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Title:
DINUCLEAR COPPER-BASED COMPOUND AND LIGAND FOR NUCLEIC ACID SCISSION AND ANTICANCER TREATMENT
Document Type and Number:
WIPO Patent Application WO2003054145
Kind Code:
A3
Abstract:
The present invention is related to a novel method for splitting nucleic acids at specific points on a complementary nucleic acid segment using a dinuclear copper-based compound of Formula I. Additionally, the present invention is related to a novel treatment of cancer, tumors, and cancer cells using a dinuclear copper-based compound of Formula I or a naked ligand of formula II: (Formula I and II).

Inventors:
ROKITA STEVEN E (US)
KARLIN KENNETH D (US)
HUMPHREYS KRISTI J (US)
LEI LI (US)
MURTHY NARASIMHA (IN)
Application Number:
US0236083W
Publication Date:
May 26, 2005
Filing Date:
November 12, 2002
Export Citation:
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Assignee:
UNIVERSITY OF MARYLAND, COLLEGE PARK
THE JOHNS HOPKINS UNIVERSITY
ROKITA, STEVEN, E.
KARLIN, KENNETH, D.
HUMPHREYS, KRISTI, J.
LEI, LI
MURTHY, NARASIMHA
International Classes:
A61K31/30; A61K31/555; C07D213/38; C07F1/00; C07F1/08; (IPC1-7): A01N55/02; A61K31/30
Other References:
HUMPHREYS K.J. ET AL: 'Recognition and Strand Scission at Junctions between Single- and Double-Stranded DNA by Trinuclear Copper Complex' vol. 123, 2001, pages 5588 - 5589
HUMPHREYS K.J. ET AL: 'Targeted Strand Scission of DNA Substrates by a Tricopper(II) Coordination Complex' JACS vol. 124, 2002, pages 8055 - 8066
HUMPHREYS K.J. ET AL: 'Efficient and specific strand scission of DNA by a dinuclear copper complex: Comparative reactivity of complexes with linked tris(2-pyridylmethyl)amine moieties' JACS vol. 124, 2002, pages 6009 - 6019, XP002964997
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