DIFFERENTIAL LABELING FOR QUANTITATIVE ANALYSIS OF COMPLEX PROTEIN MIXTURES BY TRIFUNCTIONAL SYNTHETIC PEPTIDE BASED REAGENTS WITH IODOACETAMIDO GROUPS

Title:

DIFFERENTIAL LABELING FOR QUANTITATIVE ANALYSIS OF COMPLEX PROTEIN MIXTURES BY TRIFUNCTIONAL SYNTHETIC PEPTIDE BASED REAGENTS WITH IODOACETAMIDO GROUPS

Document Type and Number:

WIPO Patent Application WO2004013636

Kind Code:

A3

Abstract:

The present invention relates to a method of simultaneously identifying and determining the levels of expression of cysteine-containing proteins in normal and perturbed cells, a method for proteomic analysis, a process for preparing fusion proteins, and compounds and reagents related thereto.

Inventors:

HAYNES PAUL
WEI JING
YATES JOHN
ANDON NANCY

Application Number:

PCT/IB2003/003863

Publication Date:

January 20, 2005

Filing Date:

July 28, 2003

Export Citation:

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Assignee:

SYNGENTA PARTICIPATIONS AG (CH)

International Classes:

C07K1/13; C07K14/395; G01N33/68; (IPC1-7): G01N33/68; C07K1/107; C07K14/085

Domestic Patent References:

WO1997035887A1	1997-10-02
WO2000011208A1	2000-03-02
WO2001096539A2	2001-12-20
WO2002059144A2	2002-08-01

Other References:

WETZEL R ET AL: "A general method for highly selective cross-linking of unprotected polypeptides via pH-controlled modification of N-terminal alpha-amino groups.", BIOCONJUGATE CHEMISTRY. UNITED STATES 1990 MAR-APR, vol. 1, no. 2, March 1990 (1990-03-01), pages 114 - 122, XP002267733, ISSN: 1043-1802

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