimethylamino)azetidin- 1 -yl)-N-(6-( 1 -methyl- 1H- 1 ,2,3 -triazol-4-yl)-2,7-naphthyridin-3 -yl) isonicotinamide [4001];

N-(6-(l-methyl-lH-l,2,3-triazol-4-yl)-2,7-naphthyridin-3-yl)-2-(l-methylpiperidin-4-yl)

isonicotinamide [4002];

2-(4-(dimethylamino)piperidin-l-yl)-N-(6-(l-methyl-lH-l,2,3-triazol-4-yl)-2,7-naphthyridin-3- yl)isonicotinamide [4003];

N-(6-(l-methyl-lH-l,2,3-triazol-4-yl)-2,7-naphthyridin-3-yl)-2-moφholinoisonicotinamide

[4004];

N-(6-( 1 -methyl-lH-1 ,2,3-triazol-4-yl)-2,7-naphthyridin-3 -yl)-2-(4-methylpiperazin- 1 -yl)

isonicotinamide [4005];

2-(4-methyl- 1 ,4-diazepan- 1 -yl)-N-(6-( 1 -methyl-lH-1 ,2,3-triazol-4-yl)-2,7-naphthyridin-3 -yl) isonicotinamide [4006]; 2-(4 sopropylpiperazin-l-yl)-N-(6-(l-methyl-lH-l,2,3-triazol-4-yl)-2,7-naphthyridin-3-yl) isonicotinamide [4007];

N-(6-(l-methyl-lH-l,2,3 riazol-4-yl)-2,7-naphthyridin-3-yl)-2-(piperidin-4-ylamino)

isonicotinamide [4008];

2-(methyl( 1 -methylpiperidin-4-yl)amino)-N-(6-( 1 -methyl- IH- 1 ,2,3 -triazol-4-yl)-2,7- naphthyridin-3 -yl)isonicotinamide [4009] ;

N-(6-(l-methyl-lH-l,2,3-triazol-4-yl)-2,7-naphthyridin-3-yl)-2-((l-methylpiperidin-4-yl)thio) isonicotinamide [4010];

2-methyl-N-(6-(l-methyl-lH-l,2,3-triazol-4-yl)-2,7-naphthyridin-3-yl)-l,2,3,4- tetrahydroisoquinoline-6-carboxamide [4011] ;

N-(6-(l-methyl-lH-l,2,3-triazol-4-yl)-2,7-naphthyridin-3-yl)-2-(piperazin-l-yl)isonicotinamide

[4012];

N-(6-(l-methyl-lH-l,2,3-triazol-4-yl)-2,7-naphthyridin-3-yl)-2-(2-(4-methylpiperazin-l-yl) pyridin-4-yl)acetamide [4013];

1 , 1 -bis(methyl-£/3)-4-(4-((6-( 1 -methyl- IH- 1 ,2,3 -triazol-4-yl)-2,7-naphthyridin-3 -yl)carbamoyl) pyridin-2-yl)piperazin-l-ium iodide [4014];

N-(6-(l-methyl-lH-l,2,3-triazol-4-yl)-2,7-naphthyridin-3-yl)-2-(4-(methyl-£/₃)piperazin-l-yl) isonicotinamide [4015];

N-(6-(l-methyl-lH-l,2,3-triazol-5-yl)-2,7-naphthyridin-3-yl)-l-(3,3,3-trifluoropropyl)piperidine- 4-carboxamide [4016];

N-(6-(4-methyl-4H-l,2,4-triazol-3-yl)-2,7-naphthyridin-3-yl)-2-moφholinoacetamide [4017]; N-(6-(4-methyl-4H-l,2,4-triazol-3-yl)-2,7-naphthyridin-3-yl)-l-(3,3,3-trifluoropropyl)piperidine- 4-carboxamide [4018];

4-fluoro- 1 -isobutyl-N-(6-(4-methyl-4H- 1 ,2,4-triazol-3 -yl)-2,7-naphthyridin-3 -yl)piperidine-4- carboxamide [4019];

N-(6-(4,5-dimethyl-4H-l,2,4-triazol-3-yl)-2,7-naphthyridin-3-yl)-2-moφholinoacetamide [4020]; N-(6-(4,5-dimethyl-4H-l,2,4-triazol-3-yl)-2,7-naphthyridin-3-yl)-l-(3,3,3-trifluoropropyl)

piperidine-4-carboxamide [4021];

N-(6-( IH- 1 ,2,3 -triazol-1 -yl)-2,7-naphthyridin-3-yl)-4-fluoro- 1 -isobutylpiperidine-4-carboxamide

[4022];

N-(6-(2H- 1 ,2,3 -triazol-2-yl)-2,7-naphthyridin-3-yl)-4-fluoro- 1 -isobutylpiperidine-4-carboxamide

[4023];

N-(6-(lH-l,2,4-triazol-l-yl)-2,7-naphthyridin-3-yl)-2-(4-methylpiperazin-l-yl)isonicotinamide

[4024]; 1- isobutyl-N-(6-(l-methyl-lH etrazol-5-yl)-2,7-naphthyridin-3-yl)piperidine-4-carboxamide

[4025];

2,2,3, 3 etramethyl-N-(6-(l-methyl-lH midazol-5-yl)-2,7-naphthyridin-3-yl)cyclopropane-l- carboxamide [4026];

4,4-difluoro-N-(6-(l-methyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)cyclohexane-l- carboxamide [4027];

N-(6-(l-methyl-lH midazol-5-yl)-2,7-naphthyridin-3-yl)-2-(piperidin-l-yl)acetamide [4028];

2 - fluoro-2 -methyl -N-(6-(l-methyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)propanamide [4029]; 1 -fluoro-N-(6-( 1 -methyl- lH-imidazol-5 -yl)-2,7-naphthyridin-3-yl)cyclopropane- 1 -carboxamide

[4030];

2-methyl-N-(6-(l-methyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)-2-azaspiro[3.3]heptane-6- carboxamide [4031];

1 -fluoro-N-(6-( 1 -methyl- lH-imidazol-5 -yl)-2,7-naphthyridin-3-yl)cyclohexane-l -carboxamide

[4032];

fr «5-4-methoxy-N-(6-(l-methyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)cyclohexane-l- carboxamide [4033];

fr «5-4-(hydroxymethyl)-N-(6-(l-methyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)cyclohexane- 1 -carboxamide [4034];

N-(6-(l-methyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)azetidine-3-carboxamide [4035];

(R)-N-(6-(l-methyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)tetrahydrofuran-2 -carboxamide

[4036];

1 -(2-methoxyethyl) -N-(6 -( 1 -methyl - 1 H-imidazol-5 -yl) -2, 7-naphthyridin-3 -yl)piperidine -4 - carboxamide [4037];

N-(6-(l-methyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)-l-(3,3,3-trifluoropropyl)piperidine-4- carboxamide [4038];

1 -isobutyl-N-(6-( 1 -methyl- lH-imidazol-5-yl)-2,7-naphthyridin -3 -yl)piperidine-4-carboxamide

[4039];

N-(6-(l-methyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)-l-(methylsulfonyl)piperidine-4- carboxamide [4040];

N-(6-( 1 -methyl-lH-imidazol-5-yl)-2,7-naphthyridin-3 -yl)-2-(pyrrolidin- 1 -yl)propanamide [4041] ;

2- isopropoxy-N-(6-(l-methyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)acetamide [4042];

3- isopropoxy-N-(6-(l-methyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)propanamide [4043]; N-(6-( 1 ,2-dimethyl- lH-imidazol-5-yl)-2,7-naphthyridin-3 -yl)cyclopropanecarboxamide [4044] ; N-(6-( 1 ,2-dimethyl- lH-imidazol-5-yl)-2,7-naphthyridin-3 -yl)cyclohexanecarboxamide [4045] ; N-(6-( 1 ,2-dimethyl- lH-imidazol-5-yl)-2,7-naphthyridin-3 -yl)-4,4-difluorocyclohexane- 1 - carboxamide [4046];

(S)-N-(6-( 1 ,2-dimethyl- lH-imidazol-5 -yl)-2,7-naphthyridin-3 -yl)tetrahydrofuran-2 -carboxamide

[4047] ;

N-(6-(l,2-dimethyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)-3,3-difluorocyclobutane-l- carboxamide [4048];

N-(6-( 1 ,2-dimethyl- lH-imidazol-5-yl)-2,7-naphthyridin-3 -yl)-l -fluorocyclopropane-1 - carboxamide [4049];

N-(6-( 1 ,2-dimethyl- lH-imidazol-5-yl)-2,7-naphthyridin-3 -yl)moφholine -4 -carboxamide [4050] ; N-(6-(l,2-dimethyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)moφholine-ί s-4-carboxamide

[4051] ;

l-methyl-N-(6-(l-methyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)-lH-pyrazole-4-carboxamide

[4052] ;

l-ethyl-N-(6-(l-methyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)-lH-pyrazole-4-carboxamide

[4053] ;

1 -isopropyl-N-(6-( 1 -methyl- lH-imidazol-5-yl)-2,7-naphthyridin-3 -yl)- lH-pyrazole-4- carboxamide [4054];

1 -cyclopropyl-N-(6-( 1 -methyl -lH-imidazol -5 -yl)-2,7-naphthyridin-3 -yl)- lH-pyrazole-4- carboxamide [4055];

l-isobutyl-N-(6-(l-methyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)-lH-pyrazole-4-carboxamide

[4056] ;

l-methyl-N-(6-(l-methyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)-lH-pyrazole-3-carboxamide

[4057] ;

N-(6-(l-methyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)-2-(l-methyl-lH-pyrazol-4-yl)

acetamide [4058];

l-methyl-N-(6-(l-methyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)-lH-imidazole-4 -carboxamide

[4059] ;

1 -isopropyl-N-(6-( 1 -methyl- lH-imidazol-5-yl)-2,7-naphthyridin-3 -yl)- lH-imidazole-4- carboxamide [4060];

N-(6-( 1 -methyl-lH-imidazol-5-yl)-2,7-naphthyridin-3 -yl)- 1 -(tetrahydro-2H-pyran-4-yl)- 1H- imidazole -4 -carboxamide [4061];

l,2-dimethyl-N-(6-(l-methyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)-lH-imidazole-5- carboxamide [4062]; 1 -methyl -N-(6-( 1 -methyl-lH-imidazol-5 -yl)-2,7-naphthyridin-3 -yl)-lH-l ,2,4-triazole-3 - carboxamide [4063];

2-methyl-N-(6-(l-methyl-lH-imidazol-5-yl)-2 -naphthyridin-3-yl)oxazole-4-carboxamide

[4064];

2-isopropyl-N-(6-(l-methyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)oxazole-4 -carboxamide

[4065];

4-methyl-N-(6-(l-methyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)oxazole-2 -carboxamide

[4066];

4- methyl-N-(6-(l-methyl-lH-imidazol-5-yl)-2 -naphthyridin-3-yl)thiazole-2 -carboxamide

[4067];

2-methyl-N-(6-(l-methyl-lH-imidazol-5-yl)-2 -naphthyridin-3-yl)thiazole-4 -carboxamide

[4068];

5- methyl-N-(6-(l-methyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)-l,3,4-oxadiazole-2- carboxamide [4069];

5 -methyl-N-(6 -( 1 -methyl - 1 H-imidazol-5 -yl) -2 ,7 -naphthyridin-3 -yl) - 1 , 3 ,4 -thiadiazole -2 - carboxamide [4070];

1 -isopropyl-N-(6-( 1 -isopropyl- lH-imidazol-5-yl)-2,7-naphthyridin-3 -yl)- lH-pyrazole-4- carboxamide [4071];

N-(6-( 1 ,2-dimethyl- lH-imidazol-5-yl)-2,7-naphthyridin-3 -yl)- 1 -methyl- lH-pyrazole-4- carboxamide [4072];

N-(6-(l,2-dimethyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)-l-isopropyl-lH-pyrazole-4- carboxamide [4073];

N-(6-(l,2-dimethyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)-2-methylthiazole-5-carboxamide

[4074];

4-fluoro-N-(6-( 1 -methyl- lH-imidazol-5 -yl)-2,7-naphthyridin-3-yl)benzamide [4075] ;

4-(difluoromethoxy)-N-(6-(l-methyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)benzamide [4076]; N-(6-(l-methyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)-3-(pyrrolidin-l-ylmethyl)benzamide

[4077];

2-fluoro-N-(6-(l-methyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)benzamide-3,4,5,6-£/4 [4078]; 4-fluoro-N-(6-(l-methyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)benzamide-2,3,5,6-£/₄ [4079]; 2-chloro-N-(6-(l-methyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)benzamide-3,4,5,6-£/4 [4080]; 4-chloro-N-(6-(l-methyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)benzamide-2,3,5,6-£/4 [4081]; 4-(methyl-£¾)-N-(6-( 1 -methyl- lH-imidazol-5-yl)-2,7-naphthyridin-3 -yl)benzamide [4082] ;

4-methyl-N-(6-(l-methyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)benzamide-2,3,5,6-£/4 [4083]; 4-(methyl-d3)-N-(6-( 1 -methyl- lH-imida^^

[4084];

4-(methoxy- 3)-N-(6-(l-memyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)benzamide [4085]; 4-(methoxy-d3)-N-(6-( 1 -memyl-lH-imidazol^^

[4086];

4-methoxy-N-(6-(l -methyl- lH-imidazol-5-yl)-2 -napht^^

[4087];

(E)-N-(6-(l,2-dimethyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)-3-(phenyl-2,3,4,5,6-£/j)

acrylamide [4088];

(E)-N-(6-(l,2-dimethyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)-3-(phenyl-2,3,4,5,6-£/j)

acrylamide-2,3-£/₂ [4089];

N-(6-(l,2-dimethyl-lH-imidazol-5-yl)-2,7-naphth^

d₂ [4090];

(E)-N-(6-(l -methyl- lH-imidazol-5-yl)-2 ,7-naphthyridin-3-yl)-3-(phenyl-2,3,4,5,6-£/j)acrylamide

[4091];

(E)-N-(6-(l-methyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)-3-(phenyl-2,3,4,5,6-£/j)acrylamide- 2,2-d₂ [4092];

2-(4-fluorophenyl)-N-(6-(l-methyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)acetamide-2,2-£/2

[4093];

N-(6-(l-methyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [4094];

2-(dimethylamino)-N-(6-(l-methyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)isonicotinamide

[4095];

2-(3 -aminoazetidin- 1 -yl) -N-(6 -( 1 -methyl - 1 H-imidazol -5 -yl) -2,7 -naphthyridin-3 -yl)

isonicotinamide [4096];

N-(6-(l-methyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)-2-(pyrrolidin-l-yl)isonicotinamide

[4097];

N-(6-(l-methyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)-2-(piperidin-l-yl)isonicotinamide

[4098];

N-(6-(l-methyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)-2-moφholinoisonicotinamide [4099]; 2-(4-isopropylpiperazin-l-yl)-N-(6-(l-methyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)

isonicotinamide [4100];

2-(4-cyclopropylpiperazin- 1 -yl)-N-(6-( 1 -methyl- lH-imidazol-5 -yl)-2,7-naphthyridin-3 -yl)

isonicotinamide [4101]; N-(6-(l-methyl-lH midazol-5-yl)-2,7-naphthyridin-3-yl)-2-(2,7-diazaspiro[3.5]nonan-2-yl) isonicotinamide [4102];

N-(6-(l-methyl-lH midazol-5-yl)-2,7-naphthyridin-3-yl)-2-(7-methyl-2,7-diazaspiro[3.5]nonan-

2-yl)isonicotinamide [4103];

N-(6-(l-methyl-lH midazol-5-yl)-2,7-naphthyridin-3-yl)isoindoline-5-carboxamide [4104] ; 2-methyl-N-(6-(l-methyl-lH-imidazol-5-yl)-2 -naphthyridin-3-yl)isoindoline-5-carboxamide

[4105] ;

2-(azetidin-l-yl)-N-(6-(l-methyl-lH midazol-5-yl)-2,7-naphthyridin-3-yl)isonicotinam

[4106] ;

2-methoxy-N-(6-( 1 -methyl- lH-imidazol -5 -yl)-2,7-naphthyridin-3-yl)isonicotinamide [4107] ; 2-methyl-N-(6-(l-methyl-lH-imidazol-5-yl)-2 -naphthyridin-3-yl)isonicotinamide [4108]; 2-cyano-N-(6-(l-methyl-lH-imidazol-5-yl)-2 -naphthyridin-3-yl)isonicotinamide [4109]; 2-(3,3-difluoroazetidin-l-yl)-N-(6-(l-methyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)

isonicotinamide [4110];

2-(4,4-difluoropiperidin-l-yl)-N-(6-(l-methyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)

isonicotinamide [4111];

2-isopropoxy-N-(6-(l-methyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)isonicotinamide [4112] ; N-(6-(l-methyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)-2-(pyrrolidin-l-yl-2,2,5,5-£/4)

isonicotinamide [4113];

N-(6-(l-methyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)-2-(pyrrolidin-l-yl- s)isonicotinamide

[4114] ;

N-(6-(l-methyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)-2-(piperidin-l-yl- ;o)isonicotinamide

[4115] ;

N-(6-(l-methyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)-2-(moφholino-ί s)isonicotinamide

[4116] ;

N-(6-( 1 ,2-dimethyl- lH-imidazol-5-yl)-2,7-naphthyridin-3 -yl)-4-isopropoxybenzamide [4117]; N-(6-(l,2-dimethyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)-4-(piperidin-4-yloxy)benzamide

[4118] ;

4-(benzyloxy)-N-(6-(l,2-dimethyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)benzamide [4119] ; N-(6-(l,2-dimethyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)-2-fluorobenzamide-3,4,5,6-£/4

[4120] ;

N-(6-(l,2-dimethyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)-4-fluorobenzamide-2,3,5,6-£/4

[4121] ; 2-chloro-N-(6-(l,2-dimethyl-lH midazol-5-yl)-2 -naphthyridin-3-yl)benzamide-3 ,4,5,6-<¾

[4122] ;

4-chloro-N-(6-(l,2-dimethyl-lH-imidazol-5-yl)-2 -naphthyridin-3-yl)benzamide-2,3,5,6-<¾

[4123] ;

N-(6-(l,2-dimethyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)-4-(methyl-ii3)benzamide [4124]; N-(6-(l,2-dimethyl-lH-imidazol-5-yl)-2,7-naphthy^

[4125] ;

N-(6-(l,2-dimethyl-lH-imidazol-5-yl)-2,7-naphthy^

[4126] ;

N-(6-(l,2-dimethyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)-4-(methoxy- 3)benzamide [4127] ; N-(6-(l,2-dimethyl-lH-imidazol-5-yl)-2,7-naphthy^

d₄ [4128] ;

N-(6-(l,2-dimethyl-lH-imidazol-5-yl)-2,7-naphthy^

[4129] ;

N-(6-( 1 ,2-dimethyl- lH-imidazol-5-yl)-2,7-naphthyridin-3 -yl)-2-(4-methylpiperazin- 1 -yl)

isonicotinamide [4130];

N-(6-(l,2-dimethyl-lH-imidazol-5-yl)-2,7-na

[4131] ;

N-(6-(l,2-dimethyl-lH-imidazol-5-yl)-2,7-naphthy^

[4132] ;

N-(6-(l,2-dimethyl-lH-imidazol-5-yl)-2,7-na

[4133] ;

N-(6-(l,2-dimethyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)-2-(pyrrolidin-l-yl-2,2,5,5-ii4) isonicotinamide [4134];

N-(6-(l,2-dimethyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)-2-(pyrrolidin-l-yl-£/s)

isonicotinamide [4135];

N-(6-(l,2-dimethyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)-2-(piperidin-l-yl-£/;o)

isonicotinamide [4136];

N-(6-(l,2-dimethyl-lH-imidazol-5-yl)-2,7-naphthyridin-3-yl)-2-(moφholino- s)isonicotinamide

[4137] ;

N-(6-(5,6,7,8-tetrahydroimidazo[l,2-a]pyrazin-3-yl)-2,7-naphthyridin-3-yl)

cyclopropanecarboxamide [4138];

N-(6-(7-methyl-5,6,7,8-tetrahydroimidazo[l,2-a]pyrazin-3-yl)-2,7-naphthyridin-3-yl)

cyclopropanecarboxamide [4139]; 3,3-difluoro-N-(6-(5,6,7,8 etrahydroimidazo[l,2-a]pyrazin-3-yl)-2,7-naphthyridin-3-yl) cyclobutane-l-carboxamide [4140];

(R)-N-(6-(5,6,7,8 etrahydroimidazo[l,2-a]pyrazin-3-yl)-2J-naphthyridin-3-yl)pyrrolidine-2- carboxamide [4141];

(R)-N-(6-(5,6,7,8 etrahydroimidazo[l,2-a]pyrazin-3-yl)-2J-naphthyridin-3-yl)piperidine-3- carboxamide [4142];

l-methyl-N-(6-(5,6,7,8 etrahydroimidazo[l,2-a]pyrazin-3-yl)-2,7-naphthyridin-3-yl)piperidm^

4-carboxamide [4143];

N-(6-(5,6J,8-tetrahydroimidazo[l,2-a]pyrazin-3-yl)-2,7-naphthyridin-3-yl)-l-((l-

(trifluoromethyl)cyclopropyl)methyl)piperidine -4 -carboxamide [4144] ;

1- benzoyl-N-(6-(5,6J,8 etrahydroimidazo[l,2-a]pyrazin-3-yl)-2,7-naphthyridin-3-yl)piperidine-

4-carboxamide [4145];

4-fluoro-l-isobutyl-N-(6-(5,6J,8 etrahydroimidazo[l,2-a]pyrazin-3-yl)-2,7-naphthyridin-3-yl) piperidine-4-carboxamide [4146];

(R)-2-(2-methylpyrrolidin-l-yl)-N-(6-(5,6,7,8 etrahydroimidazo[l,2-a]pyrazin-3-yl)-2,7- naphthyridin-3 -yl)acetamide [4147] ;

2- (cyclobutyl(methyl)amino)-N-(6-(5,6,7,8-tetrahydroimidazo[l,2-a]pyrazin-3-yl)-2,7- naphthyridin-3 -yl)acetamide [4148] ;

4-fluoro-N-(6-(5,6,7,8 etrahydroimidazo[l,2-a]pyrazin-3-yl)-2,7-naphthyridin-3-yl)benzamide

[4149];

4-isopropoxy-N-(6-(5,6,7,8 etrahydroimidazo[l,2-a]pyrazin-3-yl)-2,7-naphthyridin-3-yl)

benzamide [4150];

4-(difluoromethoxy)-N-(6-(5,6,7,8 etrahydroimidazo[l,2-a]pyrazin-3-yl)-2,7-naphthyridin-3-y^ benzamide [4151];

2-((2-(dimethylamino)ethyl)amino)-N-(6-(5,6J,8 etrahydroimidazo[l,2-a]pyrazin-3-yl)-2,7- naphthyridin-3 -yl)isonicotinamide [4152] ;

2-((l-isopropylpiperidin-4-yl)oxy)-N-(6-(5,6,7,8-tetrahydroimidazo[l,2-a]pyrazin-3-yl)-2,7- naphthyridin-3 -yl)isonicotinamide [4153] ;

N-(6-(oxazol-5-yl)-2,7-naphthyridin-3-yl)-l-(3,3,3-trifluoropropyl)piperidine-4 -carboxamide

[4154];

N-(6-(oxazol-5-yl)-2,7-naphthyridin-3-yl)cyclopropanecarboxamide [4155];

(R)-N-(6-(oxazol-5-yl)-2,7-naphthyridin-3-yl)tetrahydrofuran-2 -carboxamide [4156];

(R)-N-(6-(oxazol-5-yl)-2,7-naphthyridin-3-yl)piperidine-3-carboxamide [4157];

N-(6-(oxazol-5-yl)-2,7-naphthyridin-3-yl)tetrahydro-2H-pyran-4-carboxamide [4158]; N-(6-(oxazol-5 -yl)-2,7-naphthyridin-3 -yl)- 1 -(2-(pyrrolidin- 1 -yl)acetyl)piperidine-4-carboxamide [4159] ;

r-methyl-N-(6-(oxazol-5-yl)-2J-naphthyridin-3-yl)-[l,4'-bipiperidine]-4-carboxamide [4160]; c/. ·-4-moφholino-N-(6-(oxazol-5-yl)-2,7-naphthyridin-3-yl)cyclohexane-l -carboxamide [4161]; 2-(cyclobutyl(methyl)amino)-N-(6-(oxazol-5-yl)-2,7-naphthyridin-3-yl)acetamide [4162];

N-(6-(oxazol-5 -yl)-2,7-naphthyridin-3 -yl)-2-(pyrrolidin- 1 -yl)acetamide [4163] ;

(R)-2-(2-methylpyrrolidin- 1 -yl)-N-(6-(oxazol-5 -yl)-2,7-naphthyridin-3 -yl)acetamide [4164] ; 2-(4-methylpiperazin- 1 -yl)-N-(6-(oxazol-5 -yl)-2,7-naphthyridin-3-yl)acetamide [4165] ;

fr «5-4-((4-methylpiperazin-l -yl)methyl)-N-(6-(oxazol-5-yl)-2,7-naphthyridin-3-yl)cyclohexane- 1-carboxamide [4166];

l-(2,2-difluoropropyl)-N-(6-(oxazol-5-yl)-2,7-naphthyridin-3-yl)piperidine-4-carboxamide

[4167] ;

fr «5-4-(hydroxymethyl)-N-(6-(2-methyloxazol-5-yl)-2,7-naphthyridin-3-yl)cyclohexane-l- carboxamide [4168];

fr «5-4-(methylamino)-N-(6-(2-methyloxazol-5-yl)-2,7-naphthyridin-3-yl)cyclohexane-l - carboxamide [4169];

trans-4-(( 1 ,3 -difluoropropan-2-yl)amino)-N-(6-(2-methyloxazol-5 -yl)-2,7-naphthyridin-3 -yl) cyclohexane- 1 -carboxamide [4170];

fr «5-N-(6-(2-methyloxazol-5-yl)-2 -naphthyridin-3-yl)-4-((propan-2-yl-l, l, l,3,3,3-£/6)amino) cyclohexane -1 -carboxamide [4171];

fr «5-4-((2,2-difluoroethyl)amino)-N-(6-(2-methyloxazol-5-yl)-2,7-naphthyridin-3-yl)

cyclohexane -1 -carboxamide [4172];

fr «5-N-(6-(2-methyloxazol-5-yl)-2,7-naphthyridin-3-yl)-4-((3,3,3-trifluoropropyl)amino)

cyclohexane -1 -carboxamide [4173];

fr «5-4-((2-methoxyethyl)amino)-N-(6-(2-methyloxazol-5-yl)-2,7-naphthyridin-3-yl)

cyclohexane -1 -carboxamide [4174];

trans -4 -(dimethylamino) -N-(6 -(2 -methyloxazol -5 -yl) -2 ,7-naphthyridin-3 -yl)cyclohexane - 1 - carboxamide [4175];

fr «5-4-(bis(methyl-£/3)amino)-N-(6-(2-methyloxazol-5-yl)-2,7-naphthyridin-3-yl)cyclohexane-l- carboxamide [4176];

c/5-4-(dimethylamino)-N-(6-(2-methyloxazol-5-yl)-2,7-naphthyridin-3-yl)cyclohexane-l- carboxamide [4177];

fr «5-4-((2,2-difluoroethyl)(methyl)amino)-N-(6-(2-methyloxazol-5-yl)-2,7-naphthyridin-3-yl) cyclohexane -1 -carboxamide [4178]; fr «5-4-(methyl(oxetan-3-yl)amino)-N-(6-(2-methyloxazol-5-yl)-2,7-naphthyridin-3-yl) cyclohexane-1 -carboxamide [4179];

frara -4 -((2-fluoroemyl)amino) -N-(6 -(2 -meft

carboxamide [4180];

fr «5-4-(2-(fluoromethyl)aziridin-l-yl)-N-(6-(2-methyloxazol-5-yl)-2,7-naphthyridin-3-yl) cyclohexane-1 -carboxamide [4181];

trans-4-((3 -fluoroazetidin- 1 -yl)methyl)-N-(6-(2-methyloxazol-5 -yl)-2,7-naphthyridin-3 -yl) cyclohexane-1 -carboxamide [4182];

fr rø-N-(6-(2-methyloxazol-5-yl)-2,7-naphthyridin-3-yl)-3-moφholinocyclobutane-l- carboxamide [4183];

fr rø-N-(6-(2-methyloxazol-5-yl)-2,7-naphthyridin-3-yl)-4-moφholinocyclohexane-l- carboxamide [4184];

N-(6-(2-methyloxazol-5-yl)-2,7-naphthyridin-3-yl)-2-(piperidin-l-yl)acetamide [4185];

2-(4-methoxypiperidin-l-yl)-N-(6-(2-methyloxazol-5-yl)-2,7-naphthyridin-3-yl)acetamide

[4186];

N-(6-(2-methyloxazol-5-yl)-2,7-naphthyridin-3-yl)-2-(4-methylpiperazin-l-yl)acetamide [4187]; N-(6-(2-methyloxazol-5-yl)-2,7-naphthyridin-3-yl)mo holine-4-carboxamide [4188];

N-(6-(2-methyloxazol-5-yl)-2,7-naphthyridin-3-yl)-2-mo holinoacetamide [4189];

N-(6-(2-methyloxazol-5-yl)-2,7-naphthyridin-3-yl)-3-moφholinopropanamide [4190];

1 -methyl -N-(6 -(2 -methyloxazol -5 -yl) -2,7 -naphthyridin-3 -yl)piperidine -4 -carboxamide [4191]; 1 -(2,2-difluoropropyl)-N-(6-(2-methyloxazol-5 -yl)-2,7-naphthyridin-3 -yl)piperidine-4- carboxamide [4192];

N-(6-(2-methyloxazol-5-yl)-2,7-naphthyridin-3-yl)-4-moφholinopiperidine-l-carboxamide

[4193];

4-((l,3-difluoropropan-2-yl)amino)-N-(6-(2-methyloxazol-5-yl)-2,7-naphthyridin-3-yl)

piperidine-1 -carboxamide [4194];

( 1 R,3s,5 S)-3 -(( 1 ,3-difluoropropan-2-yl)amino)-N-(6-(2-methyloxazol-5 -yl)-2,7-naphthyridin-3 - yl)-8-azabicyclo[3.2.1] octane -8 -carboxamide [4195];

( 1 R,3s,5 S)-3 -(( 1 ,3-difluoropropan-2-yl)amino)-N-(6-(2-methyloxazol-5 -yl)-2,7-naphthyridin-3 - yl)-8-azabicyclo[3.2.1] octane -8 -carboxamide [4196];

4-(dimethylamino)-N-(6-(2-methyloxazol-5 -yl)-2,7-naphthyridin-3 -yl)piperidine- 1 -carboxamide

[4197];

4-((2,2-difluoroethyl)(methyl)amino)-N-(6-(2-methyloxazol-5-yl)-2,7-naphthyridin-3-yl)

piperidine-1 -carboxamide [4198]; (3S,4S)-4-amino-3-fluoro-N-(6-(2-methyloxazol-5-yl)-2,7-naphthyridin-3-yl)piperidine-l- carboxamide [4199];

(3S,4S)-3-fluoro-4-(methylamino)-N-(6-(2-^

1-carboxamide [4200];

(3R,4R)-4-amino-3-fluoro-N-(6-(2-methyloxazol-5-yl)-2,7-naphthyridin-3-yl)piperidine-l- carboxamide [4201];

(3R,4R)-3-fluoro-4-(methylamino)-N-(6-(2-methyloxazol-5-yl)-2,7-naphthyridin-3-yl)piperidine-

1-carboxamide [4202];

4-((2-fluoroethyl)amino)-N-(6-(2-methyloxazol-5-yl)-2,7-naphthyridin-3-yl)piperidine-l- carboxamide [4203];

4-((2,2-difluoroethyl)amino)-N-(6-(2-methyloxazol-5-yl)-2J-naphthyridin-3-yl)piperidm^

carboxamide [4204];

(lR,3s,5S)-3-amino-N-(6-(2-methyloxazol-5-yl)-2,7-naphthyridin-3-yl)-8-azabicyclo[3.2.1] octane-8-carboxamide [4205];

(lR,3r,5S)-3-amino-N-(6-(2-methyloxazol-5-yl)-2,7-naphthyridin-3-yl)-8-azabicyclo[3.2.1] octane-8-carboxamide [4206];

(lR,3r,5S)-3-((2-fluoroethyl)amino)-N-(6-(2-methyloxazol-5-yl)-2 -naphthyridin-3-yl)-8- azabicyclo[3.2.1] octane -8 -carboxamide [4207];

(lR,3r,5S)-3-((2,2-difluoroethyl)amino)-N-(6-(2-methyloxazol-5-yl)-2,7-naphthyridin-3-yl)-8- azabicyclo[3.2.1] octane -8 -carboxamide [4208];

(lR,3s,5S)-N-(6-(2-methyloxazol-5-yl)-2,7-naphthyridin-3-yl)-3-((3,3,3-trifluoropropyl)amino)-

8 -azabicyclo [3.2.1] octane -8 -carboxamide [4209] ;

(3S,4S)-3-fluoro-4-(isopropylamino)-N-(6-(2-methyloxazol-5-yl)-2,7-naphthyridin-3-yl)

piperidine- 1-carboxamide [4210];

N-(6-(2-methyloxazol-5-yl)-2,7-naphthyridin-3-yl)-5,6-dihydroimidazo[l,2-a]pyrazine-7(8H)- carboxamide [4211];

2-methyl-N-(6 -(2 -methyloxazol -5 -yl) -2 ,7 -naphthyridin-3 -yl) -5 , 6-dihydroimidazo [ 1 ,2 -a] pyrazine -

7(8H)-carboxamide [4212];

N-(6-(2-methyloxazol-5-yl)-2,7-naphthyridin-3-yl)-2-(mo holino-ί s)acetamide [4213];

fr «5-N-(6-(2-methyloxazol-4-yl)-2,7-naphthyridin-3-yl)-4-(4-methylpiperazin-l-yl)cyclohexane-

1-carboxamide [4214];

N-(6-(2-methyloxazol-5-yl)-2,7-naphthyridin-3-yl)-l-(l-methylpiperidin-4-yl)-lH-pyrazole-4- carboxamide [4215];

2-(lH-imidazol-l-yl)-N-(6-(2-methyloxazol-5-yl)-2,7-naphthyridin-3-yl)acetamide [4216]; 4-(difluoromethoxy)-N-(6-(oxazol-5-yl)-2,7-naphthyridin-3-yl)benzamide [4217];

3- ((l-methylpiperidin-4-yl)oxy)-N-(6-(oxazol-5-yl)-2,7-naphthyridin-3-yl)benzamide [4218]; N-(6 -(oxazol -5 -yl) -2,7 -naphthyridin-3 -yl)isonicotinamide [4219];

2-(3-aminoazetidin-l-yl)-N-(6-(oxazol-5-yl)-2 -naphthyridin-3-yl)isonicotinamide [4220]; 2-(l-methylpiperidin-4-yl)-N-(6-(oxazol-5-yl)-2,7-naphthyridin-3-yl)isonicotinamide [4221]; r-methyl-N-(6-(oxazol-5-yl)-2,7-naphthyridin-3-yl)-l',2',3',6'-tetrahydro-[2,4'-bipyridine]-4- carboxamide [4222];

2-(4-methylpiperazin-l-yl)-N-(6-(oxazol-5-yl)-2,7-naphthyridin-3-yl)isonicotinamide [4223]; 2-(7-methyl-2,7-diazaspiro[3.5]nonan-2-yl)-N-(6-(oxazol-5-yl)-2,7-naphthyridin-3-yl)

isonicotinamide [4224];

N-(6-(oxazol-5-yl)-2J-naphthyridin-3-yl)-2-(2,7-diazaspiro[3.5]nonan-7-yl)isonicotinamide

[4225];

N-(6-(oxazol-5 -yl)-2,7-naphthyridin-3 -yl)-2-(piperidin-4-ylamino)isonicotinamide [4226] ; 2-methyl-N-(6-(oxazol-5 -yl)-2,7-naphthyridin-3 -yl)isoindoline-5 -carboxamide [4227] ;

N-(6-(oxazol-5-yl)-2J-naphthyridin-3-yl)-l,2,3,4-tetrahydroisoquinoline-7-carboxamide [4228]; N-(6-(2-methyloxazol-5-yl)-2 -naphthyridin-3-yl)-2-(4-methylpiperazin-l-yl)isonicotinamide

[4229];

N-(6-(3-methylisoxazol-5-yl)-2,7-naphthyridin-3-yl)-l-(3,3,3-trifluoropropyl)piperidine-4- carboxamide [4230];

4- fluoro- 1 -isobutyl-N-(6-(5 -methyl- 1 ,3 ,4-oxadiazol-2-yl)-2,7-naphthyridin-3 -yl)piperidine-4- carboxamide [4231];

