Title:
DIAZAOXA HETEROCYCLIC SPIRO-DIONE PIPERAZINE ALKALOID DERIVATIVE HAVING ANTIVIRAL ACTIVITY AND PREPARATION METHOD THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/025031
Kind Code:
A1
Abstract:
Disclosed is a diazaoxa heterocyclic spiro-dione piperazine alkaloid derivative having an antiviral activity and a preparation method thereof. The compound is a compound of formula (I), has anti-RSV, HSV-1 and EV71 activities and has the following structure: wherein R1, R2, R3, R4 are each independently selected from optionally substituted H, alkyl, cycloalkyl, alkylacyl, alkoxyacyl, cycloalkylacyl, alkenyl, alkenylacyl, alkynyl, alkynylacyl, aryl, arylalkyl, arylacyl, heteroaryl, heteroarylalkyl, heteroarylacyl, saturated or unsaturated heterocyclyl, saturated or unsaturated heterocyclylalkyl, saturated or unsaturated heterocyclylacyl; n is 0 or 1; and a chemical bond (A) represents a bond (B) that points into the page or a bond (C) that points out of the page. "-----" indicates a single bond or does not exist, and when "-----" represents a single bond, R1 and R2 do not exist.
Inventors:
YU YUE (CN)
Application Number:
PCT/CN2016/094330
Publication Date:
February 16, 2017
Filing Date:
August 10, 2016
Export Citation:
Assignee:
YU YUE (CN)
International Classes:
C07D498/20; A61K31/537; A61P31/14; A61P31/22; C07D241/08
Domestic Patent References:
| WO2009000757A1 | 2008-12-31 | |||
| WO2012109256A2 | 2012-08-16 |
Foreign References:
| CN103396372A | 2013-11-20 | |||
| CN104876945A | 2015-09-02 |
Other References:
WIDMER, J. ET AL.: "Stoffwechselprodukte von Mikroorganismen.139.Synthesen in der Sideramin-Reihe: Rhodotorulasäure und Dimerumsäure", HELVETICA CHIMICA ACTA, vol. 57, no. 7, 31 December 1974 (1974-12-31), pages 1904 - 1912, XP055364150, ISSN: 0018-019X
RIGOLET, S. ET AL.: "The Reaction of a-and omega-Methylenelactams with Nitrones. Influence of Electronic and Geometric Factors on the Stereoselectivity of their 1,3-Dipolar Cycloaddition", J.CHEM.SOC., PERKIN TRANS.1, 23 March 2000 (2000-03-23), pages 1095 - 1103, ISSN: 1470-4358
JIA, Y.L. ET AL.: "+)- and (-)-Pestaloxazine A, a Pair of Antiviral Enantiomeric Alkaloid Dimers with a Symmetric Spiro[oxazinane-piperazinedione] Skeleton from Pestalotiopsis sp", ORG.LETT., vol. 17, 20 August 2015 (2015-08-20), pages 4216 - 4219, XP055364151, ISSN: 1523-7052
RIGOLET, S. ET AL.: "The Reaction of a-and omega-Methylenelactams with Nitrones. Influence of Electronic and Geometric Factors on the Stereoselectivity of their 1,3-Dipolar Cycloaddition", J.CHEM.SOC., PERKIN TRANS.1, 23 March 2000 (2000-03-23), pages 1095 - 1103, ISSN: 1470-4358
JIA, Y.L. ET AL.: "+)- and (-)-Pestaloxazine A, a Pair of Antiviral Enantiomeric Alkaloid Dimers with a Symmetric Spiro[oxazinane-piperazinedione] Skeleton from Pestalotiopsis sp", ORG.LETT., vol. 17, 20 August 2015 (2015-08-20), pages 4216 - 4219, XP055364151, ISSN: 1523-7052
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