Title:
DITHIOL DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2000/020385
Kind Code:
A1
Abstract:
Novel glutathione reductase activity intensifiers, which are compounds having general formula (I) and pharmacologically acceptable salts, thioesters, and other derivatives thereof, wherein m is 0 or 1; n is 2 when m is 0, and n is 1 when m is 1; k is an integer of 0 to 12; R?1¿ is hydrogen, one member selected from substituents $g(a), etc.; A is a group having -N(R?2¿)CO-, -CON(R?2¿)CO-, or -CON(R?2¿)SO¿2?- (R?2¿ is hydrogen, alkyl, etc.), etc; and B is a single bond, -N(R?5¿)- (R?5¿ is hydrogen, alkyl, etc.), etc. [Substituents $g(a)] optionally substituted aryls, optionally substituted heterocyclic groups [Substituents $g(b)] alkyls, halogenated lower alkyls, etc. [Substituents $g(g)] lower alkoxys, hydroxy, etc.
Inventors:
FUJITA TAKASHI (JP)
YOKOYAMA TOMIHISA (JP)
YOKOYAMA TOMIHISA (JP)
Application Number:
PCT/JP1999/005422
Publication Date:
April 13, 2000
Filing Date:
October 01, 1999
Export Citation:
Assignee:
SANKYO CO (JP)
FUJITA TAKASHI (JP)
YOKOYAMA TOMIHISA (JP)
FUJITA TAKASHI (JP)
YOKOYAMA TOMIHISA (JP)
International Classes:
C07C323/44; C07C323/60; C07D295/185; (IPC1-7): C07C323/12; A61K31/16; A61K31/165; A61K31/17; A61K31/175; A61K31/18; A61K31/185; A61K31/195; A61K31/215; A61K31/275; A61K31/40; A61K31/41; A61K31/44; A61K31/445; A61K31/495; A61K31/535; A61P3/00; A61P27/00; A61P35/00; A61P39/00; C07C323/25; C07C323/39; C07C323/52; C07C323/60; C07C335/08; C07D209/10; C07D209/12; C07D209/16; C07D209/18; C07D209/48; C07D213/30; C07D213/36; C07D213/40; C07D213/52; C07D213/54; C07D213/63; C07D213/71; C07D213/74; C07D213/75; C07D213/78; C07D285/01; C07D295/18; C07D295/22; C12N9/96
Domestic Patent References:
| WO1999050238A1 | 1999-10-07 |
Foreign References:
| FR2707983A1 | 1995-01-27 | |||
| EP0947503A1 | 1999-10-06 | |||
| JPS6426516A | 1989-01-27 |
Other References:
KLIUKIENE R. ET AL.: "The protective effects of dihydrolipoamide and glutathione against photodynamic damage by A1-phtalocyanine tetraslfonate", BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL, vol. 41, no. 4, 1997, pages 707 - 713, XP002923631
DIKALOV S. ET AL.: "Determination of Rate Constants of the Reactions of Thiols with Superoxide Radical by Electron Paramagnetic Resonance: Critical Remarks on Spectrophotomeric Approaches", ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, vol. 326, no. 2, 1996, pages 207 - 218, XP002923632
BORGULYA J. ET AL.: "Rearrangement of Derivatives of 1,3-Dithian-5-amine into Bicyclic 2-Thiazolidines. Crystal Structures of cis- and trans-1-(2-Aryl-1,3-dithian-5-yl)-2-thioureas and cis- and trans-5-Aryl-3-imino-7,7a-dihydro-1H,3H,5H-thiazolo(3,4-c)thiazoles", HELVETICA CHIMICA ACTA, vol. 67, no. 7, 1984, pages 1827 - 1842, XP002923633
DIKALOV S. ET AL.: "Determination of Rate Constants of the Reactions of Thiols with Superoxide Radical by Electron Paramagnetic Resonance: Critical Remarks on Spectrophotomeric Approaches", ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, vol. 326, no. 2, 1996, pages 207 - 218, XP002923632
BORGULYA J. ET AL.: "Rearrangement of Derivatives of 1,3-Dithian-5-amine into Bicyclic 2-Thiazolidines. Crystal Structures of cis- and trans-1-(2-Aryl-1,3-dithian-5-yl)-2-thioureas and cis- and trans-5-Aryl-3-imino-7,7a-dihydro-1H,3H,5H-thiazolo(3,4-c)thiazoles", HELVETICA CHIMICA ACTA, vol. 67, no. 7, 1984, pages 1827 - 1842, XP002923633
Attorney, Agent or Firm:
Ohno, Akio (Limited 2-58 Hiromachi 1-chome Shinagawa-ku, Tokyo, JP)
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