Title:
DKK1 PROTEIN PRESENT SPECIFICALLY IN REGULATORY T CELLS AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/208108
Kind Code:
A1
Abstract:
The present invention relates to a Dickkopf-1 protein present specifically on the surface of regulatory T cells (Treg cells) among immune cells, an antibody specific therefor, and a use thereof. Being present specifically on the surface of immune cells, inter alia, regulatory T cells, the Dickkopt-1 (DKK1) protein of the present invention can be a new target of various therapeutic agents for immune-related diseases.
Inventors:
KIM JUNG HO (KR)
KIM BEOM SEOK (KR)
KIM BEOM SEOK (KR)
Application Number:
PCT/KR2018/005398
Publication Date:
November 15, 2018
Filing Date:
May 10, 2018
Export Citation:
Assignee:
GOOD T CELLS INC (KR)
International Classes:
A61K39/395; A61K39/00; C07K16/28; G01N33/569
Foreign References:
| US20120023600A1 | 2012-01-26 | |||
| US20050084494A1 | 2005-04-21 |
Other References:
ZHANG, X. ET AL.: "Designation of a Novel DKK1 Multiepitope DNA Vaccine and Inhibition of Bone Loss in Collagen-induced Arthritic Mice", BIOMED RESEARCH INTERNATIONAL, vol. 2015, 2015, pages 1 - 9, XP055568092
QIAN, J. ET AL.: "DKK1 as a Novel Target for Myeloma Immunotherapy", ONCOIMMUNOLOGY, vol. 1, no. 5, 2012, pages 756 - 758, XP055568094
DATABASE NCBI [O] 6 May 2017 (2017-05-06), "Dickkopf-related Protein 1 Precursor [Homo sapiens", XP055559631, Database accession no. NP_036374.1
QIAN, J. ET AL.: "Dickkopf-1 (DKK1) Is a Widely Expressed and Potent Turnor-associated Antigen in Multiple Myeloma", BLOOD, vol. 110, no. 5, 2007, pages 1587 - 1594, XP055568100
CHAE, W-J. ET AL.: "Membrane-bound Dickkopf-1 in Foxp3+ Regulatory T Cells Suppresses T- cell -mediated Autoimmune Colitis", IMMUNOLOGY, vol. 152, 27 June 2017 (2017-06-27), pages 265 - 275, XP055568108
RK GERSHONK. KONDO, IMMUNOLOGY, vol. 18, 1970, pages 723 - 37
QIAN, J. ET AL.: "DKK1 as a Novel Target for Myeloma Immunotherapy", ONCOIMMUNOLOGY, vol. 1, no. 5, 2012, pages 756 - 758, XP055568094
DATABASE NCBI [O] 6 May 2017 (2017-05-06), "Dickkopf-related Protein 1 Precursor [Homo sapiens", XP055559631, Database accession no. NP_036374.1
QIAN, J. ET AL.: "Dickkopf-1 (DKK1) Is a Widely Expressed and Potent Turnor-associated Antigen in Multiple Myeloma", BLOOD, vol. 110, no. 5, 2007, pages 1587 - 1594, XP055568100
CHAE, W-J. ET AL.: "Membrane-bound Dickkopf-1 in Foxp3+ Regulatory T Cells Suppresses T- cell -mediated Autoimmune Colitis", IMMUNOLOGY, vol. 152, 27 June 2017 (2017-06-27), pages 265 - 275, XP055568108
RK GERSHONK. KONDO, IMMUNOLOGY, vol. 18, 1970, pages 723 - 37
Attorney, Agent or Firm:
LEE, Jae Young (KR)
Download PDF: