Title:
DJ-1 DERIVATIVE HAVING ACIDIFIED CYSTEINE RESIDUE
Document Type and Number:
WIPO Patent Application WO/2005/075513
Kind Code:
A1
Abstract:
A DJ-1 derivative wherein the cysteine residue at the 106-position in DJ-1 has been acidified into cysteinesulfonate. This DJ-1 derivative is useful as a diagnostic marker for neurodegenerative diseases.
Inventors:
KINUMI TOMOYA (JP)
NIKI ETSUO (JP)
KIMATA JUNKO (JP)
NIKI ETSUO (JP)
KIMATA JUNKO (JP)
Application Number:
PCT/JP2005/001478
Publication Date:
August 18, 2005
Filing Date:
February 02, 2005
Export Citation:
Assignee:
NAT INST OF ADVANCED IND SCIEN (JP)
KINUMI TOMOYA (JP)
NIKI ETSUO (JP)
KIMATA JUNKO (JP)
KINUMI TOMOYA (JP)
NIKI ETSUO (JP)
KIMATA JUNKO (JP)
International Classes:
C07K14/47; C07K14/82; C07K16/18; C07K16/32; G01N33/68; (IPC1-7): C07K14/82; C07K16/32; G01N33/68
Other References:
KINUMI T. ET AL: "Cysteine residue to hydrogen peroxide-mediated oxidation in vivo in human umbilical vein endothelial cells.", BIOCHEM. BIOPHYS. RES. COMM., vol. 317, no. 3, 7 May 2004 (2004-05-07), pages 722 - 728, XP004501921
MITSUMOTO A. ET AL: "Oxidized forms of peroxiredoxins and DJ-1 on two-dimensional gels increased in response and sublethal levels of paraquat.", FREE RADIC.RES., vol. 35, no. 3, September 2001 (2001-09-01), pages 301 - 310, XP002989098
MITSUMOTO A. ET AL: "DJ-1 is an indicator for endogenous reactive oxygen species elicited by endotoxin.", FREE RADIC. RES., vol. 35, no. 6, December 2001 (2001-12-01), pages 885 - 893, XP002989099
POOLE L. ET AL: "The non-flavin redox center of the streptococcal NADH peroxidase. II.-Evidence for a stabilized cysteine-sulfenic acid.-.", J.BIOL. CHEM., vol. 264, no. 21, 25 July 1989 (1989-07-25), pages 12330 - 12338, XP002989100
BONIFATI V. ET AL: "Mutations in the DJ-+ gene associated with autosomal recessive early-onset parkinsonism.", SCIENCE, vol. 299, no. 5604, 10 January 2003 (2003-01-10), pages 256 - 259, XP002989501
WILSON M. ET AL: "The I.1-A resolution crystal structure of DJ-1, the protein mutated in autosomal recessive early onset Parkinson's disease.", PROC. NATL. ACAD. SCI.USA, vol. 100, no. 16, August 2003 (2003-08-01), USA, pages 9256 - 61, XP002989502
MITSUMOTO A. ET AL: "Oxidized forms of peroxiredoxins and DJ-1 on two-dimensional gels increased in response and sublethal levels of paraquat.", FREE RADIC.RES., vol. 35, no. 3, September 2001 (2001-09-01), pages 301 - 310, XP002989098
MITSUMOTO A. ET AL: "DJ-1 is an indicator for endogenous reactive oxygen species elicited by endotoxin.", FREE RADIC. RES., vol. 35, no. 6, December 2001 (2001-12-01), pages 885 - 893, XP002989099
POOLE L. ET AL: "The non-flavin redox center of the streptococcal NADH peroxidase. II.-Evidence for a stabilized cysteine-sulfenic acid.-.", J.BIOL. CHEM., vol. 264, no. 21, 25 July 1989 (1989-07-25), pages 12330 - 12338, XP002989100
BONIFATI V. ET AL: "Mutations in the DJ-+ gene associated with autosomal recessive early-onset parkinsonism.", SCIENCE, vol. 299, no. 5604, 10 January 2003 (2003-01-10), pages 256 - 259, XP002989501
WILSON M. ET AL: "The I.1-A resolution crystal structure of DJ-1, the protein mutated in autosomal recessive early onset Parkinson's disease.", PROC. NATL. ACAD. SCI.USA, vol. 100, no. 16, August 2003 (2003-08-01), USA, pages 9256 - 61, XP002989502
Attorney, Agent or Firm:
Saegusa, Eiji (1-7-1 Doshomachi, Chuo-k, Osaka-shi Osaka 45, JP)
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