DIFFERENTIATION SUPPRESSION AGENT FOR MUSCLE TISSUE-DERIVED CELLS

Title:

DIFFERENTIATION SUPPRESSION AGENT FOR MUSCLE TISSUE-DERIVED CELLS

Document Type and Number:

WIPO Patent Application WO/2023/127960

Kind Code:

A1

Abstract:

In order to obtain muscle tissue-derived cells for use in the production of cultured meat, it is necessary to culture proliferative myoblasts and muscle satellite cells. However, these cells easily differentiate, and have a tendency, even in normal culture conditions, to differentiate to myotube cells which are not proliferative. Here, the objective of the present invention is to identify a component that inhibits differentiation of myoblasts and muscle satellite cells in order to culture a large amount of muscle tissue-derived cells for production of cultured meat. Food components used as additives were studied for differentiation suppressing effect, and the study revealed that when whey was added, differentiation of myoblasts and muscle satellite cells was successfully suppressed, and thus a differentiation suppressing agent is provided.

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Inventors:

SEGAWA MAKOTO (JP)
NISHIYAMA YASUTAKA (JP)
FURUSAWA YOSHIKAZU (JP)

Application Number:

PCT/JP2022/048646

Publication Date:

July 06, 2023

Filing Date:

December 28, 2022

Export Citation:

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Assignee:

NH FOODS LTD (JP)

International Classes:

C12N5/077; A23J3/00; C12N5/071; C12N5/0775

Foreign References:

JPH05508542A	1993-12-02
JPH09512536A	1997-12-16
JP2009507044A	2009-02-19

Attorney, Agent or Firm:

AOKI, Atsushi et al. (JP)

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