1- isobutyl-N-(6-(5-methyl-l,3,4-oxadiazol-2-yl)-2,7-naphthyridin-3-yl)piperidine-4-carboxamide

[4232];

N-(6-(5-(dimethylamino)-l,3,4-oxadiazol-2-yl)-2,7-naphthyridin-3-yl)piperidine-4-carboxamide

[4233];

N-(6-(5-(dimethylamino)-l,3,4-oxadiazol-2-yl)-2,7-naphthyridin-3-yl)-l-methylpiperidine-4- carboxamide [4234];

N-(6-(5-methyl-l,3,4-oxadiazol-2-yl)-2,7-naphthyridin-3-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [4235];

3,3-difluoro-N-(6-(thiazol-5-yl)-2,7-naphthyridin-3-yl)cyclobutane-l-carboxamide [4236];

2- methyl-N-(6-(thiazol-5-yl)-2,7-naphthyridin-3-yl)-2-azaspiro[3.3]heptane-6-carboxamide

[4237];

l-fluoro-N-(6-(thiazol-5-yl)-2,7-naphthyridin-3-yl)cyclohexane-l -carboxamide [4238]; fr «5-4-(dimethylamino)-N-(6-(1hiazol-5-yl)-2,7-naphthyridin-3-yl)cyclohexane-l-carboxamide [4239];

frara -4 -((3 -fluoroazetidin- 1 -yl)methyl) -N-(6 ^

carboxamide [4240];

N-(6 -(thiazol-5 -yl) -2,7 -naphthyridin-3 -yl)azetidine -3 -carboxamide [4241];

1- methyl-N-(6-(thiazol-5-yl)-2,7-naphthyridin-3-yl)piperidine-4-carboxamide [4242];

1 -(2,2-difluoropropyl)-N-(6-(thiazol-5 -yl)-2,7-naphthyridin-3 -yl)piperidine-4-carboxamide

[4243];

1 -(oxetan-3 -yl) -N-(6 -(thiazol-5 -yl) -2 ,7 -naphthyridin-3 -yl)piperidine -4 -carboxamide [4244] ; 1 -(2-(pyrrolidin- 1 -yl)acetyl)-N-(6-(thiazol-5-yl)-2,7-naphthyridin-3 -yl)piperidine-4-carboxamide

[4245];

r-methyl-N-(6-(thiazol-5-yl)-2,7-naphthyridin-3-yl)-[l,4'-bipiperidine]-4-carboxamide [4246];

2- (pyrrolidin- 1 -yl)-N-(6-(thiazol-5-yl)-2,7-naphthyridin-3 -yl)propanamide [4247] ;

2-(piperidin- 1 -yl)-N-(6-(thiazol-5-yl)-2,7-naphthyridin-3 -yl)acetamide [4248] ;

2-(4-methylpiperazin-l-yl)-N-(6-(thiazol-5-yl)-2,7-naphthyridin-3-yl)acetamide [4249];

2-moφholino-N-(6-(thiazol-5-yl)-2,7-naphthyridin-3-yl)acetamide [4250];

4-(piperidin-4-yloxy)-N-(6-(thiazol-5-yl)-2,7-naphthyridin-3-yl)benzamide [4251];

N-(6-(thiazol-5-yl)-2,7-naphthyridin-3-yl)isonicotinamide [4252];

6-(4-methylpiperazin-l-yl)-N-(6-(thiazol-5-yl)-2,7-naphthyridin-3-yl)nicotinamide [5253]; r-methyl-N-(6-(miazol-5-yl)-2,7-naphthyridin-3-yl)-l 2^3^6'-tetrahydro-[2,4'-bipyridine]-4- carboxamide [4254];

2-(3 -(dimethylamino)azetidin- 1 -yl)-N-(6-(thiazol-5 -yl)-2,7-naphthyridin-3-yl)isonicotinamide

[4255];

2-(4-(dimethylamino)piperidin-l-yl)-N-(6-(thiazol-5-yl)-2,7-naphthyridin-3-yl)isonicotinamide

[4256];

2-(4-methylpiperazin-l-yl)-N-(6-(thiazol-5-yl)-2,7-naphthyridin-3-yl)isonicotinamide [4257]; 2-(( 1 -methylpiperidin-4-yl)thio)-N-(6-(thiazol-5 -yl)-2,7-naphthyridin-3 -yl)isonicotinamide

[4258];

N-(6-(thiazol-5-yl)-2,7-naphthyridin-3-yl)-l,2,3,4-tetrahydroisoquinoline-7 -carboxamide [4259]; fr «5-4-((l,3-difluoropropan-2-yl)amino)-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)-2,7- naphthyridin-3 -yl)cyclohexane - 1 -carboxamide [4260] ;

N-(6-(2-methylthiazol-5-yl)-2,7-naphthyridin-3-yl)mo holine-4-carboxamide [4261];

N-(6-(2-methylthiazol-5-yl)-2,7-naphthyridin-3-yl)-2-(pyrrolidin-l-yl)acetamide [4262]; 2-((lR,4R)-2-oxa-5-azabicyclo[2.2. l]heptan-5-yl)-N-(6-(2-methylthiazol-5-yl)-2,7-naphthyridin-

3-yl)acetamide [4263];

N-(6-(2-methylthiazol-5-yl)-2,7-naphthyridin-3-yl)-2-moφholinoacetamide [4264];

N-(6-(2-methylthiazol-5-yl)-2,7-naphthyridin-3-yl)-2-(moφholino-ί s)acetamide [4265];

2-(4-methylpiperazin-l-yl)-N-(6-(2-methylthiazol-5-yl)-2,7-naphthyridin-3-yl)acetamide [4266];

1- methyl-N-(6-(2-methylthiazol-5-yl)-2,7-naphthyridin-3-yl)piperidine-4-carboxamide [4267]; N-(6-(2-methylthiazol-5-yl)-2,7-naphthyridin-3-yl)isonicotinamide [4268];

N-(6-(2-methylthiazol-5-yl)-2,7-naphthyridin-3-yl)nicotinamide [4269];

2- (4-methylpiperazin-l-yl)-N-(6-(2-methylthiazol-5-yl)-2,7-naphthyridin-3-yl)isonicotinamide

[4270];

fr rø-N-(6-(5-methyl-l,3,4 hiadiazol-2-yl)-2,7-naphthyridin-3-yl)-4-moφholinocyclohexane-l- carboxamide [4271];

fra«s-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)-2,7-napfa

cyclohexane-l-carboxamide [4272];

4-isopropyl-N-(6-(5-methyl-l,3,4 hiadiazol-2-yl)-2,7-naphthyridin-3-yl)piperazine-l- carboxamide [4273];

4-((2-methoxyethyl)(methyl)amino)-N-(6-(5-methyl-l,3,4 hiadiazol-2-yl)-2,7-naphthyridin-3-yl) piperidine-l-carboxamide [4274];

4-(( 1 ,3 -difluoropropan-2-yl)amino)-N-(6-(5 -methyl- 1 ,3,4-thiadiazol-2-yl)-2,7-naphthyridin-3-yl) piperidine-l-carboxamide [4275];

N-(6-(5-methyl-l,3,4-miadiazol-2-yl)-2J-naphthyridin-3-yl)-4-((3,3,3-trifluoropropyl)amino) piperidine-l-carboxamide [4276];

4-((2-fluoroethyl)amino)-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)-2J-naphthyridin-3-yl)piperidine-

1-carboxamide [4277];

(3R,4S)-4-amino-3-fluoro-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)-2,7-naphthyridin-3-yl)

piperidine-l-carboxamide [4278];

(3R,4R)-4-amino-3-fluoro-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)-2,7-naphthyridin-3-yl)

piperidine-l-carboxamide [4279];

(3S,4S)-3-fluoro-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)-2,7-naphthyridin-3-yl)-4-(methylamino) piperidine-l-carboxamide [4280];

(3R,4R)-3-fluoro-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)-2J-naphthyridin-3-yl)-4-(methylamino) piperidine-l-carboxamide [4281];

4-amino-3,3-difluoro-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)-2,7-naphthyridin-3-yl)piperidine-l- carboxamide [4282]; (3R,4R)-3-fluoro-4-(isopropylamino)-N-(6-(5-methyl-l,3,4 hiadiazol-2-yl)-2,7-naphthyridin-3- yl)piperidine - 1 -carboxamide [4283] ;

(3 R,4 S) -3 -fluoro-4 -(isopropylamino) -N-(6 -(5 -mrt^

yl)piperidine - 1 -carboxamide [4284] ;

3,3-difluoro-4-(isopropylamino)-N-(6-(5-methyl-l,3,4-miadiazol-2-yl)-2,7-naphthyridm

piperidine-1 -carboxamide [4285];

(3S,4S)-3-fluoro-N-(6-(5-methyl-l,3,4 hiadiazol-2-yl)-2,7-naphthyridin-3-yl)-4-((propan-2-yl-

1, 1,1,3,3,3 -d<;)amino)piperidine - 1 -carboxamide [4286] ;

(lR,3s,5S)-3-((l,3-difluoropropan-2-yl)amino)-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)-2,7- naphthyridin-3 -yl) -8 -azabicyclo [3.2.1] octane -8 -carboxamide [4287] ;

(lR,3s,5S)-3-((l,3-difluoropropan-2-yl)amino)-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)-2,7- naphthyridin-3-yl)-8-azabicyclo[3.2.1]octane-8-carboxamide [4288];

4-(dimethylamino)-N-(6-(2-methylthiazol-5-yl)-2,7-naphthyridin-3-yl)piperidine-l-carboxamide

[4289];

4-((2,2-difluoroethyl)amino)-N-(6-(5-methyl-l,3,4 hiadiazol-2-yl)-2,7-naphthyridin-3-yl)

piperidine-1 -carboxamide [4290];

4-((2,2-difluoroethyl)(methyl-d3)amino)-N-(6-(5-methyl-l,3,4 hiadiazol-2-yl)-2,7-naphthyridm

3 -yl)piperidine - 1 -carboxamide [4291];

N-(6-(5-methyl-l,3,4-miadiazol-2-yl)-2,7-naphthyridin-3-yl)-4-mo holinopiperidine-l- carboxamide [4292];

N-(6-(5-methyl-l,3,4-1hiadiazol-2-yl)-2,7-naphthyridin-3-yl)-4-(4-methylpiperazin-l-yl)

piperidine-1 -carboxamide [4293];

(R)-3,4-dimethyl-N-(6-(5-methyl-l,3,4 hiadiazol-2-yl)-2,7-naphthyridin-3-yl)piperazine-l- carboxamide [4294];

(S)-3,4-dimethyl-N-(6-(5-methyl-l,3,4 hiadiazol-2-yl)-2,7-naphthyridin-3-yl)piperazine-l- carboxamide [4295];

(lR,3r,5S)-3-((2-fluoroethyl)amino)-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)-2,7-naphthyridin-3- yl)-8 -azabicyclo [3.2. l]octane-8-carboxamide [4296];

(lR,3r,5S)-3-((2,2-difluoroethyl)amino)-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)-2,7-naphthyridin-

3-yl)-8-azabicyclo[3.2. l]octane-8-carboxamide [4297];

(lR,3r,5S)-3-amino-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)-2,7-naphthyridin-3-yl)-8-azabicyclo

[3.2.1] octane -8 -carboxamide [4298];

(lS,4S)-5-methyl-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)-2,7-naphthyridin-3-yl)-2,5-diazabicyclo

[2.2. l]heptane-2 -carboxamide [4299]; (lR,4R)-5-methyl-N-(6-(5-methyl-l,3,4 hiadiazol-2-yl)-2 -naphthyridin-3-yl)-2,5-diazabicyclo

[2.2. l]heptane-2-carboxamide [4300];

8-methyl-N-(6-(5-methyl-l,3,4 hiadiazol-2-yl)-2 -naphthyridin-3-yl)-3,8-diazabicyclo[3.2.1^ octane-3-carboxamide [4301];

3-methyl-N-(6-(5-methyl-l,3,4 hiadiazol-2-yl)-2 -naphthyridin-3-yl)-3,8-diazabicyclo[3.2.1^ octane-8-carboxamide [4302];

N-(6-(5-methyl-l,3,4-miadiazol-2-yl)-2J-naphthyri^^

7(8H)-carboxamide [4303];

2-(4-methylpiperazin-l-yl)-N-(6-(5-methylthiazol-2-yl)-2 -naphthyridin-3-yl)isonicotinamide

