Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
DIRECT WRITE NANOLITHOGRAPHIC DEPOSITION OF NUCLEIC ACIDS FROM NANOSCOPIC TIPS
Document Type and Number:
WIPO Patent Application WO2003048314
Kind Code:
A3
Abstract:
The use of direct-write nanolithography to generate anchored, nanoscale patterns of nucleic acid on different substrates is described, including electrically conductive and insulating substrates. Modification of nucleic acid, including oligonucleotides, with reactive groups such as thiol groups provides for patterning with use of appropriate scanning probe microscopic tips under appropriate conditions. The reactive groups provide for chemisorption or covalent bonding to the substrate surface. The resulting nucleic acid features, which exhibit good stability, can be hybridized with complementary nucleic acids and probed accordingly with use of, for example, nanoparticles functionalized with nucleic acids. Patterning can be controlled by selection of tip treatment, relative humidity, and nucleic acid structure.

More Like This:
WO/2021/153789METHOD FOR DETECTING INTRAUTERINE INFECTION
WO/2010/058974METHOD FOR COLLECTIVELY DETERMINING SENSITIVITY TO ANTI-CANCER THERAPEUTIC DRUG
JP2599096COMPOSITION FOR ASSAYING FREE LIGAND
Inventors:
MIRKIN CHAD A (US)
DEMERS M LINETTE (US)
GINGER DAVID S (US)
Application Number:
PCT/US2002/038252
Publication Date:
August 28, 2003
Filing Date:
December 02, 2002
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
NORTHWESTERN UNIVERSITY TECHNO (US)
MIRKIN CHAD A (US)
DEMERS M LINETTE (US)
GINGER DAVID S (US)
International Classes:
G01N33/53; B01J19/00; B01L3/00; B01L3/02; B82B3/00; C12M1/00; C12N15/09; C12Q1/68; C40B40/02; C40B50/06; C40B60/12; G01N37/00; G01Q60/24; G01Q60/38; G01Q60/42; G01Q80/00; G01Q90/00; G03F7/00; (IPC1-7): G01N1/10; G01N1/00; G01N15/06; B01L3/02; B01L3/00; B05D5/00; C12Q1/68
Foreign References:
US20030092029A12003-05-15
US20030087277A12003-05-08
US20030068638A12003-04-10
US20030068446A12003-04-10
US20020172953A12002-11-21
US20020165675A12002-11-07
US20020063212A12002-05-30
US20020034756A12002-03-21
US6361944B12002-03-26
US6286765B12001-09-11
US5985353A1999-11-16
US6037124A2000-03-14
Other References:
See also references of EP 1461596A4
Download PDF:
View/Download PDF      PDF Help



 
Previous Patent: CELL CULTURE MEDIA

Next Patent: ANTISENSE MODULATION OF MDM2 EXPRESSION