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Patent Searching and Data


Title:
DIDEMNIN BIOSYNTHETIC GENE CLUSTER IN TISTRELLA MOBILIS
Document Type and Number:
WIPO Patent Application WO/2013/041969
Kind Code:
A3
Abstract:
A novel Tistrella mobilis strain having Accession Deposit Number NRRL B-50531 is provided. A method of producing a didemnin precursor, didemnin or didemnin derivative by using the Tistrella mobilis strain, and the therapeutic composition comprising at least one didemnin or didemnin derivative produced from the strain or modified strain thereof are also provided.

Inventors:
QIAN PEI-YUAN (CN)
XU YING SHARON (CN)
LAI POK-YUI (CN)
Application Number:
PCT/IB2012/002361
Publication Date:
June 13, 2013
Filing Date:
September 21, 2012
Export Citation:
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Assignee:
UNIV KING ABDULLAH SCI & TECH (SA)
International Classes:
C12N1/20; C07K7/56; C07K11/02; C12N15/01; C12P21/02
Other References:
YING XU ET AL.: "Bacterial biosynthesis and maturation of the didemnin anti-cancer agents", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 134, 29 March 2012 (2012-03-29), pages 8625 - 8632, XP055071569
BIN-HAI SHI ET AL.: "Tistrella mobilis gen. nov., sp.nov., a novel polyhydroxyalkanoate-producing Bacterium belonging to a -Proteobactria", J. GEN. APPL. MICROBIOL., vol. 48, 2002, pages 335 - 343, XP003031233
ZHISONG CUI ET AL.: "Predominant strains of polycylic aromatic hydrocarbon-degrading consortia From deep sea of the Middle Atlantic Ridge", ACTA MICROBIOLOGICA SINICA, vol. 49, no. 7, 4 July 2009 (2009-07-04), pages 902 - 909, XP008173618
KL RINEHART JR ET AL.: "Didemnins: antiviral and antitumor depsipeptides from a Caribbean Tunicate", SCIENCE, vol. 212, no. 4497, 22 May 1981 (1981-05-22), pages 933 - 935, XP055071571
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