Title:
DIFLUOROMETHYLENE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2014/017643
Kind Code:
A1
Abstract:
The present invention relates to: a compound which has URAT1 inhibitory activity; and a URAT1 inhibitor, a blood uric acid level reducing agent and a pharmaceutical composition, each of which contains the compound.
The present invention more specifically relates to a compound represented by formula (I).
(In the formula, R1 represents -Q1-A1 or the like; R2 represents a hydrogen atom, a halogen atom, a lower alkyl group or the like; each of W1, W2, W3 and W4 independently represents a nitrogen atom, an optionally substituted methine group or the like; each of X and Y represents a single bond, an oxygen atom or the like; and Z represents a hydroxyl group, COOR3 or the like.)
Inventors:
NAGAI KEITA (JP)
BABA MOTOAKI (JP)
FUJIOKA SHINICHI (JP)
NAGASAWA KOH (JP)
TAKAHASHI HIROBUMI (JP)
KONDOH ERI (JP)
SOGO SACHIE (JP)
TANAKA KENICHI (JP)
ITOH YOSHIKI (JP)
BABA MOTOAKI (JP)
FUJIOKA SHINICHI (JP)
NAGASAWA KOH (JP)
TAKAHASHI HIROBUMI (JP)
KONDOH ERI (JP)
SOGO SACHIE (JP)
TANAKA KENICHI (JP)
ITOH YOSHIKI (JP)
Application Number:
PCT/JP2013/070359
Publication Date:
January 30, 2014
Filing Date:
July 26, 2013
Export Citation:
Assignee:
SATO PHARMA (JP)
International Classes:
C07D209/08; A61K31/404; A61K31/416; A61K31/437; A61K31/4439; A61K31/4709; A61K31/4725; A61P9/10; A61P13/04; A61P13/12; A61P19/02; A61P19/06; C07D231/56; C07D401/06; C07D401/14; C07D403/06; C07D409/06; C07D471/04
Domestic Patent References:
WO2006023704A2 | 2006-03-02 | |||
WO2006019831A1 | 2006-02-23 | |||
WO2005092890A2 | 2005-10-06 | |||
WO2010117932A1 | 2010-10-14 | |||
WO2011053292A1 | 2011-05-05 | |||
WO2008126898A1 | 2008-10-23 | |||
WO2012102405A1 | 2012-08-02 | |||
WO2006057460A1 | 2006-06-01 | |||
WO2007086504A1 | 2007-08-02 | |||
WO2009151695A1 | 2009-12-17 | |||
WO1998015530A1 | 1998-04-16 | |||
WO1999000372A1 | 1999-01-07 | |||
WO2007100066A1 | 2007-09-07 |
Foreign References:
JP2009528363A | 2009-08-06 |
Other References:
IAROSHENKO,V.O.: "Compound 14r", SYNTHESIS, 2009, pages 3967 - 3974, XP055187733
WOOLRIDGE,E.M. ET AL ET AL., TETRAHEDRON LETTERS, vol. 30, no. 45, 1989, pages 6117 - 6120, XP055187735
LOEB JN., ARTHRITIS RHUEUM., vol. 15, 1972, pages 189 - 192
JAPANESE SOCIETY OF GOUT AND NUCLEIC ACID METABOLISM: "Guideline of Hyperuricemia or Gout Treatment, 2nd ed.", 2010, pages: 30 - 31
CHOI HK. ET AL., ANN. INTERN. MED., vol. 43, 2005, pages 499 - 516
TANIGUCHI Y. ET AL., J. HYPERTENSION, vol. 19, 2001, pages 1209 - 1215
SUNDERSTROM J. ET AL., HYPERTENSION, vol. 45, 2005, pages 28 - 33
CHOI HK. ET AL., THE AM. J. MED., vol. 120, 2007, pages 442 - 447
ISHIZAKA N. ET AL., ARTERIOSCLER. THROMB. VASC. BIOL., vol. 25, 2005, pages 1038 - 1044
MASAKO TOMITA; SHOICHI MIZUNO, GOUT AND NUCLEIC ACID METABOLISM, vol. 30, 2006, pages 1 - 5
TORU NAKAMURA: "Treatments of Hyperuricemia and Gout", 2003, MEDICAL REVIEW CO., LTD., pages: 21 - 39
SICA DA.; SCHOOLWERTH AC.: "The Kidney", 1996, SAUBDER, pages: 680 - 700
ENOMOTO A. ET AL., NATURE, vol. 417, 2002, pages 447 - 452
ICHIDA K. ET AL., J. AM. SOC. NEPHROL., vol. 15, 2004, pages 164 - 173
IWAO OHNO, JAPAN CLINICS, vol. 66, 2008, pages 743 - 747
T. W. GREENE: "Protective Groups in Organic Synthesis, 3rd ed.", 1999, JOHN WILEY & SONS
JOURNAL OF ORGANIC CHEMISTRY, vol. 74, 2009, pages 4547
TETRAHEDRON LETTERS, vol. 36, no. 11, 1995, pages 1759 - 1762
See also references of EP 2878594A4
WOOLRIDGE,E.M. ET AL ET AL., TETRAHEDRON LETTERS, vol. 30, no. 45, 1989, pages 6117 - 6120, XP055187735
LOEB JN., ARTHRITIS RHUEUM., vol. 15, 1972, pages 189 - 192
JAPANESE SOCIETY OF GOUT AND NUCLEIC ACID METABOLISM: "Guideline of Hyperuricemia or Gout Treatment, 2nd ed.", 2010, pages: 30 - 31
CHOI HK. ET AL., ANN. INTERN. MED., vol. 43, 2005, pages 499 - 516
TANIGUCHI Y. ET AL., J. HYPERTENSION, vol. 19, 2001, pages 1209 - 1215
SUNDERSTROM J. ET AL., HYPERTENSION, vol. 45, 2005, pages 28 - 33
CHOI HK. ET AL., THE AM. J. MED., vol. 120, 2007, pages 442 - 447
ISHIZAKA N. ET AL., ARTERIOSCLER. THROMB. VASC. BIOL., vol. 25, 2005, pages 1038 - 1044
MASAKO TOMITA; SHOICHI MIZUNO, GOUT AND NUCLEIC ACID METABOLISM, vol. 30, 2006, pages 1 - 5
TORU NAKAMURA: "Treatments of Hyperuricemia and Gout", 2003, MEDICAL REVIEW CO., LTD., pages: 21 - 39
SICA DA.; SCHOOLWERTH AC.: "The Kidney", 1996, SAUBDER, pages: 680 - 700
ENOMOTO A. ET AL., NATURE, vol. 417, 2002, pages 447 - 452
ICHIDA K. ET AL., J. AM. SOC. NEPHROL., vol. 15, 2004, pages 164 - 173
IWAO OHNO, JAPAN CLINICS, vol. 66, 2008, pages 743 - 747
T. W. GREENE: "Protective Groups in Organic Synthesis, 3rd ed.", 1999, JOHN WILEY & SONS
JOURNAL OF ORGANIC CHEMISTRY, vol. 74, 2009, pages 4547
TETRAHEDRON LETTERS, vol. 36, no. 11, 1995, pages 1759 - 1762
See also references of EP 2878594A4
Attorney, Agent or Firm:
TSUJII Koichi et al. (JP)
辻居 Koichi (JP)
辻居 Koichi (JP)
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