Title:
DIFLUORO METHYLENE PIPERIDINE CARBOXAMIDE DERIVATIVE AND PREPARATION METHOD AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/082403
Kind Code:
A1
Abstract:
The invention relates to the field of compound synthesis, and mainly relates to a class of difluoro methylene piperidine carboxamide derivatives (I), a pharmaceutical composition containing same, and a preparation method and use thereof, wherein the definition of R1 is shown in the description. Pharmacodynamic tests prove that the compound of the invention has a CCR5 antagonistic action, can be used as an inhibitor for HIV virus entry, and can also be developed into an anti-AIDS medicine.
Inventors:
LU SHOUFU (CN)
ZHANG HUILI (CN)
YU JIANMING (CN)
SHI CHENGJIN (CN)
YU XINMING (CN)
ZHANG HUILI (CN)
YU JIANMING (CN)
SHI CHENGJIN (CN)
YU XINMING (CN)
Application Number:
PCT/CN2015/075463
Publication Date:
June 02, 2016
Filing Date:
March 31, 2015
Export Citation:
Assignee:
YANGZHOU AQFLUOROPHARMA CO LTD (CN)
International Classes:
C07D451/04; A61K31/46; A61P31/18
Domestic Patent References:
| WO2006130426A2 | 2006-12-07 |
Foreign References:
| CN104387379A | 2015-03-04 | |||
| CN101712679A | 2010-05-26 |
Attorney, Agent or Firm:
NANJING SUKE PATENT AGENT CO., LTD (CN)
南京苏科专利代理有限责任公司 (CN)
南京苏科专利代理有限责任公司 (CN)
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