Title:
DIPHENYL ETHER COMPOUND, PROCESS FOR PRODUCING THE SAME, AND USE
Document Type and Number:
WIPO Patent Application WO/2005/012221
Kind Code:
A1
Abstract:
A compound represented by the general formula (I): (wherein rings A, B, and D each independently represents an optionally substituted cyclic group; W represents a spacer whose main chain has 1 to 8 atoms; X represents a spacer whose main chain has 1 or 2 atoms; Y represents a bond or a spacer whose main chain has 1 to 8 atoms; and Z represents an acidic group), a salt or solvate of the compound, or a prodrug of the compound. The compound represented by the general formula (I) has PPAR&dgr agonistic activity and is useful as a preventive and/or therapeutic agent for diseases caused by sugar/lipid abnormal metabolism (diabetes, hyperlipemia, arteriosclerosis, cardiovascular diseases, obesity, metabolic syndrome, etc.), hypertension, circulartory diseases, inflammatory skin diseases, etc.
Inventors:
KUSUDA SHINYA (JP)
NAKAYAMA YOSHISUKE (JP)
IMA MASAKI (JP)
TAJIMA HISAO (JP)
KATO SACHIKO (JP)
NAKAYAMA YOSHISUKE (JP)
IMA MASAKI (JP)
TAJIMA HISAO (JP)
KATO SACHIKO (JP)
Application Number:
PCT/JP2004/011424
Publication Date:
February 10, 2005
Filing Date:
August 03, 2004
Export Citation:
Assignee:
ONO PHARMACEUTICAL CO (JP)
KUSUDA SHINYA (JP)
NAKAYAMA YOSHISUKE (JP)
IMA MASAKI (JP)
TAJIMA HISAO (JP)
KATO SACHIKO (JP)
KUSUDA SHINYA (JP)
NAKAYAMA YOSHISUKE (JP)
IMA MASAKI (JP)
TAJIMA HISAO (JP)
KATO SACHIKO (JP)
International Classes:
A61P3/04; A61P3/06; A61P3/10; A61P9/10; A61P9/12; A61P43/00; C07C65/24; C07C217/90; C07D213/30; C07D263/32; (IPC1-7): C07C59/68; A61K31/192; A61K31/357; A61K31/4164; A61K31/421; A61K31/44; A61K31/4418; A61K31/60; A61K31/625; A61K45/00; A61P3/04; A61P3/06; A61P3/10; A61P9/10; A61P9/12; A61P43/00; C07C62/34; C07C65/24; C07C65/28; C07C217/90; C07C233/29; C07D213/30; C07D263/32; C07D277/20; C07D317/46; C07D333/08
Domestic Patent References:
WO2003024395A2 | 2003-03-27 |
Foreign References:
JP2003510304A | 2003-03-18 | |||
JP2001072653A | 2001-03-21 | |||
JPH11140038A | 1999-05-25 | |||
JP2002543065A | 2002-12-17 |
Other References:
FELDMAN K.S., SAHASRABUDHE K.: "Ellegitannin chemistry sytheses of tellimangrandin II and a dehydrodigalloyl ehter-containing dimeric gallotannin analogue of coriariin A", JOURNAL OF ORGANIC CHEMISTRY, vol. 64, no. 1, 1999, pages 209 - 216, XP002162591
See also references of EP 1661879A4
See also references of EP 1661879A4
Attorney, Agent or Firm:
Ohie, Kunihisa (Selva-Ningyocho 6F 14-6, Nihonbashi-Ningyocho 2-chom, Chuo-ku Tokyo, JP)
Download PDF:
Previous Patent: CYCLOALKYLIDENE COMPOUNDS AS MODULATORS OF ESTROGEN RECEPTOR
Next Patent: ALICYCLIC ESTER WITH MUSK FRAGRANCE
Next Patent: ALICYCLIC ESTER WITH MUSK FRAGRANCE