Title:
DITHIOLTHIONE COMPOUNDS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS AND FOR MEMORY ENHANCEMENT
Document Type and Number:
WIPO Patent Application WO2001009118
Kind Code:
A3
Abstract:
The invention provides methods to treat neurological disorders such as Alzheimer's disease, or to slow the progression of such diseases, or to treat and/or prevent other disorders as disclosed in the specification, by administering to patients, or delivering to the tissues of such patients, oltipraz or related compounds as disclosed in the specification.
Inventors:
PRENDERGAST PATRICK T (IE)
ARMSTRONG PAUL
ARMSTRONG PAUL
Application Number:
PCT/IB2000/001146
Publication Date:
November 22, 2001
Filing Date:
July 28, 2000
Export Citation:
Assignee:
PRENDERGAST PATRICK T (IE)
International Classes:
A61K31/385; C07D339/02; (IPC1-7): A61K31/497; A61K31/385; A61P25/28; A61P33/02; A61P33/06; A61P39/04; A61P39/00
Domestic Patent References:
WO2000031060A1 | 2000-06-02 | |||
WO1998027970A2 | 1998-07-02 | |||
WO1995001096A1 | 1995-01-12 | |||
WO1994016563A1 | 1994-08-04 |
Foreign References:
EP0236929A2 | 1987-09-16 | |||
EP0641792A1 | 1995-03-08 | |||
DE4343592A1 | 1995-06-22 | |||
US3994923A | 1976-11-30 |
Other References:
DRUKARCH B. ET AL: "Drug treatment of Parkinson 's disease. Time for phase II.", BIOCHEMICAL PHARMACOLOGY, (2000) 59/9 (1023-1031)., XP000981492
TIROSH, OREN ET AL: "Neuroprotective effects of.alpha.-lipoic acid and its positively charged amide analog", FREE RADICAL BIOL. MED. (1999), 22(11/12), 1418-1426, XP000981627
DRINGEN, RALF ET AL: "Anethole dithiolethione, a putative neuroprotectant, increases intracellular and extracellular glutathione levels during starvation of cultured astroglial cells", NAUNYN-SCHMIEDEBERG'S ARCH. PHARMACOL. (1998), 358(6), 616-622, XP000981651
DRUKARCH, BENJAMIN ET AL: "Anethole dithiolethione prevents oxidative damage in glutathione-depleted astrocytes", EUR. J. PHARMACOL. (1997), 329(2/3), 259-262, XP000981645
PATENT ABSTRACTS OF JAPAN vol. 012, no. 037 (C - 473) 4 February 1988 (1988-02-04)
DATABASE WPI Section Ch Week 199526, Derwent World Patents Index; Class B03, AN 1995-196725, XP002160434
TIROSH, OREN ET AL: "Neuroprotective effects of.alpha.-lipoic acid and its positively charged amide analog", FREE RADICAL BIOL. MED. (1999), 22(11/12), 1418-1426, XP000981627
DRINGEN, RALF ET AL: "Anethole dithiolethione, a putative neuroprotectant, increases intracellular and extracellular glutathione levels during starvation of cultured astroglial cells", NAUNYN-SCHMIEDEBERG'S ARCH. PHARMACOL. (1998), 358(6), 616-622, XP000981651
DRUKARCH, BENJAMIN ET AL: "Anethole dithiolethione prevents oxidative damage in glutathione-depleted astrocytes", EUR. J. PHARMACOL. (1997), 329(2/3), 259-262, XP000981645
PATENT ABSTRACTS OF JAPAN vol. 012, no. 037 (C - 473) 4 February 1988 (1988-02-04)
DATABASE WPI Section Ch Week 199526, Derwent World Patents Index; Class B03, AN 1995-196725, XP002160434
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