DIPHENYLBUTANE AMIDE DERIVATIVES

Title:

DIPHENYLBUTANE AMIDE DERIVATIVES

Document Type and Number:

WIPO Patent Application WO/2003/027060

Kind Code:

A1

Abstract:

It is intended to provide compounds represented by the following general formula (1), which show a higher selectivity for muscarinic receptor in smooth muscle than for muscarinic receptor in heart and have a potent antagonism, salts thereof and hydrates of the same: (1) wherein X represents hydrogen or hydroxy&semi R₁ represents hydrogen or 1−deoxy−D−glucopyranuronate&semi and R₂ represents 4,5−dioxo−2−methylimidazolidinyl, 1−(2−methyl−1−imidazolio)−1−deoxy−β−D−puranuronate, etc.

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Inventors:

ARAYA ICHIRO (JP)
TSUBUKI TAKESHI (JP)
NUMATA MAKOTO (JP)
SAITO TATSUHIRO (JP)
MIYACHI HIROYUKI (JP)

Application Number:

PCT/JP2002/009424

Publication Date:

April 03, 2003

Filing Date:

September 13, 2002

Export Citation:

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Assignee:

KYORIN SEIYAKU KK (JP)
ARAYA ICHIRO (JP)
TSUBUKI TAKESHI (JP)
NUMATA MAKOTO (JP)
SAITO TATSUHIRO (JP)
MIYACHI HIROYUKI (JP)

International Classes:

A61K31/165; A61K31/7056; A61P1/12; C07C237/22; C07H13/04; C07H19/052; (IPC1-7): C07C233/56; A61K31/165; A61K31/7056; A61P1/12; C07C237/22; C07C257/14; C07D233/12; C07H17/02; A61K13/00

Domestic Patent References:

WO1995015951A1

1995-06-15

Attorney, Agent or Firm:

Minoura, Kiyoshi (2-2 Kudankita 3-chom, Chiyoda-ku Tokyo, JP)

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