Title:
DIMETHYLPHENYLAMMONIUM LONG-CHAIN COMPOUND, PREPARATION, SELF-ASSEMBLED STRUCTURE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/015581
Kind Code:
A1
Abstract:
Disclosed are a dimethylphenylammonium long-chain compound, a preparation, a self-assembled structure and a use thereof. The compound can have an ultra-long-acting anaesthetic effect, is a N-diethylaminoacetyl-2,6-dimethylphenylammonium compound, and the structure thereof is as shown by formula (I). The compound can perform self-assembly in an aqueous solvent to form a micelle or a gel, and the micelle or gel can exert a long-time local anaesthetic effect on an organism, wherein the local anaesthetic and/or analgetic time may exceed 72 hours. The compound can be used as a biological material capable of performing self-assembly in water to form a micelle or gel and having a local anaesthetic effect; at the same time, the compound can also be used as a biological material for wrapping a pharmaceutically active molecule and/or drug carrier, comprising a pharmaceutically active molecule and/or drug carrier used for treating pain, pruritus and other symptoms, as well as a preparation excipient used for a delivery system, etc., all having good prospects.
Inventors:
TANG LEI (CN)
LIU JIN (CN)
ZHANG WENSHENG (CN)
YANG JUN (CN)
KE BOWEN (CN)
YIN QINQIN (CN)
LIU JIN (CN)
ZHANG WENSHENG (CN)
YANG JUN (CN)
KE BOWEN (CN)
YIN QINQIN (CN)
Application Number:
PCT/CN2015/084760
Publication Date:
February 04, 2016
Filing Date:
July 22, 2015
Export Citation:
Assignee:
WEST CHINA HOSPITAL SICHUAN UNIV (CN)
International Classes:
C07C219/04; A61K31/167; A61P23/02; C07C237/20
Foreign References:
| US3998815A | 1976-12-21 | |||
| CN1989099A | 2007-06-27 |
Other References:
NIELSENET, A.B. ET AL.: "Bioreversible quaternary Nacvloxvmethvl derivatives of the tertiary amines bupivacaine and lidocainesvnthesis, aqueous solubility and stability in buffer, human plasma and simulated intestinal fluid", EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 24, no. 5, 20 December 2004 (2004-12-20), pages 433 - 440
NICHOLAS, B.: "Soft Drugs, 3, A New Class of Anticholinergic Agents", J. MED. CHEM, vol. 5, no. 23, 31 December 1980 (1980-12-31), pages 474 - 480
See also references of EP 3187485A4
NICHOLAS, B.: "Soft Drugs, 3, A New Class of Anticholinergic Agents", J. MED. CHEM, vol. 5, no. 23, 31 December 1980 (1980-12-31), pages 474 - 480
See also references of EP 3187485A4
Attorney, Agent or Firm:
GAOYUNG INTELLECTUAL PROPERTY AGENCY (GENERALPARTNERSHIP) (CN)
成都高远知识产权代理事务所(普通合伙) (CN)
成都高远知识产权代理事务所(普通合伙) (CN)
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