DMAPS-AA-AAS COPOLYMER AND PREPARATION METHOD AND USE THEREOF

WIPO Patent Application WO/2017/201686

A1

The present invention is suitable for the field of preparation and application of a high-molecular polymer, and provides a method for preparing a DMAPS-AA-AAS copolymer, comprising the steps of: adding the monomer DMAPS and the monomer AA to deionized water to obtain a mixed solution; preparaing an initiator solution, adding the initiator to the mixed solution, and then heating the resulting solution to 65 to 85 °C for a reaction of 4 to 6 hours and cooling to room temperature to obtain the DMAPS-AA copolymer; adding a sodium hydroxide solution of 5-15 wt% concentration to the DMAPS-AA copolymer to adjust the pH value and stirring for 2 to 5 hours to obtain the DMAPS-AA-AAS copolymer. Also provided in the present invention is the DMAPS-AA-AAS copolymer prepared by the preparation method descibed above. Also provided is a use of the DMAPS-AA-AAS copolymer. The DMAPS-AA-AAS copolymer provided by the present invention opens up a new way for adjustment of immunological activity of macrophages. The preparation method provided is simple to operate and convenient for mass production.

CHEN SHAOJUN (CN)
ZHUO HAITAO (CN)
REN HUANHUAN (CN)
MEI ZHANKUI (CN)

PCT/CN2016/083280

November 30, 2017

May 25, 2016

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UNIV SHENZHEN (CN)

C08F220/06; A61P17/02; A61P29/00; A61P35/00; A61P37/04; A61P37/06; C08F8/44; C08F220/38

CN104479068A	2015-04-01
US4604212A	1986-08-05
CN104193893A	2014-12-10
CN103923275A	2014-07-16
US4140664A	1979-02-20

HENSEN INTELLECTUAL PROPERTY FIRM (CN)

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