[4304];

2-(4-methylpiperazin-l-yl)-N-(6-(4-methylthiazol-2-yl)-2 -naphthyridin-3-yl)isonicotinamide

[4305];

N-(6 -(2-(methylamino)thiazol -5 -yl) -2, 7-naphthyridin-3 -yl)piperidine -4 -carboxamide [4306] ;

1- methyl-N-(6-(2-(methylamino)thiazol-5-yl)-2,7-naphthyridin-3-yl)piperidine-4-carboxamide

[4307];

N-(6-(2-(diethylamino)thiazol-5-yl)-2J-naphthyridin-3-yl)-2-(4-fluoropiperidin-l-yl)acetamide

[4308];

N-(6-(2-(diethylamino)thiazol-5-yl)-2J-naphthyridin-3-yl)-2-(4-methylpiperazin-l-yl)acetamid^

[4309];

N-(6-(2-aminothiazol-5-yl)-2 ,7-naphthyridin-3-yl)-2-(4-methylpiperazin-l-yl)isonicotinamide

[4310];

N-(6-(2-(methylamino)thiazol-5-yl)-2,7-naphthyridin-3-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [4311];

N-(6-(2-(dimethylamino)thiazol-5-yl)-2,7-naphthyridin-3-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [4312];

2- (4 sopropylpiperazin-l-yl)-N-(6-(2-(methylamino)thiazol-5-yl)-2,7-naphthyridin-3-yl)

isonicotinamide [4313];

2-(3 -(dimethylamino)azetidin- 1 -yl)-N-(6-(2-(methylamino)thiazol-5-yl)-2,7-naphthyridin-3 -yl) isonicotinamide [4314];

2-(3 -(dimethylamino)azetidin- 1 -yl)-N-(6-(2-(dimethylamino)thiazol-5 -yl)-2,7-naphthyridin-3-yl) isonicotinamide [4315];

2-(3-aminoazetidin-l-yl)-N-(6-(2-(dimethylamino)thiazol-5-yl)-2,7-naphthyridin-3-yl)

isonicotinamide [4316]; N-(6-(5-chlorothiazol-2-yl)-2,7-naphthyridin-3-yl)-2-(4-methylpiperazin-l-yl)isonicotinamide

[4317];

2-(6-(2-(4-methylpiperazin-l-yl)isonicotinamido)-2J-naphthyridin-3-yl)thiazole-5-carboxamid

[4318];

N-(6-(isothiazol-4-yl)-2J-naphthyridin-3-yl)-l-methylpiperidine-4-carboxamide [4319];

N-(6-(l,3,4 hiadiazol-2-yl)-2,7-naphthyridin-3-yl)-4-(difluoromethoxy)benzamide [4320]; N-(6-(l,3,4-thiadiazol-2-yl)-2,7-naphthyridin-3-yl)-4-(piperidin-4-yloxy)benzamide [4321]; N-(6-(l,3,4 hiadiazol-2-yl)-2,7-naphthyridin-3-yl)-4-((l-methylpiperidin-4-yl)oxy)benzam

[4322];

N-(6-(l,3,4 madiazol-2-yl)-2,7-naphthyridin- [4323];

N⁵-(6-(l,3,4 hiadiazol-2-yl)-2J-naphthyridin-3-yl)-N²-methylpyridine-2,5-dicarboxamide

[4324];

N-(6-(l,3,4-thiadiazol-2-yl)-2,7-naphthyridin-3-yl)-6-(4-^

[4325];

N-(6-(l,3,4 hiadiazol-2-yl)-2 -naphthyridin-3-yl)-l'-methyl-1^2^3^6' etrahydro-[2,4'- bipyridine] -4 -carboxamide [4326] ;

N-(6-(l,3,4 hiadiazol-2-yl)-2,7-naphthyridin-3-yl)-2-(3-(dimethylamino)azetidin-l-yl^

isonicotinamide [4327];

N-(6-( 1 ,3 ,4-thiadiazol-2-yl)-2,7-naphthyridin-3 -yl)-2-(4-methylpiperazin-l -yl)isonicotinamide

[4328];

N-(6-( 1 ,3 ,4-thiadiazol-2-yl)-2,7-naphthyridin-3 -yl)-2-(4-isopropylpiperazin-l -yl)isonicotinamide

[4329];

N-(6-(l,3,4 hiadiazol-2-yl)-2,7-naphthyridin-3-yl)-2-mo holinoisonicotinamide [4330];

l-fluoro-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)-2,7-naphthyridin-3-yl)cyclohexane-l- carboxamide [4331];

fr «5-4-methoxy-N-(6-(5 -methyl- 1 ,3,4-thiadiazol-2-yl)-2,7-naphthyridin-3 -yl)cyclohexane- 1 - carboxamide [4332];

c/5-4-methoxy-N-(6-(5-methyl- 1 ,3,4-thiadiazol-2-yl)-2,7-naphthyridin-3 -yl)cyclohexane- 1 - carboxamide [4333];

fr «5-4-amino-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)-2,7-naphthyridin-3-yl)cyclohexane-l- carboxamide [4334];

fr «5-4-(dimethylamino)-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)-2,7-naphthyridin-3-yl)

cyclohexane-1 -carboxamide [4335]; fr rø-N-(6-(5-methyl-l,3,4 hiadiazol-2-yl)-2,7-naphthyridin-3-yl)-4-moφholinocyclohexane-l- carboxamide [4336];

fr «5-4-(hydroxymethyl)-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)-2,7-naphthyridin-3-yl)

cyclohexane-l-carboxamide [4337];

N-(6-(5-methyl-l,3,4 hiadiazol-2-yl)-2J-naphthyridin-3-yl)piperidine-4-carboxamide [4338]; 4-fluoro-N-(6-(5-methyl- 1 ,3 ,4-thiadiazol-2-yl)-2,7-naphthyridin-3 -yl)piperidine-4-carboxamide

[4339];

l-methyl-N-(6-(5-methyl-l,3,4 hiadiazol-2-yl)-2J-naphthyridin-3-yl)piperidine-4-carbo

[4340];

4-fluoro-l-methyl-N-(6-(5-methyl-l,3,4 hiadiazol-2-yl)-2,7-naphthyridin-3-yl)piperidine-4- carboxamide [4341];

l-(2-fluoroethyl)-N-(6-(5-methyl-l,3,4-tma^

carboxamide [4342];

1 -(2,2-difluoroethyl)-N-(6-(5 -methyl- 1 ,3 ^

carboxamide [4343];

N-(6-(5-methyl-l,3,4-miadiazol-2-yl)-2J-naphthyridin-3-yl)-l-(3,3,3-trifluoropropyl)piperi 4-carboxamide [4344];

l-(2,2-difluoropropyl)-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)-2J-naphthyridin-3-yl)piperidm carboxamide [4345];

1- benzoyl-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)-2J-naphthyridin-3-yl)piperidine-4-carboxamide

[4346];

N-(6-(5-methyl-l,3,4-miadiazol-2-yl)-2J-naphthyridin-3-yl)-2-(pyrrolidin-l-yl)acetami

[4347];

N-(6-(5-methyl-l,3,4-miadiazol-2-yl)-2J-naphthyridin-3-yl)-2-(piperidin-l-yl)acetamide [4348];

2- (4-methoxypiperidin-l-yl)-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)-2 -naphthyridin-3-yl)

acetamide [4349];

N-(6-(5-methyl-l,3,4-miadiazol-2-yl)-2 -naphthyridin-3-yl)-2-(4-methylpiperazin-l-yl)

acetamide [4350];

N-(6-(5-methyl-l,3,4-miadiazol-2-yl)-2 -naphthyridin-3-yl)-2-mo holinoacetamide [4351]; (R)-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)-2,7-naphthyridin-3-yl)-2-(3-methylmoφholino)

acetamide [4352];

2-(7-azabicyclo[2.2 ]heptan-7-yl)-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)-2,7-naphthyridin-3-yl) acetamide [4353]; 2-((lR,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)-2,7- naphthyridin-3 -yl)acetamide [4354] ;

2-(3-oxa-8-azabicyclo[3.2 ]octan-8-yl)-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)-2,7-naphthyridin-

3-yl)acetamide [4355];

2-(8-oxa-3-azabicyclo[3.2 ]octan-3-yl)-N-(6-(5-methyl-l,3,4 hiadiazol-2-yl)-2J-naphthyridin- 3-yl)acetamide [4356];

N-(6-(5-methyl-l,3,4 hiadiazol-2-yl)-2J-naphthyridin-3-yl)-2-(l,4-oxazepan-4-yl)acetamide

[4357];

N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)-2 -naphthyridm^

[4358];

N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)-2J-naphthyr ^^ [4359]; 1 -methyl-3-(6-(5 -methyl-1 ,3,4-thiadiazol-2-yl)-2 ,7-naphthyridin-3-yl)- 1 -( 1 -methylpiperidin-4-yl) urea [4360];

(3S,4S)-4-amino-3-fluoro-N-(6-(5-methyl-l,3,4 hiadiazol-2-yl)-2,7-naphthyridin-3-yl)

piperidine-l-carboxamide [4361];

(3 S,4S)-4-(dimethylamino)-3 -fluoro-N-(6-(5 -methyl- 1 ,3,4-thiadiazol-2-yl)-2,7-naphthyridin-3-yl) piperidine-l-carboxamide [4362];

N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)-2 -naphthyridin-3-yl)mo holine-4-carboxamide [4363]; N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)-2 -naphthyridm^

carboxamide [4364];

4-(dimethylamino)-N-(6-(5-methyl-l,3,4-thiadiaz

carboxamide [4365];

4-((2,2-difluoroethyl)(methyl)amino)-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)-2 -naphthyr

yl)piperidine - 1 -carboxamide [4366] ;

(3S,4S)-3-fluoro-4-(isopropylamino)-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)-2,7-naphthyridin-3- yl)piperidine-l -carboxamide [4367];

2-methyl-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)-2 -naphthyridin-3-yl)-5,6-dihydroimida

pyrazine-7(8H)-carboxamide [4368];

4-methyl-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)-2 -naphthyridin-3-yl)piperazine-l-carboxami

[4369];

N-(6-(5-methyl-l,3,4-miadiazol-2-yl)-2J-naphthyridin-3-yl)-l-(l-methylpiperidin-4

pyrazole -4 -carboxamide [4370];

1 -( 1 -isopropylpiperidin-4-yl)-N-(6-(5 -methyl- 1 ,3,4-thiadiazol-2-yl)-2,7-naphthyridin-3-yl)- 1H- pyrazole -4 -carboxamide [4371]; N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)-2,7-naphthyridin-3-yl)-l-(l-methylpi^

l,2,3-triazole-4-carboxamide [4372];

N-(6-(5-methyl-l,3,4 hiadiazol-2-yl)-2J-naphthyridin-3-yl)-2-(piperidin-4-yl)oxazole-4- carboxamide [4373];

N-(6-(5-methyl-l,3,4 hiadiazol-2-yl)-2 -naphthyridin-3-yl)-2-(l-methylpiperidin-4-yl)oxa 4-carboxamide [4374];

2-(3 -(dimethylamino)azetidin- 1 -yl)-N-(6-(5-methyl- 1 ,3 ,4-thiadiazol-2-yl)-2,7-naphthyridin-3-yl) isonicotinamide [4375];

r-methyl-N-(6-(5 -methyl- 1 ,3,4-thiadiazol-2-yl)-2 ,7-naphthyridin-3 -yl)-l ',2',3 ',6'-tetrahydro-[2,4'- bipyridine] -4-carboxamide [4376];

N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)-2 -naphthyridin-3-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [4377];

2-(methyl( 1 -methylpiperidin-4-yl)amino)-N-(6-(5-methyl- 1 ,3 ,4-thiadiazol-2-yl)-2,7- naphthyridin-3 -yl)isonicotinamide [4378] ;

2-(azetidin-3-yloxy)-N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)-2,7-naphthyridin-3-yl)isonicotinamide

[4379];

N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)-2J-naphthyridin-3-yl)-3-((l-methylpiperidin-4-yl)oxy) benzamide [4380];

N-(6-(5-methyl-l,3,4-thiadiazol-2-yl)-2 -naphthyridin-3-yl)-2-((l-methylpiperidin-4-yl)thio) isonicotinamide [4381];

6-(4-methylpiperazin-l-yl)-N-(6-(5-(trifluoromethyl)-l,3,4-thiadiazol-2-yl)-2,7-naphthyridin-3- yl)nicotinamide [4382];

