DINUCLEOTIDE CRYSTALS

Title:

DINUCLEOTIDE CRYSTALS

Document Type and Number:

WIPO Patent Application WO/2001/002416

Kind Code:

A1

Abstract:

Crystals of P?1¿-(2'-deoxycytidine 5'-) P?4¿-(uridine 5'-) tetraphosphate (dCP4U) or salts thereof; a process for the production of the crystals; and a process for the preparation of dCP4U by reacting uridine 5'-monophosphate (UMP) with 2'-deoxycytidine 5'-monophosphate (dCMP), diphenylphosphoro-chloridate (DPC) and a pyrophospate (PPi). The crystals of dCP4U have a high purity and are easily handleable by virtue of their lower hygroscopicity and higher stability than those of the products of freeze drying, thus being useful as the raw material of drugs. The process for the preparation of dCP4U permits the production of dCP4U by the use of inexpensive UMP as the starting material in a high yield, thus being suitable for mass production of dCP4U.

Inventors:

MORI KENYA (JP)
MIYASHITA TAKANORI (JP)
MAEDA HIDEAKI (JP)
SATO HIROSHI (JP)
NODA YUTAKA (JP)

Application Number:

PCT/JP2000/004336

Publication Date:

January 11, 2001

Filing Date:

June 30, 2000

Export Citation:

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Assignee:

YAMASA CORP (JP)
MORI KENYA (JP)
MIYASHITA TAKANORI (JP)
MAEDA HIDEAKI (JP)
SATO HIROSHI (JP)
NODA YUTAKA (JP)

International Classes:

C07H1/06; C07H21/00; (IPC1-7): C07H19/10; C07H1/06

Domestic Patent References:

WO1999005155A2	1999-02-04
WO1998034942A2	1998-08-13
WO2000020430A1	2000-04-13

Foreign References:

JPH07242685A

1995-09-19

Other References: