Title:
DISPLAY PLATFORM FROM BACTERIAL SPORE COAT PROTEINS
Document Type and Number:
WIPO Patent Application WO/2016/140702
Kind Code:
A8
Abstract:
A particle construct is disclosed that includes a synthetic core with a solid surface coated with a lipid bilayer, SpoVM adhered to the lipid bilayer; and SpoIVA adsorbed to the SpoVM. In additional embodiments, an agent of interest can be covalently linked to the SpoIVA. In specific, non-limiting examples, the agent of interest is an enzyme, a detectable marker, a pharmaceutical compound, an immunosuppressant or a vaccine. Methods of using the particle constructs are disclosed, such as for treating infections, treating a tumor, delivering a vaccine, treating an autoimmune disorder or ameliorating an allergic reaction. Method are also disclosed for degrading an environmental pollutant. Methods are also disclosed for producing these particle constructs.
Inventors:
RAMAMURTHI KUMARAN S (US)
WU I-LIN (US)
WU I-LIN (US)
Application Number:
PCT/US2015/044316
Publication Date:
October 13, 2016
Filing Date:
August 07, 2015
Export Citation:
Assignee:
US HEALTH (US)
International Classes:
A61K9/12
Attorney, Agent or Firm:
SIEGEL, Susan, Alpert (LLPOne World Trade Center, Suite 1600,121 SW Salmon Stree, Portland OR, US)
Download PDF: