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Title:
DIPHOSPHINO METALLIC COMPLEXES, METHODS OF MAKING AND USING
Document Type and Number:
WIPO Patent Application WO/2018/121465
Kind Code:
A1
Abstract:
Diphosphino metallic complexes, methods of making and using are described. The complexes display cytotoxicity against a panel of cancer cell lines, and optionally display luminescent properties. They have improved solubility and are stable against hydrolysis in physiologically reducing conditions. In some aspects, the complexes are iridium (III) diphosphine complexes. The compounds and pharmaceutical compositions thereof can be administered to a subject in need thereof to treat a host of diseases and disorders including but not limited to, proliferative disorders such as cancer.

Inventors:
CHE, Chi-Ming (Flat 5, 5th Floor Block A,Parkway Court, 4 Park Roa, Hong Kong Hong Kong, Kong, CN)
FAISAL, Mehmood (Flat 722, Block 3Yat King House, Lai King Estat, Hong Kong Hong Kong, Kong, CN)
LOK, Chun Nam (Flat A, 17th Floor1-6, Ying Wah Terrac, Hong Kong Hong Kong, Kong, CN)
Application Number:
CN2017/118205
Publication Date:
July 05, 2018
Filing Date:
December 25, 2017
Export Citation:
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Assignee:
THE UNIVERSITY OF HONG KONG (Pokfulam Road, Hong Kong, Hong Kong, Kong, CN)
International Classes:
C07F15/00; A61K31/28; A61K31/295; A61P35/00; C07F11/00; C07F13/00
Domestic Patent References:
WO2005118606A12005-12-15
Foreign References:
US20060099446A12006-05-11
Other References:
YOUSEFI, REZA ET AL.: "The Anticancer Activity and HSA Binding Properties of the Structurally Related Platinum (II) Complexes", APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, vol. 167, no. 4, 24 May 2012 (2012-05-24), pages 861 - 872, XP035067027
SAMARI, FAYEZEH ET AL.: "Affinity of Two Novel Five-Coordinated Anticancer Pt(II) Complexes to Human and Bovine Serum Albumins: A Spectroscopic Approach", INORGANIC CHEMISTRY, vol. 51, no. 6, 24 February 2012 (2012-02-24), pages 3454 - 3464, XP055515832
FREZZA ET AL.: "In Vitro and In Vivo Antitumor Activities and DNA Binding Mode of Five Coordinated Cyclometalated Organoplatinum(II) Complexes Containing Biphosphine Ligands", JOURNAL OF MEDICINAL CHEMISTRY, vol. 54, no. 18, 4 August 2011 (2011-08-04), pages 6166 - 6176, XP055515833
ELLERMANN, JOCHEN ET AL.: "Neue Iridium-Komplexe mit N,N-Bis(dipheny1phosphino)alkyl und -arylaminen", CHEMISCHE BERICHTE, CHEMISTRY OF POLYFUNCTIONAL LIGANDS 62, vol. 114, no. 6, 31 December 1981 (1981-12-31), pages 2322 - 2335, XP055515836
ELLERMANN, JOCHEN ET AL.: "About Iridium(l) and platinum(II) complexes of bis(diphenylphosphino)amine and oxidative addition of small molecules to di[bis(diphenylphosphino)amine]iridium(I) chloride", ZEITSCHRIFT FUR NATURFORSCHUNG B: CHEMISTRY OF POLYFUNCTIONAL LIGANDS 57, vol. 35, 1 March 1980 (1980-03-01), pages 307 - 315, XP055515841
Attorney, Agent or Firm:
PANAWELL & PARTNERS, LLC (1002-1005, China Life Tower16 Chao Yang Men Wai Street, Chaoyang District, Beijing 0, 100020, CN)
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