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Title:
DIHYDRO-Β-AGAROFURAN SESQUITERPENOID, PREPARATION METHOD AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/086842
Kind Code:
A1
Abstract:
Provided is a dihydro-β-agarofuran sesquiterpenoid, preparation method and use thereof, having a resistive function against ectoenzyme amyloid protein (Aβ)-induced neurocyte injuries and scopolamine-induced memory and behavior injuries, and having good prospects for application in preparing neuroprotection drugs and memory improvement drugs.

Inventors:
ZHAO, Weimin (No. 555 of Zuchongzhi Road, Zhangjiang Pudong New Area, Shanghai 3, 201203, CN)
ZHANG, Haiyan (No. 555 of Zuchongzhi Road, Zhangjiang Pudong New Area, Shanghai 3, 201203, CN)
NING, Ruonan (No. 555 of Zuchongzhi Road, Zhangjiang Pudong New Area, Shanghai 3, 201203, CN)
WANG, Wei (No. 555 of Zuchongzhi Road, Zhangjiang Pudong New Area, Shanghai 3, 201203, CN)
ZHANG, Rujun (No. 555 of Zuchongzhi Road, Zhangjiang Pudong New Area, Shanghai 3, 201203, CN)
LEI, Yun (No. 555 of Zuchongzhi Road, Zhangjiang Pudong New Area, Shanghai 3, 201203, CN)
ZHU, Yingdong (No. 555 of Zuchongzhi Road, Zhangjiang Pudong New Area, Shanghai 3, 201203, CN)
LIU, Shuangzhu (No. 555 of Zuchongzhi Road, Zhangjiang Pudong New Area, Shanghai 3, 201203, CN)
Application Number:
CN2015/096134
Publication Date:
June 09, 2016
Filing Date:
December 01, 2015
Export Citation:
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Assignee:
SHANGHAI INSTITUTE OF MATERIA MEDICA,CHINESE ACADEMY OF SCIENCES (No. 555 of Zuchongzhi Road, Zhangjiang Pudong New Area, Shanghai 3, 201203, CN)
International Classes:
C07D405/12; A61K31/343; A61K31/443; A61K36/37; A61P25/28; C07D307/94
Domestic Patent References:
WO2010075282A12010-07-01
Foreign References:
CN103134827A2013-06-05
CN103109813A2013-05-22
Other References:
NING, RUONAN ET AL.: "Natural beta-Dihydro agarofuran-Type Sesquiterpenoids as Cognition-Enhancing and Neuroprotective Agents from Medicinal Plants of the Genus Celastrus", JOURNAL OF NATURAL PRODUCTS, vol. 78, 21 August 2015 (2015-08-21), pages 2175 - 2186
TORRES-ROMERO, D. ET AL.: "Dihydro-beta-agarofuran sesquiterpenes isolated from Celastrus vulcanicola as potential anti-Mycobacterium tuberculosis multidrug-resistant agents", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 19, no. 7, 26 February 2011 (2011-02-26), pages 2182 - 2189
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (Room No. 106, Building No. 1Universal High-Tech Plaza,958 Zhen Bei Road, Putuo District, Shanghai 3, 200333, CN)
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