2-(4-methylpiperazin-l-yl)-N-(6-(5-(trifluoromethyl)-l,3,4-thiadiazol-2-yl)-2,7-naphthyridin-3- yl)isonicotinamide [4383];

N-(6-(5-amino-l,3,4-thiadiazol-2-yl)-2,7-naphthyridin-3-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [4384];

N-(6-(5-(dimethylamino)-l,3,4-thiadiazol-2-yl)-2,7-naphthyridin-3-yl)-2-(4-methylpiperazin-l- yl)isonicotinamide [4385];

N-(6-(3-amino-5 -fluorophenyl)-2,7-naphthyridin-3 -yl)-2-(4-methylpiperazin- 1 -yl)

isonicotinamide [4386];

N-(6-(3-fluoro-5-(isopropylamino)phenyl)-2,7-naphthyridin-3-yl)-2-(4-methylpiperazin-l-yl) isonicotinamide [4387];

1 -methyl -N-(6 -(pyridin-2 -yl) -2, 7-naphthyridin-3 -yl)piperidine -4 -carboxamide [4388] ;

2-(4-methylpiperazin-l-yl)-N-(6-(pyridin-2-yl)-2,7-naphthyridin-3-yl)isonicotinamide [4389]; 2-(4-methylpiperazin-l-yl)-N-(6-(pyridin-4-yl)-2,7-naphthyridin-3-yl)isonicotinamide [4390]; N-(6-(pyridin-3 -yl)-2,7-naphthyridin-3 -yl)cyclopropanecarboxamide [4391] ;

N-(6 -(pyridin-3 -yl) -2,7 -naphthyridin-3 -yl) -2 -(pyrrolidin- 1 -yl)acetamide [4392] ;

1 -methyl -N-(6 -(pyridin-3 -yl) -2,7 -naphthyridin-3 -yl)piperidine -4-carboxamide [4393] ;

N-(6-(pyridin-3 -yl)-2,7-naphthyridin-3 -yl)quinuclidine-4-carboxamide [4394] ;

2-moφholino-N-(6-(pyridin-3-yl)-2,7-naphthyridin-3-yl)acetamide [4395];

2-(moφholino-ί s)- -(6-(pyridin-3-yl)-2,7-naphthyridin-3-yl)acetamide [4396];

2-(4-methylpiperazin-l-yl)-N-(6-(pyridin-3-yl)-2,7-naphthyridin-3-yl)acetamide [4397];

2-(4-methyl- 1 ,4-diazepan- 1 -yl)-N-(6-(pyridin-3-yl)-2,7-naphthyridin-3-yl)acetamide [4398] ; 2-(4-methylpiperazin-l-yl)-N-(6-(pyridin-3-yl)-2,7-naphthyridin-3-yl)isonicotinamide [4399]; 2-(2-methyl-lH-imidazol-l-yl)-N-(6-(pyridin-3-yl)-2,7-naphthyridin-3-yl)acetamide [4400]; 2-(lH-imidazol-l-yl)-N-(6-(pyridin-3-yl)-2,7-naphthyridin-3-yl)acetamide [4401];

2-(piperidin-4-yl)-N-(6-(pyridin-3-yl)-2,7-naphthyridin-3-yl)oxazole-4-carboxamide [4402]; 2-( 1 -methylpiperidin-4-yl)-N-(6-(pyridin-3 -yl)-2,7-naphthyridin-3 -yl)oxazole-4-carboxamide

[4403];

2-(l-isopropylpiperidin-4-yl)-N-(6-(pyridin-3-yl)-2,7-naphthyridin-3-yl)oxazole-4-carboxamide

[4404];

fr rø-N-(6-(5-fluoropyridin-3-yl)-2,7-naphthyridin-3-yl)-3-moφholinocyclobutane-l- carboxamide [4405];

fr «5-N-(6-(5-fluoropyridin-3-yl)-2,7-naphthyridin-3-yl)-4-((4-methylpiperazin-l-yl)methyl) cyclohexane-l-carboxamide [4406];

N-(6-(5-fluoropyridin-3 -yl)-2,7-naphthyridin-3 -yl)-2-(pyrrolidin- 1 -yl)acetamide [4407] ;

N-(6-(5-fluoropyridin-3-yl)-2,7-naphthyridin-3-yl)-l-methylpiperidine-4-carboxamide [4408]; N-(6-(5-fluoropyridin-3-yl)-2,7-naphthyridin-3-yl)-2-(4-methylpiperazin-l-yl)acetamide [4409]; N-(6-(6-fluoropyridin-3-yl)-2,7-naphthyridin-3-yl)-2-(4-methylpiperazin-l-yl)acetamide [4410]; N-(6-(5-fluoropyridin-3-yl)-2,7-naphthyridin-3-yl)-2-moφholinoacetamide [4411];

N-(6-(5-fluoropyridin-3-yl)-2,7-naphthyridin-3-yl)-3-moφholinopropanamide [4412];

N-(6-(5-fluoropyridin-3-yl)-2,7-naphthyridin-3-yl)-2-(4-methylpiperazin-l-yl)isonicotinamide

[4413];

N-(6-(5-fluoropyridin-3-yl)-2,7-naphthyridin-3-yl)-2-(piperidin-4-yl)oxazole-4-carboxamide

[4414];

N-(6-(5-fluoropyridin-3-yl)-2,7-naphthyridin-3-yl)-2-(l-methylpiperidin-4-yl)oxazole-4- carboxamide [4415]; N-(6-(5-fluoropyridin-3-yl)-2,7-naphthyridin-3-yl)-2-(l-isopropylpiperidin-4-yl)oxazole-4- carboxamide [4416];

N-(6-(5-chloropyridin-3-yl)-2 -naphthyridin-3-yl)-2-(4-methylpiperazin-l-yl)isonicotinamide

[4417];

N-(6-(5-methylpyridin-3-yl)-2,7-naphthyridin-3-yl)-2-moφholinoacetamide [4418];

N-(6-(5-(difluoromethyl)pyridin-3-yl)-2,7-naphthyridin-3-yl)-3-(piperidin-4-yl)benzamide

[4419];

N-(6-(5-(difluoromethyl)pyridin-3-yl)-2,7-naphthyridin-3-yl)-3-(l-methylpiperidin-4-yl)

benzamide [4420];

N-(6-(5-(difluoromethyl)pyridin-3-yl)-2,7-naphthyridin-3-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [4421];

2-(4-methylpiperazin-l-yl)-N-(6-(5-(trifluoromethyl)pyridin-3-yl)-2,7-naphthyridin-3-yl)

acetamide [4422];

2-(4-methylpiperazin-l-yl)-N-(6-(6-(trifluoromethyl)pyridin-3-yl)-2,7-naphthyridin-3-yl)

acetamide [4423];

N-(6-(5-(hydroxymethyl)pyridin-3-yl)-2 -naphthyridin-3-yl)-l-methylpiperidine-4-carboxamide

[4424];

N-(6-(5-cyanopyridin-3-yl)-2,7-naphthyridin-3-yl)-l-methylpiperidine-4-carboxamide [4425]; N-(6-(5-methoxypyridin-3-yl)-2,7-naphthyridin-3-yl)-l-methylpiperidine-4-carboxamide [4426]; N-(6-(5-methoxypyridin-3-yl)-2,7-naphthyridin-3-yl)-2-moφholinoacetamide [4427];

N-(6-(5-methoxypyridin-3-yl)-2,7-naphthyridin-3-yl)-2-(4-methylpiperazin-l-yl)isonicotinamide

[4428];

4-fluoro-N-(6-(5-(piperidin-4-yloxy)pyridin-3-yl)-2,7-naphthyridin-3-yl)benzamide [4429]; N-(6-(5-aminopyridin-3-yl)-2,7-naphthyridin-3-yl)-4-fluorobenzamide [4430];

N-(6-(5-aminopyridin-3-yl)-2,7-naphthyridin-3-yl)-4-(piperidin-4-yloxy)benzamide [4431]; N-(6-(5-aminopyridin-3-yl)-2,7-naphthyridin-3-yl)-2-(4-methylpiperazin-l-yl)isonicotinam

[4432];

N-(6-(5-aminopyridin-3-yl)-2,7-naphthyridin-3-yl)-2-(piperidin-4-yl)oxazole-4-carboxamide

[4433];

N-(6-(6-aminopyridin-3-yl)-2,7-naphthyridin-3-yl)-2-(4-methylpiperazin-l-yl)isonicotinamide

[4434];

N-(6-(6-(methylamino)pyridin-3-yl)-2,7-naphthyridin-3-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [4435]; N-(6-(5-(isopropylamino)pyridin-3-yl)-2J-naphthyridin-3-yl)-3-(piperidin-4-yl)benzamide [4436];

N-(6-(5-(isopropylamino)pyridin-3-yl)-2,7-naphthyridin-3-yl)-3-(l-methylpiperidin-4-yl)

benzamide [4437];

N-(6-(5-(isopropylamino)pyridin-3-yl)-2J-naphthyridin-3-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [4438];

N-(6-(5-(piperidin-4-ylamino)pyridin-3-yl)-2,7-naphthyridin-3-yl)cyclohexanecarboxamide

[4439];

4-fluoro-N-(6-(5-(piperidin-4-ylamino)pyridin-3-yl)-2,7-naphthyridin-3-yl)benzamide [4440]; 4-fluoro-N-(6-(5-((l-methylpiperidin-4-yl)amino)pyridin-3-yl)-2,7-naphthyridin-3-yl)benzami

[4441];

N-(6-(5-acetamidopyridin-3-yl)-2,7-naphthyridin-3-yl)-l-methylpiperidine-4-carboxamide

[4442];

N-(6-(5-(dimethylamino)pyridin-3-yl)-2,7-naphthyridin-3-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [4443];

N-(6-(6-(dimethylamino)pyridin-3-yl)-2,7-naphthyridin-3-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [4444];

l-methyl-N-(6-(5-(pyrrolidin-l-yl)pyridin-3-yl)-2,7-naphthyridin-3-yl)piperidine-4-carboxamide

[4445];

N-(6-(5-(pyrrolidin-l-ylmethyl)pyridin-3-yl)-2,7-naphthyridin-3-yl)cyclopropanecarboxamide

[4446];

4-fluoro-N-(6-(5-(pyrrolidin-l-ylmethyl)pyridin-3-yl)-2,7-naphthyridin-3-yl)benzamide [4447]; N-(6-(5-((4-hydroxypiperidin-l-yl)methyl)pyridin-3-yl)-2,7-naphthyridin-3-yl)

cyclopropanecarboxamide [4448];

4-fluoro-N-(6-(5-((4-hydroxypiperidin- 1 -yl)methyl)pyridin-3 -yl)-2,7-naphthyridin-3 -yl)

benzamide [4449];

N-(6-(5-(piperazin-l-ylmethyl)pyridin-3-yl)-2,7-naphthyridin-3-yl)cyclopropanecarboxamide

[4450];

N-(6-(5-((4-methylpiperazin-l-yl)methyl)pyridin-3-yl)-2,7-naphthyridin-3-yl)

cyclopropanecarboxamide [4451];

N-(6-(5-(mo holinomethyl)pyridin-3-yl)-2,7-naphthyridin-3-yl)cyclopropanecarboxamide

[4452];

N-methyl-5-(6-(l-methylpiperidine-4-carboxamido)-2,7-naphthyridin-3-yl)nicotinamide [4453]; N-methyl-5-(6-(2-(4-methylpiperazin-l-yl)isonicoti

[4454];

N-(6-(pyridin-3-yl^)-2,7-naphthyridin-3-yl)-2-(pyrrolidin-l-yl)acetamide [4455];

2-(4-methylpiperazin- 1 -yl)-N-(6-(pyridin-3 -yl-^)-2,7-naphthyridin-3-yl)acetamide [4456] ;

2-moφholino-N-(6-(pyridin-3-yl-ί ₄()-2,7-naphthyridin-3-yl)acetamide [4457];

1- methyl-N-(6-(2-methylpyrimidin-5-yl)-2 -naphthyridin-3-yl)piperidine-4-carboxamide [4458];

2- (4-methylpiperazin-l-yl)-N-(6-(2-methylpyrimidin-5-yl)-2,7-naphthyridin-3-yl)isonicotinami

[4459];

N-(6-(2-aminopyrimidin-5-yl)-2,7-naphthyridin-3 -yl)- 1 -methylpiperidine-4-carboxamide [4460] ; 2-moφholino-N-(6-(pyridazin-3-yl)-2,7-naphthyridin-3-yl)acetamide [4461];

