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Patent Searching and Data


Title:
DIPHENYL ETHER COMPOUND, PROCESS FOR PRODUCING THE SAME, AND USE
Document Type and Number:
WIPO Patent Application WO/2005/012221
Kind Code:
A1
Abstract:
A compound represented by the general formula (I): (wherein rings A, B, and D each independently represents an optionally substituted cyclic group; W represents a spacer whose main chain has 1 to 8 atoms; X represents a spacer whose main chain has 1 or 2 atoms; Y represents a bond or a spacer whose main chain has 1 to 8 atoms; and Z represents an acidic group), a salt or solvate of the compound, or a prodrug of the compound. The compound represented by the general formula (I) has PPAR&dgr agonistic activity and is useful as a preventive and/or therapeutic agent for diseases caused by sugar/lipid abnormal metabolism (diabetes, hyperlipemia, arteriosclerosis, cardiovascular diseases, obesity, metabolic syndrome, etc.), hypertension, circulartory diseases, inflammatory skin diseases, etc.

Inventors:
Kusuda, Shinya c/o Ono Pharmaceutical Co. Ltd. (1-1, Sakurai 3-chome, Shimamoto-ch, Mishima-gun Osaka, 618-8585, JP)
Nakayama, Yoshisuke c/o Ono Pharmaceutical Co. Ltd. (1-1, Sakurai 3-chome, Shimamoto-ch, Mishima-gun Osaka, 618-8585, JP)
Ima, Masaki c/o Ono Pharmaceutical Co. Ltd. (1-1, Sakurai 3-chome, Shimamoto-ch, Mishima-gun Osaka, 618-8585, JP)
Tajima, Hisao c/o Ono Pharmaceutical Co. Ltd. (1-1, Sakurai 3-chome, Shimamoto-ch, Mishima-gun Osaka, 618-8585, JP)
Kato, Sachiko c/o Ono Pharmaceutical Co. Ltd. (1-1, Sakurai 3-chome, Shimamoto-ch, Mishima-gun Osaka, 618-8585, JP)
Application Number:
PCT/JP2004/011424
Publication Date:
February 10, 2005
Filing Date:
August 03, 2004
Export Citation:
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Assignee:
ONO PHARMACEUTICAL CO., LTD. (1-5 Doshomachi 2-chome, Chuo-ku Osaka-shi, Osaka, 541-8526, JP)
Kusuda, Shinya c/o Ono Pharmaceutical Co. Ltd. (1-1, Sakurai 3-chome, Shimamoto-ch, Mishima-gun Osaka, 618-8585, JP)
Nakayama, Yoshisuke c/o Ono Pharmaceutical Co. Ltd. (1-1, Sakurai 3-chome, Shimamoto-ch, Mishima-gun Osaka, 618-8585, JP)
Ima, Masaki c/o Ono Pharmaceutical Co. Ltd. (1-1, Sakurai 3-chome, Shimamoto-ch, Mishima-gun Osaka, 618-8585, JP)
Tajima, Hisao c/o Ono Pharmaceutical Co. Ltd. (1-1, Sakurai 3-chome, Shimamoto-ch, Mishima-gun Osaka, 618-8585, JP)
Kato, Sachiko c/o Ono Pharmaceutical Co. Ltd. (1-1, Sakurai 3-chome, Shimamoto-ch, Mishima-gun Osaka, 618-8585, JP)
International Classes:
A61P3/04; A61P3/06; A61P3/10; A61P9/10; A61P9/12; A61P43/00; C07C65/24; C07C217/90; C07D213/30; C07D263/32; (IPC1-7): C07C59/68; A61K31/192; A61K31/357; A61K31/4164; A61K31/421; A61K31/44; A61K31/4418; A61K31/60; A61K31/625; A61K45/00; A61P3/04; A61P3/06; A61P3/10; A61P9/10; A61P9/12; A61P43/00; C07C62/34; C07C65/24; C07C65/28; C07C217/90; C07C233/29; C07D213/30; C07D263/32; C07D277/20; C07D317/46; C07D333/08
Attorney, Agent or Firm:
Ohie, Kunihisa (Ohie Patent Office, Selva-Ningyocho 6F 14-6, Nihonbashi-Ningyocho 2-chom, Chuo-ku Tokyo, 103-0013, JP)
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