Title:
DIQUAFOSOL-CONTAINING EYE DROP
Document Type and Number:
WIPO Patent Application WO/2013/146649
Kind Code:
A1
Abstract:
In a diquafosol eye drop containing a chelating agent at a concentration of 0.0001 to 1% (w/v), the production of insoluble precipitates during storage, which is usually observed in a diquafosol eye drop, and the deterioration in filtering performane during a production process (a filter sterilization process) can be prevented. In a diquafosol eye drop containing a chelating agent, the reduction in eye irritation and the improvement in preservative efficacy compared with those in a diquafosol eye drop that does not contain any chelating agent are observed. Therefore, in the present invention, stable physicochemical properties can be achieved during the course of production and distribution and during the course of storage by a patient, and the reduction in eye irritation and the improvement in preservative efficacy are observed. Particularly in a diquafosol eye drop containing a chelating agent, the deterioration in filtering performance during a production process (a filter sterilization process) is prevented. Therefore, highly efficient filter sterilization can be achieved during the course of production, which contributes to the reduction in production cost.
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Inventors:
SAKATANI AKIKO (JP)
IKEI TATSUO (JP)
INAGAKI KOJI (JP)
NAKAMURA MASATSUGU (JP)
HOSOI KAZUHIRO (JP)
SAITO MIKIKO (JP)
SONODA MASAKI (JP)
FUKUI YOKO (JP)
KUWANO MITSUAKI (JP)
IKEI TATSUO (JP)
INAGAKI KOJI (JP)
NAKAMURA MASATSUGU (JP)
HOSOI KAZUHIRO (JP)
SAITO MIKIKO (JP)
SONODA MASAKI (JP)
FUKUI YOKO (JP)
KUWANO MITSUAKI (JP)
Application Number:
PCT/JP2013/058519
Publication Date:
October 03, 2013
Filing Date:
March 25, 2013
Export Citation:
Assignee:
SANTEN PHARMACEUTICAL CO LTD (JP)
International Classes:
A61K31/7084; A61K9/08; A61K47/04; A61K47/12; A61K47/24; A61P27/02
Domestic Patent References:
| WO2012090994A1 | 2012-07-05 |
Foreign References:
| JP2002053492A | 2002-02-19 | |||
| JP2003160491A | 2003-06-03 | |||
| JP3652707B2 | 2005-05-25 | |||
| JP2007182438A | 2007-07-19 | |||
| JP2001510484A | 2001-07-31 |
Other References:
CORNEA, vol. 23, no. 8, 2004, pages 784 - 792
"Japanese Pharmacopoeia"
See also references of EP 2832359A4
"Japanese Pharmacopoeia"
See also references of EP 2832359A4
Attorney, Agent or Firm:
Fukami Patent Office, p. c. (JP)
Patent business corporation Fukami patent firm (JP)
Patent business corporation Fukami patent firm (JP)
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