Title:
DIHYDROXY COMPOUND OR SALT THEREOF, AND THERAPEUTIC OR PROPHYLACTIC DRUG FOR PARKINSON'S DISEASE
Document Type and Number:
WIPO Patent Application WO/2018/008737
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a compound which exerts its effect on the onset mechanism of Parkinson's disease by inhibiting the degeneration and cell death of dopamine-secreting cells, and a therapeutic or prophylactic drug for Parkinson's disease. The present invention provides a compound represented by formula (1) or a salt thereof. (In formula (1), R1-R4 each independently represent a group represented by formula (I) or formula (II), or three among R1-R4 represent a group represented by formula (I) or formula (II), and the remaining one represents a hydrogen atom or a substituent, and in formula (I) and formula (II), R5 represents an optionally substituted monovalent branched chain hydrocarbon group having 3 or more carbon atoms, an optionally substituted 5-10 membered mono- to tri-cyclic monovalent carbocyclic group, or an optionally substituted 3-10 membered mono- to tri-cyclic monovalent heterocyclic group, and X1 represents a single bond or an optionally substituted divalent hydrocarbon group having 1-10 carbon atoms.)
Inventors:
IMOTO MASAYA (JP)
IOKA SHUJI (JP)
TASHIRO ETSU (JP)
OGAWA SEIICHIRO (JP)
NISHIYAMA SHIGERU (JP)
HATTORI NOBUTAKA (JP)
SAIKI SHINJI (JP)
YOSHIKAWA YUKIKO (JP)
IOKA SHUJI (JP)
TASHIRO ETSU (JP)
OGAWA SEIICHIRO (JP)
NISHIYAMA SHIGERU (JP)
HATTORI NOBUTAKA (JP)
SAIKI SHINJI (JP)
YOSHIKAWA YUKIKO (JP)
Application Number:
PCT/JP2017/024921
Publication Date:
January 11, 2018
Filing Date:
July 07, 2017
Export Citation:
Assignee:
UNIV KEIO (JP)
JUNTENDO EDUCATIONAL FOUND (JP)
JUNTENDO EDUCATIONAL FOUND (JP)
International Classes:
C07C69/78; A61K31/216; A61K31/235; A61K31/24; A61K31/341; A61K31/381; A61P25/16; C07C69/013; C07C69/92; C07C205/57; C07C309/73; C07D307/68; C07D333/38
Domestic Patent References:
| WO1993011731A2 | 1993-06-24 |
Other References:
GAREGG, PER J. ET AL.: "Synthesis of some benzyl and methyl ethers of myo-inositol", CARBOHYDRATE RESEARCH, vol. 173, 1988, pages 205 - 216, XP026622192
SWARTS, BENJAMIN M. ET AL.: "Synthesis of a Glycosylphosphatidylinositol Anchor Bearing Unsaturated Lipid Chains", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 132, 19 May 2010 (2010-05-19), pages 6648 - 6650, XP055452441
SAITO, SHINTARO ET AL.: "Diastereoselective synthesis of D- and L-myo-inositol 3,4,5,6- tetrakisphosphates from D-glucose via dihydroxylation of (+)-conduritol B derivatives", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 52, 2004, pages 727 - 732
SUAMI, TETSUO ET AL.: "p-Toluenesulfonylation of 1 , 2-0 -cyclohexylidene-myo-inositol", BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, vol. 44, 1971, pages 835 - 41
LEE, B.-Y. ET AL.: "Synthesis of glycosylphosphatidylinositol (GPI)-anchor glycolipids bearing unsaturated lipids", CHEMICAL COMMUNICATIONS, vol. 52, 28 January 2016 (2016-01-28), pages 1586 - 1589, XP055452449
SWARTS, BENJAMIN M. ET AL.: "Synthesis of a Glycosylphosphatidylinositol Anchor Bearing Unsaturated Lipid Chains", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 132, 19 May 2010 (2010-05-19), pages 6648 - 6650, XP055452441
SAITO, SHINTARO ET AL.: "Diastereoselective synthesis of D- and L-myo-inositol 3,4,5,6- tetrakisphosphates from D-glucose via dihydroxylation of (+)-conduritol B derivatives", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 52, 2004, pages 727 - 732
SUAMI, TETSUO ET AL.: "p-Toluenesulfonylation of 1 , 2-0 -cyclohexylidene-myo-inositol", BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, vol. 44, 1971, pages 835 - 41
LEE, B.-Y. ET AL.: "Synthesis of glycosylphosphatidylinositol (GPI)-anchor glycolipids bearing unsaturated lipids", CHEMICAL COMMUNICATIONS, vol. 52, 28 January 2016 (2016-01-28), pages 1586 - 1589, XP055452449
Attorney, Agent or Firm:
SHOBAYASHI Masayuki et al. (JP)
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