Title:
DIFFERENTIATED IMMORTALISED CELL LINES CAPABLE OF PRODUCING ALBUMIN AND BLOOD COAGULATION FACTORS, METHODS OF PREPARING THEREOF FROM A LEUKAEMIA CELL LINE AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO2008081388
Kind Code:
A8
Abstract:
The invention relates to cell lines from differentiated cells with hepatocytic phenotypes capable of producing albumin and blood coagulation factors, said cells being derived from a human leukaemia cell line, preferably the human THP1 cell line, and preserving the characteristics of immortality. Among the cell lines of the invention, the cell lines known as PSC-THP1-EP, PSC-THP1-EP-FAST, PSC-THP1-HEP and PSC-THP1-EPEP are preferred. The invention also relates to methods for obtaining the cell lines of the invention and the uses of said cell lines, particularly for the production of albumin and/or blood coagulation factors.
Inventors:
GENNERO LUISA (IT)
PONZETTO ANTONIO (IT)
PESCARMONA GIAMPIERO (IT)
SAVARINO ANDREA (IT)
MERIZZI GIANFRANCO (IT)
PONZETTO ANTONIO (IT)
PESCARMONA GIAMPIERO (IT)
SAVARINO ANDREA (IT)
MERIZZI GIANFRANCO (IT)
Application Number:
PCT/IB2007/055287
Publication Date:
September 25, 2008
Filing Date:
December 21, 2007
Export Citation:
Assignee:
MEDESTEA BIOTECH S R L (IT)
GENNERO LUISA (IT)
PONZETTO ANTONIO (IT)
PESCARMONA GIAMPIERO (IT)
SAVARINO ANDREA (IT)
MERIZZI GIANFRANCO (IT)
GENNERO LUISA (IT)
PONZETTO ANTONIO (IT)
PESCARMONA GIAMPIERO (IT)
SAVARINO ANDREA (IT)
MERIZZI GIANFRANCO (IT)
International Classes:
C12N5/071; C12N5/09
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