Title:
DISCONTINUOUS FLUIDIC SYSTEMS FOR POINT-OF-CARE ANALYTE MEASUREMENT
Document Type and Number:
WIPO Patent Application WO/2015/113047
Kind Code:
A3
Abstract:
Disclosed herein are systems and methods for using the controlled movement of magnetic particles using controlled magnetic fields in a fluidic device containing separated fluidic regions to detect analytes in solution by immunoassay, such as an enzyme-linked immunosorbant assay (ELISA) for various medical and scientific applications. In order to achieve sequential exposure to the different chemical environments required in an immunoassay, magnetic particles are driven through fluid-containing chambers separated by air-gaps that may take the form of air bubbles or small open-air separations, for example. Externally controlled magnets coupled to actuators draw the flow of magnetic particles through air-liquid interfaces produced by microfluidic surface tension at the air-gap, washing the particles.
Inventors:
CHATTERJEE DEV KUMAR (US)
VARADHACHARY ATUL (US)
LINBECK LEO III (US)
VARADHACHARY ATUL (US)
LINBECK LEO III (US)
Application Number:
PCT/US2015/013097
Publication Date:
November 12, 2015
Filing Date:
January 27, 2015
Export Citation:
Assignee:
BREVITEST TECHNOLOGIES LLC (US)
International Classes:
B03C1/02
Foreign References:
| US20110008813A1 | 2011-01-13 | |||
| US20070287198A1 | 2007-12-13 | |||
| US20090246782A1 | 2009-10-01 | |||
| US20110053289A1 | 2011-03-03 | |||
| US20040241752A1 | 2004-12-02 |
Attorney, Agent or Firm:
SISTRUNK, Melissa L. (1301 Mckinney Suite 510, Houston TX, US)
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