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Title:
DISALICYLATE ANALOG BASED SIALYL LEWIS MIMETICS
Document Type and Number:
WIPO Patent Application WO1999029706
Kind Code:
A3
Abstract:
The present invention discloses medicaments that are selectin-ligand structural mimetics that bind to certain selectins wherein the mimetics may lack the sialic acid and/or fucose of the natural selecting ligand, sialyl Lewis (sLe), but have a structure capable of mimicking the structural features necessary for selectin recognition. In particular, the invention compounds mimic the key structural features of the oligosaccharides responsible for selectin-mediated cell adhesion. These features consist of the charge-distance-coordination relationship between the carboxylic acid functionality of sialic acid at a distance of 8-12 angstroms of the L-fucose moiety. The invention compounds are disalicylate, its analogs, and disalicylate-based C-glycoside compounds. The present invention also discloses methods of treating selectin-mediated disorders comprising administering the compounds disclosed.

Inventors:
ANDERSON MARK B (US)
LEVY DANIEL E (US)
HOLME KEVIN R (US)
Application Number:
PCT/US1998/025788
Publication Date:
August 12, 1999
Filing Date:
December 04, 1998
Export Citation:
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Assignee:
GLYCOMED INC (US)
SANKYO CO (JP)
ANDERSON MARK B (US)
LEVY DANIEL E (US)
HOLME KEVIN R (US)
International Classes:
C07C65/105; C07C65/40; C07C66/02; C07C69/94; C07H15/18; (IPC1-7): C07D309/10; A61K31/70
Domestic Patent References:
WO1994018189A11994-08-18
WO1998031697A11998-07-23
WO1997001335A11997-01-16
WO1992001664A11992-02-06
WO1991015200A21991-10-17
WO1997030984A11997-08-28
Foreign References:
DE4122210A11993-01-14
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