Title:
DNA APTAMER CAPABLE OF BONDING TO VWF
Document Type and Number:
WIPO Patent Application WO/2017/073536
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing an aptamer for vWF, which is superior in a binding ability, a dissociation rate and/or stability to the conventional nucleic acid aptamers. The present invention can solve the problem by a DNA aptamer which contains an artificial nucleotide and can bond to vWF.
Inventors:
HIRAO ICHIRO (JP)
HIRAO MICHIKO (JP)
MATSUNAGA KENICHIRO (JP)
HIRAO MICHIKO (JP)
MATSUNAGA KENICHIRO (JP)
Application Number:
PCT/JP2016/081518
Publication Date:
May 04, 2017
Filing Date:
October 25, 2016
Export Citation:
Assignee:
TAGCYX BIOTECHNOLOGIES (JP)
International Classes:
C12N15/115; A61K31/7115; A61P7/02; A61P9/10; C12Q1/68; G01N33/53
Domestic Patent References:
| WO2010091396A2 | 2010-08-12 | |||
| WO2013073602A1 | 2013-05-23 |
Foreign References:
| US20090203766A1 | 2009-08-13 | |||
| JP2008512098A | 2008-04-24 |
Other References:
HUANG, RH. ET AL.: "A structural explanation for the antithrombotic activity of ARC1172, a DNA aptamer that binds von Willebrand factor domain A1", STRUCTURE, vol. 17, no. 11, 2009, pages 1476 - 1484, XP026748455
KIMOTO, M. ET AL.: "Generation of high-affinity DNA aptamers using an expanded genetic alphabet", NATURE BIOTECHNOLOGY, vol. 31, no. 5, 2013, pages 453 - 457, XP055241916
See also references of EP 3369820A4
KIMOTO, M. ET AL.: "Generation of high-affinity DNA aptamers using an expanded genetic alphabet", NATURE BIOTECHNOLOGY, vol. 31, no. 5, 2013, pages 453 - 457, XP055241916
See also references of EP 3369820A4
Attorney, Agent or Firm:
HIRAKI Yusuke et al. (JP)
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