Title:
DIPEPTIDYL PEPTIDASE-IV INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2013/133031
Kind Code:
A1
Abstract:
Provided are a superior dipeptidyl peptidase-IV inhibitor and the like. Specifically provided is a peptide comprising the sequence Val-Pro-X (therein, X represents an amino acid residue other than an L-proline residue). Preferably, the group represented by X is selected from among residues of basic amino acids, neutral aliphatic amino acids, neutral amino acids having an amide group, and neutral aromatic amino acids. More preferably, the group represented by X is selected from among the residues of alanine, glutamine, methionine, asparagine, glycine, valine, tyrosine, serine and lysine. Also provided are a dipeptidyl peptidase-IV inhibitor, a hypoglycemic agent, a vascular endothelial dysfunction inhibitor, and an angiotensin-converting enzyme inhibitor, each comprising said peptide as an active ingredient.
Inventors:
YAMADA AKIO (JP)
SAKURAI TAKUMA (JP)
OCHI DAISUKE (JP)
SAKURAI TAKUMA (JP)
OCHI DAISUKE (JP)
Application Number:
PCT/JP2013/054291
Publication Date:
September 12, 2013
Filing Date:
February 21, 2013
Export Citation:
Assignee:
MORINAGA MILK INDUSTRY CO LTD (JP)
International Classes:
C07K5/083; A61K38/00; A61K38/55; A61P3/10; A61P9/14; A61P43/00; C12N9/99
Domestic Patent References:
| WO2006108211A1 | 2006-10-19 | |||
| WO2010077988A2 | 2010-07-08 | |||
| WO2010072327A2 | 2010-07-01 | |||
| WO2003031574A2 | 2003-04-17 | |||
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| WO1999048910A1 | 1999-09-30 | |||
| WO2006068480A2 | 2006-06-29 | |||
| WO2003044044A1 | 2003-05-30 |
Foreign References:
| CN1660888A | 2005-08-31 | |||
| JPH0899994A | 1996-04-16 | |||
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| JP2008527011A | 2008-07-24 | |||
| US20080075904A1 | 2008-03-27 | |||
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Other References:
MINERVINI F. ET AL.: "Angiotensin I-converting- enzyme-inhibitory and antibacterial peptides from Lactobacillus helveticus PR4 proteinase- hydrolyzed caseins of milk from six species.", APPL. ENVIRON. MICROBIOL., vol. 69, no. 9, 2003, pages 5297 - 5305, XP002991856
VAN PLATERINK C.J. ET AL.: "Application of at- line two-dimensional liquid chromatography-mass spectrometry for identification of small hydrophilic angiotensin I-inhibiting peptides in milk hydrolysates.", ANAL. BIOANAL. CHEM., vol. 391, no. 1, 2008, pages 299 - 307, XP019621367
RYAN K. ET AL.: "Construction of sequence- selective peptide receptors from conformationally restricted eta- and theta- amino acids.", BIOORG. MED. CHEM. LETT., vol. 9, no. 18, 1999, pages 2673 - 2678, XP004179950
"SHOKUHINBUNSEKIHO", 1984, KORIN PUBLISHING CO., LTD., article "Food analysis method", pages: 102
MITSUDA ET AL.: "SHOKUHINKOGAKU JIKKENSHO", 1970, YOKENDO CO., LTD., pages: 547
ENDOCRINE JOURNAL, vol. 58, no. 1, 2011, pages 69 - 73
J AM COLL CARDIOL., vol. 59, no. 3, 2012, pages 265 - 76
DIABETES CARE., vol. 34, no. 9, 2011, pages 2072 - 7
CARDIOVASCULAR DIABETOLOGY, vol. 10, no. 85, 2011, Retrieved from the Internet
KATO, T. ET AL., BIOCHEM. MED., vol. 19, 1978, pages 351
ARAUJO, M.C. ET AL., BIOCHEMISTRY, vol. 39, 2000, pages 8519
See also references of EP 2824110A4
VAN PLATERINK C.J. ET AL.: "Application of at- line two-dimensional liquid chromatography-mass spectrometry for identification of small hydrophilic angiotensin I-inhibiting peptides in milk hydrolysates.", ANAL. BIOANAL. CHEM., vol. 391, no. 1, 2008, pages 299 - 307, XP019621367
RYAN K. ET AL.: "Construction of sequence- selective peptide receptors from conformationally restricted eta- and theta- amino acids.", BIOORG. MED. CHEM. LETT., vol. 9, no. 18, 1999, pages 2673 - 2678, XP004179950
"SHOKUHINBUNSEKIHO", 1984, KORIN PUBLISHING CO., LTD., article "Food analysis method", pages: 102
MITSUDA ET AL.: "SHOKUHINKOGAKU JIKKENSHO", 1970, YOKENDO CO., LTD., pages: 547
ENDOCRINE JOURNAL, vol. 58, no. 1, 2011, pages 69 - 73
J AM COLL CARDIOL., vol. 59, no. 3, 2012, pages 265 - 76
DIABETES CARE., vol. 34, no. 9, 2011, pages 2072 - 7
CARDIOVASCULAR DIABETOLOGY, vol. 10, no. 85, 2011, Retrieved from the Internet
KATO, T. ET AL., BIOCHEM. MED., vol. 19, 1978, pages 351
ARAUJO, M.C. ET AL., BIOCHEMISTRY, vol. 39, 2000, pages 8519
See also references of EP 2824110A4
Attorney, Agent or Firm:
WATANABE Kaoru et al. (JP)
Kaoru Watanabe (JP)
Kaoru Watanabe (JP)
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