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Document Type and Number:
WIPO Patent Application WO/2014/115801
Kind Code:
This α,α-difluoroacetaldehyde production method involves reacting α,α-difluoroacetic acid esters with hydrogen gas (H2) in the presence of a ruthenium catalyst. By adopting specific reaction conditions (in particular, a reaction medium and reaction temperature), it is possible to selectively obtain α,α-difluoroacetaldehyde, which is a partial reductant of hydrogenation, and this can be an alternative method to hydride reduction, which is difficult to implement industrially.

OOTSUKA, Takashi (LIMITED 17-5, Nakadai 2-chome, Kawagoe-sh, Saitama 59, 〒3501159, JP)
IMAMURA, Mari (LIMITED 17-5, Nakadai 2-chome, Kawagoe-sh, Saitama 59, 〒3501159, JP)
ISHII, Akihiro (LIMITED 17-5, Nakadai 2-chome, Kawagoe-sh, Saitama 59, 〒3501159, JP)
UEDA, Koji (LIMITED 17-5, Nakadai 2-chome, Kawagoe-sh, Saitama 59, 〒3501159, JP)
MIMURA, Shunsuke (LIMITED 17-5, Nakadai 2-chome, Kawagoe-sh, Saitama 59, 〒3501159, JP)
Application Number:
Publication Date:
July 31, 2014
Filing Date:
January 23, 2014
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CENTRAL GLASS COMPANY, LIMITED (5253, Oaza Okiube Ube-sh, Yamaguchi 01, 〒7550001, JP)
International Classes:
C07C45/41; C07C47/14; C07B61/00
Domestic Patent References:
Foreign References:
Other References:
TAKAO IKARIYA ET AL.: "Catalytic Reductive Transformations of Carboxylic and Carbonic Acid Derivatives Using Molecular Hydrogen", ACS CATALYSIS, vol. 2, pages 1718 - 1741, XP055266853
TAKAO IKARIYA ET AL.: "Practical Selective Hydrogenation of ?-Fluorinated Esters with Bifunctional Pincer-Type Ruthenium(II) Catalysts Leading to Fluorinated Alcohols or Fluoral Hemiacetals", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 135, 13 June 2013 (2013-06-13), pages 9600 - 9603, XP055103702
See also references of EP 2949639A4
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Attorney, Agent or Firm:
KOBAYASHI, Hiromichi et al. (Ekisaikai Bldg. 1-29, Akashi-cho, Chuo-k, Tokyo 44, 〒1040044, JP)
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