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Title:
DISCOIDIN DOMAIN RECEPTOR 1 INHIBITOR AND ACTIVATOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/171726
Kind Code:
A1
Abstract:
The present invention relates to a use of a discoidin domain receptor 1 (DDR1) inhibitor in preparing a drug for preventing or treating osteoarthritis. The present invention also relates to a use of a DDR1 activator in preparing a drug for preventing or treating a disorder related to abnormal endochondral ossification.

Inventors:
WANG CHAU-ZEN (CN)
CHEN CHUNG-HWAN (CN)
CHOU LIANG-YIN (CN)
CHOU YU (CN)
HO MEI-LING (CN)
LIN YI-HSIUNG (CN)
Application Number:
PCT/CN2018/080238
Publication Date:
September 27, 2018
Filing Date:
March 23, 2018
Export Citation:
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Assignee:
UNIV KAOHSIUNG MEDICAL (CN)
International Classes:
C07D487/04; A61K31/519; A61K31/5377; A61P19/02
Domestic Patent References:
WO2008021369A22008-02-21
WO2008058341A12008-05-22
WO2010062038A22010-06-03
WO2013074986A12013-05-23
WO2016064970A12016-04-28
WO2013068836A12013-05-16
Foreign References:
CN103965195A2014-08-06
Other References:
WANG, HAILONG ET AL.: "BMP-2 Collagen Sponge Repair the Rabbit Ear Cartilage Defects in Rabbits", NATIONAL MEDICAL FRONTIERS OF CHINA, vol. 7, no. 7, 30 April 2012 (2012-04-30), pages 31 - 33
GAO M ET AL.: "Discovery and Optimization of 3-(2-(Pyrazolo[1,5-a]pyrimidin-6-yl)-ethynyl) benzamides as Novel Selective and Orally Bioavailable Discoidin Domain Receptor 1(DDR1) Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, vol. 56, no. 8, 25 April 2013 (2013-04-25), pages 3281 - 3295, XP055542037
Attorney, Agent or Firm:
TEE&HOWE INTELLECTUAL PROPERTY ATTORNEYS (CN)
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