Title:
DIPHENYL KETOALDEHYDE DERIVATIVES WITH ANTI-HIV ACTIVITY
Document Type and Number:
WIPO Patent Application WO2001070216
Kind Code:
A3
Abstract:
Use of xenaldial, xenalemine and xenalic acid for the treatment of HIV infections and related conditions, particularly AIDS. The invention also relates to pharmaceutical compositions in the form of combined preparations, comprising a compound selected from the group of xenaldial, xenalamine and xenalic acid, and at least an anti-HIV agent selected from the group of protease inhibitors, revers transcriptase inhibitors and integrase inhibitors.
Inventors:
TARRO GIULIO (IT)
Application Number:
PCT/EP2001/003343
Publication Date:
December 27, 2001
Filing Date:
March 23, 2001
Export Citation:
Assignee:
UNIHART CORP (IE)
TARRO GIULIO (IT)
TARRO GIULIO (IT)
International Classes:
A61K31/12; A61K31/121; A61K31/196; A61K45/00; A61P31/18; (IPC1-7): A61K31/12; A61K31/196; A61P31/18
Foreign References:
| US5147652A | 1992-09-15 |
Other References:
HAZUDA D J ET AL: "Inhibitors of strand transfer that prevent integration and inhibit HIV - 1 replication in cells.", SCIENCE, (2000 JAN 28) 287 (5453) 646-50., XP002175834
MAGRASSI, F. ET AL: "Mechanism of antiviral activity of biphenyl ketoaldehydes", PROC. CONGR. HUNG. ASS. MICROBIOL., 4TH, BUDAPEST (1966), VOLUME DATE 1964 11-20, XP001013381
MAGRASSI, F. ET AL: "The mechanism of action of a group of antiviral drugs (biphenyl ketoaldehydes and their derivatives), and factors which interfere with their protective activity in vivo", INTERN. CONGR. CHEMOTHERAPY, PROC., 3RD, STUTTGART (1964), 1963(1), 783-95, XP001017961
ALTUCCI, PAOLO ET AL: "Mechanism of action of biphenyl ketoaldehyde derivatives", CHEMOTHERAPY (1969), 14(2), 86-92, XP001013474
TARRO G. ET AL: "[Some biological and immunologic characteristics of the virus of murine hepatitis inactivated in vitro by xenygloxal ]. SU ALCUNE CARATTERISTICHE BIOLOGICHE ED IMMUNOLOGICHE DEL VIRUS DELL'EPATITE MURINA (MHV3) INATTIVATO IN VITRO DALLO XENALDIALE.", RASSEGNA DI MEDICINA SPERIMENTALE, (1975) 22/2-3 (81-89). CODEN: RMSPAY, XP001013519
MAGRASSI, F. ET AL: "Mechanism of antiviral activity of biphenyl ketoaldehydes", PROC. CONGR. HUNG. ASS. MICROBIOL., 4TH, BUDAPEST (1966), VOLUME DATE 1964 11-20, XP001013381
MAGRASSI, F. ET AL: "The mechanism of action of a group of antiviral drugs (biphenyl ketoaldehydes and their derivatives), and factors which interfere with their protective activity in vivo", INTERN. CONGR. CHEMOTHERAPY, PROC., 3RD, STUTTGART (1964), 1963(1), 783-95, XP001017961
ALTUCCI, PAOLO ET AL: "Mechanism of action of biphenyl ketoaldehyde derivatives", CHEMOTHERAPY (1969), 14(2), 86-92, XP001013474
TARRO G. ET AL: "[Some biological and immunologic characteristics of the virus of murine hepatitis inactivated in vitro by xenygloxal ]. SU ALCUNE CARATTERISTICHE BIOLOGICHE ED IMMUNOLOGICHE DEL VIRUS DELL'EPATITE MURINA (MHV3) INATTIVATO IN VITRO DALLO XENALDIALE.", RASSEGNA DI MEDICINA SPERIMENTALE, (1975) 22/2-3 (81-89). CODEN: RMSPAY, XP001013519
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