Title:
DIHYDROPYRIMIDINE COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/046133
Kind Code:
A1
Abstract:
Disclosed are a dihydropyrimidine compound, a preparation method therefor and an application thereof, belonging to the technical field of pharmaceutical chemistry. The present invention relates to a dihydropyrimidine compound, the structure of which is shown in formula I. Also provided in the present invention is an application of the compound represented by formula I, or a salt, solvate, isomer, metabolite, nitrogen oxide and prodrug thereof, in the preparation of a medicament for treating or preventing P2X3 and/or P2X2/3 receptor-related diseases. The dihydropyrimidine compound of the present invention has good P2X3 receptor antagonist activity and better safety.
Inventors:
ZENG YANQUN (CN)
HUANG LONG (CN)
ZHU XUCHENG (CN)
ZHU TAO (CN)
MOU XIA (CN)
FU HAIXIA (CN)
HUANG LONG (CN)
ZHU XUCHENG (CN)
ZHU TAO (CN)
MOU XIA (CN)
FU HAIXIA (CN)
Application Number:
PCT/CN2022/121194
Publication Date:
March 30, 2023
Filing Date:
September 26, 2022
Export Citation:
Assignee:
CHENGDU SHIBEIKANG BIOMEDICAL TECH CO LTD (CN)
International Classes:
C07D401/12; A61P11/00; A61P11/06; A61P11/14; A61P29/00; C07D239/545; C07D403/12; C07D413/12; C07D417/12; C07D487/04
Domestic Patent References:
| WO2013118855A1 | 2013-08-15 | |||
| WO2013089212A1 | 2013-06-20 |
Foreign References:
| CN113801097A | 2021-12-17 | |||
| CN103140221A | 2013-06-05 | |||
| CN107709299A | 2018-02-16 | |||
| CN202111137108A | 2021-09-27 |
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