Title:
DIMERIC SESQUITERPENOIDS, PREPARATION METHOD THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/242620
Kind Code:
A1
Abstract:
The present invention provides the following dimeric sesquiterpenoids, a preparation method therefor, and a use thereof. The dimeric sesquiterpenoids have novel chemical structures and remarkable anti-malarial biological activities, have good development prospects, and may be developed into novel anti-malarial drugs without cross-drug resistance.
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Inventors:
YUE JIANMIN (CN)
ZHOU BIN (CN)
CASSERA MARIA B (CN)
ZHOU BIN (CN)
CASSERA MARIA B (CN)
Application Number:
PCT/CN2022/093207
Publication Date:
November 24, 2022
Filing Date:
May 17, 2022
Export Citation:
Assignee:
SHANGHAI INST MATERIA MEDICA CAS (CN)
International Classes:
C07D307/94; A61K31/365; A61P33/06; C07D493/10
Foreign References:
| CN107868068A | 2018-04-03 | |||
| CN107865865A | 2018-04-03 | |||
| CN101671346A | 2010-03-17 |
Other References:
WANG QIU-HONG, KUANG HAI-XUE, YANG BING-YOU, XIA YONG-GANG, WANG JUN-SONG, KONG LING-YI: "Sesquiterpenes from Chloranthus japonicus", JOURNAL OF NATURAL PRODUCTS, vol. 74, no. 1, 28 January 2011 (2011-01-28), US , pages 16 - 20, XP093007146, ISSN: 0163-3864, DOI: 10.1021/np100504m
XU LILI: "Study on the Chemical Constituents of Chrysanthemum spp", CHINESE MASTER'S THESES FULL-TEXT DATABASE, 1 June 2016 (2016-06-01), pages 1 - 64, XP093007150, ISSN: 1674-0246
ZHOU BIN, WU YAN, DALAL SEEMA, MERINO EMILIO F., LIU QUN-FANG, XU CHENG-HUI, YUAN TAO, DING JIAN, KINGSTON DAVID G. I., CASSERA MA: "Nanomolar Antimalarial Agents against Chloroquine-Resistant Plasmodium falciparum from Medicinal Plants and Their Structure–Activity Relationships", JOURNAL OF NATURAL PRODUCTS, vol. 80, no. 1, 27 January 2017 (2017-01-27), US , pages 96 - 107, XP093007153, ISSN: 0163-3864, DOI: 10.1021/acs.jnatprod.6b00744
ZHOU BIN, LIU QUN-FANG, DALAL SEEMA, CASSERA MARIA B., YUE JIAN-MIN: "Fortunoids A–C, Three Sesquiterpenoid Dimers with Different Carbon Skeletons from Chloranthus fortunei", ORGANIC LETTERS, vol. 19, no. 3, 3 February 2017 (2017-02-03), US , pages 734 - 737, XP093007157, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.7b00066
XU LILI: "Study on the Chemical Constituents of Chrysanthemum spp", CHINESE MASTER'S THESES FULL-TEXT DATABASE, 1 June 2016 (2016-06-01), pages 1 - 64, XP093007150, ISSN: 1674-0246
ZHOU BIN, WU YAN, DALAL SEEMA, MERINO EMILIO F., LIU QUN-FANG, XU CHENG-HUI, YUAN TAO, DING JIAN, KINGSTON DAVID G. I., CASSERA MA: "Nanomolar Antimalarial Agents against Chloroquine-Resistant Plasmodium falciparum from Medicinal Plants and Their Structure–Activity Relationships", JOURNAL OF NATURAL PRODUCTS, vol. 80, no. 1, 27 January 2017 (2017-01-27), US , pages 96 - 107, XP093007153, ISSN: 0163-3864, DOI: 10.1021/acs.jnatprod.6b00744
ZHOU BIN, LIU QUN-FANG, DALAL SEEMA, CASSERA MARIA B., YUE JIAN-MIN: "Fortunoids A–C, Three Sesquiterpenoid Dimers with Different Carbon Skeletons from Chloranthus fortunei", ORGANIC LETTERS, vol. 19, no. 3, 3 February 2017 (2017-02-03), US , pages 734 - 737, XP093007157, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.7b00066
Attorney, Agent or Firm:
KINGSOUND & PARTNERS (CN)
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