Title:
DIMERIC AND MULTIMERIC ANTIGEN BINDING STRUCTURE
Document Type and Number:
WIPO Patent Application WO2003025018
Kind Code:
A3
Abstract:
The present invention relates to dimeric and multimeric antigen binding structures, expression vectors encoding said structures, diagnostic as well as therapeutic uses of said structures. The antigen binding structures are preferably in the form of a Fv-antibody construct.
Inventors:
LE GALL FABRICE (DE)
KIPRIYANOV SERGEY (DE)
REUSCH UWE (DE)
MOLDENHAUER GERHARD (DE)
LITTLE MELVYN (DE)
KIPRIYANOV SERGEY (DE)
REUSCH UWE (DE)
MOLDENHAUER GERHARD (DE)
LITTLE MELVYN (DE)
Application Number:
PCT/EP2002/010307
Publication Date:
August 28, 2003
Filing Date:
September 13, 2002
Export Citation:
Assignee:
AFFIMED THERAPEUTICS AG (DE)
LE GALL FABRICE (DE)
KIPRIYANOV SERGEY (DE)
REUSCH UWE (DE)
MOLDENHAUER GERHARD (DE)
LITTLE MELVYN (DE)
LE GALL FABRICE (DE)
KIPRIYANOV SERGEY (DE)
REUSCH UWE (DE)
MOLDENHAUER GERHARD (DE)
LITTLE MELVYN (DE)
International Classes:
A61P31/00; C07K16/00; C07K16/28; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12N15/13; G01N33/531; (IPC1-7): C07K16/00; C07K16/28; C07K16/30; C07K19/00; C12N15/13; C12N15/62; C12N15/63; C12N5/10; A61P31/00
Domestic Patent References:
| WO1999057150A2 | 1999-11-11 |
Foreign References:
| EP0506124A1 | 1992-09-30 | |||
| DE19816141A1 | 1999-10-14 | |||
| US6025165A | 2000-02-15 | |||
| DE19930433A1 | 2001-01-11 |
Other References:
BERESFORD GUY W ET AL: "Binding characteristics and tumor targeting of a covalently linked divalent CC49 single-chain antibody.", INTERNATIONAL JOURNAL OF CANCER, vol. 81, no. 6, 11 June 1999 (1999-06-11), pages 911 - 917, XP002238722, ISSN: 0020-7136
GOEL A ET AL: "DIVALENT FORMS OF CC49 SINGLE-CHAIN ANTIBODY CONSTRUCTS IN PICHIA PASTORIS: EXPRESSION, AND CHARACTERIZATION", JOURNAL OF BIOCHEMISTRY, JAPANESE BIOCHEMICAL SOCIETY, TOKYO, JP, vol. 127, no. 5, May 2000 (2000-05-01), pages 829 - 836, XP001063231, ISSN: 0021-924X
COLCHER D ET AL: "SINGLE-CHAIN ANTIBODIES IN PANCREATIC CANCER", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, NEW YORK ACADEMY OF SCIENCES, NEW YORK, NY, US, vol. 880, 30 June 1999 (1999-06-30), pages 263 - 280, XP000995150, ISSN: 0077-8923
HUDSON P J ET AL: "High avidity scFv multimers;diabodies and triabodies", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM, NL, vol. 231, no. 1-2, 10 December 1999 (1999-12-10), pages 177 - 189, XP004186084, ISSN: 0022-1759
KIPRIYANOV ET AL: "Bispecific tandem diabody for tumour therapy with improved antigen binding and pharmacokinetics", J.MOL.BIOL., vol. 293, 1999, pages 41 - 56, XP002185480
COCHLOVIUS B ET AL: "CURE OF BURKITT'S LYMPHOMA IN SEVERE COMBINED IMMUNODEFICIENCY MICEBY T CELLS, TETRAVALENT CD3 X CD19 TANDEM DIABODY, AND CD28 COSTIMULATION", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 60, no. 16, 15 August 2000 (2000-08-15), pages 4336 - 4341, XP001026130, ISSN: 0008-5472
VÖLKEL: "Optimized linker sequences for the expression of monomeric and dimeric bispecific single-chain antibodies", PROTEIN ENGINEERING, vol. 14, no. 10, October 2001 (2001-10-01), pages 815 - 823, XP002185481
GOEL A ET AL: "DIVALENT FORMS OF CC49 SINGLE-CHAIN ANTIBODY CONSTRUCTS IN PICHIA PASTORIS: EXPRESSION, AND CHARACTERIZATION", JOURNAL OF BIOCHEMISTRY, JAPANESE BIOCHEMICAL SOCIETY, TOKYO, JP, vol. 127, no. 5, May 2000 (2000-05-01), pages 829 - 836, XP001063231, ISSN: 0021-924X
COLCHER D ET AL: "SINGLE-CHAIN ANTIBODIES IN PANCREATIC CANCER", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, NEW YORK ACADEMY OF SCIENCES, NEW YORK, NY, US, vol. 880, 30 June 1999 (1999-06-30), pages 263 - 280, XP000995150, ISSN: 0077-8923
HUDSON P J ET AL: "High avidity scFv multimers;diabodies and triabodies", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER SCIENCE PUBLISHERS B.V.,AMSTERDAM, NL, vol. 231, no. 1-2, 10 December 1999 (1999-12-10), pages 177 - 189, XP004186084, ISSN: 0022-1759
KIPRIYANOV ET AL: "Bispecific tandem diabody for tumour therapy with improved antigen binding and pharmacokinetics", J.MOL.BIOL., vol. 293, 1999, pages 41 - 56, XP002185480
COCHLOVIUS B ET AL: "CURE OF BURKITT'S LYMPHOMA IN SEVERE COMBINED IMMUNODEFICIENCY MICEBY T CELLS, TETRAVALENT CD3 X CD19 TANDEM DIABODY, AND CD28 COSTIMULATION", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, BALTIMORE, MD, US, vol. 60, no. 16, 15 August 2000 (2000-08-15), pages 4336 - 4341, XP001026130, ISSN: 0008-5472
VÖLKEL: "Optimized linker sequences for the expression of monomeric and dimeric bispecific single-chain antibodies", PROTEIN ENGINEERING, vol. 14, no. 10, October 2001 (2001-10-01), pages 815 - 823, XP002185481
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