Title:
DIPEPTIDES AS INHIBITORS OF HUMAN IMMUNOPROTEASOMES
Document Type and Number:
WIPO Patent Application WO/2015/106200
Kind Code:
A3
Abstract:
The compounds of the present invention are represented by the following compounds having Formula (I) where the substituents R1-R10, X, Y, k, m, n, q, and s are as defined herein. These compounds are used in the treatment of cancer, immunologic disorders, autoimmune disorders, neurodegenerative disorders, or inflammatory disorders or for providing immunosuppression for transplanted organs or tissues.
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Inventors:
LIN GANG (US)
NATHAN CARL (US)
DING AIHAO (US)
MA XIAOJING (US)
NATHAN CARL (US)
DING AIHAO (US)
MA XIAOJING (US)
Application Number:
PCT/US2015/011022
Publication Date:
September 11, 2015
Filing Date:
January 12, 2015
Export Citation:
Assignee:
UNIV CORNELL (US)
International Classes:
C07K5/06
Domestic Patent References:
| WO2013005045A1 | 2013-01-10 |
Other References:
DATABASE PUBCHEM 26 March 2005 (2005-03-26), retrieved from ncbi Database accession no. 269632
LIN ET AL.: "N,C-Capped Dipeptides with Selectivity for Mycobacterial Proteasome over Human Proteasomes: Role of S3 and S1 Binding Pockets.", JOUMAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 135, no. 27, 2013, pages 9968 - 9971, XP055223106, ISSN: 0002-7863, Retrieved from the Internet [retrieved on 20150224]
LIN ET AL.: "N,C-Capped Dipeptides with Selectivity for Mycobacterial Proteasome over Human Proteasomes: Role of S3 and S1 Binding Pockets.", JOUMAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 135, no. 27, 2013, pages 9968 - 9971, XP055223106, ISSN: 0002-7863, Retrieved from the Internet
Attorney, Agent or Firm:
GOLDMAN, Michael, L. et al. (A Professional Corporation70 Linden Oaks, Suite 21, Rochester NY, US)
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