Title:
DIHYDROISOQUINOLINE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2020/143604
Kind Code:
A1
Abstract:
The present invention provides a dihydroisoquinoline compound or a pharmaceutically acceptable salt, ester, isomer, solvate, hydrate, prodrug, or isotopic label thereof, having the structure of a compound of general formula I: (I). The compound has an extremely strong activity for inhibiting a Hepatitis B surface antigen and has an extremely strong activity for inhibiting Hepatitis B DNA. In addition, the compound features high bioavailability, can develop efficacy with a low dosage, and reduces the potential toxicity of the compound.
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Inventors:
PENG CHENG (CN)
ZHANG SHAOYUN (CN)
LAI XIAOGANG (CN)
GONG CHAOJUN (CN)
HAN JIAN (CN)
XU BAOLIN (CN)
ZOU GANG (CN)
LI DANBIN (CN)
YUAN HAIQING (CN)
WU JIM ZHEN (CN)
ZHANG SHAOYUN (CN)
LAI XIAOGANG (CN)
GONG CHAOJUN (CN)
HAN JIAN (CN)
XU BAOLIN (CN)
ZOU GANG (CN)
LI DANBIN (CN)
YUAN HAIQING (CN)
WU JIM ZHEN (CN)
Application Number:
PCT/CN2020/070633
Publication Date:
July 16, 2020
Filing Date:
January 07, 2020
Export Citation:
Assignee:
SUZHOU ARK BIOPHARMACEUTICAL CO LTD (CN)
International Classes:
C07D455/06; A61K31/4375; A61P31/12; A61P31/20
Domestic Patent References:
| WO2018130152A1 | 2018-07-19 | |||
| WO2018219356A1 | 2018-12-06 | |||
| WO2018130152A1 | 2018-07-19 | |||
| WO2018130152A1 | 2018-07-19 |
Foreign References:
| CN106459032A | 2017-02-22 |
Other References:
LAMONTAGNE RJ ET AL., HEPATOMA RES, vol. 2, 2016, pages 163 - 86
VANLANDSCHOOT P ET AL., J GEN VIROL., vol. 83, June 2002 (2002-06-01), pages 1281 - 9
MARJOLEINE L ET AL., IMMUNOLOGY, vol. 126, no. 2, February 2009 (2009-02-01), pages 280 - 289
YANG Y ET AL., INT IMMUNOPHARMACOL., vol. 38, September 2016 (2016-09-01), pages 291 - 7
CAROLINA B ET AL., J VIROL., vol. 81, no. 8, April 2007 (2007-04-01), pages 4215 - 4225
CM CHUN ET AL., ANTIVIR THER., vol. 15, no. 2, 2010, pages 133 - 43
E LOGGI ET AL., DIG LIVER DIS., vol. 47, no. 10, October 2015 (2015-10-01), pages 836 - 41
SELLS ET AL., PROC NATL ACAD SCI USA., vol. 84, no. 4, February 1987 (1987-02-01), pages 1005 - 9
BERGE S.M ET AL., J.PHARM.SCI., vol. 66, 1977, pages 1 - 19
GOULD P.L., INT.J.PHARM, vol. 33, 1986, pages 201 - 277
BIGHLEY ET AL.: "Encyclopedia of Pharmaceutical Technology", vol. 13, 1996, MARCEL DEKKER INC, pages: 453 - 497
VANLANDSCHOOT P ET AL., J GEN VIROL., vol. 83, June 2002 (2002-06-01), pages 1281 - 9
MARJOLEINE L ET AL., IMMUNOLOGY, vol. 126, no. 2, February 2009 (2009-02-01), pages 280 - 289
YANG Y ET AL., INT IMMUNOPHARMACOL., vol. 38, September 2016 (2016-09-01), pages 291 - 7
CAROLINA B ET AL., J VIROL., vol. 81, no. 8, April 2007 (2007-04-01), pages 4215 - 4225
CM CHUN ET AL., ANTIVIR THER., vol. 15, no. 2, 2010, pages 133 - 43
E LOGGI ET AL., DIG LIVER DIS., vol. 47, no. 10, October 2015 (2015-10-01), pages 836 - 41
SELLS ET AL., PROC NATL ACAD SCI USA., vol. 84, no. 4, February 1987 (1987-02-01), pages 1005 - 9
BERGE S.M ET AL., J.PHARM.SCI., vol. 66, 1977, pages 1 - 19
GOULD P.L., INT.J.PHARM, vol. 33, 1986, pages 201 - 277
BIGHLEY ET AL.: "Encyclopedia of Pharmaceutical Technology", vol. 13, 1996, MARCEL DEKKER INC, pages: 453 - 497
Attorney, Agent or Firm:
LINDA LIU & PARTNERS (CN)
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