2-moφholino-N-(6-(pyridazin-4-yl)-2,7-naphthyridin-3-yl)acetamide [4462];

N-(6-(pyridazin-4-yl)-2,7-naphthyridin-3-yl)-2-(pyrrolidin-l-yl)acetamide [4463];

trans -3 -ηιοφ1ιο1ίηο-Ν-(6 -(pyrazin-2-yl) -2 ,7 -naphthyridin-3 -yl)cyclobutane - 1 -carboxamide

[4464];

trans -4 -(dimethylamino) -N-(6 -(pyrazin-2-yl) -2, 7-naphthyridin-3 -yl)cyclohexane - 1 -carboxamide

[4465];

fr rø-4-moφholino-N-(6-(pyrazin-2-yl)-2,7-naphthyridin-3 -yl)cyclohexane- 1 -carboxamide

[4466];

trans-4-((3 -fluoroazetidin- 1 -yl)methyl)-N-(6-(pyrazin-2-yl)-2,7-naphthyridin-3 -yl)cyclohexane-

1 -carboxamide [4467];

fr «5-4-((4-methylpiperazin-l-yl)methyl)-N-(6-(pyrazin-2-yl)-2,7-naphthyridin-3-yl)

cyclohexane-1 -carboxamide [4468];

N-(6-(pyrazin-2-yl)-2,7-naphthyridin-3-yl)-2-(pyrrolidin-l-yl)acetamide [4469];

l-methyl-N-(6-(pyrazin-2-yl)-2,7-naphthyridin-3-yl)piperidine-4-carboxamide [4470];

4-fluoro-l -methyl -N-(6-(pyrazin-2-yl)-2,7-naphthyridin-3-yl)piperidine-4-carboxamide [4471]; l-(2-fluoroethyl)-N-(6-(pyrazin-2-yl)-2,7-naphthyridin-3-yl)piperidine-4-carboxamide [4472];

1- (oxetan-3-yl)-N-(6-(pyrazin-2-yl)-2,7-naphthyridin-3-yl)piperidine-4-carboxamide [4473];

2- moφholino-N-(6-(pyrazin-2-yl)-2,7-naphthyridin-3-yl)acetamide [4474];

1 -methyl -N-(6-(pyrazin-2-yl)-2,7-naphthyridin-3 -yl)azepane-4-carboxamide [4475] ;

l-isobutyl-N-(6-(pyrazin-2-yl)-2,7-naphthyridin-3-yl)azepane-4-carboxamide [4476];

1- (2-hydroxy-2-methylpropyl)-N-(6-(pyrazin-2-yl)-2,7-naphthyridin-3-yl)azepane-4-carboxamide

[4477];

4-(moφholinomethyl)-N-(6-(pyrazin-2-yl)-2,7-naphthyridin-3 -yl)benzamide [4478] ;

2- (4-methylpiperazin-l-yl)-N-(6-(pyrazin-2-yl)-2,7-naphthyridin-3-yl)isonicotinamide [4479]; N-(6-(6-(methylamino)pyrazin-2-yl)-2,7-naphthyridin-3-yl)-2-(4-methylpiperazin-l-yl) isonicotinamide [4480];

N-(6-(6-(isopropylamino)pyrazin-2-yl)-2J-naphthyridin-3-yl)azetidine-3-carboxamide [4481]; N-(6-(6-(isopropylamino)pyrazin-2-yl)-2,7-naphthyridin-3-yl)piperidine-4-carboxamide [4482]; N-(6-(6-(isopropylamino)pyrazin-2-yl)-2,7-naphthyridin-3 -yl)- 1 -methylpiperidine-4-carboxamide

[4483];

l-(2-fluoroethyl)-N-(6-(6-(isopropylamino)pyrazin-2-yl)-2,7-naphthyridin-3-yl)piperidine-4- carboxamide [4484];

l-isopropyl-N-(6-(6-(isopropylamino)pyrazin-2-yl)-2,7-naphthyridin-3-yl)piperidine-4- carboxamide [4485];

l-isopentyl-N-(6-(6-(isopropylamino)pyrazin-2-yl)-2,7-naphthyridin-3-yl)piperidine-4- carboxamide [4486];

N-(6-(6-(isopropylamino)pyrazin-2-yl)-2,7-naphthyridin-3-yl)-3-(piperidin-4-yl)benzamide

[4487];

N-(6-(6-(isopropylamino)pyrazin-2-yl)-2J-naphthyridin-3-yl)-3-(l-methylpiperidin-4-yl)

benzamide [4488];

N-(6-(6-(isopropylamino)pyrazin-2-yl)-2,7-naphthyridin-3-yl)-l-(piperidin-4-yl)-lH-l,2,3- triazole -4 -carboxamide [4489];

1 -( 1 -(2-fluoroethyl)piperidin-4-yl)-N-(6-(6-(isopropylamino)pyrazin-2-yl)-2,7-naphthyridin yl)- 1H- 1 ,2,3 -triazole-4-carboxamide [4490] ;

N-(6-(6-(isopropylamino)pyrazin-2-yl)-2,7-naphthyridin-3-yl)-l-(l-isopropylpiperidin-4-yl)-lH- l,2,3-triazole-4-carboxamide [4491];

N-(6-(6-(isopropylamino)pyrazin-2-yl)-2,7-naphthyridin-3 -yl)-2-(4-methylpiperazin- 1 -yl)

isonicotinamide [4492];

N-(6-(6-(feri-butylamino)pyrazin-2-yl)-2,7-naphthyridin-3-yl)-2-(3-(dimethylamino)azetidin-l- yl)isonicotinamide [4493];

N-(6-(6-(feri-butylamino)pyrazin-2-yl)-2,7-naphthyridin-3 -yl)- 1 '-methyl- 1 ',2',3 ',6'-tetrahydro-

[2,4'-bipyridine]-4-carboxamide [4494];

N-(6-(6-(feri-butylamino)pyrazin-2-yl)-2,7-naphthyridin-3-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [4495];

N-(6-(6-(feri-butylamino)pyrazin-2-yl)-2,7-naphthyridin-3-yl)-2-(4-isopropylpiperazin-l-yl) isonicotinamide [4496];

N-(6-(6-(ferί-butylamino)pyrazin-2-yl)-2,7-naphthyridin-3-yl)-2-moφholinoisonicotinamide

[4497]; N-(6-(6-(((3-fluoroazetidin-3-yl)methyl)amino)pyrazin-2-yl)-2,7-naphthyridin-3-yl) cyclopropanecarboxamide [4498];

4-fluoro-N-(6-(6-(((3-fluoroazetidin-3-yl)methyl)amino)pyrazin-2-yl)-2,7-naphthyridin-3-yl) benzamide [4499];

N-(6-(6-(piperidin-4-ylamino)pyrazin-2-yl)-2,7-naphthyridin-3-yl)cyclobutanecarboxamide

[4500];

3.3- difluoro-N-(6-(6-(piperidin-4-ylamino)pyrazin-2-yl)-2,7-naphthyridin-3-yl)cyclobutane-l- carboxamide [4501];

N-(6-(6-(piperidin-4-ylamino)pyrazin-2-yl)-2,7-naphthyridin-3-yl)cyclopentanecarboxamide

[4502];

4.4- difluoro-N-(6-(6-(piperidin-4-ylamino)pyrazin-2-yl)-2,7-naphthyridin-3-yl)cyclohexane-l- carboxamide [4503];

N-(6-(6-(piperidin-4-ylamino)pyrazin-2-yl)-2,7-naphthyridin-3-yl)tetrahydro-2H-pyran-4- carboxamide [4504];

4-fluoro-N-(6-(6-(piperidin-4-ylamino)pyrazin-2-yl)-2,7-naphthyridin-3 -yl)benzamide [4505] ; N-(6-(6-(((3S,4S)-3-fluoropiperidin-4-yl)amino)pyrazin-2-yl)-2,7-naphthyridin-3-yl)

cyclopropanecarboxamide [4506];

4-fluoro-N-(6-(6-(((3S,4S)-3-fluoropiperidin-4-yl)amino)pyrazin-2-yl)-2,7-naphthyridin-3-yl) benzamide [4507];

N-(6-(6-(( 1 -methylpiperidin-4-yl)amino)pyrazin-2-yl)-2,7-naphthyridin-3 -yl)

cyclobutanecarboxamide [4508] ;

N-(6-(6-(( 1 -methylpiperidin-4-yl)amino)pyrazin-2-yl)-2,7-naphthyridin-3 -yl)

cyclopentanecarboxamide [4509];

4-fluoro-N-(6-(6-(( 1 -methylpiperidin-4-yl)amino)pyrazin-2-yl)-2,7-naphthyridin-3 -yl)benzamide

[4510];

N-(6-(6-((l-isopropylpiperidin-4-yl)amino)pyrazin-2-yl)-2,7-naphthyridin-3-yl)

cyclopropanecarboxamide [4511];

3,3-difluoro-N-(6-(6-((l-isopropylpiperidin-4-yl)amino)pyrazin-2-yl)-2,7-naphthyridin-3-yl) cyclobutane-1 -carboxamide [4512];

N-(6-(6-((l-isopropylpiperidin-4-yl)amino)pyrazin-2-yl)-2,7-naphthyridin-3-yl)

cyclopentanecarboxamide [4513];

4-fluoro-N-(6-(6-(( 1 -isopropylpiperidin-4-yl)amino)pyrazin-2-yl)-2,7-naphthyridin-3 -yl)

benzamide [4514]; N-(6-(6-(dimethylamino)pyrazin-2-yl)-2,7-naphthyridin-3-yl)-2-(4-methylpiperazin-l-yl) isonicotinamide [4515];

N-(6-(6-(diethylamino)pyrazin-2-yl)-2,7-naphthyridin-3-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [4516];

N-(6-(6-(3-aminoazetidin-l-yl)pyrazin-2-yl)-2,7-naphthyridin-3-yl)-4-fluorobenzamide [4517]; 2-(4-methylpiperazin- 1 -yl)-N-(6-(6-(pyrrolidin- 1 -yl)pyrazin-2-yl)-2,7-naphthyridin-3-yl)

isonicotinamide [4518];

N-(6-(6-(azetidin-3-ylmethoxy)pyrazin-2-yl)-2,7-naphthyridin-3-yl)-4-fluorobenzamide [4519]; N-(6-(6-(azetidin-3-yloxy)pyrazin-2-yl)-2,7-naphthyridin-3-yl)-4-fluorobenzamide [4520]; N-(6-(lH-pyrrolo[2,3-b]pyridin-5-yl)-2,7-naphthyridin-3-yl)-l-(l-methylpiperidin-4-yl)-lH- pyrazole-4-carboxamide [4521];

N-(6-(lH-pyrrolo[3,2-b]pyridin-6-yl)-2,7-naphthyridin-3-yl)-l-(l-methylpiperidin-4-yl)-lH- pyrazole-4-carboxamide [4522];

N-(6-( lH-pyrrolo[2,3-c]pyridin-4-yl)-2,7-naphthyridin-3 -yl)- 1 -( 1 -methylpiperidin-4-yl)- 1H- pyrazole-4-carboxamide [4523];

N-(6-(lH-pyrrolo[2,3-b]pyridin-5-yl)-2,7-naphthyridin-3-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [4524];

N-(6-(lH-pyrrolo[3,2-b]pyridin-6-yl)-2,7-naphthyridin-3-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [4525];

N-(6-(lH-pyrrolo[2,3-c]pyridin-4-yl)-2,7-naphthyridin-3-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [4526];

2-(4-methylpiperazin-l-yl)-N-(6-(oxazolo[5,4-b]pyridin-6-yl)-2,7-naphthyridin-3-yl)

isonicotinamide [4527];

N-(6-(2-methyl-lH-pyrrolo[2,3-b]pyridin-5-yl)-2,7-naphthyridin-3-yl)-2-(4-methylpiperazin-l- yl)isonicotinamide [4528];

N-(6-(3-methyl-lH-pyrrolo[2,3-b]pyridin-5-yl)-2,7-naphthyridin-3-yl)-2-(4-methylpiperazin-l- yl)isonicotinamide [4529];

N-(6-(2-methyl-lH-pyrrolo[3,2-b]pyridin-6-yl)-2,7-naphthyridin-3-yl)-2-(4-methylpiperazin-l- yl)isonicotinamide [4530];

N-(6-(5H-pyrrolo[2,3-b]pyrazin-2-yl)-2,7-naphthyridin-3-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [4531];

