Title:
DIFFERENTIALLY EXPRESSED TUMOUR-SPECIFIC POLYPEPTIDES FOR USE IN THE DIAGNOSIS AND TREATMENT OF CANCER
Document Type and Number:
WIPO Patent Application WO2005026735
Kind Code:
A3
Abstract:
The invention relates to agents and methods for the diagnosis, prognosis and treatment of cancer. Specifically, the invention relates to the use of nucleic and amino acid sequences encoding transmembrane superfamily member 6 (TM4SF6), synaptophysin like protein (SYPL), stomatin like 2 (STOML2), Ras related GTP binding protein RAGA), nucleotide sensitive chloride channel 1A (CLNS1A), prion protein (p27-30) (PRNP), guanine nucleotide binding protein beta 2-like 1 (GNB2L1), guanine nucleotide binding protein 4 (GNG4), integral membrane protein 2B (ITM2B), integral membrane protein 1 (ITM1), transmembrane 9 superfamily member 2 (TM9SF2), opiate receptor-like 1 protein (OPRL1), low density lipoprotein receptor-related protein 4 (LRP4), human glomerular epithelial protein 1 (GLEPP1), toll-like receptor 3 (TLR3), and/or zona pellucida glycoprotein 3A (ZP3) for the diagnosis of both early and late stage non-steroid specific cancers, cancer prognosis, as well as screening for therapeutic agents that regulate the gene expression and/or biological activity of said proteins. This invention further relates to the biological technologies designed to inhibit the gene expression and/or biological activity of said proteins including using agents identified in screening assays described herein, vector delivery of antisense polynucleotide sequences, and antibody targeting of said proteins. In specific embodiments, the proteins are of human origin.
Inventors:
BUSCHMANN THOMAS (DE)
FOTIADIS NIKOLETA-KYRIAKI (DE)
FUCHS MIRIAM (DE)
HEIM STEFFEN (DE)
ILYNIA TATIANA (DE)
LAMER STEPHANIE (DE)
MEUER JOERN (DE)
ROTHMANN-COSIC KIRSTEN (DE)
SEIBERT VOLKER (DE)
PEREZ SILVIA TORTOLA (DE)
FOTIADIS NIKOLETA-KYRIAKI (DE)
FUCHS MIRIAM (DE)
HEIM STEFFEN (DE)
ILYNIA TATIANA (DE)
LAMER STEPHANIE (DE)
MEUER JOERN (DE)
ROTHMANN-COSIC KIRSTEN (DE)
SEIBERT VOLKER (DE)
PEREZ SILVIA TORTOLA (DE)
Application Number:
PCT/EP2004/010780
Publication Date:
November 03, 2005
Filing Date:
September 20, 2004
Export Citation:
Assignee:
GENMAB AS (DK)
BUSCHMANN THOMAS (DE)
FOTIADIS NIKOLETA-KYRIAKI (DE)
FUCHS MIRIAM (DE)
HEIM STEFFEN (DE)
ILYNIA TATIANA (DE)
LAMER STEPHANIE (DE)
MEUER JOERN (DE)
ROTHMANN-COSIC KIRSTEN (DE)
SEIBERT VOLKER (DE)
PEREZ SILVIA TORTOLA (DE)
BUSCHMANN THOMAS (DE)
FOTIADIS NIKOLETA-KYRIAKI (DE)
FUCHS MIRIAM (DE)
HEIM STEFFEN (DE)
ILYNIA TATIANA (DE)
LAMER STEPHANIE (DE)
MEUER JOERN (DE)
ROTHMANN-COSIC KIRSTEN (DE)
SEIBERT VOLKER (DE)
PEREZ SILVIA TORTOLA (DE)
International Classes:
C12Q1/68; G01N33/574; G01N33/68; (IPC1-7): C12Q1/68; G01N33/68
Domestic Patent References:
| WO2002014500A2 | 2002-02-21 | |||
| WO2001022920A2 | 2001-04-05 | |||
| WO2003029273A2 | 2003-04-10 | |||
| WO2004110345A2 | 2004-12-23 |
Foreign References:
| US20030108926A1 | 2003-06-12 | |||
| US20020160382A1 | 2002-10-31 | |||
| US20030113753A1 | 2003-06-19 | |||
| EP1033404A1 | 2000-09-06 |
Other References:
MAEDA K ET AL: "Cloning and Characterization of a Novel Human Gene, TM4SF6, Encoding a Protein Belonging to the Transmembrane 4 Superfamily, and Mapped to Xq22", GENOMICS, ACADEMIC PRESS, SAN DIEGO, US, vol. 52, no. 2, 1 September 1998 (1998-09-01), pages 240 - 242, XP004449063, ISSN: 0888-7543
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