N-(6-(5H-pyrrolo[2,3-b]pyrazin-3-yl)-2,7-naphthyridin-3-yl)-2-(4-methylpiperazin-l-yl)

isonicotinamide [4532]; l-isopropyl-N-(6-(6-(piperidin-4-ylamino)pyrazin-2-yl)-2,7-naphthyridin-3-yl)-lH-pyrazole-4- carboxamide [4533];

l-isopropyl-N-(6-(6-((l-methylpiperidin-4-yl)amino)pyrazin-2-yl)-2,7-naphthyridin-3-yl)-lH- pyrazole-4-carboxamide [4534];

fra«s-4-((2-fluoroethyl)amino)-N-(3 -( 1 -methyl-lH-pyrazol-4-yl)- 1 ,7-naphthyridin-6-yl)

cyclohexane-l-carboxamide [4628];

fr «5-4-((2-methoxyethyl)amino)-N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)

cyclohexane-l-carboxamide [4629];

fert-butyl (fr «5-4-((3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)carbamoyl)cyclohexyl) carbamate [4630];

N-(3 -( 1 -methyl -lH-pyrazol -4 -yl)- 1 ,7-naphthyridin-6-yl)-2-(( 1 -methylpiperidin-4-yl)amino) isonicotinamide [4631];

N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)-2-(4-methylpiperazin-l-yl)thiazole-5- carboxamide [4632];

N-(3-(l-methyl-lH-pyrazol-4-yl)-l,7-naphthyridin-6-yl)-2-(4-methylpiperazin-l-yl)thiazole-5- carboxamide [4633];

N-(3 -( 1 -methyl -5 -(piperidin- 1 -ylmethyl)- lH-pyrazol-4-yl)-l ,7-naphthyridin-6-yl)-2-(2,7- diazaspiro[3.5]nonan-2-yl)isonicotinamide [4634] ;

N-(3-(l-methyl-lH-l,2,3-triazol-4-yl)-l,7-naphthyridin-6-yl)-4-(piperidin-4-yloxy)benzamide

[4635];

N-(3 -( 1 -methyl-lH-tetrazol-5 -yl)- 1 ,7-naphthyridin-6-yl)- 1 -(3,3,3-trifluoropropyl)piperidine-4- carboxamide [4636];

N-(3-(l,2-dimethyl-lH-imidazol-5-yl)-l,7-naphthyridin-6-yl)-2-(pyrrolidin-l-yl)propanamide

[4637];

N-(3 -( 1 ,2-dimethyl- lH-imidazol-5-yl)-l ,7-naphthyridin-6-yl)-2-(piperidin- 1 -yl)propanamide

[4638];

4-isopropoxy-N-(3-(7-methyl-5,6,7,8-tetrahydroimidazo[l,2-a]pyrazin-3-yl)-l,7-naphthyridin-6- yl)benzamide [4639];

trans-3 -mo holino-N-(3 -(oxazol-5 -yl)- 1 ,7-naphthyridin-6-yl)cyclobutane- 1 -carboxamide

[4640];

fr «5-4-(hydroxymethyl)-N-(3-(oxazol-5-yl)-l,7-naphthyridin-6-yl)cyclohexane-l-carboxamide

[4641];

N-(3 -(oxazol-5 -yl)- 1 ,7-naphthyridin-6-yl)piperidine-4-carboxamide [4642] ;

4-πιοφ1ιο1ίηο-Ν -(3 -(oxazol-5 -yl)- 1 ,7-naphthyridin-6-yl)piperidine- 1 -carboxamide [4643] ; N-(3 -(oxazol-5 -yl)- 1 ,7-naphthyridin-6-yl)-4-(piperidin-4-yloxy)benzamide [4644] ;

N-(3 -(oxazol-5 -yl)- 1 ,7-naphthyridin-6-yl)-3-(piperidin-4-yloxy)benzamide [4645] ;

2-methyl-N-(3-(oxazol-5-yl)-l,7-naphthyridin-6-yl)-5,6-dihydroimidazo[l,2-a]pyrazine-7(8H)- carboxamide [4646];

2-( lH-imidazol-1 -yl)-N -(3 -(oxazol-5 -yl)- 1 ,7-naphthyridin-6-yl)acetamide [4647] ;

trans -4 -(hydroxymethyl) -N -(3 -(thiazol -5 -yl) - 1 ,7 -naphthyridin-6-yl)cyclohexane - 1 -carboxamide

[4648] ;

fr «5-4-(dimethylamino)-N-(3 -(thiazol-5-yl)- 1 ,7-naphthyridin-6-yl)cyclohexane- 1 -carboxamide

[4649] ;

N-(3-(thiazol-5-yl)-l,7-naphthyridin-6-yl)-l -((l -(trifluoromethyl)cyclopropyl)methyl)piperidine- 4-carboxamide [4650];

fr «5-4-(hydroxymethyl)-N-(3-(2-methylthiazol-5-yl)- l,7-naphthyridin-6-yl)cyclohexane-l- carboxamide [4651];

fr «5-4-(dimethylamino)-N-(3 -(2-methylthiazol-5-yl)- 1 ,7-naphthyridin-6-yl)cyclohexane- 1 - carboxamide [4652];

N-(3-(2-methylthiazol-5-yl)-l,7-naphthyridin-6-yl)-l -(oxetan-3-yl)piperidine-4 -carboxamide

[4653] ;

N-(3 -(2-methylthiazol-5-yl)- 1 ,7-naphthyridin-6-yl)- 1 -(2-(pyrrolidin- 1 -yl)acetyl)piperidine-4- carboxamide [4654];

2-((l S,4S)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(3-(5-methyl-l,3,4-thiadiazol-2-yl)-l,7- naphthyridin-6-yl)acetamide [4655] ;

N-(3 -(5-(cyano(4-hydroxypiperidin- 1 -yl)methyl)pyridin-3 -yl)- 1 ,7-naphthyridin-6-yl)

cyclopropanecarboxamide [4656];

4-fluoro-N-(3 -(6-(( 1 -methylazetidin-3 -yl)methoxy)pyrazin-2-yl)- 1 ,7-naphthyridin-6-yl)

benzamide [4657] ;

l-isopropyl-N-(3-(6-(( l-methylpiperidin-4-yl)amino)pyrazin-2-yl)-l,7-naphthyridin-6-yl)-lH- pyrazole -4 -carboxamide [4658]; or a pharmaceutically acceptable salt thereof.

25. A pharmaceutical composition comprising a therapeutically effective amount of a compound according to any one of claims 1-24, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.

26. A method of treating a disorder or disease in a patient, wherein the disorder or disease is selected from the group consisting of: chronic inflammation, systemic inflammation, diabetes, cancer, pulmonary fibrosis, idiopathic pulmonary fibrosis (IPF), degenerative disc disease, bone/osteoporotic fractures, a bone or cartilage disease, a neurological condition/disorder/disease, osteoarthritis, lung disease, a fibrotic disorder, the method comprising administering to the patient a therapeutically effective amount of a compound according to any one of claims 1-24, or a pharmaceutically acceptable salt, or a pharmaceutical composition.

27. A method of claim 26, wherein the disorder or disease is cancer.

28. A method of claim 26, wherein the disorder or disease is pulmonary fibrosis.

29. A method of claim 26, wherein the disorder or disease is idiopathic pulmonary fibrosis (IPF).

30. The method of claim 26, wherein the disorder or disease is lung disease.

31. A method of claim 26, wherein the disorder or disease is degenerative disc disease.

32. A method of claim 26, wherein the disorder or disease is a bone/osteoporotic fracture.

33. A method of claim 26, wherein the disorder or disease is a bone or cartilage disease.

34. A method of claim 26, wherein the disorder or disease is osteoarthritis.

35. A method of claim 26, wherein the disorder or disease is a neurological condition/disorder/disease .

36. The method of claim 27, wherein the cancer is selected from the group consisting of: osteoma, hemangioma, granuloma, xanthoma, osteitis deformans, meningioma, meningiosarcoma, and gliomatosis, astrocytoma, medulloblastoma, glioma, ependymoma, germinoma (pinealoma), glioblastoma multiform, oligodendroglioma, oligodendrocytoma, schwannoma, retinoblastoma, and congenital tumors, neurofibroma, meningioma, glioma, and sarcoma.

37. The method of claim 35, wherein the disorder or disease is a neurological condition/disorder/disease, wherein the neurological condition/disorder/disease is selected from the group consisting of: frontotemporal dementias, dementia with lewy bodies, prion diseases, multiple system atrophy, inclusion body myositis, degenerative myopathies, diabetic neuropathy, other metabolic neuropathies, endocrine neuropathies, orthostatic hypotension, and Charcot-Marie- Tooth disease.

38. The method of claim 35, wherein the disorder or disease is a neurological condition/disorder/disease, wherein the neurological condition/disorder/disease is selected from the group consisting of: Alzheimer's disease, amyotrophic lateral sclerosis (ALS), down syndrome, frontotemporal dementia (FTD) including FTD with Parkinsonism- 17 (FTDP-17), behavioural variant frontotemporal dementia (bvFTD), FTD in patients with motor neuron disease (MND) (typically amyotrophic lateral sclerosis, also called FTD -ALS), corticobasal degeneration (CBD) (also called corticobasal ganglionic degeneration), progressive supranuclear palsy, primary progressive aphasia (PPA), Prion Diseases, globular glial tauopathy (GGT), myotonic dystrophy type 1 (DM1) (also called Steinert disease), myotonic dystrophy type 2 (DM2) (also called proximal myotonic myopathy), Guam complex, argyrophilic grain disease, dementia pugilistica, postencephalitic parkinsonism, lewy body dementia, Parkinson's disease, Pick's disease, and additional diseases with pronounced neurodegeneration such as autism, dementia, epilepsy, Huntington's disease, multiple sclerosis; diseases and disorders associated with acquired brain injury such as chronic traumatic encephalopathy, traumatic brain injury, tumor, and stroke.

39. A method of claim 38, wherein the disorder or disease is Alzheimer's disease.

40. The method of claim 35, wherein the disorder or disease is a neurological condition/disorder/disease associated with tau protein, amyloid, alpha-synuclein, Tar DNA-binding Protein of 43KDa (TDP-43), Prion protein PrP or fused in sarcoma (FUS) pathology.

41. The method of claim 26, wherein the disorder or disease is a fibrotic disorder, wherein the fibrotic disorder is selected from the group consisting of: skin fibrosis; scleroderma; progressive systemic fibrosis; lung fibrosis; muscle fibrosis; kidney fibrosis; glomerulosclerosis; glomerulonephritis; hypertrophic scar formation; uterine fibrosis; renal fibrosis; cirrhosis of the liver, liver fibrosis; adhesions; chronic obstructive pulmonary disease; fibrosis following myocardial infarction; pulmonary fibrosis; fibrosis and scarring associated with diffuse/interstitial lung disease; central nervous system fibrosis; fibrosis associated with proliferative vitreoretinopathy (PVR); restenosis; endometriosis; ischemic disease, and radiation fibrosis.

42. The method of claim 26, wherein the disorder or disease is systemic inflammation.

43. The method of claim 26, wherein the disorder or disease is chronic inflammation associated eye disorders, joint pain, arthritis (rheumatoid, osteo, psoriatic gout), cancers (colon, breast, lung, pancreas, and others), gastrointestinal disorders (ulcerative colitis and inflammatory bowel diseases), pulmonary disorders (chronic obstructive pulmonary disorder and asthma), allergies, skin disorders (atopic dermatitis and psoriasis), diabetes, pancreatitis, tendonitis, hepatitis, heart disease, myocarditis, stroke, lupus, and neurological disorders such as multiple sclerosis, Parkinson's and dementia including Alzheimer's disease.

44. The method of claim 26, wherein the patient is a human.

45. The method of claim 26, wherein the compound inhibits one or more proteins in the Wnt pathway.

46. The method of claim 26, wherein the compound inhibits signaling induced by one or more Wnt proteins.

47. The method of claim 26, wherein the compound inhibits DYRK1A.

48. The method of claim 26, wherein the compound inhibits GSK3 .

49. The method of claim 26, wherein the compound inhibits DYRK1A and GSK3 .

50. The method of claim 26, wherein the compound inhibits a kinase activity.

51. A method of preventing or reducing angiogenesis in a patient, the method comprising administering to the patient a therapeutically effective amount of a compound according to any one of claims 1-24, or a pharmaceutically acceptable salt, or a pharmaceutical composition.